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Unravel hepatic artery infusion chemotherapy in patients with resected colorectal liver metastases

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Hepatobiliary Surgery and Nutrition 2021年第2期10卷 257-260页

作者： Matteo Donadon Lorenza Rimassa guido Torzilli Department of Biomedical Sciences Humanitas UniversityPieve EmanueleMilanItaly Department of Hepatobiliary and General Surgery IRCCS Humanitas Research HospitalRozzanoMilanItaly Humanitas Cancer Center IRCCS Humanitas Research HospitalRozzanoMilanItaly

Over the past years,important progresses have been made in the treatment of patients with colorectal liver metastases(CLM).Now,5-year overall survival rate may exceed 50%by using the combination of multimodality therapies among which modern systemic chemotherapy,with or without monoclonal antibodies,and hepatic resection are the cornerstones(1,2).In such multimodality,hepatic artery infusion(HAI)has been proposed since many years with the rationale of increasing the concentration of chemotherapy agents in the liver(3).However,HAI still remains infrequently used,in particular in the adjuvant setting mainly because of the requirement of a multidisciplinary team to manage therapy,and the more widespread use of systemic chemotherapy-in particular following the perioperative“sandwich”schema(4).

关键词： infusion chemotherapy hepatic

CEREBRAL BLOOD FLOW AND METABOLISM EVALUATION IN COMATOSE PATIENTS BY DYNAMIC SPECT

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Nuclear Science and Techniques 1993年第1期4卷 33-38页

作者： AlessandroGiordano MariaLuciaCalcagni FrancescoDellaCorte MarianoAlbertoPennisi guido Galli 王凤琴赵惠杨 Institute of Nuclear Medicine Institute of Anaesthesiology and Intensive Care of the Catholic University of the Sacred Heart Roma Italy Zhongshan Hospital Shanghai Medical University Shanghai 200032 China

Thirty patients in coma state underwent dynamic SPECT with 133Xe, a validated technique for the quantitation of CBF by SPECT, using a new brain dedicated tomograph: CERTO-96. CMRO2 was computed by multiplying the mean CBF by AVDO2 according to the Fick’s principle. The mean values of CBF, AVDO2 and CMRO2 in patients with good outcome were significantly different from those with worse outcome. On the basis of the best "discriminant threshold", CBF and AVDO2 demonstrated an intermediate accuracy in separating the two groups, while CMRO2 showed a satisfactory accuracy.

关键词： Dynamic SPECT Cerebral blood flow Cerebral metabolic rate of oxygen Comatose patients

Perimesencephalic Subarachnoid Hemorrhage in Pregnancy: A Case Report

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Maternal-Fetal Medicine 2022年第4期4卷 290-292页

作者： Stefania Ruggieri Maurizia Gatto Maria Annunziata Gentile Salvatore D'Oria Filippo Tamma Domenico Caringella Alessandra Giocolano Chiara Taccalti Maurizio guido Department of Obstetrics and Gynecology Catholic University of theSacred HeartPoliclinico Agostino Gemell iRCCSRome 00168Italy Department of Obstetrics and Gynecology General Regional Hospital"F.Miull"Acquaviva delle Fonti 70021Italy Department of Neurology General Regional Hospital"F.Miuli"AcquavivadelleFonti70021litaly Department of Neuroradiology General Regional Hospital“F.Miulli"Acquaviva delle Fonti 70021Italy Department of Neurosurgery General Regional Hospital"F.Miulli"Acquavivadelle Fonti 70021Italy MeSVA Department University of L'AquilaL'Aquila 67100Italy

Perimesencephalic subarachnoid hemorrhage (P-SAH) is a benign subset of subarachnoid hemorrhage. Only two cases of P-SAH during pregnancy have been reported in the literature. We describe a case of P-SAH detected at 29 weeks’ gestation, arose with severe bilateral frontal headache, neck rigidity, and vomiting. A diagnosis of P-SAH was confirmed on magnetic resonance angiography with no evidence of vascular malformation or bleeding sources and conservatively treated. Hemorrhage, vasospasm, and cerebellar edema observed on initial magnetic resonance angiography resolved after two months. The clinical course of P-SAH during pregnancy appears to be favorable. Our case shows for the first time in literature that magnetic resonance angiography is a valid diagnostic test for P-SAH during pregnancy that circumvents radiological risk associated with conventional imaging.

关键词： Subarachnoid hemorrhage Cerebrovascular diseases Headache Magnetic resonance angiography Pregnancy

Transcript Accumulation Dynamics of Phenylpropanoid Pathway Genes in the Maturing Xylem and Phloem of Picea abies during Latewood Formation

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Journal of Integrative Plant Biology 2011年第10期53卷 783-799页

作者： Giovanni Emiliani Maria Laura Traversi Monica Anichini guido Giachi Alessio Giovannelli Trees and Timber Institute-National Research Council Department of Chemistry "U.Schiff" University of Florence

In temperate regions, latewood is produced when cambial activity declines with the approach of autumnal dormancy. The understanding of the temporal （cambium activity vs dormancy） and spatial （phloem, cambial region, maturing xylem） regulation of key genes involved in the phenylpropanoid pathway during latewood formation represents a crucial step towards providing new insights into the molecular basis of xylogenesis. In this study, the temporal pattern of transcript accumulation of 12 phenylpropanoid genes （PAL1, C4H315, C4H4, 4CL3, 4CL4, HCT1, C3H3, CCoAOMT1, COMT2, COMT5, CCR2） was analyzed in maturing xylem and phloem of Picea abies during latewood formation. Quantitative reverse transcription-polymerase chain reaction analyses revealed a well-defined RNA accumulation pattern of genes involved in the phenylpropanoid pathway during latewood formation. Differences in the RNA accumulation patterns were detected between the different tissue types analyzed. The results obtained here demonstrated that the molecular processes involved in monolignol biosynthesis are not restricted to the cambial activity timeframe but continued after the end of cambium cell proliferation. Furthermore, since it has been shown that lignification of maturing xylem takes place in late autumn, we argue on the basis of our data that phloem could play a key role in the monoliqnol biosynthesis process.

关键词： cambial region gene expression latewood formation xylogenesis.

“Pseudotumoral” hepatic pattern in acute alcoholic hepatitis:A case report

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World Journal of Gastroenterology 2009年第32期15卷 4070-4074页

作者： Andrea Tenca Sara Massironi Agostino Colli guido Basilisco Dario Conte Policlinico MangiagalliRegina Elena FoundationGastrointestinal Unit 2 and Postgraduate School of Gastro-enterologyUniversità degli Studi di MilanoF.Sforza st.3520122 MilanItaly Department of Internal Medicine Ospedale "A.Manzoni"Lecco 23900Italy

In acute alcoholic hepatitis (AAH), a "pseudotumoral" appearance of the liver parenchyma on computed tomography (CT) scan has been reported. The main findings are hypervascularized areas closely similar to those observed in large hepatocellular carcinomas. We report a case of a patient affected by AAH with an unusual appearance of these "pseudotumoral" areas on CT scan, close resembling a metastatic cancer rather than a primary hepatocellular carcinoma. In fact, in contrast with previous reports, the picture was characterized by the presence of many inhomogeneous, hypoattenuated areas highlighted during both pre- and post-contrast phases. Moreover, we report the first description of "pseudotumoral" lesions on ultrasound scan. This patient was successfully treated with corticosteroids, even if many controversies still exist regarding their efficacy in this setting.

关键词：酒精性肝炎急性计算机断层扫描原发性肝癌 CT扫描超声波扫描不均匀

Revision of the Conodont Mockina slovakensis and Its Paleogeographic Implications for the Upper Triassic Intraplatform Basins of the Alps

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Journal of Earth Science 2021年第3期32卷 657-666页

作者： Yixing Du Viktor Karadi guido Roghi Maurizio Ponton Andrea Cozzi Manuel Rigo Department of Geosciences University of Padova35131 PadovaItaly Department of Palaeontology Eotvos Lorand UniversityBudapest 1117Hungary Institute of Geosciences and Earth Resources National Research Council of Italy35131 PadovaItaly Department of Mathematics and Geosciences University of Trieste34128 TriesteItaly Eni Sharjah B.V 73500 SharjahUnited Arab Emirates

Mockina slovakensis,thought to have evolved from Epigondolella praeslovakensis,is an important species of the Norian(Upper Triassic),generally considered as the representative of the uppermost Alaunian to upper Sevatian in the *** previous description of *** was incomplete,thus has led to some *** thus update the description of *** and discuss its comparisons and occurrence based on the new conodont investigations in Dolomia di Forni and the data from previous *** conodont assemblage in the succession of Dolomia di Forni is dominated by ***,along with rare *** and *** described two morphotypes of ***(morphotypes A and B),on the basis of shape of the lateral *** two morphotypes can also be observed in the ***,*** is usually documented as almost monospecific conodont association in intraplatform basins,thus its paleogeographic implications are also discussed.

关键词： Mockina conodont morphotype intraplatform basin

Light Electrospun Polyvinylpyrrolidone Blanket for Low Frequencies Sound Absorption

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Chinese Journal of Polymer Science 2018年第12期36卷 1368-1374页

作者： Joshua Avossa Francesco Brand Francesco Marulo Giuseppe Petrone Stefano guido Giovanna Tomaiuolo Aniello Costantini Dipartimento di Ingegneria Chimica dei Materiali e della Produzione lndustriale (DICMaPI) Universitgt degli Studi di Napoli Federico II Napoli Italy Dipartimento di lngegneria Industriale (DII) Universita degli Studi di Napoli Federico II Napoli Italy

Light polymeric soundproofing materials （density = 63 kg/m3） of interest for the transportation industry were fabricated through electrospinning. Blankets of electrospun polyvinylpyrrolidone （average fiber diameter = （1.6 ± 0.5） or （2.8 ± 0.5） μm） were obtained by stacking disks of electrospun mats. The sound absorption coefficients were measured using the impedance tube instrument based on ASTM E1050 and ISO 10534-2. For a given set of disks （from a minimum of 6） the sound absorption coefficient changed with the frequency （in the range 200-1600 Hz） following a bell shape curve with a maximum （where the coefficient is greater than 0.9） that shifts to lower frequencies at higher piled disks number and greater fiber diameter. This work showed that electrospinning produced sound absorbers with reduced thickness （2-3 cm） and excellent sound-absorption properties in the low and medium frequency range.

关键词： Electrospinning Polyvinylpyrrolidone (PVP) Sound absorption Impedance tube

Vox Link—Combining sparse volumetric data and geometry for efficient rendering

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Computational Visual Media 2016年第1期2卷 45-56页

作者： Daniel Kauker Martin Falk guido Reina Anders Ynnerman Thomas Ertl VISUS University of Stuttgart Immersive Visualization Group Linkoping University

Processing and visualizing large scale volumetric and geometric datasets is mission critical in an increasing number of applications in academic research as well as in commercial enterprise. Often the datasets are, or can be processed to become, *** this paper, we present Vox Link, a novel approach to render sparse volume data in a memory-efficient manner enabling interactive rendering on common, offthe-shelf graphics hardware. Our approach utilizes current GPU architectures for voxelizing, storing, and visualizing such datasets. It is based on the idea of perpixel linked lists(pp LL), an A-buffer implementation for order-independent transparency rendering. The method supports voxelization and rendering of dense semi-transparent geometry, sparse volume data, and implicit surface representations with a unified data structure. The proposed data structure also enables efficient simulation of global lighting effects such as reflection, refraction, and shadow ray evaluation.

关键词： ray tracing voxelization sparse volumes GPGPU generic rendering

Liver resection for multifocal hepatocellular carcinoma: is it an option?

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Hepatobiliary Surgery and Nutrition 2019年第5期8卷 530-533页

作者： Luca Viganò guido Costa Luca Di Tommaso Division of Hepatobiliary&General Surgery Department of SurgeryIRCCSRozzanoMilan Pathology Unit Humanitas Clinical and Research CenterIRCCSRozzanoMilanItaly Department of Biomedical Sciences Humanitas UniversityRozzanoMilanItaly

Hepatocellular carcinoma(HCC)is the second leadingcause of cancer-related death *** firstdiagnosis,HCC is multifocal in about 35-40%of patients(1,2).According to Western guidelines,the treatmentof multifocal(non-metastatic)HCC is well codified:transplantation is indicated for HCCs within Milan criteria(2-3 nodules≤30 mm),ablation for non-transplantableHCCs within Milan criteria,and chemoembolizationfor the remaining patients(3).

关键词： multifocal diagnosis patients