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scorpiones,scolopendra and Gekko Inhibit Lung Cancer Growth and Metastasis by Amelioratin. Hypoxic Tumor Microenvironment via PI3k/AkT/mTOR/HIF-1αsignaling Pathway

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Chinese Journal of Integrative Medicine 2024年第9期30卷 799-808页

作者： MAO Qi-yuan WANG Xue-qian LIN Fei YU Ming-wei FAN Hui-tin. ZHENG Qi LIU Lan-chun ZHANG Chu-chu LI Dao-rui LIN Hong-sheng Department of Oncology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing100053China Department of Oncology Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing100010China Department of Cardiology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing100053China Institute of Traditional Chinese Medicine Information China Academy of Chinese Medical SciencesBeijing100700China

Objective:To investigate whether Buthus martensii karsch(scorpiones),scolopendra subspinipes mutilans ***(scolopendra)and Gekko gecko Linnaeus(Gekko)could ameliorate the hypoxic tumor microenvironment and inhibit lung cancer growth and metastasis by regulatin. phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin/hypoxia-inducible factor-1α(PI3k/AkT/mTOR/HIF-1α)signaling ***:Male C57BL/6J mice were inoculated with luciferase labeled LL/2-luc-M38 cell suspension to develop lung cancer models,with rapamycin and cyclophosphamide as positive *** methyl cellulose solutions of scorpiones,scolopendra and Gekko were administered intragastrically as 0.33,0.33,and 0.83 g/kg,respectively once daily for 21 *** expression were detected every 7 days after inoculation,and tumor growth curves were *** was performed to determine CD31 and HIF-1αexpressions in tumor tissue and microvessel density(MVD)was *** blot was performed to detect the expression of PI3k/AkT/mTOR/HIF-1αsignaling pathway-related ***-linked immunosorbent assay was performed to detect serum basic fibroblast growth factor(bFGF),transforming growth factor-β1(TGF-β1)and vascular endothelial growth factor(VEGF)in ***:scorpiones,scolopendra and Gekko prolonged the survival time and inhibited lung cancer metastasis and expression of HIF-1α(all Pscorpiones,scolopendra and Gekko inhibited the phosphorylation of AkT and ribosomal protein s6 kinase(p70s6k)(Pso decreased the expression of CD31,MVD,bFGF,TGF-β1 and VEGF compared with the model group(Psion:scorpiones,scolopendra and Gekko all showed beneficial effects on lung cancer by amelioratin. the hypoxic tumor microenvironment via PI3k/AkT/mTOR/HIF-1αsignaling pathway.

关键词： scorpiones scolopendra Gekko dredging collaterals and activatin. blood Chinese medicine of worms lung cancer hypoxic tumor microenvironment phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin/hypoxia-inducible factor-1α signaling pathway

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NHE7 upregulation potentiates the uptake of small extracellular vesicles by enhancing maturation of macropinosomes in hepatocellular carcinoma

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Cancer Communications 2024年第2期44卷 251-272页

作者： Yue Yao Yi Xu Liang Yu tin.-Mao Xue Zhi-Jie Xiao Pui-Chi tin.Hiu-Ling Fung Hoi-Tang Ma Jing-Ping Yun Judy Wai Ping Yam Department of Pathology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongP.R.China Department of Endocrinology and Metabolism Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjingP.R.China Department of Hepatopancreatobiliary surgery Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjingP.R.China state key Laboratory of Oncology in south China Cancer Center of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Hepatobiliary surgery II Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China scientific Research Center The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdongP.R.China state key Laboratory of Liver Research The University of Hong KongHong KongP.R.China Department of Pathology Cancer Center of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background:small extracellular vesicles(sEVs)mediate intercellular commu-nication that contributes to hepatocellular carcinoma(HCC)progression via multifaceted *** success of cell entry determines the effect of sEV on recipient ***,we aimed to delineate the mechanisms underlying the uptake of sEV in ***:AF,Alexa Fluor;ANOVA,analysis of variance;ATP9A,ATPase Phospholipid Transportin. 9A;BCECF-AM,2’,7’-bis-(2-barboxyethyl)-5-(and-6)-carboxyfluorescein,acetoxymethyl ester;BsA,bovine serum albumin;CCMR,Centre for Comparative Medicine Research;CRIsPR,clustered regularly interspaced short palindromic repeats;CTL,ctrl;CXCR4,C-X-C Chemokine Receptor Type 4;DAPI,4′,6-diamidino-2-phenylindole;DFs,disease-free survival;DMEM,Dulbecco’s Modified Eagle Medium;DMsO,dimethyl sulfoxide;Dox,doxycycline;EEA1,early endosome antigen 1;EIPA,5-(N-ethyl-N-isopropyl)-amiloride;FBs,fetal bovine serum;FITC,fluorescein isothiocyanate;GAPDH,glyceraldehyde-3-phosphate dehydrogenase;GM130,Golgi matrix protein 130;HCC,hepatocellular carcinoma;HEPEs,4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid;HPRT1,hypoxanthine phosphoribosyltransferase 1;H-score,histoscore;IAA,indole-3-acetic acid;kD,knockdown;kO,knockout;mAID,mini-auxin-inducible degron;MTT,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide;NHE7,Na(+)/H(+)exchanger 7;ns,non-significant;OD,optical density;Os,overall survival;PBs,phosphate-buffered saline;PCR,polymerase chain reaction;pHe,endosomal pH;pHi,intracellular pH;PkH67,Paul karl Horan 67;Rab21,Ras-associated binding protein 21;RIPA,radioimmunoprecipitation assay;sAM,synergistic activation mediator;sEMs,standard error of the means;sEVs,small extracellular vesicles;sgRNA,single-guide RNA;shRNA,short-hairpin RNA;sLC9,solute carrier gene 9;sLiCE,seamless Ligation Cloning Extract;TCGA,The Cancer Genome Atlas;TCL,total cell lysates;TGN,trans-Golgi network;TMA,tissue microarray;TMR,tetramethyl rhodamine;TsG101,tumor susceptibility gene *** Yao an

关键词： hepatocellular carcinoma small extracellular vesicles macropinocytosis pH regulation sodium-hydrogen exchanger

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study on the Establishment of Demonstration site for Peatland Conservation through Integrated Management and sustainable Utilization of Non-timber Forest Products(NTFPs)

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Journal of Agricultural science and Technology(A) 2024年第2期14卷 93-106页

作者： sann Lwin Mya Win Myint Myint khaing tin.Maung Htun soe Min Ye Wunna soe Forest Resource Environment Development and Conservation Association(FREDA)

A participatory action research was conducted in 2022,with the“Establishment of Demonstration site for Peatland Conservation through Integrated Management and sustainable Utilization of Non-Timber Forest Products(NTFPs)”to give recommendation on the development of guidelines on sustainable Utilization of Non-Timber Forest Products(NTFPs)and peatland *** to the peat soil assessment,it was found that peat soil content was very low and top soil was thin under the mangrove forest,and Payena paralleloneura-kan Zaw bearing forest in March *** material might be pressed by trespasser to collect kan Zaw seed,to conduct horticulture and mining near the kan Zaw bearing forest,or organic material might be damaged by burning with controlled fire in the previous years,under kan Zaw trees to collect *** material might have been carried to the downwards with running water due to the heavy rainfall,with 4,700 mm/*** forest and kan Zaw bearing evergreen forest can be assumed as“the major source of coastal peatland formation,with peat deposits eroded seawards”.It is assumed that the organic material will accumulate on top of the sands and it will lead to the formation of the peatland at coastal *** can be assumed that the accumulation of organic material found in mangrove forest and evergreen forests will promote the soil carbon storage,if we can adopt the AsEAN Policy on Zero Burning,which reflect AsEAN's commitment to controlling fires and haze,offering techniques,benefits,requirements,and challenges for implementin. zero burning practices[1].sustainable utilization of NTFP including peat and kan Zaw-Payena paralleloneura kurz seed was studied at demonstration sites,and it is recommended to make a trial on silvicultural system at mangrove forest and apply suitable silvicultural system such as Clear-Felling(in blocks or in alternate strips)system,selection system,and shelter Wood system to ensure the sustainable utilization of NTFP

关键词： silvicultural system mangrove forest moist evergreen forest peat soil kan Zaw-Payena paralleloneura kurz seed

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A Hybrid Immigrants scheme for Genetic Algorithms in Dynamic Environments

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International Journal of Automation and computin. 2007年第3期4卷 243-254页

作者： shengxiang Yang Renato tin.s Department of Computer science University of LeicesterLeicester LE1 7RHUK Department of Physics and Mathematics FFCLRPUniversity of Sao PauloRibeir Preto 14040-901Brazil

Dynamic optimization problems are a kind of optimization problems that involve changes over time. They pose a serious challenge to traditional optimization methods as well as conventional genetic algorithms since the goal is no longer to search for the optimal solution（s） of a fixed problem but to track the moving optimum over time. Dynamic optimization problems have attracted a growing interest from the genetic algorithm community in recent years. several approaches have been developed to enhance the performance of genetic algorithms in dynamic environments. One approach is to maintain the diversity of the population via random immigrants. This paper proposes a hybrid immigrants scheme that combines the concepts of elitism, dualism and random immigrants for genetic algorithms to address dynamic optimization problems. In this hybrid scheme, the best individual, i.e., the elite, from the previous generation and its dual individual are retrieved as the bases to create immigrants via traditional mutation scheme. These elitism-based and dualism-based immigrants together with some random immigrants are substituted into the current population, replacing the worst individuals in the population. These three kinds of immigrants aim to address environmental changes of slight, medium and significant degrees respectively and hence efficiently adapt genetic algorithms to dynamic environments that are subject to different severities of changes. Based on a series of systematically constructed dynamic test problems, experiments are carried out to investigate the performance of genetic algorithms with the hybrid immigrants scheme and traditional random immigrants scheme. Experimental results validate the efficiency of the proposed hybrid immigrants scheme for improving the performance of genetic algorithms in dynamic environments.

关键词： Genetic algorithms random immigrants elitism-based immigrants dualism dynamic optimization problems.

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Use of self-organizing suppression and q-Gaussian mutation in artificial immune systems

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International Journal of Intelligent Computin. and Cybernetics 2013年第3期6卷 296-322页

作者： Helder ken shimo Renato tin.s Department of Computin. and Mathematics University of Sa˜o PauloSa˜o PauloBrazil

Purpose-The purpose of this paper is to propose two operators for diversity and mutation control in artificial immune systems(AIss).Design/methodology/approach-The proposed operators are applied in substitution to the suppression and mutation operators used in *** proposed mechanisms were tested in the opt-aiNet,a contin.ous optimization algorithm inspired in the theories of *** traditional opt-aiNet uses a suppression operator based on the immune network principles to remove similar cells and add random ones to control the diversity of the *** procedure is computationally expensive,as the Euclidean distances between every possible pair of candidate solutions must be *** work proposes a self-organizing suppression mechanism inspired by the self-organizing criticality(sOC)phenomenon,which is less dependent on parameter *** work also proposes the use of the q-Gaussian mutation,which allows controlling the form of the mutation distribution during the optimization *** algorithms were tested in a well-known benchmark for contin.ous optimization and in a bioinformatics problem:the rigid docking of ***-The proposed suppression operator presented some limitations in unimodal functions,but some interestin. results were found in some highly multimodal *** proposed q-Gaussian mutation presented good performance in most of the test cases of the benchmark,and also in the docking ***/value-First,the self-organizing suppression operator was able to reduce the complexity of the suppression stage in the ***,the use of q-Gaussian mutation in AIss presented better compromise between exploitation and exploration of the search space and,as a consequence,a better performance when compared to the traditional Gaussian mutation.

关键词： Artificial immune system Evolutionary computation self-adjustin. systems

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枸杞糖肽可减轻放射治疗后人牙龈成纤维细胞来源的外泌体导致的成骨抑制

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南方医科大学学报 2024年第9期44卷 1752-1759页

作者：何思齐文楠陈勋王跃张艇牟雁东成飞医院四川成都610073 宜宾市第一人民医院四川宜宾644000 四川省人民医院口腔科四川成都610072 卷烟减害降焦四川省重点实验室四川成都610100

目的研究枸杞糖肽(LbGP)对放射后人牙龈成纤维细胞(HGFs)来源的外泌体对成骨抑制的保护作用。方法将HGFs分为对照组、放射组及枸杞糖肽组,通过RT-qPCR、Western blottin.及β-半乳糖苷酶染色检测细胞的凋亡、衰老水平以及α-平滑肌肌动... 详细信息

目的研究枸杞糖肽(LbGP)对放射后人牙龈成纤维细胞(HGFs)来源的外泌体对成骨抑制的保护作用。方法将HGFs分为对照组、放射组及枸杞糖肽组,通过RT-qPCR、Western blottin.及β-半乳糖苷酶染色检测细胞的凋亡、衰老水平以及α-平滑肌肌动蛋白(α-sMA)的差异表达。提取各组细胞分泌的外泌体,通过电镜观察、粒径分析以及Western blottin.鉴定外泌体,并分别将各组牙龈成纤维细胞产生的外泌体作用于破骨前体细胞及骨髓间充质干细胞(BMsCs)中,通过Trap染色、茜素红染色、ALP染色、RT-qPCR以及Western blottin.检测细胞的破骨及成骨情况。结果衰老细胞在放射组较对照组增多,而在枸杞糖肽组较放射组减少;与对照组相比,放射组Bcl-2/Bax降低(PsMA表达水平增加(PsMA表达水平降低(P<0.01);与对照组相比,放射组破骨细胞增多,枸杞糖肽组破骨细胞减少;钙结节、碱性磷酸酶表达水平在放射组低于对照组,在枸杞糖肽组高于放射组;成骨相关基因(BMP2、ALP、RUNX2)及成骨相关蛋白(ALP、RUNX2)的表达水平在枸杞糖肽组高于放射组(P均<0.01)。结论枸杞糖肽可通过作用于放射后的牙龈成纤维细胞的外泌体,有效抑制破骨、促进成骨和预防放射性颌骨骨髓炎的发展,这可能为放射性颌骨骨髓炎的治疗提供一种新策略。

关键词：枸杞糖肽外泌体放射性颌骨骨坏死成骨分化

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Towards sustainable solar cells: unveiling the latest developments in bio-nano materials for enhanced DssC efficiency

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CLEAN ENERGY 2024年第3期8卷 238-257页

作者： Tamilselvan, sethu Narayanan shanmugan, s. koneru Lakshmaiah Educ Fdn Coll Engn Res Ctr Solar Energy Dept Engn Phys Vaddeswaram 522502 Andhra Pradesh India

Fossil fuels-instrumental in powering the nineteenth-century Industrial Revolution-are now under heightened scrutin. due to environmental concerns and carbon emissions. Consequently, there is a global impetus towards achieving carbon-neutral energy production, with solar energy emerging as a cornerstone in this transition. Over the past three decades, dye-sensitized solar cells (DssCs) have gained increasing prominence due to their unique advantages. This review elucidates several crucial elements essential to DssC construction, notably bio-nano materials, prized for their structural flexibility, cost-effectiveness and high molar absorption coefficient. It delves into the intricate relationship between molecular structure and DssC performance, showcasing significant advancements with light-to-power conversion efficiencies reaching 11%. A comprehensive analysis of the photovoltaic performance of DssCs utilizing bio-nano-based dyes offers invaluable insights into the state of this rapidly evolving industry. key components under scrutin. include transparent conductive oxide (TCO) layers, physical techniques for metal oxide deposition onto TCO thin films, diverse dye variants and foundational knowledge of components ripe for growth and enhancement. Moreover, the review outlines the latest breakthroughs in the field, providing glimpses into the current status of prototype DssCs. This review elucidates several crucial elements essential to dye-sensitized solar cell construction, notably bio-nano materials, and delves into the intricate relationship between molecular structure and dye-sensitized solar cell performance. Graphical Abstract

关键词： DssC performance TCO thin films environmental solution FREE ORGANIC-DYEs ZINC-OXIDE NANOsTRUCTURED PHOTOANODE sILVER NANOPARTICLEs COUNTER ELECTRODEs QUANTUM-DOT tin.OXIDE LOW-COsT ELECTROLYTEs GRAPHENE

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Evolution of Collaborative Governance in the 2015,2016,and 2018 Myanmar Flood Disaster Responses:A Longitudinal Approach to a Network Analysis

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International Journal of Disaster Risk science 2021年第2期12卷 267-280页

作者： tin.Myo Aung seunghoo Lim Defence services Academy Pyin Oo Lwin05081Myanmar Public Management and Policy Analysis Program Graduate School of International RelationsInternational University of JapanMinami Uonuma-shiNiigata949-7277Japan

In disaster response,collaboration facilitates interactions among actors,such as the government,the military,nongovernmental organizations,and civil society *** study examined the longitudinal changes in collaborative governance in Myanmar’s disaster responses based on cases of flooding in 2015,2016,and *** examine the mechanisms underlying this dynamic network formation,the collaborative ties of the actors involved in search and rescue activities were converted into longitudinal relational data sets,and the evolution of collaborative governance was analyzed by relying on the assumptions of social capital,transaction cost,homophily,and resource dependency theories and using a longitudinal social network analysis *** findings show that the collaborative networks of search and rescue processes in disaster response evolved and changed over time according to the hypothesized patterns of strong,weak,and preferential tie *** study also revealed that the collaborative governance system assumes the form of a hierarchy rather than a generalized exchange,and the actors’reliance on military organizations is not obvious due to the emerging alternative non-military actors and diverse local actors observed in the cases.

关键词： Collaborative governance Longitudinal social network analysis Myanmar flood disasters Network sustainability

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steroid for chronic subdural hematoma? A prospective phase IIB pilot randomized controlled trial on the use of dexamethasone with surgical drainage for the reduction of recurrence with reoperation

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Chinese Neurosurgical Journal 2015年第1期1卷 -页

作者： david Yuen Chung Chan tin.Fung david sun Wai sang Poon Division of Neurosurgery Department of Surgery Prince of Wales HospitalThe Chinese University of Hong Kong 30-32 Ngan Shing Street Shatin NTHong Kong

Background: Chronic subdural hematoma is a common neurosurgical condition especially in the aging *** hole for drainage is an effective treatment, yet recurrence is reported at 8 to 22 ％ worldwide, and 1-year mortality rates could be as high as 32 ％.Our previous study on the use of dexamethasone as a primary nonsurgical treatment showed good response in selected group of *** study aims to assess the efficacy of dexamethasone with surgical drainage in the reduction of recurrence requiring ***: From October 2000 to september 2006, patients with chronic subdural hematoma admitted to the Prince of Wales Hospital, The Chinese University of Hong kong, were randomized to surgical drainage with steroid versus surgical drainage *** primary endpoint was symptomatic recurrence requiring ***: Two hundred forty-eight patients were recruited and consented for the randomization during the study *** hundred twenty-two received both surgery and steroid (the intervention arm) while 126 received surgery only (the control arm).The recurrence rate requiring reoperation was 6.6 ％ (8/122) and 13.5 ％ (17/126),respectively (p =0.109).There was no significant difference in complications such as chest infection (p =0.201) or wound infection (p =0.987).Favorable outcome (Glasgow Outcome score 4-5) was 104/122 (85.2 ％) in the intervention group versus 105/126 (83.3 ％) in the control group, respectively (p =0.811).Based on the recurrence rate in our study, we generate a potential sample size of at least 594 patients (type Ⅰ error =5 ％, power =80 ％,two-sided test) to detect a significant ***, brief summary, and potential implications: In this prospective pilot phase IIB randomized controlled study, steroid with surgical drainage had a lower recurrence with reoperation though statistically *** was safe with no significant difference in complication *** pilot study generates a potential sample s

关键词： Chronic subdural hematoma steroid Burr hole for drainage

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Toward Cloud Computin. Qos Architecture:Analysis of Cloud systems and Cloud services

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IEEE/CAA Journal of Automatica sinica 2017年第1期4卷 6-18页

作者： Mohammad Hossein Ghahramani MengChu Zhou Chi tin.Hon IEEE Institute of systems Engineering Macao University of Science and Technology Helen and John C. Hartmann Department of Electrical and Computer Engineering New Jersey Institute of Technology school of Management Fudan University

Cloud can be defined as a new computin. paradigm that provides scalable, on-demand, and virtualized resources for users. In this style of computin., users can access a shared pool of computin. resources which are provisioned with minimal management efforts of users. Yet there are some obstacles and concerns about the use of clouds. Guaranteeing quality of service Qos by service providers can be regarded as one of the main concerns for companies tending to use it. service provisioning in clouds is based on service level agreements representin. a contract negotiated between users and providers. According to this contract, if a provider cannot satisfy its agreed application requirements, it should pay penalties as compensation. In this paper, we intend to carry out a comprehensive survey on the models proposed in literature with respect to the implementation principles to address the Qos guarantee issue. © 2014 Chinese Association of Automation.

关键词： Cloud computin. Distributed computer systems system of systems systems engineering Telecommunication services Web services

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