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Association mapping of lignin response to Verticillium wilt through an eight-way MAGIC population in Upland cotton

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Journal of Integrative Agriculture 2023年第5期22卷 1324-1337页

作者： tian xiao-min HAN Peng WANG Jing SHAO Pan-xia AN Qiu-shuang Nurimanguli AINI YANG Qing-yong YOU Chun-yuan LIN Hai-rong ZHU Long-fu PAN Zhen-yuan NIE Xin-hui Key Laboratory of Oasis Eco-agricultural Xinjiang Production and Construction Corps/Agricultural CollegeShihezi UniversityShihezi 832003P.R.China College of Informatics Huazhong Agricultural UniversityWuhan 430070P.R.China Cotton Research Institute Shihezi Academy of Agricultural SciencesShihezi 832011P.R.China National Key Laboratory of Crop Genetic Improvement/College of Plant Sciences&Technology Huazhong Agricultural UniversityWuhan 430070P.R.China

Lignin metabolism plays a pivotal role in plant defense against pathogens and is always positively correlated as a response to pathogen infection. Thus, understanding resistance genes against plant pathogens depends on a genetic analysis of the lignin response. This study used eight Upland cotton lines to construct a multi-parent advanced generation intercross(MAGIC) population(n=280), which exhibited peculiar characteristics from the convergence of various alleles coding for advantageous traits. In order to measure the lignin response to Verticillium wilt(LRVW), the artificial disease nursery(ADN) and rotation nursery(RN) were prepared for MAGIC population planting in four environments. The stem lignin contents were collected, and the LRVW was measured with the lignin value of ADN/RN in each environment, which showed significant variations. We employed 9 323 high-quality single-nucleotide polymorphism(SNP) markers obtained from the Cotton-SNP63K array for genotyping the MAGIC population. The SNPs were distributed through the whole genome with 4.78 SNP/Mb density, ranging from 1.14(ChrA06) to 10.08(ChrD08). In addition, a genome-wide association study was performed using a Mixed Linear Model(MLM) for LRVW. Three stable quantitative trait loci(QTLs), qLRVW-A04, qLRVW-A10, and qLRVW-D05, were identified in more than two environments. Two key candidate genes, Ghi_D05G01046 and Ghi_D05G01221, were selected within the QTLs through the combination of variations in the coding sequence, induced expression patterns, and function annotations. Both genes presented nonsynonymous mutations in coding regions and were strongly induced by Verticillium dahliae. Ghi_D05G01046 encodes a leucine-rich extensin(LRx) protein involved in Arabidopsis cell wall biosynthesis and organization. Ghi_D05G01221 encodes a transcriptional co-repressor novel interactor of novel interactor of jasmonic acid ZIM-domain(JAZ–NINJA), which functions in the jasmonic acid(JA) signaling pathway. In summary, t

关键词： genome-wide association study lignin response MAGIC population Upland cotton Verticillium wilt

Niche Ant Colony Algorithm and Simulation Study

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Niche Ant Colony Algorithm and Simulation Study

Marginal living donor in kidney transplantation： experience in a Chinese single center

The 2011 Fourth International Symposium on Knowledge Acquisition and Modeling（KAM 2011）

作者： Tang Chao-li Huang You-rui Li ji-yun tian xiao-min Institute of Electrical and Information Engineering Anhui University of Science and Technology

A niche ant colony algorithm（NACA） for multi-modal function optimization, which bases on principle of ant colony algorithm, is devised. It adopts real code. By simulation research of the NACA, and comparing with correlative algorithms, the results show that the NACA has advantages, such as easy to select parameters, strong adaptability, and good convergence, and is very suitable for multi-modal functions optimization with searching for multiple optimal solutions or global optimal solutions.

关键词： niche technology ant colony algorithm multi-modal function optimization

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Chinese Medical Journal 2013年第15期126卷 2810-2814页

作者： LI Gang WANG Yun-peng MA Lu-lin ZHANG Jing ZHANG Hong-xian HUANG Yi HOU xiao-fei xiao Chun-lei ZHAO Lei WANG Guo-liang tian xiao-jun QIU min ZHENG Yi Peking Univ Hosp 3 Dept Urol Beijing 100191 Peoples R China Navy Gen Hosp Dept Special Med Beijing 100048 Peoples R China

Background Living donor kidney transplantation is becoming popular in China, whereas, in clinical situations, some kidney donors may be sub-optimal, namely marginal living donor. The present study aimed to evaluate the safety and efficacy of marginal living donor kidney transplantation in a Chinese single center. Methods Between January 2001 and December 2009, 888 kidney transplantations were performed in our center; 149 were living donor kidney transplantations. The living donors and recipients were followed up regularly after the operation. Of the living donors, 30 donors were marginal, who were older than 60 years or suffered from kidney anomaly or some benign diseases. Among the non-marginal living kidney transplantations, 58 donors and recipients had complete peri- operative and follow-up data. We compared the marginal and non-marginal living donor kidney transplantations with regard to donor age, follow-up period, donor＇s serum creatinine at the last follow-up, recipient＇s serum creatinine at the last follow-up, and graft survival at the last follow-up. Results The mean age of donors in the marginal and non-marginal living donors were （55＋9）（37-66） and （43＋12）（30- 59） years. The mean follow-up times of the marginal and non-marginal groups were （26.4＋13.4） months and （28.8＋14.8） months. The donor and recipient serum creatinine levels at the last follow-up were （1.16＋0.20） mg/dl and （1.30＋0.24） mg/dl in the marginal group, and （1.12＋0.32） mg/dl and （1.34＋0.32） mg/dl in the non-marginal group. Three recipients in the marginal group and five recipients in the non-marginal group had acute rejection episodes during the first year. Actuarial 3-year graft survival was 96.7% in the marginal group and 100% in the non-marginal group. No significant differences were detected between the two groups with regard to these data. Conclusion Utilization of highly selective marginal living donors can be a safe, feasible, and effective way for the treatment of patients with end

关键词： kidney transplantation marginal non-marginal living donor

基于故障树-模糊贝叶斯网络的装配式建筑施工质量风险分析

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科学技术与工程 2024年第30期24卷 13119-13126页

作者：田晓敏李晓冬青岛理工大学管理工程学院青岛266520 青岛理工大学城乡建设信用与风险管理研究中心青岛266520

装配式建筑施工质量直接影响装配式建筑的安全性和耐久性,以提升装配式建筑的质量管理水平为目标,针对如何有效地控制施工质量风险,提出了基于故障树-模糊贝叶斯网络方法的风险评价模型。结合装配式建筑的特点进行风险源识别、分类,采... 详细信息

装配式建筑施工质量直接影响装配式建筑的安全性和耐久性,以提升装配式建筑的质量管理水平为目标,针对如何有效地控制施工质量风险,提出了基于故障树-模糊贝叶斯网络方法的风险评价模型。结合装配式建筑的特点进行风险源识别、分类,采用故障树对风险因素的因果关系进行建模,将其映射成贝叶斯网络,引入模糊集理论和改进的相似聚合方法,将专家意见转化为节点事件的先验概率和条件概率,构建了基于故障树-模糊贝叶斯网络的装配式建筑质量风险分析模型。结合案例进行分析:将收集的数据导入GeNIe软件中,进行参数学习得到了各风险等级发生概率;反向推理获得后验概率确定了关键性因素,进行致因分析得到了最大可能致因链,最后,利用贝叶斯网络的快速预测功能进行快速预测与推断。

关键词：装配式建筑模糊集理论故障树贝叶斯网络预测

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基于模糊匹配的自动协议适配器研究与实现

南京工业职业技术学院学报 2009年第4期9卷 29-31页

作者：田小敏南京航空航天大学信息科学与技术学院江苏南京210016 南京工业职业技术学院信息工程系江苏南京210046

针对BSS/OSS系统无法快速的支持新的网元业务,对接新网元接口的可维护性差的现状,研究了利用协议、消息转换、minA和正则表达式等相关技术,在权衡现有技术的弊端的基础上,提出并设计了一种基于正则表达式解析和minA架构的协议自动适配器... 详细信息

针对BSS/OSS系统无法快速的支持新的网元业务,对接新网元接口的可维护性差的现状,研究了利用协议、消息转换、minA和正则表达式等相关技术,在权衡现有技术的弊端的基础上,提出并设计了一种基于正则表达式解析和minA架构的协议自动适配器,该适配器采用JDK自带的正则处理机制,并且在此的基础上引入了匹配解析、运算解析和SQL解析模式。

关键词：协议适配正则表达式 NIO minA SOCKET 服务开通网元

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如何画好一个项目甘特图

科技视界 2018年第29期 207-207,187页

作者：田小敏南京工业职业技术学院商务贸易学院江苏南京210046

本文从甘特图的创立背景出发,具体阐述了甘特图的使用方式、常用的绘制软件,研究了甘特图在项目管理中的具体应用,根据项目的难易,整理了两套甘特图的项目管理方案。本论文提出的方案,对项目管理的初学者具有一定的参考价值。

关键词：甘特图项目管理使用方式绘制软件参考价值初学者

控制汉江丹江口至王甫洲区间伊乐藻的生态调度及其效果评估

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水生态学杂志 2024年第1期45卷 152-159页

作者：辛小康熊斌颜剑李建田晓敏长江水资源保护科学研究所湖北武汉430051 长江水利委员会水旱灾害防御创新团队湖北武汉430010 湖北汉江王甫洲水力发电有限责任公司湖北老河口441800

为科学有效控制汉江丹江口至王甫洲区间伊乐藻(Elodea nuttallii)过度生长繁殖,研究生态调度的实施效果,采用生物量调查法、分布面积统计法、数学模型模拟法等方法分析生态调度实施前后伊乐藻总生物量和分布面积的变化情况,并探讨对丹... 详细信息

为科学有效控制汉江丹江口至王甫洲区间伊乐藻(Elodea nuttallii)过度生长繁殖,研究生态调度的实施效果,采用生物量调查法、分布面积统计法、数学模型模拟法等方法分析生态调度实施前后伊乐藻总生物量和分布面积的变化情况,并探讨对丹江口水库下泄流量的需求。结果表明,连续3年实施生态调度,伊乐藻总生物量由2019年的4.8万t减少至2022年的40.11 t,分布面积由11.60 km^(2)减少至0.23 km^(2),减幅均达到了95%以上;伊乐藻生物量占沉水植物总生物的比重从99.99%减少至17%,生态调度效果较好;春季生态调度应重点从增加流量极值比出发进行中度干扰,夏秋季生态调度重点从满足0.14 m/s临界流速出发进行大流速冲刷。研究结果明确了王甫洲水库伊乐藻的生态调度需求,为持续开展伊乐藻“灾害”防控提供了参考基础。

关键词：伊乐藻生态调度效果评估王甫洲水库

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Coagulation indices and fibrinogen degradation products as predictive biomarkers for tumor-node-metastasis staging and metastasis in gastric cancer

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 110-120页

作者： Yi-Qing Shen Qiu-Wan Wei Yi-Ren tian Yun-Zhi Ling min Zhang Clinical Laboratory Civil Aviation Shanghai HospitalGubei Branch of Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200000China Clinical Laboratory Tongji Hospital of Tongji UniversityShanghai 200000China

BACKGROUND Gastric cancer(GC)is a prevalent malignancy with a substantial health burden and high mortality rate,despite advances in prevention,early detection,and *** with the global average,Asia,notably China,reports disproportionately high GC *** disease often progresses asymptoma-tically in the early stages,leading to delayed diagnosis and compromised ***,it is crucial to identify early diagnostic biomarkers and enhance treatment strategies to improve patient outcomes and reduce *** Retrospectively analyzed the clinical data of 148 patients with GC treated at the Civil Aviation Shanghai Hospital between December 2022 and December *** associations of coagulation indices-partial thromboplastin time(APTT),prothrombin time(PT),thrombin time(TT),fibrinogen,fibrinogen degradation products(FDP),fasting blood glucose,and D-dimer(D-D)with TNM stage and distant metastasis were *** Prolongation of APTT,PT,and TT was significantly correlated with the GC TNM ***,abnormal coagulation system activation was closely related to disease *** FDP and D-D were significantly associated with distant metastasis in GC(P<0.05),suggesting that increased fibrinolytic activity contributes to increased metastatic *** Our Results reveal coagulation indices,FDPs as GC biomarkers,reflecting abnormal coagulation/fibrinolysis,aiding disease progression,metastasis prediction,and helping clinicians assess thrombotic risk for early intervention and personalized treatment plans.

关键词： Coagulation indexes Fibrinogen degradation products Gastric cancer Tumor-node-metastasis staging Distant metastasis

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基于OpenGL的台球游戏的设计与实现

信息技术 2013年第2期37卷 130-134,139页

作者：周惠田小敏南京工业职业技术学院计算机与软件学院南京210046 河海大学计算机与信息学院南京211100

小型网络游戏一般指开发规模较小的休闲类网游,随着用户人数的不断增多,对休闲类网游技术的研究也逐渐成为计算机领域的热门方向。文中首先介绍了3D图形学中的三维图形处理的方法并结合OpenGL的相关功能阐述3D图形学的一些技术。然后在... 详细信息

小型网络游戏一般指开发规模较小的休闲类网游,随着用户人数的不断增多,对休闲类网游技术的研究也逐渐成为计算机领域的热门方向。文中首先介绍了3D图形学中的三维图形处理的方法并结合OpenGL的相关功能阐述3D图形学的一些技术。然后在此基础上以台球游戏为例,完成游戏的相关内容的设计与实现,包括物理设计和画面设计。

关键词： 3D图形学 OpenGL 台球碰撞画面设计