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Mitochondrial carrier homolog 2 increases malignant phenotype of human gastric epithelial cells and promotes proliferation,invasion,and migration of gastric cancer cells

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 991-1005页

作者： jing-Wen Zhang Ling-Yan Huang Ya-Ning Li Ying tian Jia Yu xiao-Fei Wang School of Basic Medical Science NHC Key Laboratory of Metabolic Cardiovascular Diseases ResearchNingxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Pathology General Hospital of Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina School of Clinical Medicine Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Pathology North China University of Science and Technology Affiliated HospitalTangshan 063000Hebei ProvinceChin

BACKGROUND The precise role of mitochondrial carrier homolog 2(MTCH2)in promoting malignancy in gastric mucosal cells and its involvement in gastric cancer cell metastasis have not been fully *** To determine the role of MTCH2 in gastric *** We collected 65 samples of poorly differentiated gastric cancer tissue and adjacent tissues,constructed MTCH2-overexpressing and MTCH2-knockdown cell models,and evaluated the proliferation,migration,and invasion of human gastric epithelial cells(GES-1)and human gastric cancer cells(AGS)*** mito-chondrial membrane potential(MMP),mitochondrial permeability transformation pore(mPTP)and ATP fluorescence probe were used to detect mitochondrial *** function and ATP synthase protein levels were detected via Western *** The expression of MTCH2 and ATP2A2 in gastric cancer tissues was significantly greater than that in adjacent *** of MTCH2 promoted colony formation,invasion,migration,MMP expression and ATP production in GES-1 and AGS cells while upregulating ATP2A2 expression and inhibiting cell apoptosis;knockdown of MTCH2 had the opposite effect,promoting overactivation of the mPTP and promoting *** MTCH2 can increase the malignant phenotype of GES-1 cells and promote the proliferation,invasion,and migration of gastric cancer cells by regulating mitochondrial function,providing a basis for targeted therapy for gastric cancer cells.

关键词： Gastric cancer Mitochondrial carrier homolog 2 ATP synthase ATP2A2 Mitochondrial permeability transformation pore

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Design of highly active and durable oxygen evolution catalyst with intrinsic chlorine inhibition property for seawater electrolysis

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Nano Materials Science 2024年第4期6卷 413-418页

作者： Jieli Chen xiaodong Shi Suyang Feng jing Li xiaohong Gao xiao Wu Ke Li Anyuan Qi Chenghang You Xinlong tian School of Marine Science and Engineering School of Chemical Engineering and Technology Hainan University National Energy Group Ledong Power Generation Co. Ltd

High-efficiency seawater electrolysis is impeded by the low activity and low durability of oxygen evolution catalysts due to the complex composition and competitive side reactions in ***,a heterogeneousstructured catalyst is constructed by depositing NiFe-layered double hydroxides （NiFe-LDH） on the substrate of MXene （V2CTx） modified Ni foam （NF）,and abbreviated as NiFe-LDH/V2CTx/*** demonstrated,owing to the intrinsic negative charge characteristic of V2CTx,chlorine ions are denied entry to the interface between NiFeLDH and V2CTx/NF substrate,thus endowing NiFe-LDH/V2CTx/NF catalyst with high corrosion resistance and durable stability for 110 h at 500 mA ***,the two-dimensional structure and high electrical conductivity of V2CTxcan respectively enlarge the electrochemical active surface area and guarantee fast charge transfer,thereby synergistically promoting the catalytic performance of NiFe-LDH/V2CTx/NF in both deionized water electrolyte (261 m V at 100 m A cm-2) and simulated seawater electrolyte (241 mV at 100 mA cm-2).This work can guide the preparation of oxygen evolution catalysts and accelerate the industrialization of seawater electrolysis.

关键词： NiFe-LDH/V 2 CT x /NF catalyst Oxygen evolution reaction Seawater electrolysis Chlorine inhibition

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Catalyst-free and Reprocessable Aromatic Polydithiourethanes

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Chinese Journal of Polymer Science 2024年第10期42卷 1435-1441,I0007页

作者： Bo Yang Hai-Jun Feng tian-tian Ni xiao-Rui Zhou Tao Xie Ning Zheng State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou310058China Department of Colorectal Surgery and Oncology Key Laboratory of Cancer Prevention and InterventionMinistry of EducationThe Second Affiliated HospitalZhejiang University School of MedicineHangzhou310009China

The incorporation of dynamic covalent bonds into thermosets facilitates the reprocessing of polymer networks,thereby meeting the sustainable requirements for polymer ***,the mechanical properties of many materials often decline significantly upon reprocessing due to side reactions caused by harsh processing *** this work,we find that the aromatic dithiocarbamate bond can undergo dissociation under mild conditions without the need for a catalyst,enabling the efficient reprocessing of the corresponding *** a consequence,the mechanical properties of the polydithiourethane can be largely preserved after *** discovery of this dynamic chemistry is anticipated to broaden the potential for material design in dynamic covalent polymer networks.

关键词： Reprocessing Polydithiourethane Dynamic covalent bond

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An unexpected approach to enhance specific surface area and mesopore amount of polyaniline by Zn doping

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Rare Metals 2024年第9期43卷 4585-4594页

作者： Zhi-Da Zhu Yu-Zhe Han xiao-Bi jing School of Mechanical Engineering Yangzhou UniversityYangzhou 225127China School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China

Poly-p-anisidine could be easily fabricated via the oxidative polymerization reaction of p-anisidine using H_(2)O_(2)as the green *** was unexpectedly found that zinc doping could significantly improve the adsorption ability of the material versus heavy metals such as Pb,Cu,Pd,Ag and *** of nitrogen adsorption–desorption experiments demonstrated that Zn doping could enhance the specific surface area and mesopore amount of the prepared material,which might facilitate its absorption to *** work not only provides a novel material for the treatment of heavy metal-polluted water but also leads to a nice mesoporous catalyst support for environment protection and organic synthesis,*** Zn-doped poly-panisidine can be employed as the catalyst support to prepare Cu@PANI-OMe/Zn or Pd@PANI-OMe/Zn for the oxidative degradation reaction of phenol or Suzuki–Miyaura coupling reactions,*** discloses a new strategy for fabricating the mesoporous polyaniline materials with profound application potential.

关键词： Surfaces Porous materials Rare metal concentration Adsorption Catalysis

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Feasibility of medical radioisotope production based on the proton beams at China Spallation Neutron Source

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Nuclear Science and Techniques 2024年第6期35卷 26-39页

作者： Bing Jiang Bin-Bin tian Han-Tao jing Qi-Fan Dong Spallation Neutron Source Science Center Dongguan 523803China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China University of Chinese Academy of Sciences Beijing 100049China

The utilization of a proton beam from the China Spallation Neutron Source(CSNS)for producing medical radioisotopes is appealing owing to its high current intensity and high *** medical isotope production based on the proton beam at the CSNS is significant for the development of future radiopharmaceuticals,particularly for theα-emitting *** production yield and activity of typical medical isotopes were estimated using the FLUKA *** results indicate that the 300-MeV proton beam with a power of 100 kW at CSNS-II is highly suitable for proof-of-principle studies of most medical *** particular,this proton beam offers tremendous advantages for the large-scale production of alpha radioisotopes,such as 225Ac,whose theoretical production yield can reach approximately 57 Ci/*** on these results,we provide perspectives on the use of CSNS proton beams to produce radioisotopes for medical applications.

关键词： CSNS proton beam Medical isotope production α-Emitting radionuclides Nuclidic purity analysis

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Four decades of full-scale nitrous oxide emission inventory in China

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National Science Review 2024年第3期11卷 137-149页

作者： Minqi Liang Zheyan Zhou Peiyang Ren Han xiao Xu-Ri Zhongmin Hu Shilong Piao Hanqin tian Qing Tong Feng Zhou jing Wei Wenping Yuan School of Atmospheric Sciences Guangdong Province Data Center of Terrestrial and Marine Ecosystems Carbon Cycle Sun Yat-sen University State Key Laboratory of Tibetan Plateau Earth System Resources and Environment Institute of Tibetan Plateau Research Chinese Academy of Sciences Key Laboratory of Agro-Forestry Environmental Processes and Ecological Regulation of Hainan Province Hainan University Sino-French Institute for Earth System Science College of Urban and Environmental SciencesPeking University Schiller Institute for Integrated Science and Society Department of Earth and Environmental Sciences Boston College Institute of Energy Environment and Economy Tsinghua University Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)

China is among the top nitrous oxide（N2O）-emitting countries, but existing national inventories do not provide full-scale emissions including both natural and anthropogenic sources. We conducted a four-decade（1980–2020） of comprehensive quantification of Chinese N2O inventory using empirical emission factor method for anthropogenic sources and two up-to-date process-based models for natural sources. Total N2O emissions peaked at 2287.4（1774.8–2799.9） Gg N2O yr-1in 2018, and agriculture-developed regions, like the East, Northeast, and Central, were the top N2O-emitting regions. Agricultural N2O emissions have started to decrease after 2016 due to the decline of nitrogen fertilization applications, while, industrial and energetic sources have been dramatically increasing after 2005. N2O emissions from agriculture, industry,energy, and waste represented 49.3%, 26.4%, 17.5%, and 6.7% of the anthropogenic emissions in 2020,respectively, which revealed that it is imperative to prioritize N2O emission mitigation in agriculture,industry, and energy. Natural N2O sources, dominated by forests, have been steadily growing from 317.3（290.3–344.1） Gg N2O yr-1in 1980 to 376.2（335.5–407.2） Gg N2O yr-1in 2020. Our study produces a Full-scale Annual N2O dataset in China（FAN2020）, providing emergent counting to refine the current national N2O inventories.

关键词： nitrous oxide four decades anthropogenic sources natural sources

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正视国际贸易中的绿色壁垒

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兰州大学学报（社会科学版） 2005年第2期33卷 106-109页

作者：田晓菁西北师范大学经济管理学院甘肃兰州730070

随着全球的环保意识和健康意识的增强,绿色贸易已成为当今世界国际贸易的发展趋势。绿色贸易的发展在提高产品质量、保护环境的同时,又形成了一种新的贸易壁垒--绿色壁垒。由于这种壁垒有其鲜明的、不同于其他非关税壁垒的特征,因此,... 详细信息

随着全球的环保意识和健康意识的增强,绿色贸易已成为当今世界国际贸易的发展趋势。绿色贸易的发展在提高产品质量、保护环境的同时,又形成了一种新的贸易壁垒--绿色壁垒。由于这种壁垒有其鲜明的、不同于其他非关税壁垒的特征,因此,在关税壁垒逐渐降低和非关税削减之后,绿色壁垒已成为发达国家保护本国产业的主要措施。这对发展中国家既是机遇又是挑战,研究绿色壁垒具有重要的现实意义。

关键词：绿色壁垒环保绿色消费产品标准

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新时代体育强国建设背景下筹办北京冬奥会的历史价值管析——十九大报告“筹办好北京冬奥会”解读

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南京体育学院学报（社会科学版） 2017年第5期31卷 21-24页

作者：田小静北京科技大学体育部北京100083

以"筹办好北京冬奥会"新要求为题,基于十九大报告关于我国进入新时代的科学论断、加快推进体育强国建设的战略部署,研究分析了"筹办好北京冬奥会"的历史价值意涵。主要是:影响和带动了群众体育的快速发展,推动了我国竞技体育综合实力和... 详细信息

以"筹办好北京冬奥会"新要求为题,基于十九大报告关于我国进入新时代的科学论断、加快推进体育强国建设的战略部署,研究分析了"筹办好北京冬奥会"的历史价值意涵。主要是:影响和带动了群众体育的快速发展,推动了我国竞技体育综合实力和国际竞争力的快速提升,推进了我国体育产业快速走向发展壮大,促进了我国体育文化快速走向丰富和繁荣,促进了民族精神的提振和民族凝聚力的增强。

关键词：新时代北京冬奥会筹办历史价值十九大报告

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Effects of acupuncture on hypothalamic–pituitary–adrenal axis:Current status and future perspectives

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Journal of Integrative Medicine 2024年第4期22卷 445-458页

作者： Jia-yuan Zheng jing Zhu Yu Wang Zhan-zhuang tian Department of Integrative Medicine and Neurobiology School of Basic Medical SciencesState Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain ScienceInstitutes of Brain ScienceInstitute of Acupuncture ResearchAcademy of Integrative MedicineShanghai Key Laboratory for Acupuncture Mechanism and Acupoint FunctionShanghai Medical CollegeFudan UniversityShanghai 200032China Department of Human Anatomy School of Integrative MedicineShanghai University of Traditional Chinese MedicineShanghai 201203China

The hypothalamic–pituitary–adrenal(HPA) axis is a critical component of the neuroendocrine system,playing a central role in regulating the body's stress response and modulating various physiological processes. Dysregulation of HPA axis function disrupts the neuroendocrine equilibrium, resulting in impaired physiological functions. Acupuncture is recognized as a non-pharmacological type of therapy which has been confirmed to play an important role in modulating the HPA axis and thus favorably targets diseases with abnormal activation of the HPA axis. With numerous studies reporting the promising efficacy of acupuncture for neuroendocrine disorders, a comprehensive review in terms of the underlying molecular mechanism for acupuncture, especially in regulating the HPA axis, is currently in need. This review fills the need and summarizes recent breakthroughs, from the basic principles and the pathological changes of HPA axis dysfunction, to the molecular mechanisms by which acupuncture regulates the HPA axis. These mechanisms include the modulation of multiple neurotransmitters and their receptors, neuropeptides and their receptors, and microRNAs in the paraventricular nucleus,hippocampus, amygdala and pituitary gland, which alleviate the hyperfunctioning of the HPA *** review comprehensively summarizes the mechanism of acupuncture in regulating HPA axis dysfunction for the first time, providing new targets and prospects for further exploration of acupuncture.

关键词： Acupuncture Electroacupuncture Hypothalamic-pituitary-adrenal axis Mechanism Neurotransmitter microRNA

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Core shift limitation in investment casting process of hollow turbine blade

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Chinese Journal of Aeronautics 2024年第8期37卷 513-526页

作者： Kang CUI Lin jing Ruisong JIANG Longnv YU xiao GAO Automation and Software Engineering Shanxi UniversityTaiyuan 030006China Key Laboratory of High Performance Manufacturing for Aero Engine Ministry of Industry and Information TechnologySchool of Mechanical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China School of Mechanical Engineering Sichuan UniversityChengdu 610065China

The deviation in wall thickness caused by core shift during the investment casting process significantly impacts the strength and service life of hollow turbine *** address this issue,a core shift limitation method is developed in this ***,a shift model is established based on computational fluid dynamics and motion simulation to predict the movement of the ceramic core in investment casting ***,utilizing this model,an optimization method for fixturing layout inside the refractory ceramic shell is devised for the ceramic *** casting experiment demonstrates that by utilizing the optimized fixture layout,not only can core shift during the investment casting pouring process be effectively controlled,but also the maximum wall thickness error of the blade can be reduced by 42.02%.In addition,the core shift prediction is also validated,with a prediction error of less than 26.9%.

关键词： Hollow turbine blade Wall thickness Ceramic core Shift prediction Fixturing layout optimization

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