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sERPINH1 promoted the proliferation and metastasis of colorectal cancer by activating PI3k/Akt/mTOR signaling pathway

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1890-1907页

作者： Xiao-sheng Jin Lu-Xi Chen ting-ting Ji Rong-Zhou Li Department of Gastroenterology The Third Affiliated Hospital of Wenzhou Medical UniversityRuian 325000Zhejiang ProvinceChina

BACkGROUND serpin peptidase inhibitor clade H member 1(sERPINH1)was initially recognized as an oncogene implicated in various human ***,the clinical relevance and functional implications of sERPINH1 in colorectal cancer(CRC)remain largely *** To investigate the effects of sERPINH1 on CRC cells and its specific *** Quantitative real-time polymerase chain reaction,western blotting analysis,The Cancer Genome Atlas data mining and immunohistochemistry were employed to examine sERPINH1 expression in CRC cell lines and tissues.A series of in-vitro assays were performed to demonstrate the function of sERPINH1 and its possible mechanisms in *** sERPINH1 demonstrated elevated expression levels in both CRC cells and tissues,manifested at both mRNA and protein *** sERPINH1 levels correlated closely with advanced T stage,lymph node involvement,and distant metastasis,exhibiting a significant association with poorer overall survival among CRC *** investigations unveiled that sERPINH1 overexpression notably bolstered CRC cell proliferation,invasion,and migration in vitro,while conversely,sERPINH1 knockdown elicited the opposite *** set enrichment analysis underscored a correlation between sERPINH1 upregulation and genes associated with cell cycle *** findings underscored the capacity of heightened sERPINH1 levels to expedite G1/s phase cell cycle progression via phosphatidylinositol 3-kinase/AkT/mechanistic target of rapamycin pathway activation,thereby facilitating CRC cell invasion and *** These findings imply a crucial involvement of sERPINH1 in the advancement and escalation of CRC,potentially positioning it as a novel candidate for prognostic assessment and therapeutic intervention in CRC management.

关键词： serpin peptidase inhibitor clade H member 1 Colorectal cancer Proliferation Cell cycle Phosphatidylinositol 3-kinase/AkT/mechanistic target of rapamycin

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silencing of Jumonji domain-containing 1C inhibits the osteogenic differentiation of bone marrow mesenchymal stem cells via nuclear factor-κB signaling

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World Journal of stem Cells 2024年第2期16卷 151-162页

作者： Jing-Yi Li ting-ting Wang Li Ma Yu Zhang Di Zhu Department of Medical Cosmetology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Department of General Gerontology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Plastic surgery China-Japan Friendship HospitalBeijing 100029China senior Department of Hematology The Fifth Medical CentreGeneral Hospital of Chinese People’s Liberation ArmyBeijing 100071China Department of Orthopaedic surgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China

BACkGROUND Osteoporosis is a common metabolic bone disorder induced by an imbalance between osteoclastic activity and osteogenic *** osteoporosis,bone mesenchymal stem cells(BMsCs)exhibit an increased ability to differentiate into adipocytes and a decreased ability to differentiate into osteoblasts,resulting in bone *** domain-containing 1C(JMJD1C)has been demonstrated to suppress *** To examine the effect of JMJD1C on the osteogenesis of BMsCs and the potential underlying *** BMsCs were isolated from mouse bone marrow *** Red O staining,Alizarin red staining,alkaline phosphatase staining and the expression of adipo-genic and osteogenic-associated genes were assessed to determine the differen-tiation of *** marrow-derived macrophages(BMMs)were incubated with receptor activator of nuclear factor-kappaΒligand to induce osteoclast differentiation,and osteoclast differen-tiation was confirmed by tartrate-resistant acid phosphatase *** related genes were measured via reverse transcription coupled to the quantitative polymerase chain reaction and western ***-linked immunosorbent assays were used to measure the levels of inflammatory cytokines,including tumor necrosis factor alpha,interleukin-6 and interleukin-1 *** The osteogenic and adipogenic differentiation potential of BMsCs isolated from mouse bone marrow samples was ***1C mRNA and protein expression was upregulated in BMsCs after osteoblast induction,while p-nuclear factor-κB(NF-κB)and inflammatory cytokines were not significantly *** of JMJD1C repressed osteogenic differentiation and enhanced NF-κB activation and inflammatory cytokine release in ***,JMJD1C expression decreased during BMM osteoclast *** The JMJD1C/NF-κB signaling pathway is potentially involved in BMsC osteogenic differentiation and may play vital roles in the pathogenesis of osteoporosis.

关键词： Osteoporosis Mesenchymal stem cells Osteogenesis Jumonji domain-containing 1C Nuclear factor-κB

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Engineering classification recycling of spent lithium-ion batteries through pretreatment:a comprehensive review from laboratory to scale-up application

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Rare Metals 2024年第3期43卷 915-941页

作者： shu-Xuan Yan You-Zhou Jiang Xiang-Ping Chen Lu Yuan ting-ting Min Yu Cao Wan-Li Peng Tao Zhou Hunan Provincial key Laboratory of Chemical Power sources College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China College of Chemistry and Chemical Engineering Hunan Normal UniversityChangsha 410083China school of Public Policy and Management Tsinghua UniversityBeijing 100084China China Nonferrous Metal Industry's Foreign Engineering and Construction Co. LtdBeijing 100029China

The lithium-ion batteries(LIBs)have been widely equipped in electric/hybrid electric vehicles(EVs/HEVs)and the portable electronics due to their excellent electrochemical ***,a large number of retired LIBs that consist of toxic substances(e.g.,heavy metals,electrolytes)and valuable metals(e.g.,Li,Co)will inevitably flow into the waste stream,and their incineration or landfill treatment will cause severe risks to ecosystem and human *** sustainable and efficient treatment or recycling of valuable resources from spent LIBs should be fully recognized for environmental and resource *** one of the most important processes for spent LIBs recycling,the pretreatment is an indispensable step,which is directly related to the subsequent metal extraction and separation *** considerable progresses have been made regarding the pretreatment technologies,there are few summarized reports concerning critical processes of spent LIBs recycling,especially combination of currently available recycling technologies with industrialized applications during ***,comprehensive review of the current prevailing pretreatment technologies in laboratory to existing scale-up applications is quite necessary to reveal cutting-edge development in the field of *** this review,the current pretreatment technologies are systematically categorized and introduced,along with critical *** review focused on the various options for pretreatment processes itself,instead of general spent LIBs recycling technologies without the focused topics that have been sophisticatedly reviewed by previous ***,the deactivation,discharge,dismantling,separation,liberation of active material and electrolyte treatment have been summarized with the in-depth discussion of the technology development and current status of each ***,current states of industrial development are also reviewed and discussed for the development of

关键词： spent lithium-ion batteries(LIBs) Recycling Pretreatment Valuable metals Cutting-edge technologies Industrialized application

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Dietary inflammatory index and its impact on severity and recurrence of Tourette syndrome in children

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World Journal of Psychiatry 2024年第8期14卷 1208-1215页

作者： Xiao-Ping Wu Rong-Rong Fang ting-ting Ji Department of Pediatrics Qingdao Chengyang People’s HospitalQingdao 266109Shandong ProvinceChina

BACkGROUND Tourette syndrome(Ts)is a neurodevelopmental disorder characterized by the presence of motor and vocal tics,typically beginning in *** signifi-cant research efforts,the exact pathophysiology of Ts remains incompletely *** studies suggest that inflammation may play a role in the severity and progression of Ts,pointing to the potential influence of dietary and lifestyle factors on the ***,research on the specific connection between dietary inflammatory index(DII)and Ts is still in its early stages,requir-ing additional clinical and epidemiological studies to validate the strength and specific mechanisms of this *** A total of 207 children diagnosed with Ts in the pediatric department of Qingdao Chengyang People’s Hospital from January 2022 to January 2023 were *** were divided into stable and unstable groups based on follow-up *** enrollment,general information of the children[age,gender,body mass index(BMI),guardian’s education level,DII score,medical history,family history,academic stress,electronic device usage,medication,and disease progression]was assessed,and serum inflammatory levels were measured during follow-up *** scores and Yale Global Tic severity scale(YGTss)scores were ***,based on YGTss scores,the children were classified into mild,moderate,and severe *** DII,interleukin-6(IL-6),C-reactive protein(CRP),and tumor necrosis factor-alpha(TNF-α)levels in each group were *** Follow-up surveys were completed by 207 children and their *** them,117 children were in the stable group,and 90 were in the recurrent *** found no statistically significant differences in age,gender,comorbidities,BMI,and disease duration between the two groups(P>0.05).However,academic stress,electronic device usage,medication,guardian’s education level,and DII scores showed statistically significant differences between the groups(P

关键词： Dietary inflammation index Tourette's syndrome Correlation analysis Pro-inflammatory foods Inflammation levels Impact on severity and recurrence

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Neuroimmune interactions and their roles in neurodegenerative diseases

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Fundamental Research 2024年第2期4卷 251-261页

作者： Bai-Rong Chen ting Wu ting-Hui Chen Yun Wang Neuroscience Research Institute and Department of Neurobiology School of Basic Medical SciencesKey Laboratory for NeuroscienceMinistry of Education/National Health Commission and State Key Laboratory of Natural and Biomimetic DrugsPeking UniversityBeijing 100083China PkU-IDG/McGovern Institute for Brain Research Peking UniversityBeijing 100871China

The nervous system possesses bidirectional,sophisticated and delicate communications with the immune *** neuroimmune interactions play a vitally important role in the initiation and development of many disorders,especially neurodegenerative *** scientific advancements have made tremendous progress in this field during the last few years,neuroimmune communications are still far from being *** organizing recent research,in this review,we discuss the local and intersystem neuroimmune interactions and their roles in Alzheimer’s disease,Parkinson’s disease and amyotrophic lateral *** these will help us gain a better understanding of the process of interplay inside the body and how the organism maintains *** will also facilitate a view of the diseases from a holistic,pluralistic and interconnected perspective,thus providing a basis of developing novel and effective methods to diagnose,intervene and treat diseases.

关键词： Nervous system Immune system Neuroimmune interactions Alzheimer’s disease Parkinson’s disease Amyotrophic lateral sclerosis

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Z-scheme Bi_(4)O_(5)Br_(2)/NH_(2)-MIL-125(Ti)heterojunctions enable exceptional visible photocatalytic degradation of organic pollutant

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Rare Metals 2024年第7期43卷 3161-3172页

作者： Feng Huang Muhammad Humayun Gang Li ting-ting Fan Wen-Lin Wang Yu-Lin Cao Anton Nikiforov Chun-Dong Wang Jing Wang key Laboratory of Analytical science and Technology of Hebei Province Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of EducationState Key Laboratory of New Pharmaceutical Preparations and ExcipientsCollege of Chemistry and Materials ScienceHebei UniversityBaoding071002China Energy Water and Environment LabCollege of Humanities and SciencesPrince Sultan University11586 RiyadhSaudi Arabia Baoding Green Yijia Environmental Protection Technology Ltd Baoding 071051China Physics Laboratory Industrial Training CenterShenzhen Polytechnic UniversityShenzhen 518055China Department of Applied Physics Ghent University9000 GhentBelgium school of Integrated Circuits Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074China

One key strategy to enhance photocatalytic performance is to improve the transfer and separation efficiency of photogenerated carriers by building optimized ***,novel Bi_(4)O_5Br_(2)/NH_(2)-MIL-125(Ti)Z-scheme heterojunctions are fabricated and used as photocatalysts for organic pollutant *** NH_(2)-MIL-125(Ti)nanosheets are exfoliated via a self-developed alkali solution stripping approach and then uniformly decorated on Bi_(4)O_(5)Br_(2).The as-prepared Bi_(4)O_(5)Br_(2)/NH_(2)-MIL-125(Ti)presents more than 90%degradation of various pollutants,outperforming the counterpart individual *** various characterization results suggest that the enhanced degradation rate is due to the more intimate face-to-face interfacial contact of the lamellar Z-scheme heterojunction materials,in which the migration path of carriers from the material's interior to the surface can be reduced,in turn enhancing migration efficiency and separation capability significantly.A possible photocatalytic reaction mechanism is proposed based on the photoelectric behaviors,radical trapping experiments and liquid chromatography mass spectrometry *** work promotes the development of new photocatalytic materials for heterojunctions with face-to-face interfacial contacts,as well as the effective purification of wastewater in environmental remediation.

关键词： Z-scheme heterojunctions Photocatalysis Alkaline solution stripping Bi_(4)O_(5)Br_(2) NH_(2)-MIL-125(Ti)

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Assessing the energy saving potential of using adaptive setpoint temperatures:The case study of a regional adaptive comfort model for Brazil in both the present and the future

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Building simulation 2024年第3期17卷 459-482页

作者： Daniel sánchez-García david Bienvenido-Huertas Carlos Rubio-Bellido Ricardo Forgiarini Rupp Department of Electrical Engineering University Carlos III of MadridMadridSpain Department of Building simulation ZEROCEM SLSevilleSpain Department of Building Constructions University of GranadaGranadaSpain Department of Building Constructions II University of SevilleSevilleSpain section of Design for sustainability Department of Civil and Mechanical EngineeringTechnical University of DenmarkKgs.LyngbyDenmark

It has been found in recent years that using setpoint temperatures based on adaptive thermal comfort models is a successful method of energy *** studies using adaptive setpoint temperatures incorporate international models from AsHRAE standard 55 and *** study,however,has instead considered a regional Brazilian adaptive comfort *** study investigates the energy demand arising from the use of a local Brazilian comfort model in order to assess the energy implications from the use of the worldwide AsHRAE standard 55 adaptive model and various fixed setpoint *** of Brazil’s climate zones,full air-conditioning,mixed-mode building operating modes,present-day climate change scenarios,and future scenarios—specifically Representative Concentration Pathways(RCP)2.6,4.5,and 8.5 for the years 2050 and 2100—have all been taken into account in building energy *** use of adaptive setpoint temperatures based on the Brazilian local model considering mixed-mode has been found to significantly reduce energy consumption when compared to static setpoint temperatures(average energy-saving values ranging from 52%to 58%)and the AsHRAE 55 adaptive model(average values ranging from 15%to 21%).Considering climate change and the mixed-mode Brazilian model,the overall energy demand for the three groups of climatic zones(annual average outdoor temperatures≤21℃,>21 and≤25℃and>25℃)ranged between 2%decrease and 5%increase,4%and 27%increase,and 13%and 45%increase,*** is concluded as a consequence that setting setpoint temperatures based on the Brazilian local adaptive comfort model is a very efficient energy-saving method.

关键词： adaptive thermal comfort building energy simulation energy efficiency climate change adaptive setpoint temperatures local comfort mode

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Loss to specialized Cardiology Follow-Up in Adults Living with Congenital Heart Disease

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Congenital Heart Disease 2024年第1期19卷 49-63页

作者： Cheryl Dickson Danielle Osborn david Baker Judith Fethney david s.Celermajer Rachael Cordina Department of Cardiology Royal Prince Alfred HospitalSydneyAustralia Department of Cardiothoracic surgery Westmead HospitalSydneyAustralia susan Wakil school of Nursing and Midwifery The University of SydneySydneyAustralia sydney Medical school The University of SydneySydneyAustralia

Background:Much has been written about the loss to follow-up in the transition between pediatric and adult Congenital Heart Disease(CHD)care *** less is understood about the loss to follow-up(LTF)after a successful *** is critical too,as patients lost to specialised care are more likely to experience mor-bidity and premature ***:To understand the prevalence and reasons for loss to follow-up(LTF)at a large Australian Adult Congenital Heart Disease(ACHD)***:Patients with moderate or highly complex CHD and gaps in care of>3 years(deﬁned as LTF)were identiﬁed from a comprehensive ACHD *** telephone interviews examined current care and barriers to clinic ***:Overall,407(22%)of ACHD patients(n=1842)were *** mean age at LTF was 31(sD 11.5)years and 54%were male;311(76%)were *** to adults seen regularly,lost patients were younger,with a greater socio-economic disadvantage,and had less complex CHD(ps(14%).The top 3 responses for care absences were“feeling well”(61%),losing track of time(36%),and not needing fol-low-up care(25%).Conclusions:A large proportion of the ACHD population becomes lost to specialised cardiac care,even after a successful *** Australian study reports younger age,moderate complexity defects,and socio-economic disadvantage as predictive of loss to *** study highlights the need for novel approaches to patient-centered service delivery even beyond the age of transition and resources to maintain patient engagement within the ACHD service.

关键词： Loss to follow-up follow-up adult congenital heart disease lapse in care gaps in care care gaps care continuity ACHD predictors

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sulfur vacancies and heterogeneous interfaces promote high performance sodium storage of bimetallic chalcogenide hollow nanospheres

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Journal of Energy Chemistry 2024年第8期95卷 596-610,I0013页

作者： shiyue Cao Xiaoting Xu Qiming Liu Huijuan Zhu ting Hu key Laboratory of Artificial Micro-and Nano-structures of Ministry of Education School of Physics and TechnologyWuhan UniversityWuhan 430072HubeiChina

Transition metal sulfides have high theoretical capacities and are considered as potential anode materials for sodium-ion ***,due to low inherent conductivity and significant volume expansion,the electrochemical performance is greatly *** this study,a nickel/manganese sulfide material(Ni_(0.96)s_(x)/Mns_(y)-NC)with adjustable sulfur vacancies and heterogeneous hollow spheres was prepared using a simple *** introduction of a concentration-adjustable sulfur vacancy enables the generation of a heterogeneous interface between bimetallic sulfide and sulfur *** interface collectively creates an internal electric field,improving the mobility of electrons and ions,increasing the number of electrochemically active sites,and further optimizing the performance of Na~+*** direction of electron flow is confirmed by Density functional theory(DFT)*** hollow nano-spherical material provides a buffer for expansion,facilitating rapid transfer *** innovative discovery involves the interaction between the ether-based electrolyte and copper foil,leading to the formation of Cu_9s_5,which grafts the active material and copper current collector,reinforcing mechanical *** results in a new heterostructure of Cu_9s_5 with Ni_(0.96)s_(x)/Mns_(y),contributing to the stabilization of structural integrity for long-cycle ***,Ni_(0.96)s_(x)/Mns_(y)-NC exhibits excellent electrochemical properties following our modification *** stability performance,Ni0_(.96)s_(x)/Mns_(y)-NC demonstrates an average decay rate of 0.00944%after 10,000 cycles at an extremely high current density of 10000 mA g^(-1),A full cell with a high capacity of 304.2 mA h g^(-1)was also successfully assembled by using Na_(3)V_(2)(PO_(4))_(3)/C as the *** study explores a novel strategy for interface/vacancy co-modification in the fabrication of high-performance sodium-ion batteries electrode.

关键词： sulfur vacancies Heterogeneous interface Interactions sodium ion batteries

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Proteomic study of vitreous in proliferative diabetic retinopathy patients after treatment with aflibercept:a quantitative analysis based on 4D label-free technique

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 676-685页

作者： ting-ting Feng Xiang Gao An-Ran Liang Bo-Wen Zhao Guang-Hui He song Chen Clinical College of Ophthalmology Tianjin Medical UniversityTianjin 300070China Tianjin key Laboratory of Ophthalmology and Visual science Tianjin Eye InstituteTianjin Eye HospitalTianjin 300020China key Laboratory of Ophthalmology Anyang Eye HospitalAnyang 455000Henan ProvinceChina Department of Ophthalmology Jining No.1 People’s HospitalJining 272011Shandong ProvinceChina

AIM:To identify different metabolites,proteins and related pathways to elucidate the causes of proliferative diabetic retinopathy(PDR)and resistance to anti-vascular endothelial growth factor(VEGF)drugs,and to provide biomarkers for the diagnosis and treatment of ***:Vitreous specimens from patients with diabetic retinopathy were collected and analyzed by Liquid Chromatography-Mass spectrometry(LC-Ms/Ms)analyses based on 4D label-free *** differentially expressed proteins(DEPs),Gene Ontology(GO),kyoto Encyclopedia of Genes and Genomes.kEGG)pathway representation and protein interactions were ***:A total of 12 samples were *** proteomics results showed that a total of 58 proteins were identified as DEPs,of which 47 proteins were up-regulated and 11 proteins were *** found that C1q and tumor necrosis factor related protein 5(C1QTNF5),Clusterin(CLU),tissue inhibitor of metal protease 1(TIMP1)and signal regulatory protein alpha(sIRPα)can all be specifically regulated after aflibercept *** functional analysis showed that some DEPs are related to changes in inflammatory regulatory pathways caused by *** addition,protein-protein interaction(PPI)network evaluation revealed that TIMP1 plays a central role in neural *** addition,CD47/sIRPαmay become a key target to resolve anti-VEGF drug resistance in ***:Proteomic analysis is an approach of choice to explore the molecular mechanisms of *** data show that multiple proteins are differentially changed in PDR patients after intravitreal injection of aflibercept,among which C1QTNF5,CLU,TIMP1 and sIRPαmay become targets for future treatment of PDR and resolution of anti-VEGF resistance.

关键词： vitreous proliferative diabetic retinopathy proteome 4D label-free

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