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Progress in Natural Science:Materials International 2006年第5期16卷 492-500页

作者： tian wei, liu shuwen, liu chaohui, yu shengqiang, li qiugen and wang yueran (Key Laboratory of Orogenic Belt and Crustal Evolution, MOE, School of Earth and Space Sciences, Peking University, Beijing 100871, China) [a]Key Laboratory of Orogenic Belt and Crustal Evolution MOE School of Earth and Space Sciences Peking Univenity Beijing China

The tonalite-trondhjemite-granodiorite (TTG) rocks in Sushui Complex of Zhongtiao Block can be divided into two series according to their zircon U-Pb ages and geochemical characteristics: one is subduction-related (SR) and the other collision-related (CR) . The SR TTG rocks, together with other Late Archean island arc magmatism, were developed as a result of oceanic subduction between the Eastern and Western blocks in Late Archean; while the CR TTG rocks formed in a thickened crustal environment, which was responding to the collision between the Eastern and Western blocks in Paleoproterozoic. All these features support a model that the Zhongtiao Block is a part of the Trans-North China Orogen in the middle of North China Craton.

关键词： Sushui Complex Zhongtiao Block Trans-North China Orogen zircon U-Pb geochronology trace element simulation.

SHRIMP Zircon U-Pb Chronology and Geochemistry of the Henglingguan and Beiyu Granitoids in the Zhongtiao Mountains,Shanxi Province

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Acta Geologica Sinica(English Edition) 2006年第6期80卷 912-924页

作者： yu shengqiang liu shuwen tian wei li qiugen FENG Yonggang The Key Laboratory of Orogenic Belts and Crustal Evolution Ministry of EducationSchool of Earth and Space SciencesPeking UniversityBeijing 100871

Henglingguan and Beiyu metamorphic granitoids, distributed in the northwest of the Zhongtiaoshan Precambrian complex, comprise trondhjemites and calc-alkaline monzogranites, displaying intrusive contacts with the Archean Zhaizi TTG gneisses. And the Beiyu metamorphic granitoids consist mainly of trondhjemites, distributed at the core of the Hujiayu anticline fold. New SHRIMP zircon U-Pb dating data show that the weighted mean ^207pb/^206pb ages are 2435.9 Ma and 2477 Ma for the Henglingguan metamorphic calc-alkaline monzogranites and Beiyu metamorphic trondhjemites, respectively, and reveal -2600 Ma inherited core in magmatic zircons. Whole-rock geochemical data indicate that all the Henglingguan and Beiyu metamorphic trondhjemites and calc- alkaline monzogranites belong to the metaluminous medium- and high-potassium calc-alkaline series. These rocks are characterized by relatively high total alkali contents (Na2O+K2O, up to 9.08%), depleted Nb, Ta, P and Ti, and right-declined REE patterns with moderate to high LREEs/HREEs fractionation (the mean ratio of (La/Yb)n = 25). The Henglingguan and Beiyu metamorphic trondhjemites display negative Rb, Th and K anomalies in the multi-dement spider diagrams normalized by primitive mantle. Sm-Nd isotopic data reveal that these granitoids have initial εNd(t) =-1.2 to +2.4 and Nd depleted mantle model ages of TMD = 2622 Ma-2939 Ma. All these geochemical features indicate that these granitoids were formed in an continent-marginal arc, and the trondhjemites mainly originated from partial melting of juvenile basaltic materials and, howbeit, the Henglingguan metamorphic calc-alkaline monzogranites derived from recycling of materials in the ancient crust under a continent-marginal arc. The granitic magma underwent contamination and fractional crystallization during their formation.

关键词： Henglingguan and Beiyu granitoids SHRIMP zircon U-Pb geochronology geochemistry Sm-Nd isotopes continent-marginal arc Shanxi

Geochemical characteristics of the metapelites from the Xingxingxia group in the Eastern Segment of the Central tianshan:Implications for the provenance and paleoweathering

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Science China Earth Sciences 2005年第10期48卷 1637-1648页

作者： li qiugen liu shuwen HAN Baofu wang yueran DANG Qingning The Key Laboratory of Orogenic Belts and Crustal Evolution Ministry of EducationSchool of Earth and Space SciencesPeking UniversityBeijing 100871China

Metapelites from the Mesoproterozoic Xingxingxia group in the Eastern Segment of the Central tianshan,Northwestern China,were analyzed for major and trace elements,includ-ing rare earth *** with post-Archean shales,the metapelites are enriched in Sr,Hf and *** other elements are similar to the compositions of the Phanerozoic North American Shale Composite and the Post-Archean Australian average Shale(PAAS).The characteristics of Al_(2)O_(3)/TiO_(2),Cr/Zr,Cr/Th,Th/Sc and high Zr concentration suggest that these pelites could be derived from a significant proportion of felsic and a few proportion of participation of mafic mate-rials in *** rocks display highly fractionated REE patterns,and average(La/Yb)_(n)=*** samples have slightly negative Eu anomalies(Eu/Eu^(*)=0.7―0.84)in comparison with PAAS(Eu/Eu^(*)=0.65),indicating contribution from young immature *** low K_(2)O/Al_(2)O_(3) values of these metapelites suggest that their source materials could contain minimal alkali *** the A-CN-K triangular diagram,the sample data array intersects the feldspar join,indicating that the source had a plagioclase:K-feldspar ratio of approximately 5:1,repre-senting weathered products from components that could approximately correspond to granodio-rites and *** low Chemical Index of Alteration(CIA)and high Index of Compositional Variability(ICV)values suggest low degrees of weathering of the source and low compositional maturity of the sediments,*** geochemical characteristics of the metapelites from the Xingxingxia group also demonstrate that these sediments were deposited in a back-arc background within a continental-arc system.

关键词： Eastern Segment of the Central tianshan metapelites from the Xingxingxia group geochemistry provenance paleoweathering tectonic setting.

Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism

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Neural Regeneration Research 2025年第1期20卷 93-106页

作者： yujie Yang Xinyi li Jiaying Lu Jingjie Ge Mingjia Chen Ruixin Yao Mei tian Jian wang Fengtao liu Chuantao Zuo Key Laboratory of Arrhythmias Ministry of EducationDepartment of Medical GeneticsShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Neurology National Research Center for Aging and MedicineNational Center for Neurological Disordersand State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghaiChina Department of Nuclear Medicine&PET Center National Center for Neurological Disordersand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghaiChina International Human Phenome Institutes(Shanghai) ShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of *** review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest *** conducted a thorough literature search using reputable databases such as PubMed and Web of *** criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical *** findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting ***,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo *** validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic *** summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders.

关键词： aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease parkinsonism positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2

Petrogenesis of Indosinian Granitoids in Middle-Segment of South Qinling Tectonic Belt:Constraints from Sr-Nd Isotopic Systematics

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Acta Geologica Sinica(English Edition) 2011年第3期85卷 610-628页

作者： liu shuwen li qiugen tian wei wang Zongqi YANG Pengtao wang wei BAI Xiang GUO Rongrong Key Laboratory of Orogenic Belt and Crustal Evolution Ministry of Education Peking University Beijing 100871 China Institute of Mineral Resources Chinese Academy of Geological Sciences Beijing 100037 China

South Qinling Tectonic Belt（SQTB）is located between the Shangzhou-Danfeng and Mianxian-Lueyang *** are a lot of early Mesozoic granitoid plutons in its middle segment, comprising the Dongjiangkou-Zhashui granitoid plutons at the northeast,Huayang-Wulong-Laocheng granitoid plutons at the central part,Xiba granitoid pluton at the northwest and Guangtoushan-liuba granitoid plutons at the *** Indonisian granitoids contain a mass of various scale mafic enclaves,which show sometimes clear boundaries and sometimes transitional boundaries with their host *** granitoids also exhibit metaluminous to peraluminous series,commonly higher Mg# and a wide range of petrochemistry from low-K tholeiite series,through mid-K and high-K calc-alkaline series to shoshonite series and predominated samples are attributed to mid-K and high-K calc-alkaline *** analyses in Sr-Nd isotopic systematics and petrochemistry reveal that there may be regionally initial granitoid magma of the Indonisian granitoid plutons,comprising Dongjiangkou-Zhashui,Huayang-Wulong-Laocheng,Xiba,and Guangtoushan-liuba granitoid plutons,which were produced by hybrids of magmas in various degrees,and the initial magmas were derived from both the mantle and the lower continental crust（LCC）sources in the *** initial granitoid magma further did the magma hybrid with the magmas from the LCC,crystallization fractionation,and assimilation with upper crustal materials during their emplacement to produce these granitoid plutons in the *** magmatism processes are most likely to occur under continent marginal arc and syn-collision to post-collision tectonic backgrounds.

关键词： South Qinling tectonic belt Indonisian granitoids Petrochemistry Sr-Nd isotopic svstematics petrogenesis early Mesozoic tectonic backgrounds

Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 39-51页

作者： Si-yun lin Hou Huang Jin-Jie yu Feng Su tian Jiang Shao-yuan Zhang Lu Lv Tao Long Hui-Wen Pan Jun-Qing Qi Qiang Zhou wei-Feng Tang Guo-Wen Ding li-Ming wang li-Jie Tan Jun Yin Department of Thoracic Surgery Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Clinical Geriatric Medicine Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Cardiothoracic Surgery The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002Jiangsu ProvinceChina Department of Thoracic Surgery Sichuan Cancer Hospital&InstituteChengdu 610042Sichuan ProvinceChina Department of Cardiothoracic Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210000Jiangsu ProvinceChina Department of Respiratory and Critical Care Medicine Shanghai Xuhui Central HospitalShanghai 200032China

BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and *** A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent *** To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han *** In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were *** SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction ***-weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were *** Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male *** the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to *** ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.

关键词： Activin A receptor type 1C Single nucleotide polymorphisms Esophageal squamous cell carcinoma Genetic susceptibility Hospital-based cohort study

Petrogenesis of Paleoproterozoic Luyashan charnockitic rocks in Shanxi Province: Constraints from Geochemistry and Nd isotope

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Progress in Natural Science:Materials International 2006年第2期16卷 183-191页

作者： liu chaohui, liu shuwen, li qiugen, wang yueran, DANG Qingning, GU libing, YANG Bin and ZHAO Fengsan (Key Laboratory of Orogenic Belts and Crustal Evolution, Ministry of Education School of Earth and Space Sciences, Peking University, Beijing 100871, China) [a]Key Laboratory of Orogenic Belts and Crustal Evolution Ministry of Education Beijing China [b]School of Earth and Space Science Peking University Beijing China

Luyashan charnockite pluton mainly consists of monzonite, adamellite, charnockite and syenogranite, which are characterized by the enrichment of TiO2, P2O5, K2O, Zr, Nb, Y, Pb, La, Ce, Ba and a higher K2O/Na2O and depletion of MgO, CaO, Mg#, Th, U and lower Sr/Ba and Rb/Ba. The negative correlations between Zr, Nb, Ce and SiO2 are distinct from I-type granites. Iso-topically Luyashan charnockite plutons are relatively uniform in Nd isotope, displaying initial εNd(t) (-5.93 to -6.97) and Nd depleted mantle model ages (2.67 Ga to 2.78Ga). These features indicate that Luyashan charnockitic magma derived from pre-existing late Archean crustal sources and the partial melting of mafic granulites probably under exceptionally high temperature with CO2-rich fluid. The garnet is a main residual phase during the partial melting. The original dry charnockitic magma experienced crystal fractionation of pyroxene, plagioclase, apatite and ilmenite during early crystallization. The geochemical evidence suggests that the Luyashan charnockitic magma was probably generated in the post-collision thermal relaxation and uplift tectonic setting after the main collision ( - 1850 Ma) between the Eastern and Western continental blocks.

关键词： Luyashan charnockite geochemistry Sm-Nd isotopes petrogenesis Paleoproterozoic.

Indosinian Tectonic Setting of the Southern Yidun Arc: Constraints from SHRIMP Zircon Chronology and Geochemistry of Dioritic Porphyries and Granites

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Acta Geologica Sinica(English Edition) 2006年第3期80卷 387-399页

作者： liu shuwen wang Zongqi YAN Quanren li qiugen ZHANG Dehui The Key Laboratory of Orogenic Belts and Crustal Evolution Ministry of Education School of Earth and Space Sciences Peking University Beijing 100871 Institute of Geology Chinese Academy of Geological Sciences Beijing 100037 China University of Geosciences Beijing 100083

A mass of granitoid and dioritic intrusions are distributed in the southern Yidun Arc, among which the representative Indosinian intrusions include the Dongco and Maxionggou granitoid intrusions in Daocheng County and hypabyssal intrusions intruding into arc volcanic rocks near the Xiangcheng town. The Dongco and Maxionggou granitoid intrusions consist mainly of porphyraceous monzogranites, megacryst monzogranites and aplite granites. The Xiangcheng hypabyssal intrusions are composed dominantly of dioritic porphyries. SHRIMP zircon ages of 224±3 Ma and 222±3 Ma have been obtained for the Dongco granitoid intrusion and the Xiangcheng dioritic porphyries, respectively. The Xiongcheng dioritic porphyries show a calc-alkaline geochemical feature, and are characterized by higher Sr/Y ratios, depletive Nb, Ta, P and Ti, enriched liLEs, and lower εNd （t）（=-3.27）, suggesting that they might be derived from mantle source magmas that were obviously contaminated by continent crustal materials. However, the Dongco and Maxionggou granitoids belong to high-potassium calcalkaline series with a per-metaluminous feature, and are characterized by higher CaO/（∑FeO＋MgO） and Al2O3/（∑FeO＋ MgO） ratios, lower （La/Yb）n and Sr/Y ratios, depletive Nb, Ta, Sr, P and Ti, enriched liLEs, and very low εNd （t）（=-8.10）, indicating that the granitoids might be derived from partial melting of continental crust materials mainly of graywacke. Petrogenesis of Dongco and Maxionggou granitoids implies that there was an oceanic crust between the Zongza continental block （ZCB） and western margin of the Yangtze Craton （WMYZC）. And the oceanic crust slab subducted westward during the Indosinian Epoch, producing an Andes-type continent marginal arc and a backarc basin at the WMSCC. Then the oceanic basin closed and a sinistrally lateral collision occurred at ca. 224 Ma-222 Ma between the ZCB and the WMYZC, causing partial melting of sediments in the back-arc basin to generate granitoid magmas of the Dongco a

关键词： southern Yidun Arc dioritic porphyries and monzogranites SHRIMP zircon age,geochemistry and Nd isotope petrogenesis and geodynamics

Mechanism of action of linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-lin li Xin-Ran Song Qian-Qian Wan yu-Ming wang Han-Zhou li wei-Quan Xu Jia-Bao liao wei-Bo Wen Jing Miao Huan-tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

Geochemistry and Zircon U–Pb–Hf Isotopic Systematics of the Sanchahe Quartz Monzonite Intrusion in the North Qinling Tectonic Zone, Central China: Implications for its Petrogenesis and Tectonic Setting

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Acta Geologica Sinica(English Edition) 2014年第1期88卷 154-175页

作者： YAN Ming liu shuwen li qiugen ZHANG Wanyi YANG Pengtao YAN Zhen wang Ruiting wang wei GUO Rongrong Key Laboratory of Orogenic Belt and Crustal Evolution Ministry of Education School of Earth and Space Sciences Peking University Development Research Center China Geological Survey Institute of Geology Chinese Academy of Geological Sciences Geological Exploration Institution of Northwest Mining and Geological Exploration Bureau for Nonferrous Metals

The Sanchahe quartz monzonite intrusion is situated in the middle segment of the North Qinling tectonic belt, Central China mainland, and consists chiefly of sanukitoid–like and granodioritic-monzogranitic rocks. The sanukitoid–like rocks are characterized by quartz monzonites, which display higher Mg#（55.0–59.0）, and enrichments in Na2 O＋K2 O（7.28–8.94 %）, Ni（21-2312 ppm）, Cr（56-4167 ppm）, Sr（553-923 ppm）, Ba（912-1355 ppm） and LREE（（La/Yb）N =9.47–15.3）, from negative to slightly positive Eu anomalies（δEu=＋0.61 to ＋1.10）, but also depletion in Nb, Ta and Ti. The granodioritic-monzogranitic rocks diaplay various Mg#of 6.00-53.0, high Na2 O＋K2 O（7.20– 8.30%）, Sr（455–1081 ppm） and（La/Yb）N（27.6–47.8）, with positive Eu anomalies（δEu=1.03–1.57） and depleted Nb, Ta and Ti. Laser ablation inductively coupled plasma mass spectrometry（LA-ICPMS） zircon U-Pb isotopic dating reveals that the sanukitoid-like rocks were emplaced at two episodes of magmatism at 457±3 Ma and 431±2 Ma, respectively. The monzogranites were emplaced at 445±7Ma. Sanukitoid–like rocks have their εHf（t） values ranging from ＋0.3 to ＋15.1 with Hf–depleted mantle model ages of 445 to 1056 Ma, and the monzogranite shows its εHf（t） values ranging from 21.6 to ＋10.8 with Hf–depleted mantle model ages of 635 to 3183 Ma. Petrological, geochemical and zircon Lu –Hf isotopic features indicate that the magmatic precursor of sanukitoid–like rocks was derived from partial melting of the depleted mantle wedge materials that were metasomatized by fluids and melts related to subduction of oceanic slab, subsequently the sanukitoid magma ascended to crust level. This emplaced mantle magma caused partial melting of crustally metamorphosed sedimentary rocks, and mixing with the crustal magma, and suffered fractional crystallization, which lead to formations of quartz monzonites. However, the magmatic precursor of the granodioritic-monzogranitic rocks were derived from partial melting of subducted oceanic slab basalts. Integr

关键词： Sanchahe quartz monzonite intrusion zircon U–Pb ages and Lu–Hf isotopes petrochemistry and petrogenesis tectonic setting North Qinling tectonic zone.