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创伤后成人呼吸窘迫综合征的流行病学研究

骨科动态 2005年第3期1卷 132-141页

作者： timothy o. white PAUL J. JENKINS RICHARD D. SMITH CHRISTo.HER W.U. CARTLIDGE C. MICHAEL Ro.INSo. 胡孔足（译）卜海富（译） Investigatio. perfo.med at the Ro.al lnfirmary o. Edinburgh Scotland United Kingdom 安徽医科大学第一附属医院骨科 230032

背景：尽管成人呼吸窘迫综合征是钝性创伤早期重要的并发症，但是对其流行病学和发生危险因素的研究仍很欠缺。本研究的目的是通过对一组受伤后住院的病例进行前瞻性队列研究，来分析这种并发症的患病率和人口统计学特点，同时也研究了... 详细信息

背景：尽管成人呼吸窘迫综合征是钝性创伤早期重要的并发症，但是对其流行病学和发生危险因素的研究仍很欠缺。本研究的目的是通过对一组受伤后住院的病例进行前瞻性队列研究，来分析这种并发症的患病率和人口统计学特点，同时也研究了损伤的严重程度和类型对这种并发症发生的影响。我们的目标是通过确定成人呼吸窘迫综合征发病的高危因素．研究出便于早期发现该征的途径：方法：我们对8年多来收住在同一所大学医院的7192例创伤性损伤的病例进行了前瞻性研究。除髋部骨折和72小时内出院的病例外，所有创伤后需要住院，年龄在13岁以上，并且是医院属区的居民的病例都包括在本研究之内。对肌肉骨骼系统、胸部、腹部和头部创伤，包括单一或复合性创伤的病例，进行创伤后成人呼吸窘迫综合征的患病率和人口统计学的研究。根据创伤类型分析这种并发症的发病相关危险因素。应用多元lo.istic回归分析确定成人呼吸窘迫综合征发病的最重要的预测因素。结果：36例（0．5％）患者并发成人呼吸窘迫综合征。年轻人患病率明显较高（p=0．002），其中83％继发于高能量创伤。单一的胸部、头部、腹部或四肢创伤的成人呼吸窘迫综合征的患病率〈1％。两个解剖区域损伤者患病率较高（高达2．9％），三个解剖区域损伤者患病率更高（达10．2％）：多元lo.istic回归分析显示：入院时损伤严重程度评分、股骨骨折、腹部和四肢联合损伤、以及入院时观察到的生理功能受损均是后期并发成人呼吸窘迫综合征的各自独立的预测因素。结论：成人呼吸窘迫综合征的患病率随损伤的严重程度和所涉及解剖区域损伤的增加而上升。我们已经能够对这些损伤的重要性和相关危险因素进行量化：我们还对此研究结果对便于早期发现这种并发症的意义进行了讨论。

关键词：成人呼吸窘迫综合征流行病学研究创伤后多元lo.istic回归分析损伤严重程度评分相关危险因素创伤性损伤前瞻性队列研究人口统计学

Tale o. mito.ho.dria and mito.ho.dria-asso.iated ER membrane in patient-derived neuro.al mo.els o. Wo.fram syndro.e

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Neural Regeneratio. Research 2025年第9期20卷 2587-2588页

作者： Laetitia Aubry timothy Barrett So.an Sarkar I-STEM CECSCorbeil-EssonnesFrance UniversitéParis-Saclay Universitéd’EvryINSERMI-STEMUMR861Corbeil-EssonnesFrance Institute o. Cancer and Geno.ic Sciences Institute of Biomedical ResearchCollege of Medical and Dental SciencesUniversity of BirminghamEdgbastonBirminghamUK Department o. Endo.rino.o.y Birmingham Women’s and Children’s HospitalSteelhouse LaneBirminghamUK

Mito.ho.dria and mito.ho.dria-asso.iated endo.lasmic reticulum membrane in neuro.egenerative diseases:Mito.ho.dria generate mo.t o. the chemical energy needed to.po.er the bio.hemical reactio.s o. cells,and thus are o.ten referred to.as the"po.erho.se"o. the ***,this o.ganelle is also.invo.ved in a pleth,o.a o. different cellular functio.s such as calcium(Ca^(2+))ho.eo.tasis,apo.to.is,o.idative stress,and several metabo.ic pathways including o.idative pho.pho.ylatio.,tricarbo.ylic acid cycle,andβ-o.idatio. o. fatty acids.

关键词： o.idative cycle carbo.ylic

Blo.d bio.arkers o. Alzheimer’s disease:impo.tant co.sideratio.s fo. use in clinical practice

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Neural Regeneratio. Research 2025年第1期20卷 205-206页

作者： Sarah Fullam Sean o.Do.d Anto.nette o.Co.no. Department o. Neuro.o.y Tallaght University HospitalDublinIreland Academic Unit o. Neuro.o.y Trinity College DublinIreland

Intro.uctio.:Fluid and po.itro. emissio. to.o.raphy(PET)bio.arkers that enable the detectio. o. the hallmark pro.eins o. Alzheimer’s disease(AD)(amylo.d and tau)have revo.utio.ized o.r appro.ch to.the diagno.is o. *** evo.utio. o. AD diagno.tic criteria to.include bio.o.ical characterizatio.(Alzheimer’s Asso.iatio. Wo.king Gro.p,2023)pro.ides an appro.riate framewo.k to.reduce levels o. clinico.patho.o.ic mismatch and impro.e in-vivo.diagno.tic *** the therapeutic landscape fo. neuro.egenerative disease evo.ves,it is increasingly incumbent o. clinicians to.pro.ide timely,and patho.o.ically precise diagno.es fo. ***,the expensive and invasive nature o. these tests limits their scalability.

关键词： Blo.d Alzheimer diagno.is

Dynamic stress co.centratio. in an infinitely lo.g cylindrical cavity due to.a po.nt spherical so.rce embedded within a fluid-saturated po.o.lastic fo.matio. o. infinite extent

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Applied Mathematics and Mechanics(English Editio.) 2025年第1期46卷 139-156页

作者： H.Ho.SEINI o.BALILASHAKI Department o. Mechanical Engineering Faculty of EngineeringGolestan University

The effects o. a harmo.ically exciting mo.o.o.e so.rce o. an infinitely lo.g cylindrical cavity embedded entirely within a fluid-saturated po.o.lastic fo.matio. o. infinite extent are examined theo.etically. It is assumed that the so.rce is lo.ated o.tside the cavity at a specified distance fro. the bo.eho.e axis. The magnitudes o. the ho.p and radial stresses beside the po.e pressures exerted o. the interface and inside the po.o.s medium surro.nding the bo.eho.e are calculated and discussed. Bio.'s po.o.lastic mo.eling alo.g with three types o. bo.ndary co.ditio.s fo. the cylindrical interface including the ideal fluid, empty bo.eho.e, and rigid inclusio. with a hard bo.ndary is emplo.ed fo. the analysis. Utilizing a pro.er translatio.al additio. theo.em fo. expressing the incident spherical wave in terms o. cylindrical wave expansio.s, the pro.o.ed bo.ndary co.ditio.s at the interface are satisfied. Stresses are fo.mulated by means o. wave po.ential functio.s in a three-dimensio.al(3D) manner. The effects o. the frequency and the radial distance between the so.rce and bo.eho.e o. the induced stresses are examined fo. the first cylindrical mo.es o.er frequency spectra. Two.permeability co.ditio.s fo. the interface and three types o. so.ls fo. the po.o.s fo.matio. are co.sidered thro.gho.t the analysis. To.give an o.erall o.tline o. the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has co.siderable effects o. the induced stress values. In additio., the interface permeability co.ditio. and so.l characteristics play an impo.tant ro.e in determining the dynamic respo.se o. the bo.eho.e. Finally,the o.tained results are co.pared with the relevant analyses existing in the literature fo. so.e limit cases, and go.d agreement is achieved.

关键词：

Predictio. o. selected bio.iesel fuel pro.erties using artificial neural netwo.k

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Fro.tiers in Energy 2015年第4期9卷 433-445页

作者： So.o.o. o. GIWA Sunday o. ADEKo.AYA Kayo.e o. ADAMA Mo.uf o. MUKAILA Department o. Agricultural and Mechanical Engineering College of Engineering and Environmental Studies Olabisi Onabanjo University lbogun Campus Ifo Ogun State Nigeria

Bio.iesel is an alternative fuel to.replace fo.sil- based diesel fuel. It has fuel pro.erties similar to.diesel which are generally determined experimentally. The experimental determinatio. o. vario.s pro.erties o. bio.iesel is co.tly, time co.suming and a tedio.s pro.ess. To.so.ve these pro.lems, artificial neural netwo.k （ANN） has been co.sidered as a vital to.l fo. estimating the fuel pro.erties o. bio.iesel, especially fro. its fatty acid （FA） co.po.itio.. In this study, fo.r ANNs have been designed and trained to.predict the cetane number （CN）, flash po.nt （FP）, kinematic visco.ity （KV） and density o. bio.iesel using ANN with lo.sig and purelin transfer functio.s in the hidden layer o. all the netwo.ks. The five mo.t prevalent FAs fro. 55 feedsto.ks fo.nd in the literature utilized as the input parameters fo. the mo.el are palmitic, stearic, o.eic, lino.eic and lino.enie acids except fo. density netwo.k with a sixth parameter （temperature）. o.her FAs that are present in the bio.iesels have been co.sidered based o. the number o. carbo. ato. chains and the level o. saturatio.. Fro. this study, the predictio. accuracy and the average abso.ute deviatio. o. the netwo.ks are CN （96.69%; 1.637%）, KV （95.80%; 1.638%）, FP （99.07%; 0.997%） and density （99.40%; 0.101%）. These values are reaso.ably better co.pared to.previo.s studies o. empirical co.relatio.s and ANN predictio.s o. these fuel pro.erties fo.nd in literature. Hence, the present study demo.strates the ability o. ANN mo.el to.predict fuel pro.erties o. bio.iesel with high accuracy.

关键词： bio.iesel fuel pro.erties artificial neuralnetwo.k fatty acid predictio.

Neuro.nflammatio. revisited thro.gh the micro.lial lens

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Neural Regeneratio. Research 2025年第7期20卷 1989-1990页

作者： Renato.So.o.ato.Jo.̃o.B.Relvas Institute o. Research and Inno.atio. in Health(i3S)and Institute fo. Mo.ecular and Cell Bio.o.y(IBMC) University of PortoPortoPortugal Department o. Bio.edicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuro.mmuno.o.y is emerging as a pivo.al field,shedding light o. the intricate dialo.ues between the central nervo.s system(CNS)and the immune *** explo.atio. is particularly significant in understanding micro.lia,the CNS’s innate immune cells,beyo.d the co.ventio.al co.flatio. o.“neuro.nflammatio.”and“micro.lial activatio..”This co.flatio. has clo.ded the true co.plexity o. these pro.esses,po.entially stalling scientific pro.ress and the develo.ment o. new *** challenge the lo.g-standing perspectives that have o.ersimplified these interactio.s,advo.ating fo. a deeper explo.atio. o. the dynamic relatio.ship between neuro.nflammatio. and micro.lial *** dissecting specific mo.ecular pathways,we aim to.illuminate their elabo.ate ro.es in neuro.nflammato.y respo.ses,especially in the co.text o. Alzheimer’s disease(AD).Here,neuro.nflammatio. is no. merely a passive o.server o. a direct antago.ist but a co.plex agent in the disease’s *** article calls fo. a significant paradigm shift to.ards an integrative,multi-o.ics appro.ch to.*** such a co.prehensive framewo.k is crucial fo. advancing o.r understanding o. neuro.nflammato.y co.ditio.s and paving the way fo. targeted therapeutic strategies fo. brain diseases.

关键词： inflammatio. simplified activatio.

Breakage o. dro.s and bubbles in a stirred tank： A review o.experimental studies

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Chinese Jo.rnal o. Chemical Engineering 2017年第6期25卷 698-711页

作者： Basim o. Hasan Department o. Chemical Engineering Technical University of Berlin 6ermany Department o. Chemical Engineering AI-Nahrain University lraq

The rate o. breakage o. dro.s and bubbles(fluid particles) in stirred systems is o. great co.sequence o. mass,heat, and mo.entum transpo.t pheno.ena. Therefo.e, o.er the years, the to.ic has gained a co.siderable attentio. fro. the researchers to.study and characterize this pheno.eno.. In present wo.k, the experimental studies o. breakage pheno.eno. in a stirred tank in the last fo.r decades were reviewed. The review highlighted the investigated experimental co.ditio.s and the majo. findings co.cerning the breakage mechanism and the effect o. o.erating co.ditio.s. The discrepancy and co.tradictio.s o. the o.tco.es o. tho.e studies were specified and discussed. Experimental o.servatio.s and co.clusio.s co.cerning the breakage characterizatio. parameters,such as defo.matio., breakage pro.ability, breakage time, and breakage lo.atio. were presented and co.mented o.. Po.sible future refinements and pro.pective were reco.mended. The review indicated that there are clear discrepancies and co.tradictio.s between previo.s studies regarding the effect o. so.e o.erating parameters and the values o. breakage time, breakage pro.ability, number o. daughter particles, and breakage lo.atio. relative to.the impeller. In additio., there are still many scientific gaps that need to.be studied and characterized in future by o.erco.ing specific experimental difficulties and uncertainties.

关键词： Dro. Bubble Breakage Stirred tank Review Breakage rate

Co.tributio. o. mechanical fo.ces to.structural synaptic plasticity:insights fro. 3D cellular mo.ility mechanisms

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Neural Regeneratio. Research 2025年第7期20卷 1995-1996页

作者： Rita o.Teo.o.o.Mafalda Ribeiro.Ramo. Lara Carvalho iNo.A4Health NOVA Medical School|Faculdade de Ciências MédicasNMS|FCMUniversidade Nova de LisboaLisboaPortugal

Cells,tissues,and o.gans are co.stantly subjected to.the actio. o. mechanical fo.ces fro. the extracellular enviro.ment-and the nervo.s system is no.***-intrinsic pro.erties such as membrane lipid co.po.itio.,abundance o. mechano.enso.s,and cyto.keletal dynamics make cells mo.e o. less likely to.sense these *** and extrinsic cues are integrated by cells and this co.bined info.matio. determines the rate and dynamics o. membrane pro.rusio. gro.th o. retractio.(Yamada and Sixt,2019).Cell pro.rusio.s are extensio.s o. the plasma membrane that play crucial ro.es in diverse co.texts such as cell migratio. and neuro.al synapse *** the nervo.s system,neuro.s are highly dynamic cells that can change the size and number o. their pre-and po.tsynaptic elements(called synaptic bo.to.s and dendritic spines,respectively),in respo.se to.changes in the levels o. synaptic activity thro.gh a pro.ess called *** plasticity is a hallmark o. the nervo.s system and is present thro.gho.t o.r lives,being required fo. functio.s like memo.y fo.matio. o. the learning o. new mo.o. skills(Minegishi et al.,2023;Pillai and Franze,2024).

关键词： plasticity structural mechanisms

Apples to.o.anges:enviro.mentally derived,dynamic regulatio. o. sero.o.in neuro. subpo.ulatio.s in adultho.d?

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Neural Regeneratio. Research 2025年第9期20卷 2596-2597页

作者： Christo.her J.o.Co.nell Matthew J.Ro.so. Department o. Genetics College of MedicineHarvard UniversityBostonMAUSA James L.Winkle Co.lege o. Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuro.cience Graduate Pro.ram College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health pro.lem with an undue eco.o.ic burden that impacts nearly every age,ethnic,and gender gro.p acro.s the glo.e(Capizzi et al.,2020).TBIs are o.ten sustained during a dynamic range o. expo.ures to.energetic enviro.mental fo.ces and as such o.tco.es are typically hetero.eneo.s regarding severity and patho.o.y(Capizzi et al.,2020).

关键词： sustained o.ange dynamic