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The role of aerial algae in the formation of the landscape of the Yunnan Stone Forest,Yunnan Province, china

Science china Earth Sciences 2004年第9期47卷 846-864页

作者： tian youping1,3. zhang {2. {3. linhua1 & bao haosheng2.1. institute of geographic Sciences and natural resources research, Chinese Academy of Sciences, beijing 100101,{13., nanjing university, nanjing 2.0093. china 3. School of Earth Sciences and resources, china university of Geosciences, beijing 100083. china institute of geographic Sciences and {2. {3. research Chinese Academy of Sciences Beijing China School of Earth Sciences and resources China University of Geosciences Beijing China department of geography Nanjing University Nanjing China

Aerial algae on the surface of carbonate rocks at the Stone Forest, Shilin County, Yunnan Province, china, and their bioerosion were investigated in the field and studied in the laboratory in detail. Through the observation, identification and statistics of more than one hun- dred algal samples and rock samples with the optical microscopes (stereomicroscope, biological microscope) and the scanning electronic microscope (SEM), the relationships between erosional forms on the surface of the Stone Forest and algae and/or algal communities and the genetic mechanism for the formation of erosional forms were analyzed. It is suggested that aerial algae play an active role in bioerosive processes that may affect the formation of karst erosional forms. These effects include both direct and indirect ones. The direct effect is the initiative control (algal shape-controlling role) of algae on the formation of karst forms of various scales, mostly mi- cro-scale (3.) and minor-scale (10-3.10-1m) erosional forms. The algal shape-controlling roles can be divided into the algal individual shape-controlling role and the algal community shape-controlling role. The former mostly controls the formation of micro-scale erosional forms, while the latter mostly controls the formation of micro-scale and smaller minor-scale erosional forms. The indirect effect refers to the promoting role of algae in the formation of karst forms, which may affect the formation of karst forms of all types and scales. The bioerosion of algae accelerates the weathering process of the whole Stone Forest karst landforms.

关键词： aerial algae, bioerosion, the Stone Forest, Yunnan Province, china.

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Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n

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Nuclear Science and Techniques 2024年第1期35卷 178-187页

作者： Sheng-Da Tang Yong-Hao Chen Jing-Yu Tang Rui-Rui Fan Qiang Li Gong Li Dong Liu Zheng-Yao Jin Xing-Zhu Cui tian-Xiang Chen Yi-Wei Yang Rong Liu Han Yi Yang Li Zhen Yang Qi An Hao-Fan Bai Jiang-Bo Bai jie {2. Ping Cao Qi-Ping Chen Zhen Chen Zeng-Qi Cui An-Chuan Fan Chang-Qing Feng Fan-Zhen Feng Ke-Qing Gao Min-Hao Gu Chang-Cai Han Zi-jie Han Guo-Zhu He Yong-Cheng He Yang Hong Yi-Wei Hu Han-Xiong Huang Wei-Hua Jia Hao-yu Jiang Wei Jiang Zhi-jie Jiang Ling Kang Bo Li Chao Li Jia-Wen Li Xiao Li jie Liu Shu-Bin Liu Guang-Yuan Luan Chang-Jun Ning Bin-Bin Qi jie Ren Zhi-Zhou Ren Xi-Chao Ruan Zhao-Hui song Kang Sun Zhi-Xin Tan Li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang Zhong-Wei Wen Xiao-Guang Wu Xuan Wu Li-Kun Xie Yong-Ji Yu Guo-Hui {2. Lin-Hao {2. Mo-Han {2. Qi-Wei {2. Xian-Peng {2. Yu-Liang {2. Yue {2. Zhi-Yong {2. Mao-Yuan Zhao Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu Sino-French institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China institute of High-Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China USTC Archaeometry Laboratory University of Science and Technology of ChinaHefei 230026China institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Northwest institute of Nuclear Technology Xi’an 710024China university of Chinese Academy of Sciences Beijing 100049China

Nondestructive and noninvasive neutron assays are essential applications of neutron *** resonance transmission analysis(NRTA)is a powerful nondestructive method for investigating the elemental composition of an *** back-streaming neutron line(Back-n)is a newly built time-of-flight facility at the china Spallation Neutron Source(CSNS)that provides neutrons in the eV to 3.0 MeV range.A feasibility study of the NRTA method for nuclide identification was conducted at the CSNS Back-n via two test *** results demonstrate that it is feasible to identify different elements and isotopes in samples using the NRTA method at *** study reveals its potential future applications.

关键词： CSNS White neutron beam NRTA Nuclide identification Nondestructive method

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Measurement of the neutron total cross section of^(9)Be at the Back-n white neutron source of CSNS

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Chinese Physics C 2024年第8期48卷 140-152页

作者： Jiangbo Bai Jingyu Tang Liqun Shi Yonghao Chen Han Yi jie bao Yu bao Ping Cao Haolei Chen Zhen Chen Zengqi Cui Ruirui Fan Changqing Feng Keqing Gao Xiaolong Gao MinHao Gu Changcai Han Guozhu He Yongcheng He Yang Hong Yiwei Hu Hanxiong Huang Xiru Huang Haoyu Jiang Wei Jiang Zhijie Jiang Hantao Jing Ling Kang Bo Li Chao Li Jiawen Li Qiang Li Xiao Li Yang Li jie Liu Shubin Liu Ze Long Guangyuan Luan Changjun Ning Mengchen Niu Binbin Qi jie Ren Xichao Ruan Zhaohui song Kang Sun Zhijia Sun Zhixin Tan Xinyi Tang Binbin tian Lijiao Wang Pengcheng Wang Zhaohui Wang Xiaoguang Wu Xuan Wu Likun Xie Xiaoyun Yang Li Yu Tao Yu Yongji Yu Guohui {2. Linhao {2. Qiwei {2. Xianpeng {2. Yuliang {2. Zhiyong {2. Luping Zhou Zhihao Zhou Kejun Zhu institute of Modern Physics Fudan UniversityShanghai 200433China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China Sate Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China State Key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Northwest institute of Nuclear Technology Xi’an 710024China university of Chinese Academy of Sciences Beijing 100049China

The neutron total cross section data of^(9)Be are essential in the nuclear structure model research of light nuclei and nuclear power *** neutron total cross section of^(9)Be in the 0.3.eV−12. MeV energy region has been measured using time-of-flight and transmission methods with the Neutron Total Cross Sectional Spectrometer(NTOX)based on the multi-cell fast fission chamber at the {2. Spallation Neutron Source(CSNS)-Back-n white neutron source(Back-n).The fission count-neutron energy distributions of ^(2.1})U and ^(2.1})U without samples and with Be samples with three thicknesses were measured in the double-bunch operation mode for a beam power of 100 *** Bayesian method was used to eliminate the influence of the double-bunch problem on neutron measurement in the energy region above 10 *** neutron total cross section of^(9)Be results was consistent with ENDF/B-VIII.0 evaluation library data in the 0.3.eV−2. MeV energy *** the energy ranges of 0.3.eV to 10 keV and 0.01 to 2. MeV,the deviations between our results and the evaluation results of ENDF/B-VIII.0 were within 2.5%and 15%,*** the resonance energy region,the measured resonance energies in our experiment were 0.63.0.82.and 2.8 MeV,*** results showed that the total cross section uncertainties of three Be samples were within 2.2.in the energy region below 1 *** total cross section uncertainty of 3. mm Be from ^(2.1})U was the smallest and less than 5%in the energy region of 0.3.eV−12. *** results of this experiment can provide technical support for further data analysis and related nuclear data evaluation.

关键词： ^(9)Be neutron total cross section CSNS Back-n time-of-flight method transmission method multi-cell fast fission chamber

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云南石林碳酸盐岩表面气生蓝藻(蓝细菌)研究

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生态学报 2002年第11期22卷 1793-1802,2020,T001,T002页

作者：田友萍张捷宋林华包浩生中国科学院地理科学与资源研究所北京100101 南京大学城市与资源学系南京210093

云南石林的黑石头及其颜色会随着天气的变化而变化的自然景观 ,是由于其碳酸盐岩表面长满黑色气生蓝藻 (蓝细菌 )之故。经鉴定 ,气生蓝藻共 4目 ,1 1科 ,3.1属 ,1 88种。种类十分丰富。其优势种主要为寄生微囊藻、红色星球藻、伯氏伪枝... 详细信息

云南石林的黑石头及其颜色会随着天气的变化而变化的自然景观 ,是由于其碳酸盐岩表面长满黑色气生蓝藻 (蓝细菌 )之故。经鉴定 ,气生蓝藻共 4目 ,1 1科 ,3.1属 ,1 88种。种类十分丰富。其优势种主要为寄生微囊藻、红色星球藻、伯氏伪枝藻和皮壳伪枝藻等 ;寄生微囊藻和红色星球藻呈面状分布 ,相对均衡 ;伯氏伪枝藻和皮壳伪枝藻呈点状分布 ,相对集中。这些气生蓝藻的胶被色泽鲜艳 ,宽厚而坚硬 ,是适宜高山岩石表面生活的典型进化特征。在野外肉眼观察时 ,气生蓝藻还表现出不同形态的微群落 ;发现气生蓝藻能溶解石灰石 ,形成钻孔 ,加速岩石的溶蚀与风化。这些现象表明 ,气生蓝藻与云南石林岩石表面的微形态及整个石林景观的形成都有着十分密切的关系。

关键词：云南石林碳酸盐岩表面气生蓝藻蓝细菌石头颜色自然景观表面微形态岩石溶蚀

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Cropland redistribution to marginal lands undermines environmental sustainability

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National Science Review 2022年第1期9卷 66-78页

作者： Wenhui Kuang Jiyuan Liu Hanqin tian Hao Shi Jinwei Dong Changqing song Xiaoyong Li Guoming Du Yali Hou Dengsheng Lu Wenfeng Chi Tao Pan Shuwen {2. Rafiq Hamdi Zherui Yin Huimin Yan Changzhen Yan Shixin Wu Rendong Li Jiuchun Yang Yinyin Dou Wenbin Wu Liqiao Liang {3. Xiang Shiqi Yang Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences International Center for Climate and Global Change research School of Forestry and Wildlife Sciences Auburn University Faculty of geographical Science Beijing Normal University State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences College of resources and Environment University of Chinese Academy of Sciences School of Public Administration and Law Northeast Agricultural University School of geographical Sciences Fujian Normal University School of resources and Environmental Economics Inner Mongolia University of Finance and Economics School of geography and Tourism Qufu Normal University Northeast institute of geography and Agroecology Chinese Academy of Sciences Royal Meteorological institute of Belgium Xinjiang institute of Ecology and geography Chinese Academy of Sciences Key Laboratory for resources Use & Environmental Remediation Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Northwest institute of Eco-Environment and resources Chinese Academy of Sciences Hubei Province’s Key Laboratory for Environment & Disaster Monitoring and Evaluation Innovation Academy for Precision Measurement Science and Technology Chinese Academy of Sciences institute of Agricultural resources and Regional Planning Chinese Academy of Agricultural Sciences Key Laboratory of Tibetan Environment Changes and Land Surface Processes Institute of Tibetan Plateau Research Chinese Academy of Sciences institute of Ecology Chinese Research Academy of Environmental Sciences College of Environment and Planning Henan University

Cropland redistribution to marginal land has been reported worldwide;however,the resulting impacts on environmental sustainability have not been investigated *** we investigated the environmental impacts of cropland redistribution in *** a result of urbanization-induced loss of high-quality croplands in south china(～8.5 t ha),croplands expanded to marginal lands in northeast(～4.5 t ha) and northwest china(～2.9 t ha) during 1990-{2.5 to pursue food ***,the reclamation in these low-yield and ecologically vulnerable zones considerably undermined local environmental sustainability,for example increasing wind erosion(+3.47%),irrigation water consumption(+3..42.),fertilizer use(+2..02.) and decreasing {3. habitats(-3.11%).Forecasts show that further reclamation in marginal lands per current policies would exacerbate environmental costs by *** future cropland security risk will be remarkably intensified because of the conflict between food production and environmental *** research suggests that globally emerging reclamation of marginal lands should be restricted and crop yield boost should be encouraged for both food security and environmental benefits.

关键词： cropland redistribution environmental sustainability marginal lands wind erosion irrigation water consumption

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Measurement of the ^(2.0})Th(n,f)cross section in the 1-2.0 MeV range at the CSNS Back-n

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Nuclear Science and Techniques 2023年第8期34卷 142-153页

作者： Zhi-Zhou Ren Yi-Wei Yang Yong-Hao Chen Rong Liu Bang-Jiao Ye jie Wen Hai-Rui Guo Zi-jie Han Qi-Ping Chen Zhong-Wei Wen Wei-Li Sun Han Yi Xing-Yan Liu Tao Ye Jiang-Bo Bai Qi An jie {3. Yu {3. Ping Cao Hao-Lei Chen Zhen Chen Zeng-Qi Cui Rui-Rui Fan Chang-Qing Feng Ke-Qing Gao Xiao-Long Gao Min-Hao Gu Chang-Cai Han Guo-Zhu He Yong-Cheng He Yang Hong Yi-Wei Hu Han-Xiong Huang Xi-Ru Huang Hao-Yu Jiang Wei Jiang Zhi-jie Jiang Han-Tao Jing Ling Kang Bo Li Chao Li Jia-Wen Li Qiang Li Xiao Li Yang Li jie Liu Shu-Bin Liu Ze Long Guang-Yuan Luan Chang-Jun Ning Meng-Chen Niu Bin-Bin Qi jie Ren Xi-Chao Ruan Zhao-Hui song Kang Sun Zhi-Jia Sun Zhi-Xin Tan Jing-Yu Tang Xin-Yi Tang Bin-Bin tian Li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang Xiao-Guang Wu Xuan Wu Li-Kun Xie Xiao-Yun Yang Li Yu Tao Yu Yong-Ji Yu Guo-Hui {2. Lin-Hao {2. Qi-Wei {2. Xian-Peng {2. Yu-Liang {2. Zhi-Yong {2. Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu department of Modern Physics University of Science and Technology of ChinaHefei 230026China institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China institute of Applied Physics and Computational Mathematics Beijing 100088China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230027China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijingChina Northwest institute of Nuclear Technology Xi’an 710024China university of Chinese Academy of Sciences Beijing 100049China department of Engineering and Applied Physics University of Science and Technology of ChinaHefei 230026China

The ^(2.0})Th(n,f)cross section is very important in basic nuclear physics and applications based on the Th/U fuel *** the time-of-flight method and a multi-cell fast-fission ionization chamber,a novel measurement of the^(2.0})Th(n,f)cross sec-tion relative to^(2.0})U in the 1–2.0 MeV range was performed at the china Spallation Neutron Source Back-n white neutron source(Back-n).The fission event-neutron energy spectra of^(2.0})Th and^(2.0})U fission cells were measured in the single-bunch *** 2.0}Th/2.0}U fission cross-sectional ratios were obtained,and the measurement uncertainties were 2.5–3.7%for energies in the 2.2. MeV range and 3.6–6.2.for energies in the 2.–2.0 MeV ***^(2.0})Th(n,f)cross section was obtained by introducing the standard cross section of^(2.0})U(n,f).The results were compared with those of previous theoreti-cal calculations,measurements,and *** measured 2.0}Th fission cross section agreed with the main evaluation results in terms of the experimental uncertainty,and 2.0}Th fission resonances were observed in the 1–3.MeV *** present results provide^(2.0})Th(n,f)cross-sectional data for the evaluation and design of Th/U cycle nuclear systems.

关键词： 2.0}Th(n f)cross section Fast-fission ionization chamber Back-n white neutron source

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Efficacy and safety of sirolimus early conversion protocol in liver transplant patients with hepatocellular carcinoma:A single-arm, multicenter, prospective study

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 106-112页

作者： Ren-Yi Su Sun-Bin Ling Qiao-Nan Shan Xu-Yong Wei Rui Wang Chang-Ku Jia Li Zhuang tian Shen Li-Min Ding Zhi-Dan Xu Lai-Bang Luo Li-Bo Sun Guang-Ming Li Tai-Shi Fang Nan Jiang Kun zhang Zhao-{2. Su Zhi-Hai Peng Ren Lang Tao Jiang Qiang He Lin-Sen Ye Yang Yang Yu-Ting He Wen-Zhi Guo Liu-Gen Lan Xu-Yong Sun Dong Chen Zhi-Shui Chen Da-Wei Zhou Shao-Jun Ye Qi-Fa Ye Min tian Jian-Hua Shi Bo Wang Jiang Liu Qian Lu Wei Rao Jin-Zhen Cai Tao Lv Jia-Yin Yang Pu-Sen Wang Lin Zhong Jing-Sheng Ma Qi-Gen Li Sheng-Dong Wu Chang-Jiang Lu Cai-De Lu Dong-Hua zhang Xuan Wang Zi-Qiang Li Mu-Jian Teng Jun-{2. Li Wen-Tao Jiang Jian-Hua Li Quan-bao zhang Ning-Qi Zhu Zheng-Xin Wang Kang He Qiang Xia Shao-Hua song Zhi-Ren Fu Wei Qiu Guo-Yue Lv Rui-Peng song Ji-Zhou Wang Zheng Wang Jian Zhou Gang Chen Ying-Peng Zhao Li Li Ze-Min Hu Qi-{2. Luo Zhong-Zhou Si Bin Xie Xiao-Shun He Zhi-Yong Guo Shu-Sen Zheng Xiao Xu department of Hepatobiliary and Pancreatic Surgery The Center for Integrated Oncology and Precision MedicineAffiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China department of Transplantation Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang 330006China Liver Transplantation Center Beijing You’an HospitalCapital Medical UniversityBeijing 100069China department of Hepatic Surgery National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyShenzhen 518112China department of General Surgery Xiang’an Hospital of Xiamen UniversityXiamen 361000China Deartment of Hepatobiliary and Pancreaticosplenic Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China department of Hepatic Surgery and Liver Transplantation Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China department of Liver Transplantation The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530000China institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China institute of Hepatobiliary Diseases of Wuhan university Transplant Center of Wuhan UniversityHubei Key Laboratory of Medical Technology on TransplantationZhongnan Hospital of Wuhan UniversityWuhan 430071China department of Hepatobiliary Surgery The First Affiliated Hos

Mammalian target of rapamycin(m TOR) inhibitor as an attractive drug target with promising antitumor effects has been widely investigated. High quality clinical trial has been conducted in liver transplant(LT) recipients in Western countries. However, the pertinent studies in Eastern world are paucity. Therefore, we designed a clinical trial to test whether sirolimus can improve recurrence-free survival(RFS) in hepatocellular carcinoma(HCC) patients beyond the Milan criteria after LT. This is an open-labeled, single-arm, prospective, multicenter, and real-world study aiming to evaluate the clinical outcomes of early switch to sirolimus-based regimens in HCC patients after LT. Patients with a histologically proven HCC and beyond the Milan criteria will be enrolled. The initial immunosuppressant regimens are center-specifc for the frst 4-6 weeks. The following regimens integrated sirolimus into the regimens as a combination therapy with reduced calcineurin inhibitors based on the condition of patients and centers. The study is planned for 4 years in total with a 2.year enrollment period and a 2.year follow-up. We predict that sirolimus conversion regimen will provide survival benefts for patients particular in the key indicator RFS as well as better quality of life. If the trial is conducted successfully, we will have a continued monitoring over a longer follow-up time to estimate indicator of overall survival. We hope that the outcome will provide better evidence for clinical decision-making and revising treatment guidelines based on Chinese population data.

关键词： Sirolimus Immunosuppressive agents Hepatocellular carcinoma Liver transplantation Conversion

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Protocol on transcranial alternating current stimulation for the treatment of major depressive disorder:a randomized controlled trial

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Chinese Medical Journal 2020年第1期133卷 61-67页

作者： Hong-Xing Wang Kun Wang Wen-Rui zhang Wen-Feng Zhao Xiao-Tong Yang Li Wang Mao Peng Zhi-Chao Sun Qing Xue Yu Jia Ning Li Kai Dong Qian zhang Shu-Qin Zhan {2.-Quan Min Chun-Qiu Fan Ai-Hong Zhou Hai-Qing {3. Lu Yin tian-Mei Si Jing Huang jie Lu Hai-Xia Leng Wei-Jun Ding Yuan Liu tian-Yi Yan Yu-Ping Wang Departm ent of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China beijing Key Laboratory of Neuromodulation Beijing 100053China Center of Epilepsy Beijing Institute for Brain DisordersCapital Medical UniversityBeijing 100053China department of Neurology Beijing Puren HospitalBeijing 100062China Medical research&Biometrics Centre National Centre for Cardiovascular DiseasesBeijing 102300China Peking university Sixth Hospital Beijing 100083China department of Radiology Xuanwu HospitalCapital Medical UniversityBeijing 100053China School of Life Science Beijing Institute of TechnologyBeijing 100081China

Background:Transcranial alternating current stimulation(tACS)offers a new approach for adult patients with major depressive disorder(MDD).The study is to evaluate the efficacy and safety of tACS treating ***:This is an 8-week,double-blind,randomized,placebo-controlled ***-two drug-naive patients with MDD aged 18 to 65 years will receive 2. daily 40-min,77.5-Hz,15-mA sessions of active or sham tACS targeting the forehead and both mastoid areas on weekdays for 4 consecutive weeks(week 4),following a 4-week observation period(week 8).The primary outcome is the remission rate defined as the 17-item Hamilton depression rating scale(HDRS-17)score≤7 at week *** outcomes are the rates of response at weeks 4 and 8 and rate of remission at week 4 based on HDRS-17,the proportion of participants having improvement in the clinical global impression-improvement,the change in HDRS-17 score(range,0-52.with higher scores indicating more depression)over the study,and variations of brain imaging and neurocognition from baseline to week *** will be assessed by vital signs at weeks 4 and 8,and adverse events will be collected during the entire ***:The tACS applied in this trial may have treatment effects on MDD with minimal side *** registration:Chinese Clinical Trial Registry,ChiCTR1800016479;http://***/***?proj=2.048.

关键词： Major depressive disorder Transcranial alternating current stimulation Treatment Trial

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由超拍电子伏特加速器产生的超高能伽马射线气泡

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Science Bulletin 2024年第4期69卷 449-457页

作者： LHAASO Collaboration Zhen Cao Chuandong Gao Cong Li Ruo-Yu Liu Ruizhi Yang 不详 Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China university of Chinese Academy of Sciences Beijing 100049China tianFU Cosmic Ray research Center ChengduChina institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China university of Science and Technology of china Hefei 230026China

We report the detection of aγ-ray bubble spanning at least 100deg2.in ultra-high energy(UHE)up to a few PeV in the direction of the star-forming region Cygnus X,implying the presence super PeVatron(s)accelerating protons to at least 10 PeV.A log-parabola form with the photon indexΓ(E)=(2.71±0.02.+(0.11±0.02.×log10(E/10 TeV)is found fitting the gamma-ray energy spectrum of the bubble *** sources,“hot spots”correlated with very massive molecular clouds,and a quasi-spherical amorphousγ-ray emitter with a sharp central brightening are observed in the *** the core of~0.5°,spatially associating with a region containing massive OB association(Cygnus OB2.and a microquasar(Cygnus X-3.,as well as previously reported multi-TeV sources,an enhanced concentration of UHEγ-rays is observed with 2.photons at energies above 1 *** general feature of the bubble,the morphology,and the energy spectrum,are reasonably reproduced by the assumption of a particle accelerator in the core,continuously injecting protons into the ambient medium.

关键词： Cosmic rays γ-rays Interstellar medium Star cluster

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Biomarkers of aging

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Science china(Life Sciences) 2023年第5期66卷 893-1066页

作者： Aging Biomarker Consortium Hainan bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Ying{2. Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le {3. Weiwei {3. Wenwan {3. Xing {3. Zhuo {3. Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu {2. Ren Ruibao Ren Moshi song Zhou songyang Yi Eve Sun Yu Sun Mei tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai {3. Hongbo {3. Liang {3. Weiqi {3. Yong {3. Yun-Wu {3. Zhuohua {3. Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu Aging Biomarker Consortium(ABC) Beijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Aging Biology Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Clinic Center of Human Gene research Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Clinical research Center of Metabolic and Cardiovascular Disease Huazhong University of Science and TechnologyWuhan 430022China Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging Huazhong University of Science and TechnologyWuhan 430022China Stem Cell Translational research Center Tongji HospitalTongji University School of MedicineShanghai 200065China department of Nuclear Medicine Daping HospitalThird Military Medical UniversityChongqing 400042China CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Shanghai Key Laboratory of Maternal Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchShanghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China The department of Endovascular Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Ageing and Regenerative MedicineJ

Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological *** a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly *** immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this ***,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory *** fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant.

关键词： aging senescence biomarker clock

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