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Comparison of hepatitis B prophylactic outcomes in living donor liver transplantation recipients who meet the Milan or UCSF criteria

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Hepatobiliary & Pancreatic Diseases International 2013年第5期12卷 494-499页

作者： Li Jiang Lu-Nan Yan tian-Fu wen Bo Li Jia-Yin Yang Liver Transplantation Center Department of Liver SurgeryWest China HospitalSichuan University

BACKGROUND:The tumor burden before liver transplantation indicates that hepatitis B virus(HBV) may hide in the extrahepatic and micrometastatic sites which serve as a source of HBV ***,many liver transplant centers,especially in Western countries,use the Milan or UCSF criteria to select patients with hepatocellular carcinoma for liver *** study was undertaken to compare the HBV prophylactic outcomes in two groups of living donor liver transplantation(LDLT) *** in group A met the Milan criteria and those in group B exceeded the Milan criteria but were within the UCSF ***:A database of adult-to-adult right-lobe LDLT performed at our institution for HBV-related hepatocellular carcinoma within the Milan or UCSF criteria between June 2002 and May 2012 was used to compare the HBV prophylactic outcomes between patients within the Milan criteria(group A,41 patients) and those exceeding the Milan criteria but within the UCSF criteria(group B,19 patients).RESULTS:The 1-,3-,and 5-year survival rates were similar between groups A and B(87.8%,85.1% and 74.0% vs 73.3%,61.1% and 61.1%,respectively,P=0.067).HBV recurred in 1 patient in 3.1 months after LDLT in group A and in 2 patients in group B(1 in 11.9 months and 1 in 24.1 months after LDLT).The 1-,3-,and 5-year HBV recurrence rates were 2.6%,2.6% and 2.6% in group A,and 7.3%,17.9% and 17.9% in group B,respectively(P=0.118).CONCLUSION:LDLT recipients who exceed the Milan criteria but remain within the UCSF criteria may have post-transplant HBV prophylactic outcomes similar to those who meet the Milan criteria.

关键词： living donor liver transplantation hepatitis B virus hepatocellular carcinoma antiviral therapy

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Electrochemical Activation of CO_2 for the Synthesis of Ethyl Carbanilate under Mild Conditions

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Chemical Research in Chinese Universities 2007年第6期23卷 708-711页

作者： NIU Dong-fang XU Cheng-tian LUO Yi-wen ZHANG Li LU Jia-xing Shanghai Key Laboratory of Green Chemistry and Chemical Processes Department of Chemistry East China Normal University Shanghai 200062 P. R. China

A novel electrochemical procedure for the synthesis of ethyl carbanilate from aniline and carbon dioxide was developed via the selective cathodic reduction of carbon dioxide in CO2-saturated DMF solution containing 0. 1 mol/L TEABr at room temperature, followed by the addition of Eft as an alkylating agent. The synthesis was carried outun der mild[p（CO2） = 1.0×10^5 Pa, t =20 ℃ ] and safe conditions. Influences of the nature of the electrodes, the current densities, the passed charges during electrolysis, temperatures, and supporting electrolytes on the yield of ethyl carbanilate were studied to optimize the electrolytic conditions. The selectivity of ethyl carbanilate is 100%.

关键词： Carbon dioxide Electrochemistry Aniline Synthesis Ethyl carbanilate Mild condition

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Responses of milk production of dairy cows to jugular infusions of a mixture of essential amino acids with or without exclusion leucine or arginine

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Animal Nutrition 2017年第3期3卷 271-275页

作者： wen tian tianyou Wu Rui Zhao Jinhao Xu Yao He Hongrong Wang College of Animal Science and Technology Yangzhou University Shanghai Bright Holstan Co. Ltd

The purpose of this study was to determine effects of jugular infusion of either balanced or imbalanced amino acid mixture on milk production and composition in dairy cows. Eight mid-lactation Holstein cows were randomly assigned to 5-d continuous jugular infusions of saline(CTL), essential amino acid(EAA) mixture prepared on the profile of casein(CSN, 160 g/d), EAA mixture excluding leucine(Leu)(-Leu, 163 g/d) or EAA mixture excluding arginine(Arg)(-Arg, 158 g/d) in a duplicated 4×4 Latin square design with 4 infusion periods separated by a 7-d interval period. The basal diet was formulated with corn grain, soybean meal, cottonseed meal, corn silage, alfalfa hay and Chinese wildrye grass hay according to NRC(2001) and supplied 1.6 Mcal net energy for lactation(NEL) and 94.4 g metabolizable protein(MP) per kg dry matter(DM) to meet requirements for lactation. The results showed that the dry matter intake(DMI) and normal physiological status were not affected by amino acid mixture *** with CTL treatment, the CSN treatment increased milk yield(14.9%, P < 0.001), milk lactose yield(14.5%, P = 0.001), milk fat yield(16.6%, P = 0.01), milk protein yield(18.2%, P < 0.001) and the contents of α_(S1)-casein(α_(S1)-CN,11,8%,P = 0,007),β-casein(β-CN,4.2%.P=0.035) and K-casein(κ-CN,8.5%, P = 0.003). However, the-Leu and-Arg treatments had lower milk yield(6.3%, P = 0.058 and 5.7%,P = 0.073, respectively), milk protein yield(8.8%, P = 0.010 and 8.2%, P = 0.011, respectively) and the contents of α_(S1)-CN(7.3%,P = 0.057 and 8.4%,P = 0.026, respectively),β-CN(4.2%,P = 0.033 and 3.8%,P = 0.048, respectively) and κ-CN(5.8%, P = 0.023 and 7.6%, P = 0.003, respectively) than those of the CSN treatment. Milk lactose yield(5.9%, P = 0.076) tended to decrease when Leu was removed from amino acid mixture infusate. In conclusion, the supply of casein profile can increase milk production in dairy cows, but a deficiency of Leu or Arg had negative effects on milk yield and mil

关键词： Dairy cows Casein Leucine Arginine Lactation performance

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Stability characteristics of ring-stiffened cylindrical shells under different longitudinal and transverse external pressures

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Journal of Marine Science and Application 2007年第3期6卷 33-38页

作者： WANG Xiao-tian YAO wen LIANG Chao JI Nan College of Shipbuilding Engineering Harbin Engineering University Harbin 150001 China

Because ring-stiffened cylindrical shell structures have many merits, they are widely used in many areas. However, as the strength of steel increase continuously, ensuring of the structure stability is becoming more and more important. Therefore, it is necessary to carry on a more particular analysis. Based on the understanding and analysis of the characteristics of stability for a ring-stiffened cylindrical shell under uniform external pressure and under external single pressure, the characteristics under different cross uniform external pressures are analyzed, and the regularity of it is also gotten. The curve of stability given various geometrical parameters under different cross uniform external pressures is protracted by the analysis of the theory. The conclusion not only improves the theory structural mechanics, it also was important effects on engineering calculation and design.

关键词： ring-stiffened cylindrical shell characteristics of stability different cross uniform external pressures

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Experimental investigation of tubing collar's influence on hydrodynamic behavior of annular duct flow

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Petroleum Science 2022年第5期19卷 2326-2342页

作者： Yi-Su Zhou Zhong-Wei Huang Zhuang-Zhuang Zhang tian-wen Jiang Rui-Yue Yang Ming-He Zhang State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum ChangpingBeijing 102249China China University of Petroleum(Beijing) ChangpingBeijing 102249China

Tubing collars’influence on hydrodynamic behavior of annular duct flow has been investigated using Particle Image Velocity(PIV)*** has become an efficient method for complex transient flows visualization.A water flow loop with two replaceable variable cross-sections(VCS),75-90 mm and 90-110 mm,in a 129 mm inner diameter(ID)pipe was *** whole field of the variable cross-section annulus(VCSA)was visualized,including forward-facing step(FFS),narrow annulus(NA),and backwardfacing step(BFS)*** VCSA ratio and Reynolds(Re)number influence on streamline distribution,velocity distribution,and turbulence intensity were *** showed that the recirculation is easier to form in BFS than FFS flow under the same *** VCSA ratio affects the formation of recirculation zones and the location of the reattachment *** number mainly affects BFS flow by influencing the main velocity component-axial *** turbulence intensity is relatively high in BFS than FFS flow and is larger at y/h>1.0 than y/h<***,the streamwise cohere nt structures reveal that the first two modes are predominant and represent the main characteristics of the flow by proper orthogonal decomposition(POD)method.

关键词： Variable cross-section annulus flow Sudden contraction and expansion Hydrodynamic behavior PIV POD

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Synthesis of Large Pore Molecular Sieve VPI-5 by Using Various Organic Amines

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Chemical Research in Chinese Universities 1993年第1期9卷 1-5页

作者： YAO Shang-qing, tian wen-tong, QIU Shi-lun and PANG wen-qin (Department of Chemistry, Jilin University, Changchun, 130023)

The molecular sieve VPI-5 was synthesized by using various organic amines (DEA, Di-PA, DBA, DPenA, TBA, DEOA and TEOA) as the structure-directing agent. The use of DPA enlarged the range of the crystallization temperature from 110℃ to 190℃ in the synthesis of VPI-5, while the use of TEOA changed the composition of the reactants in a broad variety. Diamines are the typical amines in the synthesis of VPI-5. Among them DBA and DPA are the most favorite structure-directing agents for the synthesis of VPI-5 molecular sieve.

关键词： VPI-5 Molecular sieve Amines

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Development and validation of novel models for the prediction of intravenous corticosteroid resistance in acute severe ulcerative colitis using logistic regression and machine learning

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Gastroenterology Report 2022年第1期10卷 498-506页

作者： Si Yu Hui Li Yue Li Hui Xu Bei Tan Bo-wen tian Yi-Min Dai Feng tian Jia-Ming Qian Department of Gastroenterology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingP.R.China Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyangLiaoningP.R.China

Background The early prediction of intravenous corticosteroid(IVCS)resistance in acute severe ulcerative colitis(ASUC)patients remains an unresolved *** study aims to construct and validate a model that accurately predicts IVCS *** A retrospective cohort was established,with consecutive inclusion of patients who met the diagnosis criteria of ASUC and received IVCS during index hospitalization in Peking Union Medical College Hospital between March 2012 and January *** primary outcome was IVCS *** models,including logistic regression and machine learning-based models,were *** validation was conducted in an independent cohort from Shengjing Hospital of China Medical *** A total of 129 patients were included in the derivation *** index hospitalization,102(79.1%)patients responded to IVCS and 27(20.9%)failed;18(14.0%)patients underwent colectomy in 3 months;6 received cyclosporin as rescue therapy,and 2 eventually escalated to colectomy;5 succeeded with infliximab as rescue *** Ulcerative Colitis Endoscopic Index of Severity(UCEIS)and C-reactive protein(CRP)level at Day 3 are independent predictors of IVCS *** areas under the receiver-operating characteristic curves(AUROCs)of the logistic regression,decision tree,random forest,and extreme-gradient boosting models were 0.873(95%confidence interval[CI],0.704–1.000),0.648(95%CI,0.463–0.833),0.650(95%CI,0.441–0.859),and 0.604(95%CI,0.416–0.792),*** logistic regression model achieved the highest AUROC value of 0.703(95%CI,0.473–0.934)in the external *** In patients with ASUC,UCEIS and CRP levels at Day 3 of IVCS treatment appeared to allow the prompt prediction of likely IVCS *** found no evidence of better performance of machine learning-based models in IVCS resistance prediction in ASUC.A nomogrambased on the logistic regression model might aid in the management of ASUC

关键词： acute severe ulcerative colitis steroid resistance colectomy machine learning

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Congenital symbrachydactyly： outcomes of surgical treatment in 120 webs

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Chinese Medical Journal 2013年第15期126卷 2871-2875页

作者： LI wen-jun ZHAO Jun-hui tian wen tian Guang-lei Beijing Jishuitan Hosp Dept Hand Surg Beijing 100035 Peoples R China

yBackground Symbrachydactyly is defined as a combination of short fingers with syndactyly. There are few published reports estimating the incidence of symbrachydactyly. The aim of this study was to investigate the clinical features and the outcome of surgical treatment for congenital symbrachydactyly. Methods One hundred and twenty webs of thirty-four patients of symbrachydactyly were involved in the study. The sex ratio was 21 males/13 females. The age ranged from 1 year to 8 years, average 2.6 years. Four cases had both hands involved and 30 patients had one hand involvement. Release of the syndactylous digits webs were completed by one surgical procedure in 14 cases and more than one surgical procedure in 20 cases; 3 to 6 months between the procedures. In the meantime, some of the associated hand deformities were treated. Results Postoperative follow-up time was 10 to 18 months, average 12 months. All the fingers involved in this study were separated successfully. However, 6 fingers had scar tissue contracture and 8 had web scar adhesion. All complications needed further surgical treatment. Parents of 94.1% of the patients were satisfied with the overall function of the hand, and 76.5% were satisfied with the cosmetic appearance of hand. Conclusions The combination of syndactyly and brachydactyly is the main clinical feature in symbrachydactyly. Separation of the digital webs can greatly improve the function of the hand. However, more work needs to be done to improve the cosmetic appearance of the hand.

关键词： congenital deformity treatment outcome clinical feature symbrachydactyl

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FedQMIX:Communication-efficient federated learning via multi-agent reinforcement learning

High-Confidence Computing

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High-Confidence Computing 2024年第2期4卷 96-104页

作者： Shaohua Cao Hanqing Zhang tian wen Hongwei Zhao Quancheng Zheng Weishan Zhang Danyang Zheng Qingdao Institute of Software College of Computer Science and TechnologyChina University of Petroleum(East China)Qingdao 266580China School of Computing and Artificial Intelligence Xipu CampusSouthwest Jiaotong UniversityChengdu 611756China

Since the data samples on client devices are usually non-independent and non-identically distributed(non-IID),this will challenge the convergence of federated learning(FL)and reduce communication *** paper proposes FedQMIX,a node selection algorithm based on multi-agent reinforcement learning(MARL),to address these ***,we observe a connection between model weights and data distribution,and a clustering algorithm can group clients with similar data distribution into the same ***,we propose a QMIX-based mechanism that learns to select devices from clustering results in each communication round to maximize the reward,penalizing the use of more communication rounds and thereby improving the communication efficiency of ***,experiments show that FedQMIX can reduce the number of communication rounds by 11%and 30%on the MNIST and CIFAR-10 datasets,respectively,compared to the baseline algorithm(Favor).

关键词： Communication efficient Federated learning MARL

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Low-grade slightly elevated and polypoid colorectal adenomas display differential β-catenin-TCF/LEF activity, c-Myc, and cyclin D1 expression

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World Journal of Gastroenterology 2017年第17期23卷 3066-3076页

作者： tian-wen Yang Yun-han Gao Sha-Ying Ma Qiang wu Zhong-fu Li Department of Gastroenterology Yongchuan Hospital Chongqing Medical University Department of General Surgery Chongqing Emergency Medical Center

AIM To comparatively investigate the cellular and molecular characteristics of low-grade slightly elevated adenomas and polypoid *** Colorectal tumors were collected from 24 patients with slightly elevated adenomas and 23 patients with polypoid adenomas. five commonly mutated genes(APC, BRAf, KRAS, NRAS, and PIK3CA) were selected for mutational analysis. Paraffin-embedded tumor sections were used to calculate the apoptotic index(AI) and Ki-67 labeling index(KLI). Two pure colorectal epithelial cell lines were created by pooling the slightly elevated and polypoid tumors. western blots, luciferase assays for β-catenin-T-cell factor protein/β-cateninlymphoid enhancer factor(β-catenin-TCf/LEf)-driven transcriptional activity, and caspase activity assays were conducted on the two cell *** Slightly elevated lesions showed a significantly lower APC mutational frequency and a significantly higher KRAS mutational frequency(both P < 0.05). Slightly elevated lesions showed a significantly lower AI(P < 0.05). β-catenin and β-catenin-TCf/LEf-driven transcriptional activity was significantly upregulated in slightly elevated lesions(both P < 0.05). In slightly elevated lesions, c-Myc was significantly downregulated, while cyclin D1 was significantly upregulated(both P < 0.05). β-catenin-TCf/LEf-driven transcriptional activity was negatively correlated with c-Myc(ρ =-0.78). Slightly elevated lesions displayed significant Bcl-2 and Bcl-x L upregulation(both P < 0.05) along with significant decreases in caspase-9 and caspase-3 activity(both P < 0.05). c-Myc was negatively correlated with Bcl-2 and Bcl-x L(ρ =-0.74 and-0.78, respectively).CONCLUSION The lower apoptotic activity of low-grade slightly elevated adenomas can be partly attributed to upregulated β-catenin pathway activity and downregulated c-Myc expression.

关键词： Cancer Carcinoma Colorectal Adenoma β-catenin Non-polypoid

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