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CCL9/CCR1 axis-driven chemotactic nanovesicles for attenuating metastasis of smAD4-deficient colorectal cancer by trapping TGF-β

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Acta Pharmaceutica sinica B 2024年第8期14卷 3711-3729页

作者： Boning Niu tianyi tian Lu Wang Yinmei tian tian tian Yuanyuan Guo Hu Zhou Zhiping Zhang Tongji school of Pharmacy Huazhong University of Science and TechnologyWuhan 430030China Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pharmacy Liyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China school of Pharmaceutical sciences Fujian Provincial Key Laboratory of Innovative Drug Target ResearchHigh Throughput Drug Screening PlatformXiamen UniversityXiamen 361102China National Engineering Research Center for Nanomedicine Huazhong University of Science and TechnologyWuhan 430030China Hubei Engineering Research Centre for Novel Drug Delivery system Huazhong University of Science and TechnologyWuhan 430030China

smAD4 deficiency in colorectal cancer(CRC)is highly correlated with liver metastasis and high mortality,yet there are few effective precision therapies ***,we show that CCR1^(+)-granulocytic myeloid-derived suppressor cells(G-m.sCs)are highly infiltrated in smAD4-deficient CRC via CCL15/CCR1 and CCL9/CCR1 axis in clinical specimens and mouse models,*** excessive TGF-β,secreted by tumor-infiltrated CCR1^(+)-G-m.sCs,suppresses the immune response of cytotoxic T lymphocytes(CTLs),thus facilitating ***,we develop engineered nanovesicles displaying CCR1 and TGFBR2 molecules(C/T-NVs)to chemotactically target the tumor driven by CCL9/CCR1 axis and trap TGF-βthrough TGF-β-TGFBR2 specific *** C/T-NVs counteract CCR1^(+)-G-m.sC infiltration through competitive responding CCL9/CCR1 axis.C/T-NVs-induced intratumoral TGF-βexhaustion alleviates the TGF-β-suppressed immune response of ***,C/T-NVs attenuate liver metastasis of smAD4-deficient *** further exploration,high expression of programmed cell death ligand-1(PD-L1)is observed in clinical specimens of smAD4-deficient *** C/T-NVs with anti-PD-L1 antibody(aPD-L1)induces tertiary lymphoid structure formation with sustained activation of CTLs,CXCL13^(+)-CD4^(+)T,CXCR5^(+)-CD20^(+)B cells,and enhanced secretion of cytotoxic cytokine interleukin-21 and IFN-γaround tumors,thus eradicating metastatic *** strategy elicits pleiotropic antimetastatic immunity,paving the way for nanovesicle-mediated precision immunotherapy in smAD4-deficient CRC.

关键词： smAD4-deficient CRC metastasis G-m.sCs TGF-β CCR1 TGFBR2

How forest age impacts on net primary productivity: Insights from future multi-scenarios

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Forest Ecosystems 2024年第5期11卷 708-719页

作者： Lei tian Yu Tao sim.s Joanna Annikki mäakelä mingyang Li Co-Innovation Center for sustainable Forestry in southern China Nanjing Forestry UniversityNanjingChina Faculty of Agriculture and Forestry University of HelsinkiHelsinkiFinland

Forest net primary productivity(NPP)constitutes a key flux within the terrestrial ecosystem carbon cycle and serves as a significant indicator of the forests carbon sequestration capacity,which is closely related to forest *** its significance,the impact of forest age on NPP is often ignored in future NPP ***,we mapped forest age in Hunan Province at a 30-m resolution utilizing a combination of Landsat time series stack(LTss),national forest inventory(NFI)data,and the relationships between height and ***,NPP was derived from NFI data and the relationships between NPP and age was built for various forest *** forest NPP was predicted based on the NPP-age relationships under three future scenarios,assessing the impact of forest age on *** findings reveal substantial variations in forest NPP in Hunan Province under three future scenarios:under the age-only scenario,NPP peaks in 2041(133.56TgC·yr^(−1)),while NPP peaks three years later in 2044(141.14TgC·yr^(−1))under the natural development *** maximum afforestation scenario exhibits the m.st rapid increase in NPP,with peaking in 2049(197.95TgC·yr^(−1)).However,with the aging of the forest,NPP is projected to then decrease by 7.54%,6.07%,and 7.47%in 2060,and 20.05%,19.74%,and 28.38%in 2100,respectively,compared to their peaks under the three *** indicates that forest NPP will continue to decline *** the age structure of forests through selective logging,afforestation and reforestation,and encouraging natural regeneration after disturbance could mitigate this declining trend in forest NPP,but implications of these measures on the full forest carbon balance remain to be *** from the future multi-scenarios are expected to provide data to support sustainable forest management and national policy development,which will inform the achievement of carbon neutrality goals by 2060.

关键词： Net primary productivity Forest age NPP-Age relationships NPP projections Afforestation

Tribological evaluation of thermoplastic polyurethane-based bearing materials under water lubrication:Effect of load,sliding speed,and temperature

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Friction 2024年第8期12卷 1801-1815页

作者： shaoli JIANG Janet ssWONG Debashis PUHAN tian YUAN Xiuqin BAI Chengqing YUAN state Key Laboratory of maritime Technology and safety Wuhan University of TechnologyWuhan 430063China Department of mechanical Engineering Imperial College LondonLondon SW72AZUK Yusuf Hamied Department of Chem.stry University of CambridgeLensfield RoadCambridge CB21EWUK

Polymers are widely used in bearing *** the case of water-lubricated stern tube bearings,thermoplastic polyurethane(TPU)-based composites are used due to their excellent wear resistance,corrosion resistance,and tunable mechanical *** tribological performance,however,depends on operating *** this work,TPU was blended with carbon fiber,graphene platelet,and ultra-high molecular weight polyethylene(UHmWPE).Friction tests of TPU based-composites against copper countersurface were carried out in water to mimic the actual operating conditions of the *** of the resulting contacts were in the boundary lubrication regime,in which friction was attributed to both contact mechanics of asperities as well as water *** results show that the viscoelasticity of TPU has a considerable impact on its tribological *** lubrication at 50°C promotes the softening of polymer surface material during sliding,resulting in higher fluctuation in the coefficient of friction and wear *** is attributed to the reduced thermomechanical *** addition,schallamach waviness is observed on worn *** tribological properties of TPU are significantly improved by the inclusion of carbon fiber,graphene platelet,and *** formation of graphene transfer-layers and UHmWPE transfer film reduces friction and wear loss,while the inclusion of carbon fiber enhances wear resistance due to improved mechanical properties and load bearing capacity.

关键词： friction thermoplastic polyurethane(TPU) water-lubricated bearings graphene platelet carbon fibers ultra-high molecular weight polyethylene(UHmWPE)

Frequency Domain Fatigue Evaluation on sCR Girth-Weld Based on structural stress

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China Ocean Engineering 2024年第2期38卷 255-270页

作者： ZHANG Long ZHAO tian-feng College of safety and Ocean Engineering China University of Petroleum(Beijing)Beijing 102249China

The steel Catenary Riser(sCR)is a vital component for transporting oil and gas from the seabed to the floating *** harsh environmental conditions and complex platform motion make the sCR’s girth-weld prone to fatigue *** structural stress fatigue theory and m.ster s-N curve method provide accurate predictions for the fatigue damage on the welded joints,which demonstrate significant potential and compatibility in multi-axial and random fatigue ***,we propose a new frequency fatigue model subjected to welded joints of sCR under multiaxial stress,which fully integrates the m.sh-insensitive structural stress and frequency domain random process and transforms the conventional welding fatigue technique of sCR into a spectrum analysis technique utilizing structural ***,a full-scale FE model of sCR with welds is established to obtain the modal structural stress of the girth weld and the frequency response function(FRF)of modal coordinate,and a biaxial fatigue evaluation about the girth weld of the sCR can be achieved by taking the effects of multi-load correlation and pipe-soil interaction into *** research results indicate that the frequency-domain fatigue results are aligned with the time-domain results,meeting the fatigue evaluation requirements of the sCR.

关键词： sCR girth weld random vibration self(cross)power spectrum structural stress method biaxial fatigue damage

Numerical investigation on characteristics of interfacial wave of liquid film in gas-liquid two-phase flow using OpenFOAm

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Chinese Journal of Aeronautics 2024年第2期37卷 233-248页

作者： Xiaoqi mA Yueshe WANG Jiaming tian state Key Laboratory of multiphase Flow in Power Engineering Xi’an Jiaotong UniversityXi’an 710049China

Liquid film cooling as an advanced cooling technology is widely used in space *** operation of liquid film along the rocket combustion inner wall is crucial for thermal protection of rocket *** stability of liquid film is mainly determined by the characteristics of interfacial wave,which is rarely investigated right *** to improve the stability of thin film has become a hot *** view of this,an advanced model based on the conventional Volume of Fluid(VOF)model is adopted to investigate the characteristics of interfacial wave in gas-liquid flow by using OpenFOAm,and the mechanism of formation and development of wave is revealed intuitively through numerical *** effects from gas velocity,surface tension and dynamic viscosity of liquid(three factors)on the wave are studied *** can be found that the gas velocity is critical to the formation and development of wave,and four modes of droplets generation are illustrated in this ***,a gas vortex near the gas-liquid interface can induce formation of wave easily,so changing the gas vortex state can regulate formation and development of ***’s more,the change rules of three factors influencing on the interfacial wave are obtained,and the surface tension has a negative effect on the formation and development of wave only when the surface tension coefficient is above the critical value,whereas the dynamic viscosity has a positive effect in this ***,the maximum height and maximum.slope angle of wave will level off as the gas velocity ***,the maximum.slope angle of wave is usually no more than 38°,no matter what happens to the three factors.

关键词： Interfacial wave Gas-liquid Two-phase flow VOF model OpenFOAm

Women’s empowerment and food consumption:Evidence from female-headed households in Tanzania

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Journal of Integrative Agriculture 2024年第2期23卷 457-467页

作者： m.sses Lufuke Xu tian College of Economics and management Nanjing Agricultural UniversityNanjing 210095China Department of Economics The University of DodomaDodoma 41218Tanzania College of Economics and management China Agricultural UniversityBeijing 100083China Academy of Global Food Economics and Policy China Agricultural UniversityBeijing 100083China

Despite the growing recognition of women’s increasing role in the household and corresponding empowerment programs in sub-saharan Africa,intensive research on the relationship between women’s influence and household food consumption is *** the m.st recent(2017-2018)national household survey data from Tanzania,this study examined the influence of women’s empowerment on household food ***,we compared the monthly consumption of eight food categories between female-headed households(FHHs)and male-headed households(mHHs)using both descriptive statistics and the propensity score matching(Psm)***,we adopted the two-stage Linear Expenditure system and Alm.st Ideal Demand system model(LEs-AIDs)to estimate income and price elasticities for the two household *** results show that FHHs consume bread and cereals,fish,oils and fats,vegetables,and confectionery(sugar,jam,honey,chocolate,etc.)more than ***,FHHs have a significantly higher income elasticity of demand for all food groups than *** are also more price elastic than mHHs in meat,fish,oils,fats,sugar,jam,honey,chocolate,etc.

关键词： women’s empowerment food consumption income elasticity price elasticity

An Energy Trading method Based on Alliance Blockchain and multi-signature

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Computers, materials & Continua 2024年第2期78卷 1611-1629页

作者： Hongliang tian Jiaming Wang College of Electrical Engineering Northeast Electric Power UniversityJilin132012China

Blockchain,known for its secure encrypted ledger,has garnered attention in financial and data transfer realms,including the field of energy ***,the decentralized nature and identity anonymity of user nodes raise uncertainties in energy *** broadcast consensus authentication slows transaction speeds,and frequent single-point transactions in multi-node settings pose key exposure risks without protective measures during user *** address these,an alliance blockchain scheme is proposed,reducing the resource-intensive identity verification among *** integrates multi-signature functionality to fortify user resources and transac-tion security.A novel multi-signature process within this framework involves neutral nodes established through central *** neutral nodes participate in multi-signature’s signing and verification,ensuring user identity and transaction content *** interactions among user nodes enhances transaction efficiency by minimizing communication overhead during verification and consensus *** assessments on reliability and operational speed highlight superior security performance,resilient against conventional attack *** shows that compared to traditional solutions,this scheme has advantages in terms of running *** conclusion,the alliance blockchain framework introduces a novel approach to tackle blockchain’s limitations in energy *** integrated multi-signature process,involving neutral nodes,significantly enhances security and *** scheme’s efficiency,validated through analytical assessments and simulations,indicates robustness against security threats and improved transactional *** research underscores the potential for improved security and efficiency in blockchain-enabled energy trading systems.

关键词： Alliance blockchain multi-signature energy trading security performance transaction efficiency

New method for multibody dynamics based on unknown constraint force

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science China(Technological sciences) 2024年第3期67卷 791-808页

作者： tian Ying JIA YingHong ZHANG Jun school of Astronautics Beihang UniversityBeijing 100191China Beijing Institute of Control Engineering Beijing 100190China National Laboratory of space Intelligent Control Beijing 100190China

This paper presents a new method for the dynamics of multibody systems based on unknown constraint force. The method can uniformly solve multibody systems with typical configurations, including the system with rigid-flexible coupling, the system in tree topology, and the system with loop constraints. Unlike common methods, the proposed method can model the loop system without “cutting off” loop constraints, leading to the exact same modelling process as the tree-like system performs. Based on graph theory, a topological record matrix m_(rec) is proposed to capture the arbitrary system configuration. moreover, constraint forces are selected as the key variables in semi-recursive framework. With the recursive kinematics relationship between adjacent bodies, the constraint force equation is further assembled to achieve the full-state system.solution. The numerical simulations demonstrate the accuracy of the proposed method.

关键词： multibody system dynamic modelling rigid-flexible coupling unknown constraint force graph theory semi-recursive algorithm

Engineering of efficient visible light photocatalysts:Ti_(1-x+y)Cu_(x)La_(y)O_(2)(x=0.03;y=0,0.005,0.01) compositions

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Journal of Rare Earths 2024年第3期42卷 497-505,I0003页

作者： s.m.Yakout A.m.Youssef Inorganic Chem.stry Department National Research Centre(NRC)El Buhouth StDokkiCairo12622Egypt

In dye-photocatalysis, widening the wavelengths absorption range of catalysts as well as aborting the recombination of the photoexcited charge carriers(electrons-holes pairs) are of paramount *** the current study, we report the photocatalytic characteristics of four compositions composed of TiO_(2),Ti_(0.97)Cu_(0.03)O_(2), Ti_(0.965)Cu_(0.03)La_(0.005)O_(2)and Ti_(0.96)Cu_(0.03)La_(0.01)O_(2)powders for two harmful dyes(Congo red and methylene blue). The X-ray diffraction technique verified the configuration of mixed anatase and rutile phases in pure TiO_(2)and Ti_(0.97)Cu_(0.03)O_(2)powders while Ti_(0.965)Cu_(0.03)La_(0.005)O_(2)and Ti_(0.96)Cu_(0.03)La_(0.01)O_(2)powders possess anatase phase only. The changes of the band gap structure and dimensions of the unit cell volume of TiO_(2)confirm the substitution of Ti^(4+)sites by Cu^(2+)and La^(3+)ions. Remarkable widening of wavelengths absorption with formation of long absorption tails were found in TiO_(2)(3.13 e V) through insertion of La^(3+)plus Cu^(2+)ions. Ti_(0.965)Cu_(0.03)La_(0.005)O_(2)and Ti_(0.96)Cu_(0.03)La_(0.01)O_(2)samples exhibit a visible light band gap of 2.3 and 2.7 e V, respectively. Based on sEm images, incorporation of Cu^(2+)and La^(3+)ions influences the surface morphology of TiO_(2). The resulting Ti_(0.97)Cu_(0.03)O_(2), Ti_(0.965)Cu_(0.03)La_(0.005)O_(2)and Ti_(0.96)Cu_(0.03)La_(0.01)O_(2)powders present enhanced photocatalytic activity towards Congo red dye degradation compared to pure one under natural solar spectrum. The best Ti_(0.96)Cu_(0.03)La_(0.01)O_(2)catalyst exhibits superior photocatalytic activity of 96% for 10 ppm CR dye in 20 min as well as above average photocatalytic efficiency of 63% for 30 ppm CR dye in 120 min. As well, it showed acceptable photodegradation activity of 52% for 30 ppm mB solution in 140 min of sunlight irradiation. The heightened photodegradation efficiency of Ti_(0.96)Cu_(0.03)La_(0.01)O_(2)catalyst can be clarified in terms of higher ch

关键词： semiconductor TiO_(2) Rare earths Congo red methylene blue solar spectrum Photodegradation