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Study of visualized simulation and analysis of nuclear fuel cycle system based on multilevel flow model

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Nuclear Science and Techniques 2005年第6期16卷 358-370页

作者： YOSHIKAWA hidekazu Graduate School of Energy Science Kyoto University Engineering Building 2 Room 123Kyoto University Yoshida Honmachi Sakyoku Kyoto Japan 606-8501

Complex energy and environment system, especially nuclear fuel cycle system recently raised socialconcerns about the issues of economic competitiveness, environmental effect and nuclear proliferation. Only underthe condition that those conflicting issues are gotten a consensus between stakeholders with different knowledgebackground, can nuclear power industry be continuingly developed. In this paper, a new analysis platform has beendeveloped to help stakeholders to recognize and analyze various socio-technical issues in the nuclear fuel cycle systembased on the functional modeling method named Multilevel Flow Models (MFM) according to the cognition theoryof human being. Its character is that MFM models define a set of mass, energy and information flow structures onmultiple levels of abstraction to describe the functional structure of a process system and its graphical symbol representationand the means-end and part-whole hierarchical flow structure to make the represented process easy to beunderstood. Based upon this methodology, a micro-process and a macro-process of nuclear fuel cycle system wereselected to be simulated and some analysis processes such as economics analysis, environmental analysis and energybalance analysis related to those flows were also integrated to help stakeholders to understand the process of decision-making with the introduction of some new functions for the improved Multilevel Flow Models Studio, and finallythe simple simulation such as spent fuel management process simulation and money flow of nuclear fuel cycleand its levelised cost analysis will be represented as feasible examples.

关键词：核燃料功能模型能源工业核能环境友好性核电厂

Three-Dimensional Leaf Edge Reconstruction Combining Two-and Three-Dimensional Approaches

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Plant Phenomics 2024年第3期6卷 532-546页

作者： hidekazu Murata Koji Noshita Department of Biology Kyushu UniversityFukuokaFukuoka 819-0395Japan Plant Frontier Research Center Kyushu UniversityFukuokaFukuoka 819-0395Japan

Leaves,crucial for plant physiology,exhibit various morphological traits that meet diverse functional *** leaf morphology quantification,largely 2-dimensional(2D),has not fully captured the 3-dimensional(3D)aspects of leaf *** improvements in 3D data acquisition,accurately depicting leaf morphologies,particularly at the edges,is *** study proposes a method for 3D leaf edge reconstruction,combining 2D image segmentation with curve-based 3D *** deep-learning-based instance segmentation for 2D edge detection,structure from motion for estimation of camera positions and orientations,leaf correspondence identification for matching leaves among images,and curve-based 3D reconstruction for estimating 3D curve fragments,the method assembles 3D curve fragments into a leaf edge model through B-spline curve *** method's performances were evaluated on both virtual and actual leaves,and the results indicated that small leaves and high camera noise pose greater challenges to *** developed guidelines for setting a reliability threshold for curve fragments,considering factors occlusion,leaf size,the number of images,and camera error;the number of images had a lesser impact on this threshold compared to *** method was effective for lobed leaves and leaves with fewer than 4 ***,challenges still existed when dealing with morphologies exhibiting highly local variations,such as *** nondestructive approach to 3D leaf edge reconstruction marks an advancement in the quantitative analysis of plant *** is a promising way to capture whole-plant architecture by combining 2D and 3D phenotyping approaches adapted to the target anatomical structures.

关键词： edge leaf approaches combining dimensional reconstruction three

Activities of nicotinic acetylcholine receptors modulate neurotransmission and synaptic architecture

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Neural Regeneration Research 2014年第24期9卷 2128-2131页

作者： Akira Oda hidekazu Tanaka CNS Drug Discovery Unit Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Laboratory of Pharmacology Department of Biomedical Sciences College of Life Sciences Ritsumeikan University

The cholinergic system is involved in a broad spectrum of brain function, and its failure has been implicated in Alzheimer＇s disease. Acetylcholine transduces signals through muscarinic and nicotinic acetylcholine receptors, both of which influence synaptic plasticity and cognition. However, the mechanisms that relate the rapid gating of nicotinic acetylcholine receptors to persistent changes in brain function have remained elusive. Recent evidence indicates that nicotinic acetylcholine receptors activities affect synaptic morphology and density, which result in persistent rearrangements of neural connectivity. Further investigations of the relationships between nicotinic acetylcholine receptors and rearrangements of neural circuitry in the central nervous system may help understand the pathogenesis of Alzheimer＇s disease.

关键词： cholinergic system nicotinic acetylcholine receptors (nAChRs) Alzheimer's disease (AD) synaptic transmission synaptic plasticity synaptic morphology dendritic spine remodeling cognition

Research on welding simulation methods and software development

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China Welding 2014年第1期23卷 19-26页

作者： hidekazu Murakawa Ninshu Ma Osaka University Japan

To develop highly efficient and useful software, we need to understand the essential feature of the welding phenomenon. From the mechanical point view, welding is a transient nonlinear problem in which small but strongly nonlinear region is moving with the welding torch. Noting this characteristic, ISM （Iterative Substructure Method） was developed for the thermal-elastic-plastic analysis of large scale structures. It is also known that the welding distortion and the residual stress are produced by inherent strain. The inherent strain is the sum of irreversible strains such as plastic strain due to welding thermal cycles or phase transformation and creep strain. In addition to the inherent strain, the mismatch produced by cutting error and fitting is also an important cause of the welding distortions and residual stresses. Based on this understanding, an elastic FEM introducing the inherent strain and mismatch is developed. The potential capabilities of these methods are demonstrated through some examples.

关键词： welding distortion residual stress FEM large structure practical method

Update on quinolone-containing rescue therapies for Helicobacter pylori infection

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World Journal of Gastroenterology 2020年第15期26卷 1733-1744页

作者： Hideki Mori hidekazu Suzuki Department of Clinical and Experimental Medicine Translational Research Center for Gastrointestinal DisordersUniversity of LeuvenLeuven 3000Belgium Division of Gastroenterology and Hepatology Department of Internal MedicineTokai University School of MedicineIsehara 259-1193Japan

Third generation of quinolones,such as levofloxacin and moxifloxacin,-containing regimens are often used in second-line or rescue treatment of Helicobacter pylori ***,the increasing antibiotic resistance to quinolones affects the efficacies of quinolones-containing therapies in recent ***,there is a need to enhance the effectiveness of quinolonescontaining ***,a fourth-generation quinolone,and vonoprazan,a novel potassium-competitive acid blocker,are now available as more effective treatment *** aim of this paper is to summarize the current evidence of quinolone-containing therapies in rescue treatments,and to discuss the importance of drug sensitivity tests or analysis of gyrA mutation before treatments.

关键词： Helicobacter pylori Levofloxacin Sitafloxacin Moxifloxacin gyrA Vonoprazan

Feature-aware regularization for sparse online learning

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Science China(Information Sciences) 2014年第5期57卷 65-85页

作者： OIWA hidekazu MATSUSHIMA Shin NAKAGAWA Hiroshi Graduate School of Information Science and Technology The University of Tokyo Information Technology Center The University of Tokyo

Learning a compact predictive model in an online setting has recently gained a great deal of *** combination of online learning with sparsity-inducing regularization enables faster learning with a smaller memory space than the previous learning *** optimization methods and learning algorithms have been developed on the basis of online learning with L1-regularization.L1-regularization tends to truncate some types of parameters,such as those that rarely occur or have a small range of values,unless they are emphasized in ***,the inclusion of a pre-processing step would make it very difficult to preserve the advantages of online *** propose a new regularization framework for sparse online *** focus on regularization terms,and we enhance the state-of-the-art regularization approach by integrating information on all previous subgradients of the loss function into a regularization *** resulting algorithms enable online learning to adjust the intensity of each feature’s truncations without pre-processing and eventually eliminate the bias of *** show theoretical properties of our framework,the computational complexity and upper bound of *** demonstrated that our algorithms outperformed previous methods in many classification tasks.

关键词： online learning supervised learning sparsity-inducing regularization feature selection sentiment analysis

Prediction of the Residual Welding Stress in 2.25Cr-1Mo Steel by Taking into Account the Effect of the Solid-State Phase Transformations

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Acta Metallurgica Sinica(English Letters) 2013年第3期26卷 333-339页

作者： Dean DENG Yangang TONG Ninshu MA hidekazu MURAKAWA College of Materials Science and Engineering Chongqing University State Key Laboratory of Advanced Welding and Joining Harbin Institute of Technology JWRI Osaka University11-1 MihogaokaIbaraki Osaka 567-0047 Japan

A computational approach based on the thermal elastic plastic finite element method was developed for predicting welding residual stress in low carbon alloyed steel welds by taking into account the effect of the solid-state phase transformations. The kinetics of phase transformations was described by Johnson Mehl Avrami Kolmogrov （JMAK） equation for bainitic transition and by Koistinen-Marburger （K-M） relationship for martensitic transition. Moreover, an additive rule depending on volumetric phase fraction was adopted to represent the material property changes during heating and cooling. Consequently, the residual welding stresses in a 2.25Cr1Mo steel TIG welded plate were computed. Early calculation results suggest that the bainitic and martensitic transformations took place in the weld the heat-affected zone drastically reduce the residual longitudinal tensile stress in the region.

关键词： Computational approach Numerical simulation Phase transformation Welding residual stress

Characteristic Tensor for Evaluation of Singular Stress Field Under Mixed-Mode Loadings

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Computer Modeling in Engineering & Sciences 2020年第2期122卷 415-432页

作者： Kei Saito Tei Hirashima Ninshu Ma hidekazu Murakawa JSOL Corporation 2-5-24 HarumiChuo-kuTokyo104-0053Japan. Osaka University 11-1 MihogaokaIbarakiOsaka567-0047Japan.

A characteristic tensor is defined using stress tensor averaged in a small circular domain at the crack tip and multiplied by the root of domain *** possesses the original stress tensor characteristics and has a simple relationship with conventional fracture-mechanics ***,it can be used to estimate stress intensity factors(SIFs)for cracks of arbitrary shape subjected to multiaxial stress loads.A characteristic tensor can also be used to estimate SIFs for kinked *** study examines the relation between a characteristic tensor and SIFs to demonstrate the correlation between the characteristic tensor and fracture-mechanics ***,a single straight crack and a kinked crack of finite length existing in a twodimensional,infinite isotropic elastic body in a plane stress state,were considered to investigate the properties of the characteristic tensor under mixed-mode *** demonstrate the practical utility of the characteristic tensor,the stress distribution obtained through finite element analysis(FEA)was used to estimate mixed-mode SIFs,and the values of estimated SIFs were compared with those obtained using an analytical *** demonstrate that SIFs estimated under mixed-mode loadings exhibit a good agreement with the analytical *** indicates that the proposed characteristictensor-based approach is effective in extracting features of singular stress fields at crack tips,and can be employed to estimate values of fracture-mechanics parameters,such as *** to its simplicity,the proposed approach can be easily incorporated in commercial FE codes for practical applications to simulate the crack-growth problem under both static and dynamic loading *** excellent applicability of the characteristic tensor greatly contributes to efficiency of the design process in industries.

关键词： Characteristic tensor stress-intensity factor mixed-mode loading kinked crack.

Effect of Degree of Cure on Sandwich Structural Capacitor Using Ion-Conductive Polymer with Carbon Fabric Skins

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Open Journal of Composite Materials 2016年第4期6卷 112-120页

作者： Akira todoroki Department of Mechanical Sciences of Engineering Tokyo Institute of Technology Tokyo Japan

Structural capacitors are composite structures that function as energy storage capacitors. An electric double-layer capacitor with a composite structure using a solid polymer electrolyte matrix with a glass fiber fabric separator has recently been developed. In the present study, new foam core sandwich structure is adopted and the effect of the degree of cure is experimentally investigated. Carbon fiber fabric cloth is used as electrodes, and the polystyrene foam core is used as separator. Material system of Poly Ethylene Glycol DiGlycidyl Ether (PEGDGE) with Lithium bisTriFluoromethane Sulfonyl Imide (LiTFSI) and hardener of TriEthylene TetrAmine (TETA) is adopted as ion-conductive polymer matrix. The effect of the cure degree is experimentally investigated by using 100% cure degree, 70% cure degree and 0% cure degree specimens. As a result, the polystyrene foam-core sandwich system is proved to be effective, but the capacitance is not enough because of the lack of surface area of the carbon fiber electrodes. As the remained TETA impedes the movement of Li+ cation in the solid polymer by means of the segment-motion-assisted diffusion process, the low degree of cure causes small capacitance with this material system.

关键词： Composites Woven Carbon Fabric Capacitor Supercapacitor Sandwich Foam Core