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Estimation of eddy heat transport in the global ocean from Argo data

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Acta Oceanologica Sinica 2014年第1期33卷 42-47页

作者： ZHANG Zhiwei zhong Yisen tian Jiwei YANG Qingxuan ZHAO Wei Key Laboratory of Physical Oceanography Ocean University of China School of Earth and Atmospheric Sciences Georgia Institute of Technology

The Argo data are used to calculate eddy（turbulence） heat transport（EHT） in the global ocean and analyze its horizontal distribution and vertical *** calculate the EHT by averaging all the v ′,T ′ profiles within each 2 ×2 *** velocity and temperature anomalies are obtained by removing their climatological values from the Argo ＂instantaneous＂ values *** the Student＇s t-test and an error evaluation,we obtained a total of 87% Argo bins with significant depth-integrated EHTs（D-EHTs）.The results reveal a positive-and-negative alternating D-EHT pattern along the western boundary currents（WBC） and Antarctic Circumpolar Current（ACC）.The zonally-integrated D-EHT（ZI-EHT） of the global ocean reaches 0.12 PW in the northern WBC band and –0.38 PW in the ACC band *** strong ZI-EHT across the ACC in the global ocean is mainly caused by the southern Indian *** ZI-EHT in the above two bands accounts for a large portion of the total oceanic heat transport,which may play an important role in regulating the *** analysis of vertical structures of the EHT along the 35 N and 45 S section reveals that the oscillating EHT pattern can reach deep in the northern WBC regions and the Agulhas Return Current（ARC） *** also shows that the strong EHT could reach 600 m in the WBC regions and 1 000 m in the ARC region,with the maximum mainly located between 100 and 400 m *** results would provide useful information for improving the parameterization scheme in models.

关键词： eddy heat transport Argo mesoscale eddy global ocean

Reactive dividing wall column for hydrolysis of methyl acetate:Design and control

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Chinese Journal of Chemical Engineering 2016年第10期24卷 1360-1368页

作者： Lumin Li Lanyi Sun Delian Yang Wang zhong Yi Zhu Yuanyu tian State Key laboratory of Heavy Oil Processing China University of PetroleumQingdao 266580China Synopsys.Inc. 690 East Middlefield RoadMountain ViewCA 94043USA

Reactive distillation and dividing wall column distillation are two kinds of effective separation technologies,and their integrated configuration,reactive dividing wall column(RDWC),presents attractive *** this study,the rigorous simulation of RDWC for methyl acetate hydrolysis is performed,and sensitivity analysis is conducted to obtain the minimum reboiler *** a comparison is made between the conventional process and RDWC process,and it shows that 20.1% energy savings can be achieved by RDWC *** addition,the dynamic characteristic of RDWC is studied and an effective control strategy is *** simple PI control scheme with three temperature loops can obtain reasonable control performance and maintain products at desired *** is proved that this RDWC process is an energy efficiency alternative with good controllability.

关键词： Reactive dividing wall column Methyl acetate Hydrolysis Design Control

Identification of deregulated miRNAs and their targets in hepatitis B virus-associated hepatocellular carcinoma

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World Journal of Gastroenterology 2012年第38期18卷 5442-5453页

作者： Wen Wang Lan-.luan Zhao Hao Ren zhong-tian Qi De-partment of Microbiology Shanghai Key Laboratory of Medi-cal Biodefense Second Military Medical University Shanghai200433 China Laboratory of Signal Transduction Eastem Hepa-tobiliary-Surgery Hospital Second Military Medical UniversityShanghai 200433 China

AIM： TO identify the differentially expressed miRNAs and their targets in hepatitis B virus （HBV）-associated hepatocellular carcinoma （HCC）. METHODS： Six hundred and sixty seven human miRNAs were quantitatively analyzed by Taqman lowdensity miRNA array （TLda） in HBV-HCC tissues. Gene ontology （GO） and Kyoto Encyclopedia of Genes and Genomes （KEGG） pathway analyses were used to analyze the significant function and pathway of the differentially expressed miRNAs in HBV-HCC. TargetScan software was used to predict the targets of deregulated miRNAs. Western blotting and luciferase assay were performed to verify the targets of these ***： Ten up-regulated miRNAs （miR-217, miR- 518b, miR-517c, miR-520g, miR-519a, miR-522, miR- 518e, miR-525-3p, miR-512-3p, and miR-518a-3p） and 11 down-regulated miRNAs （miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275） were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. GO and KEGG pathway analysis revealed that ＂regulation of actin cytoskeleton＂ and ＂pathway in cancer＂ are most likely to play critical roles in HCC tumorigenesis. MiR- 519a and ribosomal protein S6 kinase polypeptide 3 （RPS6KA3） were predicted as the most significant can-didates by miRNA-mRNA network. In addition, cyclin D3 （CCND3） and clathrin heavy chain （CHC）, usually up-regulated in HCC tissues, were validated as the di- rect target of miR-138 and miR-199a-5p, respectively.

关键词： Hepatocellular carcinoma miR-138 miR- 199a-5p Cyclin D3 Clathrin heavy chain Bioinformatics Taqman array

Revisiting Mid-Holocene Temperature over China Using PMIP3 Simulations

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Atmospheric and Oceanic Science Letters 2015年第6期8卷 358-364页

作者： tian Zhi-Ping JIANG da-Bang Climate Change Research Center Chinese Academy of Sciences Nansen-Zhu International Research Centre Institute of Atmospheric Physics Chinese Academy of Sciences

Using the simulations performed by 15 cli mate models under the latest protocol of the Paleoclimate Modeling Intercomparison Project(PMIP)Phase 3(PMIP3),the authors revisited the annual and seasona temperature changes over China during the mid-Holocene Similar to the previous results produced by PMIP Phase 1(PMIP1)and 2(PMIP2)models,14(15)of the 15 PMIP3models reproduced colder annual(boreal winter and spring)temperature in response to mid-Holocene insola tion changes,with an average cooling of 0.33 K(1.31 K and 1.58 K)over *** mid-Holocene boreal sum mer(autumn)temperature increased in all(13)of the 15PMIP3 models,with an average warming of 1.02 K(0.61K)at the national *** changes simulated by the PMIP3 models were similar to those from the PMIP2simulations but generally weaker than those from the PMIP1 models.A considerable mismatch still existed between the simulated cooling by the PMIP3 models and the reconstructed warming for annual and winter tem peratures over China during the mid-Holocene,as wa also the case between the previous PMIP1/2 simulation and proxy data.

关键词： Mid-Holocene temperature over China PMIP3 simulati

Forward and backward secure searchable encryption with multi-keyword search and result verification

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Science China(Information Sciences) 2022年第5期65卷 270-272页

作者： Jie CUI Yue SUN Yan XU Miaomiao tian Hong zhong School of Computer Science and Technology Anhui University Institute of Physical Science and Information Technology Anhui University Anhui Engineering Laboratory of LoT Security Technologies Anhui University

Dear editor,Searchable encryption [1] is a new search method that not only protects personal privacy, but also searches over encrypted data. The multi-keyword scheme can search documents with more keywords so that the... 详细信息

关键词： Forward Security Backward Security Multi-keyword Search Verification Searchable Encryption

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Intra-beam scattering and beam lifetime in a candidate lattice of the soft X-ray diffraction-limited storage ring for the upgraded SSRF

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Nuclear Science and Techniques 2021年第8期32卷 57-66页

作者： Xin-zhong Liu Shun-Qiang tian Xu Wu Meng Wang Zhen-Tang Zhao Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201204China Shanghai University Shanghai 200444China

New-generation synchrotron light sources are being designed and operated worldwide to provide brighter radiation by reducing the beam emittance to X-ray diffraction ***-beam scattering(IBS)and Touschek scattering in such facilities are significant and require attention because of their ultra-low ***,cure strategies need to be carefully studied to obtain highquality photon *** the Shanghai Synchrotron Radiation Facility Upgrade(SSRF-U),a candidate lattice of the storage ring,reaching the soft X-ray diffraction limit,was designed and presented for the first time in this *** emittance growth and beam lifetime in the SSRF-U storage ring were studied using particle simulations for a series of different machine *** gains with RF frequencies of 100 MHz and 500 MHz were *** with a better filling pattern,a more suitable RF frequency was adopted in the *** variations in the equilibrium beam emittance with beam coupling and bunch-lengthening were identified using *** beam coupling and required bunch-lengthening for the SSRF-U storage ring were thus *** fitness of the beam energy in the SSRF-U was subsequently assessed using the obtained ***,the Touschek scattering and beam lifetime were calculated,and an acceptable total beam lifetime was obtained.

关键词： Diffraction-Limited Storage Ring(DLSR) Shanghai Synchrotron Radiation Facility Upgrade(SSRFU) Intra-Beam Scattering(IBS) Touschek scattering Beam lifetime

Probing the new strategy for the oral formulations of taxanes:changing the method with the situation

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Chinese Journal of Natural Medicines 2021年第9期19卷 656-665页

作者： WANG He-Lin SUN Jin tian Chu-Tong HE zhong-Gui Department of Pharmaceutics Wuya College of InnovationShenyang Pharmaceutical UniversityShenyang 110016China

The first-generation taxanes(including paclitaxel and docetaxel)are widely used for the treatment of various cancers in clinical *** the past decade,a series of new-generation taxanes have been developed which are effective in the inhibition of tumor ***,intravenous(i.v.)infusion is still the only route of administration,and may result in serious adverse reactions with respect to the utilization of Cremophor EL or Tween-80 as ***,the dosing schedule is also ***,oral administration of taxanes is urgently needed to avoid the adverse reactionss and increase dosing *** this review,we first outlined the discovery and development of taxane-based anticancer ***,we summarized the research progress on the oral formulations of taxanes and proposed some thoughts on the future development of oral taxane formulations.

关键词： Taxanes Oral delivery Oral bioavailability Anti-tumor

Identification of key genes regulating the synthesis of quercetin derivatives in Rosa roxburghii through integrated transcriptomics and metabolomics

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Journal of Integrative Agriculture 2024年第3期23卷 876-887页

作者： Liyao Su Min Wu tian Zhang Yan zhong Zongming(Max) Cheng State Key Laboratory of Crop Genetics and Germplasm Enhancement College of HorticultureNanjing Agricultural UniversityNanjing210095China

Rosa roxburghii fruit is rich in flavonoids, but little is known about their biosynthetic pathways. In this study, we employed transcriptomics and metabolomics to study changes related to the flavonoids at five different stages of R. roxburghii fruit development. Flavonoids and the genes related to their biosynthesis were found to undergo significant changes in abundance across different developmental stages, and numerous quercetin derivatives were identified. We found three gene expression modules that were significantly associated with the abundances of the different flavonoids in R. roxburghii and identified three structural UDP-glycosyltransferase genes directly involved in the synthesis of quercetin derivatives within these modules. In addition, we found that RrBEH4, RrLBD1 and RrPIF8could significantly increase the expression of downstream quercetin derivative biosynthesis genes. Taken together,these results provide new insights into the metabolism of flavonoids and the accumulation of quercetin derivatives in R. roxburghii.

关键词： Rosa roxburghii quercetin derivatives weighted gene co-expression network analysis transcription factor transcriptome metabolome

FCC-to-HCP Phase Transformation in CoCrNi_x Medium-Entropy Alloys

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Acta Metallurgica Sinica(English Letters) 2020年第8期33卷 1151-1158页

作者： Jia-Qi Zhao Hua tian zhong Wang Xue-Jiao Wang Jun-Wei Qiao College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China College of Information and Computer Taiyuan University of TechnologyTaiyuan 030024China

A hybrid first-principles/Monte Carlo simulation is combined with experiments to study the structure and elastic properties of CoCrNi_x(x=1-0.5)*** experimental X-ray diffraction patterns show that the structures have changed from the single-phase face-centered cubic(FCC)structure at x=1-0.8 to the coexistence of FCC and the hexagonal close-packed structures at x=0.7-0.5,which is further confirmed by calculations on mixing *** elastic moduli by calculation are basically in agreement with ***-temperature tension shows that the six alloys have a certain plasticity,the strength and plasticity of the alloys have a linear decrease with the decrease in Ni contents,and the plasticity of the alloys drops from 84 to 23%.Furthermore,first-principles density function theory calculations were employed to reveal the electronic and magnetic structures of *** electron density of states for all alloys is asymmetrical,which illustrates that the alloys are *** is found that Cr atoms can suppress the ferromagnetism of alloys,since Cr atoms have both positive and negative magnetic moments in all alloys.

关键词： Hexagonal close-packed(HCP)structure Medium-entropy alloys Magnetic Mechanical properties Phase transformation High-entropy alloys