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Mechanism Exploration of Euphorbia fischeriana Steud. for Liver Cancer Based on Aspartic Acid Identification in Metabolomics

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Chinese Journal of Integrative Medicine 2024年第6期30卷 507-514页

作者： ZHAO Jing tian xin-chen ZHANG Jia-qi HUANG chen SUN Yan QIAO Sen JIANG Shu-long Clinical Medical Laboratory Center Jining First People’s HospitalJiningShandong Province272000China Cheeloo College of Medicine Shandong UniversityJinan250000China

Objective:To investigate the anti-liver cancer effects and aspartic acid(Asp)-related action mechanism of Euphorbia fischeriana Steud.(LD).Methods:The mice model of liver cancer was established by injection of H22 *** 5 days,mice were randomly divided into model group,sorafenib group(20 mg/kg),LD high-dose(LDH,1.36 g/kg) group,LD medium-dose(LDM,0.68 g/kg) group,and LD low-dose(LDL,0.34 g/kg)group,10 mice each *** were intragastrically administered to the mice once daily for 10 days,*** weight,tumor size and tumor weight were *** index was *** changes of liver cancer tissues were evaluated by hematoxylin and eosin staining and TUNEL *** chromatography-mass spectrometer was used to analyze different metabolites between the model and LDH ***:After LD treatment,tumor weight,tumor size and hepatic index were reduced compared with the model *** and karyorrhexis of tumor cells were ***,61 differential metabolites(18 up-regulated,43 down-regulated) were affirmed and 20 pathways of KEGG(P<0.05) were *** addition,Bel-7402,HepG2 and H22 cell viabilities were significantly increased after adding Asp into the *** then,the cell proliferation effect induced by Asp was ameliorated by ***:The anti-liver cancer efficacy of LD extract was validated in H22 mice model,and inhibition of Asp level might be the underlying mechanism.

关键词： liver cancer Euphorbia fischeriana Steud. aspartic acid metabolomics

Research status and prospects of the fractal analysis of metal material surfaces and interfaces

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 20-38页

作者： Qinjin Dai Xuefeng Liu xin Ma Shaojie tian Qinghe Cui Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation University of Science and Technology BeijingBeijing 100083China Laboratory for Advanced Materials Processing of Ministry of Education University of Science and Technology BeijingBeijing 100083China School of Mechanical and Electrical Engineering Xinjiang Institute of EngineeringUrumqi 830023China

As a mathematical analysis method,fractal analysis can be used to quantitatively describe irregular shapes with self-similar or self-affine *** analysis has been used to characterize the shapes of metal materials at various scales and *** methods make it difficult to quantitatively describe the relationship between the regular characteristics and properties of metal material surfaces and ***,fractal analysis can be used to quantitatively describe the shape characteristics of metal materials and to establish the quantitative relationships between the shape characteristics and various properties of metal *** the perspective of two-dimensional planes and three-dimensional curved surfaces,this paper reviews the current research status of the fractal analysis of metal precipitate interfaces,metal grain boundary interfaces,metal-deposited film surfaces,metal fracture surfaces,metal machined surfaces,and metal wear *** relationship between the fractal dimensions and properties of metal material surfaces and interfaces is *** from three perspectives of fractal analysis,namely,research scope,image acquisition methods,and calculation methods,this paper identifies the direction of research on fractal analysis of metal material surfaces and interfaces that need to be *** is believed that revealing the deep influence mechanism between the fractal dimensions and properties of metal material surfaces and interfaces will be the key research direction of the fractal analysis of metal materials in the future.

关键词： metal material surfaces and interfaces fractal analysis fractal dimension homogeneity

基于网络团购与广告投入的商家销售策略选择问题研究

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管理评论 2016年第11期28卷 235-244页

作者：吴翠莲王谦田歆陈庆洪中国科学院大学经济与管理学院北京100190 中国科学院虚拟经济与数据科学研究中心北京100190 中国科学院大数据挖掘与知识管理重点实验室北京100190 上海海鼎信息工程股份有限公司上海201112

网络团购作为一种新兴的销售策略,受到越来越多商家的重视和青睐。本文结合我国网络团购的特点,分别构建商家投入广告、参与网络团购、同时投入广告和参与网络团购三种销售策略下的定价模型,研究与传统的广告促销相比,网络团购能否有效... 详细信息

网络团购作为一种新兴的销售策略,受到越来越多商家的重视和青睐。本文结合我国网络团购的特点,分别构建商家投入广告、参与网络团购、同时投入广告和参与网络团购三种销售策略下的定价模型,研究与传统的广告促销相比,网络团购能否有效增加商家利润。最后,通过数值算例分析各参数的变化对商品价格、需求量、广告投入水平以及商家利润的影响。研究表明,在高端市场的规模较大,高端市场的需求对价格变化较不敏感,商品的单位成本较小,团购网站的广告效应较大,团购网站的收益分成比例较小几种情况下,建议商家选择参与网络团购,反之则建议商家考虑进行广告投入。

关键词：网络团购广告投入定价销售策略

Transforming growth factor-beta 1 enhances discharge activity of cortical neurons

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Neural Regeneration Research 2025年第2期20卷 548-556页

作者： Zhihui Ren tian Li Xueer Liu Zelin Zhang Xiaoxuan chen Weiqiang chen Kangsheng Li Jiangtao Sheng Department of Microbiology and Immunology Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular ImmunopathologyShantou University Medical CollegeShantouGuangdong ProvinceChina Department of Neurosurgery First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong ProvinceChina

Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system *** neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may depend on the pathological process and cell types ***-gated sodium channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related ***,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons remain *** this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in primary cortical neurons from *** found that TGF-β1 increased VGSC current density in a dose-and time-dependent manner,which was attributable to the upregulation of Nav1.3 *** VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of mitogen-activated protein kinase kinase(PD98059),p38 mitogen-activated protein kinase(SB203580),and Jun NH2-terminal kinase 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical *** findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-JNK-MAPK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological ***,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.

关键词： central nervous system cortical neurons ERK firing properties JNK Nav1.3 p38 transforming growth factor-beta 1 traumatic brain injury voltage-gated sodium currents

野生型和突变型荞麦蛋白酶抑制剂的活性比较及抗肿瘤功能分析

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生物化学与生物物理进展 2010年第6期37卷 654-661页

作者：田欣李晨李玉英王转花山西大学生物技术研究所化学生物学与分子工程教育部重点实验室太原030006

运用定点突变技术研究重组荞麦胰蛋白酶抑制剂(rBTI)的作用位点,先后构建了R45A-aBTI和R45F-fBTI两个突变体.抑制活性测定显示,aBTI和fBTI均丧失了胰蛋白酶抑制活性,却分别增加了对弹性蛋白酶和胰凝乳蛋白酶的抑制活性,确定Arg45为野生... 详细信息

运用定点突变技术研究重组荞麦胰蛋白酶抑制剂(rBTI)的作用位点,先后构建了R45A-aBTI和R45F-fBTI两个突变体.抑制活性测定显示,aBTI和fBTI均丧失了胰蛋白酶抑制活性,却分别增加了对弹性蛋白酶和胰凝乳蛋白酶的抑制活性,确定Arg45为野生型rBTI的作用位点.稳定性分析表明,rBTI、aBTI和fBTI均具有很高的热稳定性及酸碱稳定性.采用MTT比色法分别检测野生型和突变型抑制剂对肿瘤细胞生长的抑制作用.结果表明,突变前后的3种抑制剂对HL-60和EC9706细胞的生长均显示出很强的抑制作用,并且具有明显的浓度依赖性和时间依赖性.通过研究不仅确定了rBTI的作用位点,而且获得了两种新型蛋白酶抑制剂,且作用位点的改变并不影响其对肿瘤细胞的生长抑制作用.为进一步研究胰蛋白酶抑制剂的结构与功能的关系以及抗肿瘤药物的研制提供了新的思路.

关键词：荞麦蛋白酶抑制剂作用位点突变体细胞增殖

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地铁列车火灾安全疏散研究

科学技术与工程 2016年第31期16卷 281-284,289页

作者：田鑫苏燕辰席亚军李冬西南交通大学机械工程学院成都610031 西南交通大学牵引动力国家重点实验室成都610031

为了研究地铁列车的火灾安全疏散性能,利用Pyrosim火灾数值模拟软件,结合真实材料的物理化学参数,对地铁火灾的毒害气体和能见度分析,确定满载乘客的单节车厢应满足的最低转移时间。模拟地铁火灾真实的疏散场景,进行大规模疏散演练实验... 详细信息

为了研究地铁列车的火灾安全疏散性能,利用Pyrosim火灾数值模拟软件,结合真实材料的物理化学参数,对地铁火灾的毒害气体和能见度分析,确定满载乘客的单节车厢应满足的最低转移时间。模拟地铁火灾真实的疏散场景,进行大规模疏散演练实验,探讨了人群实际转移时间和相关注意事项。利用Pathfinder疏散模拟软件,针对站台疏散和隧道疏散进行了比较分析。

关键词：地铁火灾疏散实验火灾仿真 Pathfinder Pyrosim

Alternative Strategy for Development of Dielectric Calcium Copper Titanate‑Based Electrolytes for Low‑Temperature Solid Oxide Fuel Cells

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Nano-Micro Letters 2025年第1期17卷 310-332页

作者： Sajid Rauf Muhammad Bilal Hanif Zuhra Tayyab Matej Veis MAKYousaf Shah Naveed Mushtaq Dmitry Medvedev Yibin tian chen Xia Martin Motola Bin Zhu College of Mechatronics and Control Engineering Shenzhen UniversityShenzhen 518060People’s Republic of China Department of Inorganic Chemistry Faculty of Natural SciencesComenius University BratislavaIlkovicova684215 BratislavaSlovakia Energy Storage Joint Research Center School of Energy and EnvironmentSoutheast UniversityNanjing 210096People’s Republic of China Hydrogen Energy Laboratory Ural Federal University620002 EkaterinburgRussia Laboratory of Electrochemical Devices Based on Solid Oxide Proton Electrolytes Institute of High Temperature Electrochemistry620066 EkaterinburgRussia School of Microelectronics Hubei UniversityWuhan 430062People’s Republic of China

The development of low-temperature solid oxide fuel cells(LT-SOFCs)is of significant importance for realizing the widespread application of *** has stimulated a substantial materials research effort in developing high oxide-ion conductivity in the electrolyte layer of *** this context,for the first time,a dielectric material,CaCu_(3)Ti_(4)O_(12)(CCTO)is designed for LT-SOFCs electrolyte application in this *** individual CCTO and its heterostructure materials with a p-type Ni_(0.8)Co_(0.15)Al_(0.05)LiO_(2−δ)(NCAL)semiconductor are evaluated as alternative electrolytes in LT-SOFC at 450–550℃.The single cell with the individual CCTO electrolyte exhibits a power output of approximately 263 mW cm^(-2) and an open-circuit voltage(OCV)of 0.95 V at 550℃,while the cell with the CCTO–NCAL heterostructure electrolyte capably delivers an improved power output of approximately 605 mW cm^(-2) along with a higher OCV over 1.0 V,which indicates the introduction of high hole-conducting NCAL into the CCTO could enhance the cell performance rather than inducing any potential short-circuiting *** is found that these promising outcomes are due to the interplay of the dielectric material,its structure,and overall properties that led to improve electrochemical mechanism in CCTO–***,density functional theory calculations provide the detailed information about the electronic and structural properties of the CCTO and NCAL and their heterostructure CCTO–*** study thus provides a new approach for developing new advanced electrolytes for LT-SOFCs.

关键词： LT-SOFCs Dielectric CaCu_(3)Ti_(4)O_(12) Semiconductor Ni_(0.8)Co_(0.15)Al_(0.05)LiO_(2−δ) Ionic conductivity Heterostructure electrolyte

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浙江外贸行业应对绿色壁垒的对策研究

特区经济 2009年第9期 33-36页

作者：田信桥陈擘徐金锋浙江林学院浙江杭州311300

绿色壁垒自产生以来,对发展中国家影响巨大,我国尤为严重。而作为我国出口大省的浙江,外贸行业近年来更是损失巨大,研究相应对策具有现实意义。本文从分析浙江外贸行业的整体特征入手,探寻了其遭受绿色壁垒的内、外因素,从政府、行业协... 详细信息

绿色壁垒自产生以来,对发展中国家影响巨大,我国尤为严重。而作为我国出口大省的浙江,外贸行业近年来更是损失巨大,研究相应对策具有现实意义。本文从分析浙江外贸行业的整体特征入手,探寻了其遭受绿色壁垒的内、外因素,从政府、行业协会和企业三个层面提出了应对绿色壁垒的具体策略。

关键词：浙江外贸行业绿色壁垒行业协会

基于网络药理学和实验验证探究狼毒大戟醇提物治疗肝细胞癌的分子机制

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中国药理学通报 2023年第7期39卷 1354-1361页

作者：田辛晨王浩辰张一鸣张家琪张登甜颜廷昊赵静蒋树龙山东大学齐鲁医学院山东济南250000 济宁医学院临床医学院山东济宁272000 济宁医学院附属济宁市第一人民医院山东济宁272000

目的基于网络药理学和实验验证解析狼毒大戟醇提物治疗肝细胞癌作用机制。方法通过TCMSP、Swiss ADME、Swiss Target Prediction数据库以及参考文献获得狼毒大戟醇提物活性成分和作用靶点;运用GeneCards和DisGeNET数据库筛选肝细胞癌... 详细信息

目的基于网络药理学和实验验证解析狼毒大戟醇提物治疗肝细胞癌作用机制。方法通过TCMSP、Swiss ADME、Swiss Target Prediction数据库以及参考文献获得狼毒大戟醇提物活性成分和作用靶点;运用GeneCards和DisGeNET数据库筛选肝细胞癌相关基因;利用Venny平台、STRING平台和Cytoscape软件构建蛋白质-蛋白质互作网络图;使用DAVID数据库进行GO和KEGG富集分析。CCK-8、EdU和流式细胞术实验检测狼毒大戟醇提物对BEL-7402细胞增殖、凋亡的影响,Western blot分析狼毒大戟醇提物对JAK2/STAT3信号通路的作用,H22肝癌小鼠模型观察狼毒大戟醇提物的体内疗效。结果共筛选获得狼毒大戟醇提物活性成分30个,潜在作用靶点567个,肝细胞癌疾病靶点916个,药物-疾病交集靶点115个;KEGG富集分析得到主要信号通路JAK2/STAT3;体外实验显示狼毒大戟醇提物能够抑制BEL-7402细胞增殖,促进其凋亡,并呈浓度依赖性的抑制JAK2/STAT3信号通路;此外,狼毒大戟醇提物单独或联合索拉非尼显著抑制H22肝癌小鼠肿瘤的生长。结论狼毒大戟醇提物具有抗肝癌治疗作用,其分子机制可能与调控JAK2/STAT3信号通路有关。

关键词：肝细胞癌狼毒大戟醇提物药物靶点分子对接 JAK2/STAT3信号通路网络药理学

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