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International Journal of Minerals,Metallurgy and Materials 2016年第8期23卷 881-890页

作者： ying-yi Zhang Wei Lü Yuan-hong Qi Zong-shu Zou College of Materials Science and Engineering Chongqing University State Key Laboratory of Advance Steel Processes and Products Central Iron and Steel Research Institute School of Material and Metallurgy Northeastern University

A high-temperature reduction and smelting process was used to recover iron and calcium aluminate slag from high-ferrous bauxite. The effects of w（CaO）/w（SiO_2） ratio, anthracite ratio, and reduction temperature and time on the recovery and size of iron nuggets and on the Al_2O_3 grade of the calcium aluminate slag were investigated through thermodynamic calculations and experiments. The optimized process conditions were the bauxite/anthracite/slaked lime weight ratio of 100：16.17：59.37, reduction temperature of 1450°C and reduction time of 20 min. Under these conditions, high-quality iron nuggets and calcium aluminate slag were obtained. The largest size and the highest recovery rate of iron nuggets were 11.42 mm and 92.79wt%, respectively. The calcium aluminate slag mainly comprised Ca_2 SiO_4 and Ca_（12）Al_（14）O_（33）, with small amounts of Fe Al_2O_4, CaAl_2O_4, and Ca_2Al_2SiO_7.

关键词： bauxite reduction smelting recovery rate calcium aluminate slag

Environmental enrichment combined with fasudil treatment inhibits neuronal death in the hippocampal CA1 region and ameliorates memory deficits

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Neural Regeneration Research 2021年第8期16卷 1460-1466页

作者： Gao-Jing Xu Qun Zhang Si-Yue Li yi-Tong Zhu Ke-Wei Yu Chuan-Jie Wang Hong-Yu Xie yi Wu Department of rehabilitation Medicine Huashan HospitalFudan UniversityShanghaiChina Department of Rehabilitation Medicine Jinshan Hospital of Fudan UniversityShanghaiChina

Currently, no specific treatment exists to promote recovery from cognitive impairment after a stroke. Dysfunction of the actin cytoskeleton correlates well with poststroke cognitive declines, and its reorganization requires proper regulation of Rho-associated kinase(ROCK) proteins. Fasudil downregulates ROCK activation and protects neurons against cytoskeleton collapse in the acute phase after stroke. An enriched environment can reduce poststroke cognitive impairment. However, the efficacy of environmental enrichment combined with fasudil treatment remains poorly understood. A photothrombotic stroke model was established in 6-week-old male C57 BL/6 mice. Twenty-four hours after modeling, these animals were intraperitoneally administered fasudil(10 mg/kg) once daily for 14 successive days and/or provided with environmental enrichment for 21 successive days. After exposure to environmental enrichment combined with fasudil treatment, the number of neurons in the hippocampal CA1 region increased significantly, the expression and proportion of p-cofilin in the hippocampus decreased, and the distribution of F-actin in the hippocampal CA1 region increased significantly. Furthermore, the performance of mouse stroke models in the tail suspension test and step-through passive avoidance test improved significantly. These findings suggest that environmental enrichment combined with fasudil treatment can ameliorate memory dysfunction through inhibition of the hippocampal ROCK/cofilin pathway, alteration of the dynamic distribution of F-actin, and inhibition of neuronal death in the hippocampal CA1 region. The efficacy of environmental enrichment combined with fasudil treatment was superior to that of fasudil treatment alone. This study was approved by the Animal Ethics Committee of Fudan University of China(approval No. 2019-Huashan Hospital JS-139) on February 20, 2019.

关键词： cognitive environment hippocampus injury neuroprotection pathway repair stroke

Allowable variation of cold-rolled strip transverse profiles in high tension

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International Journal of Minerals,Metallurgy and Materials 2010年第5期17卷 608-616页

作者： Xiao-chen Wang Quan Yang Xiao-zhong Du Zheng-yi Jiang National Engineering Research Center of Flat Rolling Equipment University of Science and Technology Beijing Beijing 100083 China School of Mechanical Materials ＆ Mechatronic Engineering University of Wollongong Wollongong NSW 2522 Australia

The formation mechanism of the cold-rolled strip shape with high tension was studied. An advanced method to calculate the allowable variation of strip transverse profiles was established by the strip buckling criterion, which can be more properly used in cold rolling. With this method, the aim allowable variation of the product strip transverse profile and the required transverse profile range of incoming strips can be reached. Besides, this method has been successfully applied in a domestic tandem cold mill, and the transverse profile range of incoming strips suggested with this method is more practicable and complete. Consequently, the good performance is acquired.

关键词： cold rolling strips high tension buckling

Experimental and Numerical Study on the Hydrodynamic Characteristics of Solitary Waves Passing Over A Submerged Breakwater

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China Ocean Engineering 2019年第3期33卷 253-267页

作者： ZHAO Xi-zeng CHENG Du ZHANG yi-fei LI Meng-yu Ocean College Zhejiang University Zhoushan 316021 China Troops Zhoushan 316021 China Troops Ningbo 315171 China

In this study, solitary waves passing over a submerged breakwater are investigated both experimentally and numerically. A total of 9 experimental conditions are carried out, including different incident wave heights and water depths. Numerical simulations are performed using a high-order finite-difference model solving Navier–Stokes (N–S) equations. The predicted water wave elevation, velocity and pressure show good agreement with experimental data, verifying the accuracy and capacity of the numerical model. Furthermore, parametric studies are conducted by numerical modelling to examine the effects of the geometrical features of submerged dike on hydrodynamic characteristics around the breakwater.

关键词： submerged breakwater solitary wave CIP method Navier-Stokes model VOF method

Analysis of Penetration Depth of Pipeline on Cohesive Soil Seabed

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China Ocean Engineering 2019年第6期33卷 739-745页

作者： ZHANG Qi-yi ZHANG Yuan YAN Yun-qiang WU Shao-xuan College of Engineering Ocean University of ChinaQingdao 266100China Key Laboratory of Marine Engineering in Shandong Province Qingdao 266100China

This paper conducts laboratory tests to investigate detailedly the soil deformation law around the pipeline and its penetration depth under self-gravity. The seabed model is prepared by consolidating saturated soil using vacuum pressure technology, and the pipeline models are specifically designed to possess different radii. Based on the experimental results and digital images, the soil deformation process is analyzed and summarized, a kinematic admissible velocity field is given and an upper bound solution of pipeline penetration depth and soil reaction force is derived and proposed in this paper. In order to verify the accuracy of the upper bound solution deduced in this paper,a comparison is made among some published results and the solution suggested in this paper, the comparison results confirm that the upper bound solution and the soil failure mode are reasonable. Finally two empirical formulas are given in this paper to estimate the soil reaction force of seabed and the penetration depth of pipeline. The empirical formulas are in agreement with the upper bound solution derived in this paper, and the conclusion of this paper could provide some theoretical reference for the further study of the interaction between the pipeline and the soil.

关键词： upper bound solution kinematic admissible velocity field soil reaction force penetration depth

Prediction of properties distribution of 7B50 alloy thick plates after quenching and aging by quench factor analysis method

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Rare Metals 2019年第11期38卷 1043-1050页

作者： Lei Kang yi-Ran Zhou Gang Zhao Kun Liu Ni Tian Key Laboratory for Anisotropy and Texture of Materials Ministry of EducationSchool of Materials Science and EngineeringNortheastern UniversityShenyang 110819China Department of Applied Science University of Quebec at ChicoutimiSaguenayQC G7H 2B1Canada

In the present work,continuous cooling curves were accurately measured by the modified Jominy specimen of 7B50 alloy during water-spray quenching ***,the time-temperature-properties(TTP) curves of this alloy were obtained during isothermal *** on the accurate cooling curves and TTP curves,the hardness distribution along the thickness direction of 7B50 alloy thick plates was predicted by quench factor analysis *** is found that the quench sensitive temperature range of 7B50 alloy is 240-410℃,the nose temperature is 335℃,and the incubation period at the nose temperature is about 0.87 *** 7B50 alloy was isothermal treated at 180-400℃ after solid solution treatment(470℃ for 1 h followed by 483℃ for 2 h),the exponent(n) in the Johnson-Mehl-Avrami equation is close to 1 until transformed fraction of new precipitates is up to 60%,indicating that new precipitates first grow into rodlike shape and then coarsen or *** the distance is less than 65 mm from the spray quenching surface of the modified Jominy specimen,the deviation between the predicted and measured hardness is less than 2.7%,confirming the quench factor analysis method as the feasible way to predict the hardness distribution along the thickness direction of 7B50 alloy thick *** the distance from the spray quenching surface is 25 mm,the average cooling rate in quench sensitive temperature range is 9.93 ℃·s^-1,while the quench factor(τ) is 9.89 and the corresponding predicted hardness is HV 185.1 equivalent to 97.3% of the maximum measured hardness of 7B50 alloy in T6 temper.

关键词： 7B50 aluminum alloy Quench factor analysis method Time-temperature-properties curve Continuous cooling curve Properties prediction

PLGA-based implants for sustained delivery of peptides/proteins:Current status,challenge and perspectives

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Chinese Chemical Letters 2023年第11期34卷 41-51页

作者： Fangfei Hu Jianping Qi yi Lu Haisheng He Wei Wu Key Laboratory of Smart Drug Delivery of MOE School of PharmacyFudan UniversityShanghai 201203China Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China Fudan Zhangjiang Institute Shanghai 201203China Center for Medical Research and Innovation Shanghai Pudong HospitalFudan University Pudong Medical CenterShanghai 201399China

Peptide and protein drugs with therapeutic effects suffer from their short half-life and low stability,albeit their high efficiency and *** overcome these demerits,long-acting drug delivery systems have been developed,wherein poly(lactic-co-glycolic acid)(PLGA)implants are most preferred owing to their excellent biodegradability and *** of PLGA based products have been approved since1986,when the first product,named Decapeptyl R,successfully marched into *** meet the increasing demand for delivering various peptides and proteins,different kinds of technologies have been developed for lab-scale fabrication or industrial *** review aims to introduce recent advances of PLGA implants,and give a brief summary of fundamental properties of PLGA,fabrication technologies of peptides/proteins-loaded PLGA implants as well as factors influencing the drug release ***,challenges and future perspectives are also highlighted.

关键词： PLGA Implant Peptide/protein delivery Fabrication technology Drug release

Abdominal-B regulates structure and development of the Harmonia axyridis cremaster

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Insect Science 2021年第4期28卷 965-975页

作者： yi Zhang Xing-Xing Wang Ling-Feng Shen Zhu-Jun Feng Song-Qi Zhang Hong-Gang Tian yi Feng Tong-Xian Liu Key Laboratory of Integrated Pest Management on Crops in Northwestern Loess Plateau Ministry of AgricultureNorthwest A&F UniversityYanglingShaanxiChina

The ladybird Harmonia axyridis is an insect that exhibits pupal attachment to plants,which facilitates development and environmental *** cremaster is highly specialized for this ***,the underlying molecular regulation of the cremaster remains unclear;therefore,we performed experiments to investigate the transcriptional regulation of cremaster ***,we examined the morphological structure of the cremaster to reveal its function in pupal attachment of ***,we analyzed the Hox gene Ha-Abd-B using RNA interference(RNAi)to determine its function in regulating cremaster formation;Ha-Abd-B up-regulation promoted effective pupal attachment,whereas successful RNAi caused severe down-regulation of this gene,and pupae were unable to ***,successful RNAi and subsequent Ha-Abd-B down-regulation caused phenotypic changes in cremaster structure,including its complete disappearance from some ***,we observed unique development of the cremaster and dynamic expression of Ha-Abd-B during pre-pupal development;consequently,we hypothesized that there was specific pre-pupal development of the ***,based on these results,the specialized cremasteric structure located on the posterior side of *** was determined to be a key organ for pupal *** identification in *** is regulated by Ha-Abd-B and exhibits preferential *** attachment of *** reveals an environmental adaptation of this species;thus,this study and future molecular studies will help determine the role of Hox genes in regulation of insect attachment and further our understanding of the multiple functions of Hox genes.

关键词： Abdominal-B appendage development cremaster Harmonia axyridis insect attachment

A novel technology for quick acclimation of an anaerobic microbial consortia used for biodegrading teraphthalic acid (TA)

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Journal of Environmental Sciences 2002年第2期14卷 204-209页

作者： LI Xiao ming ZENG Guang-ming CHEN Jian LUN Shi yi Department of Environmental Science and Engineering Hunan UniversityChangsha 410082China School of Biotechnology Wuxi University of Light IndustryWuxi 214036China

The seed sludge originated from a methane fermentation reactor was enriched and acclimated with TA as sole carbon source under nitrate respiration mode first for 6 week, and then can be turned to methane fermentation conditions. After 6 weeks processing, the specific rate of TA degradation under nitrate respiration mode reached 23.8 mgTA/(L·gVSS), more than two times of that under methane fermentation mode 11.4 mg TA/(L·gVSS). The TA reductive cleavers' population density increased about 6 times and 20 times after 30 days and 90 days acclimation. After a total of 90 days for the enrichment and acclimation, the fermentative bacteria which originally existed in the seed sludge nearly disappeared, and instead of them, the TA reductive and cleaving bacteria group was formed in the new consortia, which was confirmed by the MPN counts and roll tube counts. Compared with the control experiment, the acclimation period can be shortened by about 50%.

关键词： acclimation anaerobic sludge enrichment nitrate terephthalic acid (TA)

Time-delay identification for vibration systems with multiple feedback

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Acta Mechanica Sinica 2016年第6期32卷 1138-1148页

作者： yi-Qiang Sun Meng-Shi Jin Han-Wen Song Jian Xu School of Aerospace Engineering and Applied Mechanics Tongji University

An approach for time-delay identification is proposed in multiple-degree-of-freedom (MDOF) linear systems with multiple feedback. The applicability of the approach is discussed in detail. Based on the characteristics of frequency domain in feedback controlled system with multiple time-delays, this paper proposes a time-delay identification approach, which is based on the pseudo impedance function of reference point. Treating feedback time-delays as the 'frequencies' of the oscillation curve, the time-delays can be obtained from the 'frequencies' of the curve. Numerical simulation is conducted to validate the proposed approach. The application scope of the approach is discussed with regard to different forms of feedback.

关键词： Multiple time-delays Parameter identification Feedback Frequency response functions