检索结果-南通市图书馆

China CDC weekly 2024年第5期6卷 77-82,I0002-I0005页

作者： Huiyun Chang Mingjun li Ying Wang liangliang Cui tiantian li Jinan Municipal Center for Disease Control and Prevention Jinan Municipal Center for Disease Control and Prevention Affiliated to Shandong UniversityJinan CityShandong ProvinceChina Chinese Filed Epidemiology Training Program Chinese Center for Disease Control and PreventionBeijingChina China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?The mortality rate due to pneumonia varies depending on the infectious agents present in a low-temperature *** is added by this report?This study aimed to examine the relationship between low temperatures and cold waves and the risk of mortality from infectious pneumonia in the *** findings indicate a significant increase in the risk of infectious pneumonia.

关键词： environment Shandong finding

A novel insight of enhancing the hydrogen peroxide tolerance of unspecific peroxygenase from Daldinia caldariorum based on structure

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第4期35卷 426-430页

作者： tiantian li Ruochen Jin Bin Wu Dongming Lan Yunjian Ma Yonghua Wang School of Food Science and Engineering South China University of TechnologyGuangzhou 510640China School of Bioscience and Bioengineering South China University of TechnologyGuangzhou 510006China Guangdong Youmei Institute of Intelligent Bio-manufacturing Co. Ltd.Foshan 528200China

Unspecific peroxygenases(UPOs, EC 1.***.2.1) is a kind of thioheme enzyme capable of catalyzing various oxidations of inert C–H bonds using H_(2)O_(2) as an oxygen donor without cofactors. However, the enhancement of the H_(2)O_(2) tolerance of UPOs is always challenging. In this study, the A161C mutant of r Dca UPO,which originates from Daldinia caldariorum, was found to be highly H_(2)O_(2)-resistant. Compared with the wild type, the mutant r Dca UPO-A161C showed a 10-h prolonged half-life and a 64% improved enzyme activity when incubated in 10 mmol/L H_(2)O_(2). The crystal structure analysis at 1.47 A showed that r Dca UPOA161C exhibited 10 α-helixes(cyan) and a series of ordered rings, forming a single asymmetric spherical structure. The two conserved domains near heme formed an active site with the catalytic PCP and EHD regions(Glu86, His87, Asp88 residues). The H_(2)O_(2) tolerance of r Dca UPO-A161C was preliminarily explored by comparing its structure with the wild type. Notably, r Dca UPO-A161C showed significantly higher catalytic efficiency than the wild type for the production of hydroxyl fatty acids. This study is anticipated to provide an insight into the structure-function relationship and expand potential applications of UPOs.

关键词： Unspecific peroxygenase Molecular modification Hydrogen peroxide stability Crystal structure Hydroxyl fatty acids

The role and applications of extracellular vesicles in osteoporosis

在线全文

学校读者我要写书评

暂无评论

Bone Research 2024年第1期12卷 62-77页

作者： Fei Fang Jie Yang Jiahe Wang tiantian li Erxiang Wang Demao Zhang Xiaoheng liu Chenchen Zhou Institute of Biomedical Engineering West China School of Basic Medical Sciences&Forensic MedicineSichuan UniversityChengdu 610041China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu 610041China

Osteoporosis is a widely observed condition characterized by the systemic deterioration of bone mass and microarchitecture,which increases patient susceptibility to fragile *** intricate mechanisms governing bone homeostasis are substantially impacted by extracellular vesicles(EVs),which play crucial roles in both pathological and physiological *** derived from various sources exert distinct effects on ***,EVs released by osteoblasts,endothelial cells,myocytes,and mesenchymal stem cells contribute to bone formation due to their unique cargo of proteins,miRNAs,and ***,EVs secreted by osteoclasts and immune cells promote bone resorption and inhibit bone ***,the use of EVs as therapeutic modalities or biomaterials for diagnosing and managing osteoporosis is ***,we review the current understanding of the impact of EVs on bone homeostasis,including the classification and biogenesis of EVs and the intricate regulatory mechanisms of EVs in ***,we present an overview of the latest research progress on diagnosing and treating osteoporosis by using ***,we discuss the challenges and prospects of translational research on the use of EVs in osteoporosis.

关键词： osteoporosis homeostasis biomaterials

High performance wide bandgap perovskite solar cell with low V_(OC) deficit less than 0.4 V

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第4期91卷 313-322页

作者： Haikuo Guo Fuhua Hou Xuli Ning Xiaoqi Ren Haoran Yang Rui liu tiantian li Chengjun Zhu Ying Zhao Wei li Xiaodan Zhang School of Physical Science and Technology Key Laboratory of Semiconductor Photovoltaic Technology and Energy Materials at Universities of Inner Mongolia Autonomous RegionInner Mongolia UniversityHohhot 010021Inner MongoliaChina Institute of Photoelectronic Thin Film Devices and Technology of Nankai University Key Laboratory of Photoelectronic Thin Film Devices and Technology of TianjinSolar Energy Research Center of Nankai UniversityTianjin 300350China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430000HubeiChina

Wide bandgap perovskite solar cells(PSCs)have attracted significant attention because they can be applied to the top cells of tandem solar ***,high open-circuit voltage(V_(OC))deficit(>0.4 V)result from poor crystallization and high non-radiative recombination losses become a serious limitation in the pursuit of high ***,the relevance between different Pbl_(2)proportions and performance parameters are revealed through analysis of surface morphology,residual stress,and *** increase of Pbl_(2)proportion promotes crystal growth and reduces the work function of the perovskite film surface and promotes the energy level alignment with the carrier transport layer,which decreased the V_(OC)***,residual PbI_(2)exacerbated the stress level of perovskite film,and the resulting lattice disorder deteriorated the photostability of the ***,after the synergistic passivation of residual PbI_(2)and PEAI,the V_(OC)achieves 1.266 V and V_(OC)deficit is less than 0.4 V,the record value in wide bandgap PSCs.

关键词： Pb management Perovskite solar cell Strain Wide bandgap Stability

Statement on Establishment of Public Health Protection Guideline for Cold Spells—China

在线全文

学校读者我要写书评

暂无评论

China CDC weekly 2024年第5期6卷 92-94页

作者： tiantian li Qinghua Sun Chen Chen Qing Wang Jie Ban Runmei Ma Yi Zhang lijun Pan Yuanyuan liu Qiutong li Leyao Chang Hanshuo Zhang Yirong liu Miaoyou Niu Xiangxiang Wei lin Wang China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijingChina

Cold spells are extreme weather events characterized by the invasion of cold air from high latitudes into the middle and low latitudes,resulting in significant *** spells have various adverse health effects,including epidermal damage,respiratory tract spasms,respiratory immune abnormalities,acute cardiopulmonary diseases,and exacerbation of urinary and endocrine *** response to the frequent cold spells in recent years.

关键词： respiratory invasion acute

Multifunctional mixed analog/digital signal processor based on integrated photonics

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Opto-Electronic Science 2024年第8期3卷 1-12页

作者： Yichen Wu Qipeng Yang Bitao Shen Yuansheng Tao Xuguang Zhang Zihan Tao Luwen Xing Zhangfeng Ge tiantian li Bowen Bai Haowen Shu Xingjun Wang State Key Laboratory of Advanced Optical Communication Systems and Networks School of ElectronicsPeking UniversityBeijing 100871China College of Engineering Peking UniversityBeijing 100871China Peking University Yangtze Delta Institute of Optoelectronics Nantong 226010China School of Electronic Engineering Xi’an University of Posts&TelecommunicationsXi’an 710121China Frontiers Science Center for Nano-optoelectronics Peking UniversityBeijing 100871China Peng Cheng Laboratory Shenzhen 518055China

Photonic signal processing offers a versatile and promising toolkit for contemporary scenarios ranging from digital optical communication to analog microwave *** to its electronic counterpart,it eliminates inherent bandwidth limitations and meanwhile exhibits the potential to provide unparalleled scalability and flexibility,particularly through integrated ***,by far the on-chip solutions for optical signal processing are often tailored to specific tasks,which lacks versatility across diverse ***,we propose a streamlined chip-level signal processing architecture that integrates different active and passive building blocks in silicon-on-insulator(SOI)platform with a compact and efficient *** and in-depth analyses for the architecture are conducted at levels of device,system,and *** by appropriate configuring schemes,the photonic circuitry supports loading and processing both analog and digital signals *** distinct tasks are facilitated with one single chip across several mainstream fields,spanning optical computing,microwave photonics,and optical ***,it has demonstrated competitive performance in functions like image processing,spectrum filtering,and electro-optical bandwidth *** high universality and a compact form factor,the proposed architecture is poised to be instrumental for next-generation functional fusion systems.

关键词： silicon photonics multifunctional signal process microwave photonics optical computing optical communica-tion equalization

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

再论汉语方言“支微入鱼”演变的阶段性

语文研究 2024年第1期 53-60页

作者：桑宇红李甜甜河北师范大学文学院河北石家庄050024

文章认为,“支微入鱼”的演变不仅是蟹止摄与遇摄分合关系的变化,同时也是音节声韵拼合关系的改变,与声母的发音部位关系密切并呈现出演变的阶段性,而且在唐宋西北方音中均有反映:唐五代时只有牙喉音及舌齿音止摄字与遇摄字的合流,宋代... 详细信息

文章认为,“支微入鱼”的演变不仅是蟹止摄与遇摄分合关系的变化,同时也是音节声韵拼合关系的改变,与声母的发音部位关系密切并呈现出演变的阶段性,而且在唐宋西北方音中均有反映:唐五代时只有牙喉音及舌齿音止摄字与遇摄字的合流,宋代才有唇音止摄字与遇摄字的合流。现代汉语方言中各地“支微入鱼”的类型仍然依照中古牙喉、舌齿、唇音声母的发音部位划分,与今声母的读音无关。

关键词：支微入鱼唐宋西北方音现代汉语方言声韵拼合中古声母的发音部位

区块链增信农业供应链金融的瓶颈约束与破解机制

在线全文

学校读者我要写书评

暂无评论

农村经济 2024年第6期 88-94页

作者：王性玉任乐李田田河南大学商学院河南开封475004

本文以农业供应链金融所面临的信任问题为出发点,按照“区块链+供应链”的技术逻辑与制度逻辑,分析区块链技术增信农业供应链金融的瓶颈约束,并通过农业“区块链+供应链”信息服务平台搭建和融资信任机制构建,有效保障初始信息上链真实... 详细信息

本文以农业供应链金融所面临的信任问题为出发点,按照“区块链+供应链”的技术逻辑与制度逻辑,分析区块链技术增信农业供应链金融的瓶颈约束,并通过农业“区块链+供应链”信息服务平台搭建和融资信任机制构建,有效保障初始信息上链真实性、链上交易数据和链下实物交易匹配性和智能合约设置与执行风险可控性,破解农业供应链融资的信息约束、资源配置约束和制度约束,提升农业供应链的融资效率,助力农村产业发展和乡村振兴目标的实现。

关键词：区块链农业供应链金融增信瓶颈约束破解机制

不同颈椎前路椎间融合系统内固定颈椎的生物力学变化

在线全文

学校读者我要写书评

暂无评论

中国组织工程研究 2024年第6期28卷 821-826页

作者：王强李世芸熊鹰李甜甜昆明理工大学机电工程学院云南省昆明市650000 昆明医科大学附属延安医院骨科云南省昆明市650051 山能新能源(东营)有限公司山东省东营市257000

背景:针对在颈椎病治疗过程中,颈椎前路椎间融合系统Zero-P系统在术后会出现螺钉松动、断裂等问题,研发出一种新型Low-P系统。目的:对比新型Low-P与Zero-P型颈椎前路椎间融合系统对颈椎邻近节段生物力学的影响,并对内固定系统进行应力分... 详细信息

背景:针对在颈椎病治疗过程中,颈椎前路椎间融合系统Zero-P系统在术后会出现螺钉松动、断裂等问题,研发出一种新型Low-P系统。目的:对比新型Low-P与Zero-P型颈椎前路椎间融合系统对颈椎邻近节段生物力学的影响,并对内固定系统进行应力分析,从而为临床治疗提供理论参考。方法:建立无损颈椎C_(1)-C_(7)节段完整模型,基于模型有效性,建立在C_(4)-C_(5)节段置入Low-P型(Z型Low-P和H型Low-P)与Zero-P型系统的有限元模型,在前屈、后伸、侧弯和旋转4种工况下,分析置入器械、邻近椎体髓核、纤维环与终板的应力分布情况。结果与结论:(1)置入Low-P型与Zero-P型内固定器械后,H型Low-P系统活动范围大,Z型Low-P系统最大应力值较小,Zero-P型对邻近节段髓核最大应力较大,终板最大应力较小;(2)3种内固定系统对邻近节段纤维环的影响相接近;(3)Zero-P型内固定系统螺钉应力远大于Low-P系统;(4)提示相比Zero-P型内固定系统,新型Low-P系统降低了钢板和螺钉的应力值,可以降低螺钉松动、内固定系统失效等问题;Low-P型系统对于邻近椎间盘髓核的应力较小,可降低邻近节段椎间盘退变;此次研究结果可为Low-P型内固定系统的临床研究提供理论依据。

关键词：颈椎前路内固定系统 Low-P型 Zero-P型颈椎生物力学有限元分析

基于无人机高光谱遥感与机器学习的小麦品系产量估测研究

在线全文

学校读者我要写书评

暂无评论

农业机械学报 2024年第7期55卷 260-269页

作者：齐浩吕亮杰孙海芳李偲李甜甜侯亮河北省农林科学院农业信息与经济研究所石家庄050051 河北省农林科学院粮油作物研究所石家庄050035

为快速、准确地估测小麦产量,有效提高育种工作效率,本文以小麦品系为研究对象,收集小麦灌浆期无人机高光谱数据和产量数据。首先基于递归特征消除法筛选出特征波长作为模型输入变量,然后利用岭回归(Ridge regression,RR)、偏最小二乘回... 详细信息

为快速、准确地估测小麦产量,有效提高育种工作效率,本文以小麦品系为研究对象,收集小麦灌浆期无人机高光谱数据和产量数据。首先基于递归特征消除法筛选出特征波长作为模型输入变量,然后利用岭回归(Ridge regression,RR)、偏最小二乘回归(Partial least squares regression,PLS)、多元线性回归(Multiple linear regression,MLR)3种线性算法和随机森林(Random forest,RF)、梯度提升回归(Gradient boosting regression,GBR)、极限梯度提升(eXtreme gradient boosting,XGB)、高斯过程回归(Gaussian process regression,GPR)、支持向量回归(Support vector regression,SVR)、K最邻近算法(K-nearest neighbor,KNN)6种非线性算法构建单一算法产量估测模型并进行精度比较,最后基于Stacking算法构建多模型集成组合,筛选最佳集成模型。结果表明,基于不同算法的产量估测模型精度差异显著,非线性模型优于线性模型,基于GBR的产量估测模型在单一模型中表现最优,训练集R^(2)为0.72,RMSE为534.49 kg/hm^(2),NRMSE为11.10%,测试集R^(2)为0.60,RMSE为628.73 kg/hm^(2),NRMSE为13.88%。基于Stacking算法构建的集成模型性能与初级模型和次级模型的选择密切相关,以KNN、RR、SVR为初级模型组合,GBR为次级模型的集成模型有效提高了估测精度,相比单一模型GBR,训练集R^(2)提高1.39%,测试集R^(2)提高3.33%。本研究可为基于高光谱技术的小麦品系产量估测提供应用参考。

关键词：小麦品系产量估测无人机高光谱遥感机器学习 Stacking算法

维普期刊数据库博看期刊