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Mapping QTLs with epistatic effects and QTL×environment interactions for plant height using a doubled haploid population in cultivated wheat

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Journal of Genetics and Genomics 2008年第2期35卷 119-127页

作者： Kunpu Zhang Jichun tian Liang Zhao shanshan Wang State Key Laboratory of Crop Biology Group of Quality Wheat Breeding of Shandong Agricultural University Tai＇an 271018 China

Quantitative trait loci （QTLs） for plant height in wheat （Triticum aestivum L.） were studied using a set of 168 doubled haploid （DH） lines, which were derived from the cross Huapei 3/Yumai 57. A genetic linkage map was constructed using 283 SSR and 22 EST-SSR markers. The DH population and the parents were evaluated for wheat plant height in 2005 and 2006 in Tai＇an and 2006 in Suzhou. QTL analyses were performed using the software of QTLNetwork version 2.0 based on the mixed linear model. Four additive QTLs and five pairs of epistatic effects were detected, which were distributed on chromosomes 3A, 4B, 4D, 5A, 6A, 7B, and 7D. Among them, three additive QTLs and three pairs of epistatic QTLs showed QTL×environment interactions （QEs）. Two major QTLs, Qph4B and Qph4D, which accounted for 14.51% and 20.22% of the phenotypic variation, were located similar to the reported locations of the dwarfing genes Rhtl and Rht2, respectively. The Qph3A-2 with additive effect was not reported in previous linkage mapping studies. The total QTL effects detected for the plant height explained 85.04% of the phenotypic variation, with additive effects 46.07%, epistatic effects 19.89%, and QEs 19.09%. The results showed that both additive effects and epistatic effects were important genetic bases of wheat plant height, which were subjected to environmental modifications, and caused dramatic changes in phenotypic effects. The information obtained in this study will be useful for manipulating the QTLs for wheat plant height by molecular marker-assisted selection （MAS）.

关键词： doubled haploid population epistatic effects plant height quantitative trait loci QTL×environment interactions wheat (Triticum aestivum L.)

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Gravity Flow on Slope and Abyssal Systems in the Qiongdongnan Basin,Northern South China Sea

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Acta Geologica Sinica(English Edition) 2011年第1期85卷 243-253页

作者： SU Ming XIE Xinong LI Junliang JIANG Tao ZHANG Cheng HE Yunlong tian shanshan ZHANG Cuimei Key Laboratory of Tectonics and Petroleum Resources （China University of Geosciences） Ministry of Education Wuhan 430074 China CAS Key Laboratory of Marginal Sea Geology South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou 510301 China Department of Technology Zhanjiang Branch of CNOOC Zhanjiang 524057 China

The study of new seismic data permits the identification of sediment gravity flows in terms of internal architecture and the distribution on shelf and abyssal setting in the Qiongdongnan Basin （QDNB）. Six gravity flow types are recognized：（1） turbidite channels with a truncational basal and concordant overburden relationship along the shelf edge and slope, comprising laterally-shifting and vertically-aggrading channel complexes; （2） slides with a spoon-shaped morphology slip steps on the shelf-break and generated from the deformation of poorly-consolidated and high water content sediments; （3） slumps are limited on the shelf slope, triggered either by an anomalous slope gradient or by fault activity; （4） turbidite sheet complexes （TSC） were ascribed to the basin-floor fan and slope fan origin, occasionally feeding the deep marine deposits by turbidity currents; （5） sediment waves occurring in the lower slope-basin floor, and covering an area of approximately 400 km2, were generated beneath currents flowing across the sea bed; and （6） the central canyon in the deep water area represents an exceptive type of gravity flow composed of an association of debris flow, turbidite channels, and TSC. It presents planar multisegment and vertical multiphase characteristics. Turbidite associated with good petrophysical property in the canyon could be treated as a potential exploration target in the QDNB.

关键词： gravity flow slope and abyssal system Qiongdongnan Basin South China Sea

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Piceatannol enhances Beclin-1 activity to suppress tumor progression and its combination therapy strategy with everolimus in gastric cancer

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Science China(Life Sciences) 2023年第2期66卷 298-312页

作者： Longtao Huangfu Xiaoyang Wang shanshan tian Junbing Chen Xueying Wang Biao Fan Qian Yao Gangjian Wang Cong Chen Jing Han Xiaofang Xing Jiafu Ji Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Division of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital&InstituteBeijing 100142China Department of Pharmacy Peking University Cancer Hospital&InstituteBeijing 100142China National Institute on Drug Dependence Peking UniversityBeijing 100191China Gastrointestinal Cancer Center Peking University Cancer Hospital&InstituteBeijing 100142China Department of Pathology Peking University Cancer Hospital&InstituteBeijing 100142China

The effects and regulation of Beclin-1-an autophagy-related protein-have not been fully defined, however, a negative correlation has been reported between Beclin-1 expression and carcinogenesis. Meanwhile, no compound has been shown to directly inhibit its activity. Here, we evaluate piceatannol, a naturally occurring polyphenolic compound, as a potential targeting agonist of Beclin-1, to assess its efficacy as an antitumor agent against gastric cancer. More specifically, we determine the effects of piceatannol treatment on cell viability using a monitoring system and colony forming assay. Piceatannol was found to efficiently inhibit the proliferation of several human gastric cancer cell lines. Autophagic flux is increased by piceatannol treatment, and correlates with inhibition of cell proliferation and colony formation. Additionally, microscale thermophoresis and surface plasmon resonance results show a direct interaction between piceatannol and Beclin-1, which reduces the phosphorylation activity of Beclin-1 at the Ser-295 site. Notably, piceatannol impairs the binding of Beclin-1 to Bcl-2 and enhances the recruitment of binding of UV radiation resistance-associated gene protein, which further triggers Beclin-1-dependent autophagy signaling. An increase in autophagic activity via treatment with the mTOR inhibitor, everolimus, effectively sensitizes piceatannol-induced antitumor effects. Xenograft models confirmed that piceatannol inhibits tumor development and elicits a potent synergistic effect with everolimus in vivo. Taken together, the findings of this study strongly support the application of combinatorial piceatannol and everolimus therapy in future clinical trials for gastric cancer patients.

关键词： piceatannol Beclin-1 autophagy everolimus gastric cancer drug synergy

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Research on township enterprises＇ problems and countermeasures of human resource management in China

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International English Education Research 2016年第5期 55-56页

作者： ZHANG Libo SHI Minghong tian shanshan Shanghai University of Engineering Science China

After the reform and opening up in China, the development of township enterprises is growing very fast. Tt has made outstanding contributions to China＇s development, and has become an important part of China＇ s economy. However, with the new economy＇s coming, the exterior and interior environment of human resource managementhas been changed greatly and the old human resource management system of township enterprises has restrictedtheir development. Based on the analysis on the problems existing in the human resource management of townshipenterprises, the paper advances a series of countermeasuresto elevate the level of the human resource management of township enterprises, to enhance their competence.

关键词： township enterprises human resource human resource management

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Photocatalytic Characteristics of TiO2/Hangjin 2# Clay Composites

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Journal of Chemistry and Chemical Engineering 2010年第2期4卷 7-14页

作者： Huaixiang Li Hao tian Lei Yu shanshan Chen College of Chemistry Chemical Engineering and Material Science Shandong Normal University Jinan 250014 China

Composite photocatalyst of TiOg/Hangjin 2# clay has been used as a carrier for the composite photocatalyst due to its low cost prepared by acid-catalyzed sol-gel method. Hangjin 2# clay was and abundant reserves in Inner Mongolia, China. The samples were characterized by X-ray diffraction （XRD）, Fourier transformed infrared spectroscopy （FT-IR）, scanning electron microscopy （SEM） and Brunauer-Emmett-Teller （BET） specific surface area measurements. XRD patterns proved that anatase and rutile phases were coexisted with 52% anatase and 48% ruffle for the TiO2 in the composite. FT-IR analysis demonstrated that the insertion of TiO2 in composite photocatalyst did not destroy the basal framework structure of the clay. SEM results proved the addition of Hangjin 2# clay restrained TiO2 grain growth and the grain size in the composite was smaller than that of pure TiO2 in the same process. Photocatalytic characteristics of TiO2/Hangiin 2~ clay composites were evaluated by measuring degradation ratio of methylene blue （MB） in aqueous solution under ultraviolet （UV） irradiation. Effects of TiO2 wt%, gelling temperature and heat-treating temperature on the photocatalytic activity of the composites were investigated. The composite catalyst showed higher photocatalytic activity than the pure TiO2 under the same experimental conditions. In addition, the composite photocatalysts were easier to recover and reuse than pure TiO2 samples.

关键词： Titanium dioxide clay photocatalysis sol-gel method.

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Photoluminescence Enhancement of Porous Silicon by Adding Titanium Sol during Electrochemically Etching

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材料科学与工程（中英文版） 2010年第4期4卷 77-83页

作者： Lei Yu Huaixiang Li Hao tian shanshan Chen College of Chemistry Chemical Engineering and Material Science Shandong Normal University Jinan 250014 China

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Causal relationships between chronotype and risk of multiple cancers by using longitudinal data and Mendelian randomization analysis

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Science China(Life Sciences) 2023年第10期66卷 2433-2436页

作者： shanshan tian Longtao Huangfu Sizhi Ai Junwei Zheng Le Shi Wei Yan Ximei Zhu Qianwen Wang Jiahui Deng Yanping Bao Suhua Chang Lin Lu Peking University Sixth Hospital Peking University Institute of Mental HealthNHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)Beijing 100191China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Division of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital&InstituteBeijing 100142China Department of Cardiology Heart CenterThe First Affiliated Hospital of Xinxiang Medical UniversityXinxiang 453100China National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence Peking UniversityBeijing 100191China Chinese Academy of Medical Sciences Research Unit(No.2018RU006) Peking UniversityBeijing 100191China Peking-Tsinghua Center for Life Sciences PKU-IDG/McGovern Institute for Brain ResearchBeijing 100871China

Dear Editor,Cancer is the second leading cause of death worldwide,and the cancer situation is becoming more complicated(Zhou et al.,2022).The International Agency for Research on Cancer(IARC)Monographs Working Group c... 详细信息

关键词： Cancer death

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终结法国模式:法国大学自治化改革难以完成的使命

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现代大学教育 2024年第3期40卷 59-68,F0003页

作者：田珊珊东华大学外语学院上海201620

在全球高等教育竞争日趋激烈的背景下,法国于2007年开启了以建设世界一流大学为目标的大学自治化改革。这次改革受知识经济和新公共管理理念的影响,主要有三大举措:引入政署化代理和市场性竞争、调整大学治理架构和推行高校重组。改革... 详细信息

在全球高等教育竞争日趋激烈的背景下,法国于2007年开启了以建设世界一流大学为目标的大学自治化改革。这次改革受知识经济和新公共管理理念的影响,主要有三大举措:引入政署化代理和市场性竞争、调整大学治理架构和推行高校重组。改革在大学治理方式、政府管理机制、资源整合配置等方面取得了一些成效。改革触动了法国现行高等教育体制的基本原则,引发了人们对法国模式会被终结的担忧。深入考察改革的制度逻辑、改革路径与理念局限可以发现,法国大学自治化改革对法国模式的突破仅限于政策层面,远未触及理念层面。法国高等教育的公共属性和双轨制在法国社会的文化价值观体系下难以改变。这决定了法国高等教育改革的方向只能是完善结构而非改变结构,这也是法国经验的重要启示。

关键词：世界一流大学法国模式大学自治化改革文化价值观

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Improvement of Photoactivity of Titanium Oxide by Codoping Sn-Li-F Elements

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材料科学与工程（中英文版） 2010年第6期4卷 44-50页

作者： Huaixiang Li Yingshuai Lv Lusheng Chen Hao tian Lei Yu shanshan Chen College of Chemistry Chemical Engineering and Material Science Shandong Normal University Jinan 250014 China

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社会文化视角下法国社会保障制度“碎片化”特征解析

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社会保障评论 2017年第2期1卷 151-159页

作者：田珊珊东华大学外语学院武汉大学法国研究中心

传统政治经济学视角下的研究倾向于认为,法国社会保障制度"碎片化"特征是利益和政治力量博弈的结果。这一认识给法国社会保障制度的研究制造了盲区,因为它忽视了制度安排的社会文化基础。本文以"基本担忧"和"集体想象"为切入点,把法国... 详细信息

传统政治经济学视角下的研究倾向于认为,法国社会保障制度"碎片化"特征是利益和政治力量博弈的结果。这一认识给法国社会保障制度的研究制造了盲区,因为它忽视了制度安排的社会文化基础。本文以"基本担忧"和"集体想象"为切入点,把法国社会保障制度安排置于整个法国社会宏观的管理结构与社会及政治游戏规则的体系之中,并与微观层面的社会关系相结合进行分析后发现,法国社会保障制度的"碎片化"本质上反映的是法国社会结构以职业分层为特征的"碎片化"。这一制度安排根植于法国深厚的行会主义文化传统,同时支撑了以职业身份认同为核心的"荣誉的逻辑"。

关键词：法国社会保障制度碎片化文化职业身份

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