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Sevoflurane plays a reduced role in cognitive impairment compared with isoflurane: limited effect on fear memory retention

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Neural Regeneration Research 2020年第1期15卷 96-102页

作者： Ying Du Xiang-Dan Gong Xin Fang Fang Xing tian-Jiao Xia xiao-Ping Gu Department of Anesthesiology Affiliated Drum Tower Hospital of Medical Department of Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory of Molecular Medicine Nanjing UniversityNanjingJiangsu ProvinceChina

Isoflurane and sevoflurane are both inhalation anesthetics,but in clinical application,sevoflurane has been considered to be less suitable for long-term anesthesia because of its catabolic compounds and potential ***,recent studies have shown that these two inhalation anesthetics are similar in hepatorenal toxicity,cost,and long-term anesthetic ***,sevoflurane possibly has less cognitive impact on young *** this study,C57BL/6 mice aged 8–10 weeks were exposed to 1.2%isoflurane or 2.4%sevoflurane for 6 *** function and memory were examined in young mice using the novel object recognition,contextual fear conditioning,and cued-fear extinction *** blot assay was performed to detect expression levels of D1 dopamine receptor,catechol-O-methyltransferase,phospho-glycogen synthase kinase-3β,and total glycogen synthase kinase-3βin the *** results show that impaired performance was not detected in mice exposed to sevoflurane during the novel object recognition *** memory impairment in the fear conditioning test was shorter in the sevoflurane group than the isoflurane ***-term sevoflurane exposure did not affect memory consolidation,while isoflurane led to memory consolidation and reduced *** of hippocampal D1 dopamine receptors and phosphorylated glycogen synthase kinase-3β/total glycogen synthase kinase-3βand upregulation of catechol-O-methyltransferase may be associated with differing memory performance after exposure to isoflurane or *** results confirm that sevoflurane has less effect on cognitive impairment than isoflurane,which may be related to expression of D1 dopamine receptors and catechol-O-methyltransferase and phosphorylation of glycogen synthase kinase-3βin the *** study was approved by the Institutional Animal Care and Use Committee,Nanjing University,China on November 20,2017(approval No.20171102).

关键词： catechol-O-methyltransferase cognitive impairment D1 dopamine receptors fear memory glycogen synthase kinase-3β isoflurane neurotoxicology sevoflurane

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Comparison of Clinical Characteristics and Outcomes of MAFLD and NAFLD in Chinese Health Examination Populations

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Journal of Clinical and Translational Hepatology 2023年第4期11卷 777-786页

作者： Xin Xu xiaohua Zhou Ting tian Yuqing Ding Chengxiao Yu Wei Zhao xiao Wang jing Lu Wen Guo Longfeng Jiang Quanrongzi Wang Qun Zhang Ci Song Department of Epidemiology Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsuChina The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhouJiangsuChina Department of Infectious Disease the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuChina Department of Health Promotion Center the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuChina Department of Radiology the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuChina

Background and Aims:The recently proposed concept of metabolic dysfunction-associated fatty liver disease(MAFLD)has remained *** aimed to describe the features and associated outcomes to examine the diagnostic ability of MAFLD for identifying high-risk ***:In this retrospective cohort study,we enrolled 72,392 Chinese participants between 2014 and *** were classified as MAFLD,nonalcoholic fatty liver disease(NAFLD),non-MAFLD-NAFLD,and a normal control *** primary outcomes were liver-related and cardiovascular disease(CVD)***-years of follow-up were calculated from enrolment to the diagnosis of the event,or the last date of data(June,2020).Results:Of the 72,392 participants,31.54%(22,835)and 28.33%(20,507)qualified the criteria for NAFLD or MAFLD,*** with NAFLD,MAFLD patients were more likely to be male,overweight,and have higher biochemical indices including liver enzyme *** MAFLD diagnosed with≥2 or≥3 metabolic abnormalities presented similar clinical *** the median follow-up of 5.22 years,919 incident cases of severe liver disease and 2,073 CVD cases were *** with the normal control group,the NAFLD and MAFLD groups had a higher cumulative risk of liver failure and cardiac-cerebral vascular *** were no significant differences in risk between the non-MAFLD-NAFLD and normal ***-MAFLD group had the highest incidence of liver-related and cardiac-cerebral vascular diseases,lean MAFLD came second,and obese-MAFLD had the lowest ***:This real-world study provided evidence for rationally assessing the benefit and practicability of the change in terminology from NAFLD to *** may be better than NAFLD in identifying fatty liver with worse clinical features and risk profile.

关键词： Metabolic-associated fatty liver disease Non-alcoholic fatty liver disease Liver-related disease Cardiac vascular disease Cerebral vascular disease

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High levels of serum interleukin-6 increase mortality of hepatitis B virus-associated acute-on-chronic liver failure

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World Journal of Gastroenterology 2020年第30期26卷 4479-4488页

作者： Chao Zhou Ning Zhang Ting-Ting He Yao Wang Li-Fu Wang Yong-Qiang Sun jing jing jing-jing Zhang Shuang-Nan Fu Xuan Wang xiao-xiao Liang Xin Li Man Gong Jun Li Department of Integrative Medicine 5th Medical Center of Chinese PLA General HospitalBeijing 100039China

BACKGROUND Patients with hepatitis B virus-associated acute-on-chronic liver failure(HBVACLF)present a complex and poor *** inflammation plays an important role in its pathogenesis,and interleukin-6(IL-6)as a pro-inflammatory cytokine is related with severe liver impairment and also plays a role in promoting liver *** serum IL-6 influences HBV-ACLF prognosis has not been *** To determine the impact of serum IL-6 on outcome of patients with *** We performed a retrospective study of 412 HBV-ACLF *** findings were analyzed with regard to mortality and the serum IL-6 level at baseline,as well as dynamic changes of serum IL-6 within 4 *** The serum IL-6 level was associated with *** 4 wk,deceased patients had significantly higher levels of IL-6 at baseline than surviving patients[17.9(7.3-57.6)vs 10.4(4.7-22.3),P=0.011].Patients with high IL-6 levels(>11.8 pg/mL)had a higher mortality within 4 wk than those with low IL-6 levels(≤11.8 pg/mL)(24.2%vs 13.2%,P=0.004).The odds ratios calculated using univariate and multivariate logistic regression were 2.10(95%confidence interval[CI]:1.26-3.51,P=0.005)and 2.11(95%CI:1.15-3.90,P=0.017),*** mortality between weeks 5 and 8 in patients with high IL-6 levels at 4 wk was 15.0%,which was significantly higher than the 6.6%mortality rate in patients with low IL-6 levels at 4 wk(hazard ratio=2.39,95%CI:1.05-5.41,P=0.037).The mortality was 5.0%in patients with high IL-6 levels at baseline and low IL-6 levels at 4 wk,7.5%in patients with low IL-6 levels both at baseline and at 4 wk,11.5%in patients with low IL-6 levels at baseline and high IL-6 levels at 4 wk,and 16.7%in patients with high IL-6 levels both at baseline and at 4 *** increasing trend of the mortality rate with the dynamic changes of IL-6 was significant(P for trend=0.023).CONCLUSION A high level of serum IL-6 is an independent risk factor for mortality in patients with HBV-ACLF

关键词： Hepatitis B virus Liver failure Prognosis Interleukin-6

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Interaction between cyclooxygenase-2,Snail,and E-cadherin in gastric cancer cells

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World Journal of Gastroenterology 2013年第37期19卷 6265-6271页

作者： xiao-Jun Liu Zhao-Feng Chen Hai-Long Li Ze-Nan Hu Min Liu Ai-Ping tian Da Zhao jing Wu Yong-Ning Zhou Liang Qiao The First Hospital of Lanzhou University Key Laboratory for Gastrointestinal Disease of Gansu Province Beijing Shijitan Hospital Storr Liver Unit Westmead Millennium InstituteWestern Clinical School of the Faculty of Medicine at Westmead Hospital

AIM:To investigate the mechanisms of how cyclooxygenase-2(COX-2)regulates E-cadherin in gastric cancer ***:COX-2 expression in human gastric cancer cell lines SGC-7901,BGC-823,MGC-803 and AGS were measured at the mRNA and protein ***-2 rich cell line SGC-7901 was chosen for subsequent *** mediated gene knockdown was used to investigate the impact of COX-2 on nuclear factor-κB (NF-κB),Snail,and E-cadherin in gastric cancer *** expression was determined by Western blot and real-time polymerase chain *** analyze whether NF-κB inhibition could interrupt the modulatory effect of COX-2 or prostaglandin E2(PGE2)on E-cadherin,gastric cancer cells were treated with celecoxib or PGE2,in the presence of NF-κB specific ***:Highest expression level of COX-2 was found in SGC-7901 cells,both at mRNA and protein *** mediated down-regulation of COX-2 led to a reduced expression of NF-κB and Snail,but an increased expression of E-cadherin in SGC-7901 *** mediated down-regulation of NF-κB also led to a reduced expression of E-cadherin and Snail in SGC-7901 ***,COX-2 expression did not alter after cells were treated with NF-κB specific siRNA in SGC-7901 *** of SGC-7901 cells with celecoxib led to a reduced expression of Snail but an increased expression of *** contrast,treatment of SGC-7901 cells with PGE2 led to an increased Snail and a decreased ***,siRNAmediated knockdown of NF-κB partially abolished the effect of celecoxib and PGE2 on the regulation of E-cadherin and Snail in SGC-7901 ***:COX-2 likely functions upstream of NF-κB and regulates the expression of E-cadherin via NF-κB/Snail signaling pathway in gastric cancer cells.

关键词： Cyclooxygenase-2 E-cadherin celecoxib Prostaglandin E2 Gastric cancer

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发电车mtu183柴油机组换型改造选型探讨

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内燃机与配件 2024年第8期 36-38页

作者：李晓静崔德安赵文海中车南京浦镇车辆有限公司江苏南京210031

因铁路发电车装用的mtu183柴油机组产品升级换代、原厂配件在全球范围内停产,严重影响了发电车检修和铁路运输生产秩序。本文针对此情况提出了相应的应对措施,根据国家铁路集团公司推荐的五款可替代机型,从技术参数包括产品质量及配套... 详细信息

因铁路发电车装用的mtu183柴油机组产品升级换代、原厂配件在全球范围内停产,严重影响了发电车检修和铁路运输生产秩序。本文针对此情况提出了相应的应对措施,根据国家铁路集团公司推荐的五款可替代机型,从技术参数包括产品质量及配套周期、维保检修体系、经济性以及车辆改造技术可行性等几个方面进行了分析及综合评估,最后确定了五款机型的推荐方案,为各铁路局后期进行发电车机组换型改造提供参考意见。

关键词： mtu183柴油机改造选型

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Diversity and dynamics of microbial communities in brown planthopper at different developmental stages revealed by high-throughput amplicon sequencing

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Insect Science 2020年第5期27卷 883-894页

作者： Zheng-Liang Wang tian-Zhao Wang Hang-Feng Zhu Hai-Bo Pan xiao-Ping Yu Zhejiang Provincial Key Laboratory of Biometrology and Inspection and Quarantine College of Life SciencesChina Jiliang UniversityHangzhouChina

The microbiome associated with brown planthopper(BPH)plays an important role in mediating host health and *** of the microbial community and its structure is prerequisite for understanding the intricate symbiotic relationships between microbes and host ***,we investigated the bacterial and fungal communities of BPH at different developmental stages using high-throughput amplicon *** results revealed that both the bacterial and fungal communities were diverse and dynamic during BPH *** bacterial communities were generally richer than fungi in each developmental *** 97%similarly,19 phyla and 278 genera of bacteria were an-notated,while five fungal phyla comprising 80 genera were *** highest species richness for the bacterial communities was detected in the nymphal *** taxonomic diversity of the fungal communities in female adults was generally at a relatively higher level when compared to other developmental *** most dominant phylum of bacteria and fungi at each developmental stage all belonged to Proteobacteria and Ascomycota,re-spectively.A significantly lower abundance of bacterial genus Acinetobacter was recorded in the egg stage when compared to other developmental stages,while the dominant fun-gal genus Wallemia was more abundant in the nymph and adult stages than in the egg ***,the microbial composition differed between male and female adults,suggesting that the microbial communties In BPH were ***,our study enriches our knowledge on the microbial communities associated with BPH and will provide clues to develop potential biocontrol techniques against this rice pest.

关键词： amplicon sequencing brown planthopper dynamics microbial diversity microbiome

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ASM E2000硅外延片异常背圈现象研究与分析

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电子与封装 2024年第1期24卷 51-55页

作者：徐卫东肖健何晶袁夫通南京国盛电子有限公司南京211111

ASM E2000外延炉在生产硅外延片的过程中,晶圆背面有时会出现异常背圈的现象,包括背圈大小异常、背圈形状异常、背圈偏心等。经研究发现,背圈现象只会在非二氧化硅背封的晶圆上出现。针对异常背圈的产生,进行了滑片、气流、温度、时间... 详细信息

ASM E2000外延炉在生产硅外延片的过程中,晶圆背面有时会出现异常背圈的现象,包括背圈大小异常、背圈形状异常、背圈偏心等。经研究发现,背圈现象只会在非二氧化硅背封的晶圆上出现。针对异常背圈的产生,进行了滑片、气流、温度、时间等相关参数的实验验证,得到背圈形成的原因及异常背圈产生的原因。晶圆经900℃烘烤60 s就会形成背圈,这是外延过程中的正常现象,但是不规则的背圈通常伴随着其他外延工艺参数的同步变差,异常背圈可以通过调整工艺参数、设备滑片、跳片以及更换石墨件来解决。

关键词：硅外延缺陷背圈晶圆背圈 ASM E2000外延炉

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面向目标频率的声学超结构带隙优化设计研究

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舰船科学技术 2024年第8期46卷 58-64页

作者：孙旭阳周景军王谦张志民耿小明郭君中国船舶集团有限公司第七〇五研究所陕西西安710077

本文对悬臂梁式局域共振声子晶体的带隙特性进行研究,并提出一种通用的带隙优化设计方法。首先,分析声子晶体的带隙结构和形成机理,发现模态有效质量占比是带隙能否打开的关键因素。其次,基于响应面法对声子晶体的带隙进行优化设计研究... 详细信息

本文对悬臂梁式局域共振声子晶体的带隙特性进行研究,并提出一种通用的带隙优化设计方法。首先,分析声子晶体的带隙结构和形成机理,发现模态有效质量占比是带隙能否打开的关键因素。其次,基于响应面法对声子晶体的带隙进行优化设计研究,借助参数相关性分析筛选出关键的设计变量,通过最优空间填充设计获取试验点,构建响应面模型进行多目标优化,从而获得能够匹配特定目标频率的带隙优化设计方案。最后,对提出的优化方案进行验证。结果显示,优化后的局域共振单元2条带隙均在目标频率处打开。本研究成果可为局域共振型声子晶体的带隙优化设计提供一种方法和思路。

关键词：局域共振声子晶体带隙参数优化设计响应面法

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高职院校产业学院建设的基本逻辑与路径探索

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湖北开放职业学院学报 2024年第15期37卷 70-72页

作者：肖毅王利徐静兰孔维敏北京青年政治学院北京100102

产业学院建设是高职院校深化现代职业教育体系建设改革,推进人才培养供给侧与产业需求侧紧密对接,推动校企合作、产教深度融合的创新实践。近年来,国家日渐重视产业学院建设,在国家政策指引下,遵循源于产业、协同育人、服务产业的基本逻... 详细信息

产业学院建设是高职院校深化现代职业教育体系建设改革,推进人才培养供给侧与产业需求侧紧密对接,推动校企合作、产教深度融合的创新实践。近年来,国家日渐重视产业学院建设,在国家政策指引下,遵循源于产业、协同育人、服务产业的基本逻辑,越来越多的高职院校探索开展产业学院建设。为推动高职院校高质量发展,应从依托专业群打造特色产业学院、推进产业学院实体化运行、整合各方优质资源凝聚育人合力等方面引导和推进产业学院建设。

关键词：高职院校产业学院基本逻辑实践路径

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The complete genome of hydrocarbon-degrading Pseudoalteromonas sp. NJ289 and its phylogenetic relationship

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Acta Oceanologica Sinica 2017年第2期36卷 88-93页

作者： LIU Fangming WANG Yibin QU Changfeng ZHENG Zhou MIAO Jinlai XU Hua xiao tian Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China University of Chinese Academy of Sciences Beijing 100049 China The First Institute of Oceanography State Oceanic Administration Qingdao 266061 China Key Laboratory of Sustainable Development of Marine Fisheries of Ministry of Agriculture Yellow Sea Fisheries Research Institute Chinese Academy of Fishery Sciences Qingdao 266071 China

Genus Pseudoalteromonas belongs to Family Pseudoalteromonadaceae in Gammaproteobacteria. A cold-adapted gram-negative bacterium, hydrocarbon-degrading Pseudoalteromonas sp. NJ289, was isolated from sea-ice of the Antarctica region, and sequenced the whole genome through the next generation sequencing platform. The assembly yielded three contigs representing two chromosomes and one plasmid with the sizes of 3.2 Mb, 636 kb and 1.8 kb, respectively. The G＋C contents of genome were 40.83% and included 3 589 ORFs. Functional annotation indicated some potential roles in enzymatic activity and environmental adaptability. This study may help for understanding the population diverse, evolutionary ecology and the microbial interaction.

关键词： Pseudoalteromonas low temperature environmental adaptability sequencing phylogenetic tree

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