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Induction of Endoplasmic Reticulum Stress by Cadmium and Its Regulation on Nrf2 Signaling Pathway in Kidneys of Rats

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Biomedical and Environmental Sciences 2019年第1期32卷 1-10页

作者： CHEN Zhi Jian CHEN Jia Xing WU Li Kang LI Bi Yun tian ya feng XIAN Min HUANG Zi Pei YU Ri An School of Public Health Guangdong Pharmaceutical University Bao'an Center for Disease Control and Prevention of Shenzhen

Objective This study was conducted to investigate the regulation of endoplasmic reticulum stress on Nrf2 signaling pathway in the kidneys of rats. Methods Rats were divided into twelve groups of six animals each. Some groups were pre-administered with bacitracin or tauroursodeoxycholic acid(TUDCA), and all of them were treated with 5-20 μmol/kg cadmium(Cd) for 48 h. The oxidative stress levels were analyzed using kits. The mRNA and protein expression levels of endoplasmic reticulum stress-related factors and Nrf2 signaling pathway-related factors were determined using RT-PCR and western blot. Results Cd exposure resulted in oxidative stress in the kidneys of rats and upregulated the expression of endoplasmic reticulum stress(ERS)-related factors and Nrf2 signaling pathway-related factors, especially at doses of 10 and 20 μmol/kg Cd, and the expression changes were particularly obvious. Moreover, after pretreatment with bacitracin, Cd upregulated the expression of ERS-related factors to a certain extent and, at higher doses, increased the mRNA expression of Nrf2. After pretreatment with TUDCA, Cd reduced the level of ERS to a certain extent; however, at these doses, there were no significant changes in the expression of Nrf2. Conclusion Cadmium can result in ERS and oxidative stress in the kidneys of rats, activate Nrf2, and upregulate the transcriptional expression of phase II detoxification enzymes under these experimental conditions. ERS has a positive regulation effect on Nrf2 signaling pathway but has little effect on the negative regulation of Nrf2 signaling pathway in cadmium toxicity.

关键词： Cadmium Endoplasmic reticulum stress PERK Nrf2 Kidney Rat

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Critical new insights into the interactions of hexafluoropropylene oxide-dimer acid(GenX or HFPO-DA)with albumin at molecular and cellular levels

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Journal of Environmental Sciences 2025年第3期149卷 88-98页

作者： Shi-ya Peng ya-Di yang Rong tian Naihao Lu Jiangxi Key Laboratory of Green Chemistry College of Chemistry and Chemical EngineeringJiangxi Normal UniversityNanchang 330022China

A key characteristic to be elucidated,to address the harmful health risks of environmental perfluorinated alkyl substances(PFAS),is their binding modes to serum albumin,the most abundant protein in *** oxide-dimer acid(GenX or HFPO-DA)is a new industrial replacement for the widespread linear long-chain ***,the detailed interaction of new-generation short-chain PFAS with albumin is still ***,the binding characteristics of bovine serum albumin(BSA)to GenX were explored at the molecular and cellular *** found that this branched short-chain GenX could bind to BSA with affinity lower than that of legacy linear long-chain perfluorooctanoic acid(PFOA).Site marker competitive study and molecular docking simulation revealed that GenX interacted with subdomain IIIA to form BSA-GenX *** with its weaker affinity to albumin protein,the cytotoxicity of branched short-chain GenX was less susceptible to BSA binding compared with that of the linear long-chain *** contrast to the significant effects of strong BSA-PFOA interaction,the weak affinity of BSA-GenX binding did not influence the structure of protein and the cytotoxicity of *** detailed characterization and direct comparisons of serum albumin interaction with new generation short-chain GenX will provide a better understanding for the toxicological properties of this new alternative.

关键词： GenX Protein binding Albumin Cytotoxicity Risk assessment

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宝安区基本职业卫生服务之职业健康检查模式探索

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中华劳动卫生职业病杂志 2008年第6期26卷 382-384页

作者：田亚锋深圳市宝安区疾病预防控制中心 518101

《中华人民共和国职业病防治法》（下称《职业病防治法》）及其配套法规《职业健康监护管理办法》的颁布实施，使职业健康监护工作走上了法制化、规范化的轨道，职业健康监护工作迈上了一个新台阶。职业健康检查作为职业健康监护工作的... 详细信息

《中华人民共和国职业病防治法》（下称《职业病防治法》）及其配套法规《职业健康监护管理办法》的颁布实施，使职业健康监护工作走上了法制化、规范化的轨道，职业健康监护工作迈上了一个新台阶。职业健康检查作为职业健康监护工作的重要内容，具有很强的专业性，和普通健康体检有很大区别，做好这项工作，是使劳动者减少或免受职业性有害因素对健康影响的重要措施，是职业病防治工作的重要环节。

关键词：职业健康检查职业卫生服务《中华人民共和国职业病防治法》宝安区健康监护工作《职业病防治法》职业性有害因素职业病防治工作

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Optimizing battery deployment: Aging trajectory prediction enabling homogenous performance grouping

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Journal of Energy Chemistry 2025年第1期100卷 565-577页

作者： Shuquan Wang feng Gao Zhan Ma Hao tian Yusen Zhang School of Control Science and Engineering Shandong UniversityJinan 250061ShandongChina Key Lab of Power System Intelligent Dispatch and Control of Ministry of Education Shandong UniversityJinan 250061ShandongChina

As battery deployments in electric vehicles and energy storage systems grow, ensuring homogeneous performance across units is crucial. We propose a multi-derivative imaging fusion(MDIF) model, employing advanced imaging and machine learning to predict battery aging trajectories from minimal initial data, thus facilitating effective performance grouping before deployment. Utilizing a derivative strategy and Gramian Angular Difference Field for dimensional enhancement, the MDIF model uncovers subtle predictive features from discharge curve data after only ten cycles. The architecture includes a parallel convolutional neural network with lateral connections to enhance feature integration and *** on a self-developed dataset, the model achieves an average root-mean-square error of 0.047 Ah and an average mean absolute percentage error of 1.60%, demonstrating high precision and *** robustness is further validated through transfer learning on two publicly available datasets, adapting with minimal retraining. This approach significantly reduces the testing cycles required, lowering both time and costs associated with battery testing. By enabling precise battery behavior predictions with limited data, the MDIF model optimizes battery utilization and deployment strategies, enhancing system efficiency and sustainability.

关键词： Lithium-ion battery Battery prognostics Fusion model Convolutional neural network Transfer learning

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基于生态承载力差值的生态用地调控研究——以河北省霸州市为例

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湖北农业科学 2013年第6期52卷 1474-1477页

作者：田凤雅河北省科学院地理科学研究所石家庄050011

以河北省霸州市为研究区域,在生态环境分析的基础上,构建生态承载力综合评价体系,计算综合评价指数,通过指数差值预测生态用地调控量。在可供生态用地约束下,制定生态用地调控方案,并有针对性地提出对策与建议。

关键词：生态承载力生态用地调控

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基于挖潜系数的农村居民点土地集约利用潜力研究

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湖北农业科学 2013年第5期52卷 1214-1217页

作者：田凤雅河北省科学院地理科学研究所石家庄050011

挖掘农村居民点内部潜力是解决当前土地供需矛盾的重要途径之一。以河北省霸州市为研究区域,根据用地性质和人口分布状况,对全国第二次土地调查数据进行修正;以人均建设用地面积为评价指标,将全市农村居民点土地利用按照集约程度分为集... 详细信息

挖掘农村居民点内部潜力是解决当前土地供需矛盾的重要途径之一。以河北省霸州市为研究区域,根据用地性质和人口分布状况,对全国第二次土地调查数据进行修正;以人均建设用地面积为评价指标,将全市农村居民点土地利用按照集约程度分为集约利用、一般集约利用和粗放利用三个等级;根据现状人均建设用地面积计算农村居民点理论整理潜力;选择自然、经济、社会3类因素5项评价指标计算挖潜系数;分别以人均建设用地120 m2、150 m2为界线计算可实现的农村居民点集约利用潜力值。

关键词：挖潜系数农村居民点集约利用潜力

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农用地集约利用潜力评价与应用研究——以山东省临沂市为例

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安徽农业科学 2007年第23期35卷 7248-7249,7251页

作者：田凤雅河北省地理科学研究所河北石家庄050011

土地集约利用是建设节约型社会的重要内容。以临沂市为研究区域,从农用地分等成果入手,界定了农用地集约利用潜力的内涵,提出用产能潜力系数和效益潜力系数相乘计算农用地集约利用潜力系数的方法。研究结果表明,该方法具有较强的实用性。

关键词：农用地集约利用潜力评价

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Reduced graphene oxide-mediated electron-hole separation using titanium dioxide increases the photocatalytic antibacterial activity of bone scaffolds

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Bio-Design and Manufacturing 2025年第1期8卷 100-115,I0044页

作者： Pei feng Haifeng tian feng yang Shuping Peng Hao Pan Cijun Shuai State Key Laboratory of Precision Manufacturing for Extreme Service Performance College of Mechanical and Electrical EngineeringCentral South UniversityChangsha 410083China NHC Key Laboratory of Carcinogenesis of Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine Cancer Research InstituteSchool of Basic Medical ScienceCentral South UniversityChangsha 410013China RESEARCH ARTICLE The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education of Xiangya Hospital and School of Basic Medical Science Central South UniversityChangsha 410013China Department of Periodontics&Oral Mucosal Section Xiangya Stomatological Hospital&Xiangya School of StomatologyCentral South UniversityChangsha 410013China Institute of Additive Manufacturing Jiangxi University of Science and TechnologyNanchang 330013China College of Mechanical Engineering Xinjiang UniversityUrumqi 830017China

Fast electron-hole recombination issues during titanium dioxide(TiO_(2))photocatalysis limit its application in preventing bacterial infection during bone defect *** this study,TiO_(2)@reduced graphene oxide(rGO)composites were synthesized using a hydrothermal method in which rGO,which possesses very high electrical conductivity,promotes the separation of photoelectron-hole pairs of TiO_(2),thus improving the efficiency of photocatalytic production of reactive oxygen species(ROS).Subsequently,TiO_(2)@rGO composites were introduced into poly-L-lactic acid(PLLA)to prepare bone scaffolds with photocatalytic antibacterial function via selective laser *** results showed that TiO_(2)grew on the surface of rGO and formed a covalent bond connection(Ti-O-C)with rGO.A decreased electrochemical impedance of TiO_(2)@rGO composites was observed,and the transient photocurrent intensity increased from 0.05 to 0.5μA/cm^(2).Analysis of electron spin resonance found that the photocatalytic products of TiO_(2)were·OH and·O^(2-),two kinds of ROS capable of killing bacteria via disrupting the structure of the bacterial membrane in *** experiments showed that the PLLA/TiO_(2)@rGO scaffolds had good antibacterial properties against Escherichia coli and Staphylococcus ***,we report that these scaffolds exhibited both enhanced mechanical properties due to the addition of TiO_(2)@rGO as a reinforcement material and good biocompatibility during cell proliferation.

关键词： Reduced graphene oxide Photocatalysis Reactive oxygen species Antibacterial properties Bone scaffold

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丝绸工业废水中丝胶蛋白质的回收技术

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丝绸 2001年第7期38卷 23-25页

作者：田亚峰段亚峰尉霞西北纺织工学院陕西西安710048

从丝绸工业废水的特点和丝胶结构与性质出发 ,论述了从废水中提取丝胶蛋白质的方法 ,提出膜分离技术回收丝胶蛋白质的工艺流程与技术关键。

关键词：丝绸工业废水丝胶蛋白质回收技术膜分离技术丝胶粉

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Advances in the Development of Gradient Scaffolds Made of Nano‑Micromaterials for Musculoskeletal Tissue Regeneration

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Nano-Micro Letters 2025年第3期17卷 455-500页

作者： Lei Fang Xiaoqi Lin Ruian Xu Lu Liu Yu Zhang feng tian Jiao Jiao Li Jiajia Xue Beijing Laboratory of Biomedical Materials Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China School of Biomedical Engineering Faculty of Engineering and ITUniversity of Technology SydneySydneyNSW 2007Australia

The intricate hierarchical structure of musculoskeletal tissues,including bone and interface tissues,necessitates the use of complex scaffold designs and material structures to serve as tissue-engineered *** has led to growing interest in the development of gradient bone scaffolds with hierarchical structures mimicking the extracellular matrix of native tissues to achieve improved therapeutic *** on the anatomical characteristics of bone and interfacial tissues,this review provides a summary of current strategies used to design and fabricate biomimetic gradient scaffolds for repairing musculoskeletal tissues,specifically focusing on methods used to construct compositional and structural gradients within the *** latest applications of gradient scaffolds for the regeneration of bone,osteochondral,and tendon-to-bone interfaces are ***,the current progress of testing gradient scaffolds in physiologically relevant animal models of skeletal repair is discussed,as well as the challenges and prospects of moving these scaffolds into clinical application for treating musculoskeletal injuries.

关键词： Gradient scaffolds Musculoskeletal tissues Advanced manufacturing Biomaterials Tissue regeneration

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