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Vitamin A deficiency suppresses CEACAM1 to impair colonic epithelial barrier function via downregulating microbial-derived short-chain fatty acids

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Genes & Diseases 2024年第2期11卷 1066-1081页

作者： Junyan Yan Lu Xiao Di Feng Baolin Chen Ting Yang bei tong Ruifang Luo Yuting Wang Jie Chen Children Nutrition Research Center Children's Hospital of Chongqing Medical UniversityChongqing Key Laboratory of Child Nutrition and HealthMinistry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChongqing 401122China Department of Gastroenterology Children's Hospital of Chongqing Medical UniversityChongqing 401122China

Vitamin A (VA) plays an essential role in modulating both the gut microbiota and gut barrier ***-chain fatty acids (SCFAs),as metabolites of the gut microbiota,protect the physiological intestinal barrier;however,they are compromised when VA is ***,there is an urgent need to understand how and which SCFAs modulate colonic epithelial barrier integrity in VA deficiency (VAD).Herein,compared with normal VA rats (VAN),at the beginning of pregnancy,we confirmed that the colonic desmosome junction was impaired in the VAD group,and the amounts of acetate,propionate,and butyrate declined because of the decreased abundance of SCFA-producing bacteria (Romboutsia ,Collinsella ,and Allobaculum ).The differentially expressed genes correlated with the gut barrier and the histone deacetylase complex between the VAD and VAN groups were enriched by RNA *** the VAD group,the expression levels of colonic CEA cell adhesion molecule 1 (CEACAM1) were down-regulated,and the levels of histone deacetylase 1 (HDAC1) and HDAC3 were ***,the above changes in the VAD groups were rescued by VA supplementation in the early postnatal *** study indicated that in Caco-2 cells,butyrate treatment significantly repressed the enrichment of HDAC3 on the promoter of the CEACAM1 gene to induce its *** findings support that butyrate intervention can alleviate the impairment of colonic barrier function caused by VAD,and timely postnatal VA intervention may reverse the damage caused by VAD on gut barrier integrity during pregnancy.

关键词： CEACAM1 Colonic epithelial barrier HDAC3 Short-chain fatty acids Vitamin A deficiency

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审计提升企业合规有效性的作用研究

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经济问题 2024年第1期 123-128,F0003页

作者：徐彰童北南南京审计大学法学院江苏南京211815

如何建立有效的合规计划是企业合规实践中监管机构和企业面临的核心问题。审计通过主动调查企业经营中留存的文件和凭证,依靠实证分析发现危险信号、考核合规效果,使合规计划从“响应式”的被动合规转向主动合规。同时,我国企业合规改... 详细信息

如何建立有效的合规计划是企业合规实践中监管机构和企业面临的核心问题。审计通过主动调查企业经营中留存的文件和凭证,依靠实证分析发现危险信号、考核合规效果,使合规计划从“响应式”的被动合规转向主动合规。同时,我国企业合规改革强调通过合规建立现代化企业治理体系,提升产业水平。这意味着合规实践应以提升企业整体治理水平为目标,综合运用各类治理手段。审计作为成熟的经济监督方法,在防范企业风险、提升企业治理水平的目标上与企业合规高度一致,企业和监管机构应当运用包括审计与合规在内的不同治理机制,注重不同机制间的联动和互补,通过发挥体系效应提升企业整体治理水平。

关键词：企业合规有效合规审计综合治理

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Enhancement in the Response of Pb(Zr,Ti)O_3/Terfenol-D/Metglas Magnetoelectric Laminate Composites

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Journal of Wuhan University of Technology(Materials Science) 2013年第4期28卷 664-667页

作者：李杨欧阳君 tong bei CHEN Shi YANG Xiaofei School of Optical and Electronic Information Huazhong University of Science & Technology

The magnetic field response results on a five-layer structure given as Metglas/Terfenol-D/ Pb（Zr,Ti）O3frerfenol-D/Metglas were reported. Due to its high permeability, Metglas can be incorporated as the third phase into conventional Pb（Zr, Ti）OJTerfenol-D laminates, which results in a stronger magnetoelectric（ME） response. The increase in Metglas thickness significantly influences the ME response as well. The ME voltage coefficient for a structure with a 150 grn thick Metglas layer on both sides of Terfenol-D/Pb（Zr, Ti）O3 laminates at 1 kHz was found to be 1.2 V/cmOe at dc magnetic bias field of 590 Oe under an ac magnetic drive of 1 Oe, which was notably higher in comparison to similar structures with other different Metglas thickness. Key words： laminates composites; magnetoelectric response; magnetic field; Metglas thickness

关键词： laminates composites magnetoelectric response magnetic field Metglas thickness

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Lymphocyte integrins mediate entry and dysregulation of T cells by SARS-CoV-2

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Signal Transduction and Targeted Therapy 2023年第3期8卷 916-920页

作者： Mengwen Huang Xingchao Pan Xinling Wang Qingfei Ren bei tong Xianchi Dong Gaoxiang Ge Lu Lu Shibo Jiang Jianfeng Chen Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China State Key Laboratory of Cell Biology Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) Shanghai Institute of Infectious Disease and BiosecuritySchool of Basic Medical SciencesShanghai Frontiers Science Center of Pathogenic Microbes and InfectionFudan UniversityShanghai 200032China State Key Laboratory of Pharmaceutical Biotechnology School of Life SciencesNanjing UniversityNanjing 210023China

Dear Editor,T-cell infection by SARS-CoV-2 and associated immune responses are correlated with disease severity and prognosis of *** is associated with increased disease severity in *** lower circulating T and B cell counts were observed in patients who died from COVID-19 compared with ***,SARS-CoV-2 infection causes aberrant lymphocyte activation and dysfunction.

关键词： severity infection prognosis

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Research Progress on the Growth-Promoting Effect of Plant Biostimulants on Crops

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Phyton-International Journal of Experimental Botany 2024年第4期93卷 661-679页

作者： Qi Lu Longfei Jin Cuiling tong Feng Liu bei Huang Dejian Zhang College of Horticulture and Gardening Hubei Key Laboratory of Waterlogging Disaster and Agricultural Use of WetlandYangtze UniversityJingzhou434020China Institute of Citrus Research Zhejiang Academy of Agricultural SciencesTaizhou318026China Jingzhou Institute of Technology Jingzhou434025China

A Plant Biostimulant is any substance or microorganism applied to plants to enhance nutrition efficiency,abioticstress tolerance,and/or crop quality traits,regardless of its nutrient *** application of Plant biostimulants(PBs)in production can reduce the application of traditional pesticides and chemical fertilizers and improvethe quality and yield of crops,which is conducive to the sustainable development of *** in-depthunderstanding of the mechanism and effect of various PBs is very important for how to apply PBs reasonablyand effectively in the practice of crop *** paper summarizes the main classification of PBs;Thegrowth promotion mechanism of PBs was analyzed from four aspects:improving soil physical and chemical properties,enhancing crop nutrient absorption capacity,photosynthesis capacity,and abiotic stress tolerance;At thesame time,the effects of PBs application on seed germination,seedling vigor,crop yield,and quality were summarized;Finally,how to continue to explore and study the use and mechanism of PBs in the future is analyzedand prospected,to better guide the application of PBs in crop production in the future.

关键词： Plant biostimulants growth promoting effect crop production

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基于层次分析法的我国物流企业区位选择影响因素研究

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物流技术 2012年第9期31卷 323-325页

作者：仝若贝河南科技学院河南新乡453003

从物流企业区位选择的原则及其影响因素进行分析,建立物流企业区位选择影响因素的层次分析评价模型,为物流企业的区位选择提供一定的指导意义。

关键词：物流企业区位选择层次分析法

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基于供应链管理的物流企业流程优化研究

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物流技术 2012年第6期31卷 119-121页

作者：仝若贝河南科技学院河南新乡453003

物流企业的现代化发展和激烈的市场竞争对物流企业业务流程提出了新的要求,首先概述了传统物流业务流程方案的现状及存在的问题,然后以航空物流公司为例,制定了一种新的物流企业业务流程优化方案并提出了相应的保障措施,通过流程的优化... 详细信息

物流企业的现代化发展和激烈的市场竞争对物流企业业务流程提出了新的要求,首先概述了传统物流业务流程方案的现状及存在的问题,然后以航空物流公司为例,制定了一种新的物流企业业务流程优化方案并提出了相应的保障措施,通过流程的优化设计,以实现物流企业综合竞争力的提升。

关键词：供应链管理物流企业流程优化

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Numerical Study of Two Opposing Weak Polyelectrolyte Brushes by the Self-consistent Field Theory

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Chinese Journal of Polymer Science 2024年第11期 1668-1678页

作者： bei-Ning Wang Huan-Da Ding Zhi-Kuan Chen Chao-Hui tong Department of Physics Ningbo University Ningbo Institute of Northwestern Polytechnical University

The self-consistent field theory(SCFT) was employed to numerically study the interaction and interpenetration between two opposing weak polyelectrolyte(PE) brushes formed by grafting weak PE chains onto the surfaces of two long and parallel columns with rectangularshaped cross-section immersed in a salty aqueous solution. The dependences of the brush heights and the average degree of ionization on various system parameters were also investigated. When the brush separation is relatively large compared with the unperturbed brush height, the degree of interpenetration between the two opposing PE brushes was found to increase with increasing grafting density and bulk degree of ionization. The degree of interpenetration also increases with the bulk salt concentration in the osmotic brush regime. Numerical results further revealed that, at a brush separation comparable to the unperturbed brush height, the degree of interpenetration does not increase further with increasing bulk degree of ionization, bulk salt concentration in the osmotic regime and grafting density. The saturation of the degree of interpenetration with these system parameters indicates that the grafted PE chains in the gap between the two columns retract and tilt in order to reduce the unfavorable electrostatic and steric repulsions between the two opposing PE brushes. Based on salt ion concentrations at the midpoint between the two opposing brushes, a quantitative criterion in terms of the unperturbed brush height and Debye screening length was established to determine the threshold value of the brush separation beyond which they are truly independent from each other.

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电子式电压互感器谐波准确度试验系统的建立

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高电压技术 2018年第3期44卷 835-840页

作者：刘翔童悦胡蓓杨帆叶国雄中国电力科学研究院有限公司

谐波对电网的计量、品质测量和继电保护均有影响,而电子式互感器由于具有频带宽的优点,为电力系统中的谐波测量提供了解决方式。但国内尚无法进行电子式互感器谐波准确度试验。为此建立了电子式电压互感器谐波准确度试验系统,利用标准... 详细信息

谐波对电网的计量、品质测量和继电保护均有影响,而电子式互感器由于具有频带宽的优点,为电力系统中的谐波测量提供了解决方式。但国内尚无法进行电子式互感器谐波准确度试验。为此建立了电子式电压互感器谐波准确度试验系统,利用标准电容器组成了分压系统,测量不同频率下电容量,得出分压系统的实际分压比,设定了分压系统的标称分压比。研制出了连接分压系统与校验系统的电压跟随装置,以提高测量准确性,并通过自校准的方法测量了电压跟随器的误差。最终对由分压系统与电压跟随器组成的测量标准系统进行整体的误差分析,将量值溯源到现有标准体系,并对误差结果的不确定度进行了分析。试验数据表明该电子式电压互感器谐波准确度试验系统在2~13次谐波频率下能够满足标准GB/T 20840.8—2007和IEC 60044-8：2002的要求,可对1 000k V及以下电压等级电子式电压互感器的谐波误差进行测量。

关键词：电子式电压互感器谐波准确度测量标准系统电容分压系统电压跟随装置

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Amplified circularly polarized luminescence of chiral metal-organic frameworks via post-synthetic installing pillars

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Chinese Chemical Letters 2024年第10期35卷 485-489页

作者： Xue-Zhi Wang Yi-tong Liu Chuang-Wei Zhou bei Wang Dong Luo Mo Xie Meng-Ying Sun Yong-Liang Huang jie Luo Yan Wu Shuixing Zhang Xiao-Ping Zhou Dan Li Department of Radiology The First Affiliated HospitalJinan UniversityGuangzhou 510632China College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and ApplicationsJinanUniversityGuangzhou510632China Department of Medicinal Chemistry Shantou University Medical CollegeShantou 515041China Department of Anesthesiology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 50080China

Post-synthetic installation strategy is an effective approach to improve the functions of metal-organic frameworks(MOFs).Herein,a pair of chiral MOFs is successfully constructed through solvothermal subcomponent self-assembly and exhibit circularly polarized luminescence(CPL).These MOFs contain coordinatively unsaturated Zn sites and channels,which allow the installation of pyridyl-terminated pillars into the original *** a post-synthetic installation process reinforces the MOFs'rigidity and increases the photoluminescence quantum yields(PLQYs).Furthermore,the luminescence dissymmetry factors(glum)of these post-modified MOFs are amplified after installing the *** work provides an appealing strategy for boosting the CPL performance of chiral MOFs.

关键词： Chiral metal-organic frameworks Circularlypolarized luminescence Post-synthetic installation Pyridyl-terminated pillars Chirality transfer

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