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Acta Pharmaceutica Sinica B 2024年第3期14卷 1400-1411页

作者： shuo Wang tian Liu Yuetong Huang Chaoying Du Danping Wang Xiyan Wang Qingzhi Lv Zhonggui He Yinglei Zhai Bingjun Sun Jin Sun Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China School of Medical Devices Shenyang Pharmaceutical UniversityShenyang 110016China School of Pharmacy Binzhou Medical UniversityBinzhou 256600China

The self-assembly prodrugs are usually consisted of drug modules,activation modules,and assembly modules.Keeping the balance between efficacy and safety by selecting suitable modules remains a challenge for developing prodrug nanoassemblies.This study designed four docetaxel(DTX)prodrugs using disulfide bonds as activation modules and different lengths of branched-chain fatty alcohols as assembly modules(C_(16),C_(18),C_(20),and C_(24)).The lengths of the assembly modules determined the self-assembly ability of prodrugs and affected the activation modules’sensitivity.The extension of the carbon chains improved the prodrugs’self-assembly ability and pharmacokinetic behavior while reducing the cytotoxicity and increased cumulative toxicity.The use of C_(20) can balance efficacy and safety.These results provide a great reference for the rational design of prodrug nanoassemblies.

关键词： Prodrugs Nanoassemblies Self-assembly Branched-chain fatty alcohols Disulfide bond Docetaxel Efficacy Safety

Genetically modified pigs:Emerging animal models for hereditary hearing loss

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Zoological Research 2024年第2期45卷 284-291页

作者： Xiao Wang tian-Xia Liu Ying Zhang Liang-Wei Xu shuo-Long Yuan A-Long Cui Wei-Wei Guo Yan-Fang Wang Shi-Ming Yang Jian-Guo Zhao State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Savaid Medical School University of Chinese Academy of SciencesBeijing 100049China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Department of Otolaryngology-Head and Neck Surgery Institute of OtolaryngologyChinese PLA General HospitalBeijing 100853China Division of Life Sciences and Medicine University of Science and Technology of ChinaHefeiAnhui 230022China State Key Laboratory of Animal Biotech Breeding Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing100193China

Hereditary hearing loss(HHL),a genetic disorder that impairs auditory function,significantly affects quality of life and incurs substantial economic losses for society.To investigate the underlying causes of HHL and evaluate therapeutic outcomes,appropriate animal models are necessary.Pigs have been extensively used as valuable large animal models in biomedical research.In this review,we highlight the advantages of pig models in terms of ear anatomy,inner ear morphology,and electrophysiological characteristics,as well as recent advancements in the development of distinct genetically modified porcine models of hearing loss.Additionally,we discuss the prospects,challenges,and recommendations regarding the use pig models in HHL research.Overall,this review provides insights and perspectives for future studies on HHL using porcine models.

关键词： Pigs Animal models Hereditary hearing loss Genetic modification Inner ear

Non-saturated throughput analysis of IEEE 802.11-based cognitive radio networks

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The Journal of China Universities of Posts and Telecommunications 2012年第6期19卷 6-13页

作者： ZHAO Yuan JIN Shun-fu tian nai-shuo College of Information Science and Engineering Yanshan University College of Science Yanshan University

Technology of cognitive radio networks has emerged as an effective method to enhance the utilization of the radio spectrum where the primary users have priority to use the spectrum, and the secondary users try to exploit the spectrum unoccupied by the primary users. In this paper, considering the non-saturated condition, the performance analysis for the IEEE 802.11-based cognitive radio networks is presented with single-channel and multi-channel, respectively. For the single-channel case, an absorbing Markov chain model describing the system transitions is constructed, and one-step transition probability matrix of the Markov chain is given. By using the method of probability generating function, the non-saturated throughput of the secondary users is obtained. For the multi-channel case, taking into account the negotiation-based sensing policy, the mean number of unused channels perceived by the second users is given, and then the non-saturated aggregate throughput of the secondary users is derived. Finally, numerical examples are provided to show the influences of the non-saturated degree, the number of the secondary users and the channel utilization of the primary users on the performance measures for the non-saturated throughput with single-channel and the non-saturated aggregate throughput with multi-channel.

关键词： cognitive radio networks IEEE 802.11 non-saturated throughput absorbing Markov chain probability generating function

Multiscale control of MnO2 growth via [WO6]-perturbed[MnO6] assembly toward a favorable balance between capacitance and rate performance

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Rare Metals 2024年第4期43卷 1658-1671页

作者： Jin-Kang Liu tian-shuo Yang Zhi-Bin Ren Adekunle-Adedapo Obisanya Xin-Yi Tan Yan-Di Rao Jun-Shuang Zhou Fa-Ming Gao Jian-Ren Wang Hebei Key Laboratory of Applied Chemistry Yanshan University

Although pseudocapacitive manganese dioxide（MnO2） integrates the high-power merit of carbonaceous materials with the high-energy merit of battery-type materials,it still has a long way to go in achieving a more satisfactory balance of higher energy and power density,and in decoupling the relationship of structural characteristics with energy storage performance.To realize such goals,a bottom-up [WO6]-perturbed [MnO6] assembly strategy has been developed here due to their similar structure,yet mismatched lattice parameters.This facile protocol is capable of finely controlling the morphology and crystal structure of MnO2by adjusting its internal[WO6] concentration.Therefore,the as-prepared WxMnO2is treated as an ideal platform to scrutinize the correlations of the structure with the energy storage performance.The operando Raman spectra and finite element analysis have fully demonstrated the superiority of the locally ordered defects-enriched structure of W0.02-MnO2,which could reach a favorable balance between the ion diffusion equilibrium time and the number of active sites.As a result,the W0.02-MnO2is able to deliver a high capacitance of 292 F·g-1at a current density of 1 A·g-1and a remarkable rate performance with a 60% capacity retention at a current density of 50 A·g-1.The further unveiled structure-performance relationship provides a guideline for the design of better pseudocapacitive energy storage devices.

关键词： Supercapacitors Pseudocapacitive materials MnO 2 Tungsten doping Crystal structure regulation

Modeling and performance evaluation of the sleep mode in the IEEE 802.16e wireless networks with self-similar traffic

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The Journal of China Universities of Posts and Telecommunications 2009年第4期16卷 34-41页

作者： HUO Zhan-qiang JIN Shun-fu tian nai-shuo WANG Yan College of Information Science and Engineering Yanshan University Qinhuangdao 066004 China College of Science Yanshan University Qinhuangdao 066004 China School of Computer Science and Engineering Hebei University of Technology Tianjin 300401 China

IEEE 802.16e is currently the latest broadband wireless access standard designed to support mobility. In mobile networks, how to control energy consumption is one of the most important issues for battery-powered mobile stations. The standard proposes an energy saving mechanism named ＇sleep mode＇ for conserving the power of mobile stations. According to the operation principle of the sleep mode for downlink traffic in the type I power saving class, considering the self-similar nature of massive multimedia data in wireless networks, a discrete-time batch arrival Geom^x/G/1 queuing model with a close-down time and multiple vacations is built. The batch size is supposed to be Pareto distributed. By employing an embedded Markov chain method, the average queue length and the average sojourn time of the system model are derived. Correspondingly, the performance measures are obtained of the energy saving rate and the average packet delay time for the sleep mode in the IEEE 802.16e. The numerical results demonstrate the dependency relationships between the system performance measures and the system parameters with different offered loads and different self-similar degrees. Furthermore, a cost model is developed to determine the optimum length of the close-down time for minimizing the total system cost.

关键词： IEEE 802.16e sleep mode close-down self-similar energy saving rate

Achieving an ion-homogenizing and corrosion-resisting interface through nitro-coordination chemistry for stable zinc metal anodes

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Journal of Energy Chemistry 2024年第7期94卷 10-18页

作者： Jizhen Wang Long Jiao Qiaoyun Liu Wei Xin Yechen Lei tian Zhang Leixin Yang Dengkun Shu shuo Yang Kaihua Li Chenyang Li Chao Yi Hongyuan Bai Yuchao Ma Huan Li Wenjun Zhang Bowen'Cheng schoolof Light Industry Science and Engineering State Key Laboratory of Biobased Fiber Manufacturing TechnologyTianjin Key Laboratory of Pulp and PaperChina Light Industry Key Laboratory of Papermaking and BiorefineryTianjin University of Science&TechnologyTianjin 300457China Department of Materials Science and Engineering &Center of Super-Diamond and Advanced FilmsCity University of Hong Kong83 Tat Chee AvenueHong Kong 999077China School of Chemical Engineering and Advanced Materials The University of AdelaideAdelaideSA 5005Australia

Suppression of uncontrollable dendrite growth and water-induced side reactions of Zn metal anodes is crucial for achieving long-lasting cycling stability and facilitating the practical implementations of aqueous Zn-metal batteries.To address these challenges,we report in this study a functional nitro-cellulose interfacial layer(NCIL)on the surface of Zn anodes enlightened by a nitro-coordination chemistry strategy.The NCIL exhibits strong zincophilicity and superior coordination capability with Zn^(2+)due to the highly electronegative and highly nucleophilic nature of the nitro functional group.This characteristic facilitates a rapid Zn-ion desolvation process and homogeneous Zn plating,effectively preventing H_(2) evolution and dendrite formation.Additionally,the negatively charged surface of NCIL acts as a shield,repelling SO_(4)^(2-)anions and inhibiting corrosive reactions on the Zn surface.Remarkably,reversible and stable Zn plating/stripping is achieved for over 5100 h at a current density of 1 mA cm^(-2),which is nearly 30 times longer than that of bare Zn anodes.Furthermore,the Zn/V_(2)O_(5) full cells with the functional interface layer deliver a high-capacity retention of 80.3%for over 10,000 cycles at 5 A g^(-1).This research offers valuable insights for the rational development of advanced protective interface layers in order to achieve ultra-long-lifeZnmetal batteries.

关键词： Zinc metal anode Nitro-cellulose interfacial layer Coordination capability Dendrite-free deposition Long-term cycling

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我国交通运输业碳达峰时间预测

交通运输系统工程与信息 2024年第1期24卷 2-13,54页

作者：李宁海陈硕梁肖田佩宁北京交通大学综合交通运输大数据应用技术交通运输行业重点实验室北京100044

碳达峰战略背景下,交通运输业作为高碳排放行业面临一系列挑战。本文分析我国交通运输客货运碳排放现状。基于统计数据与相关研究成果,推算含私人小汽车的交通运输业碳排放量,并计算各交通方式的碳排放因子。借鉴部分发达国家经验,预测2... 详细信息

碳达峰战略背景下,交通运输业作为高碳排放行业面临一系列挑战。本文分析我国交通运输客货运碳排放现状。基于统计数据与相关研究成果,推算含私人小汽车的交通运输业碳排放量,并计算各交通方式的碳排放因子。借鉴部分发达国家经验,预测2019—2040年我国客货运周转量发展趋势。以2040年为目标年,设计未来交通结构和碳排放因子情景,研究我国交通运输业碳达峰时间和达峰值。结果表明:2020年,含私人小汽车的交通运输业碳排放量为11.1亿t。2040年,我国旅客运输需求规模在8.2万亿~8.7万亿人公里,货物运输需求规模在27.3万亿~28.7万亿吨公里。最后,验证了单纯依赖交通结构改善难以实现2040年前碳达峰,还须结合交通清洁技术升级。情景分析表明,采取“公转铁”“公转水”等交通结构转型,公路运输清洁化等政策措施,交通运输业有望于2031—2034年实现碳达峰。

关键词：综合运输碳达峰情景分析交通运输业碳排放因子

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高校线上教学常态化发展路径探索

辽宁高职学报 2024年第5期26卷 49-52页

作者：田硕沈阳职业技术学院辽宁沈阳110045

一场突如其来的疫情倒逼了高校信息化建设和教学改革的步伐,疫情防控之后各高校将实现一次信息化水平和线上教学的飞跃发展,这使高校线上教学常态化成为可能,也为线上线下混合式教学模式提供了有利的契机和思路。从高校线上教学的现状... 详细信息

一场突如其来的疫情倒逼了高校信息化建设和教学改革的步伐,疫情防控之后各高校将实现一次信息化水平和线上教学的飞跃发展,这使高校线上教学常态化成为可能,也为线上线下混合式教学模式提供了有利的契机和思路。从高校线上教学的现状和特点入手,提出了高校线上教学常态化的三层次一平台一保障模式,并从硬环境、软实力和真优势三方面对推进高校建立线上教学常态化给出了合理化建议,对高校线上教学常态化发展路径进行探索。

关键词：高校线上教学常态化发展路径

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适应新型电力系统的多维协同电力市场体系

电力系统自动化 2024年第4期48卷 2-12页

作者：谢开刘敦楠李竹孙田庞博刘硕张显北京电力交易中心有限公司北京市100031 华北电力大学经济与管理学院北京市102206 清华大学电机工程与应用电子技术系北京市100084

构建适应新型电力系统的电力市场体系,既是实现能源电力转型的必然要求,也是实现“碳达峰·碳中和”目标的重要途径。在全面分析新型电力系统结构改变给电力系统带来的变化与挑战的基础上,构建了适应新型电力系统的目标、时间、空间、... 详细信息

构建适应新型电力系统的电力市场体系,既是实现能源电力转型的必然要求,也是实现“碳达峰·碳中和”目标的重要途径。在全面分析新型电力系统结构改变给电力系统带来的变化与挑战的基础上,构建了适应新型电力系统的目标、时间、空间、价值、主体多维协同的电力市场体系。围绕安全保供、低碳转型与经济的多目标协同,中长期、现货与实时运行的多时间协同,多层次全国统一电力市场的多空间协同,安全-绿色-经济的多价值协同,新型市场主体快速发展下的多主体协同五方面关键问题,提出了多维协同的市场设计思路和核心机制。最后,给出了建设全国统一电力市场的实施路径和建议。

关键词：电力市场多维协同新型电力系统新能源

基于航空摄影测量的填埋堆体动态重构精度及影响因素

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中国环境监测 2024年第3期40卷 260-270页

作者：林汀能昌信徐亚张鲁玉代硕山东工商学院信息与电子工程学院山东烟台264005 中国环境科学研究院固体废物污染控制技术研究所环境基准与风险评估国家重点实验室北京100012

填埋堆体表面形变监测是填埋场库容管理和堆体失稳等风险分析的核心,其时空高分辨率监测研究近年来引起广泛关注。基于航空摄影的地表测量技术具有采集速度快、时空分辨率高等优点,但在填埋场特殊环境下,面对高频填埋活动、显著的堆体... 详细信息

填埋堆体表面形变监测是填埋场库容管理和堆体失稳等风险分析的核心,其时空高分辨率监测研究近年来引起广泛关注。基于航空摄影的地表测量技术具有采集速度快、时空分辨率高等优点,但在填埋场特殊环境下,面对高频填埋活动、显著的堆体变化以及防雨膜覆盖等干扰时,要同时满足高时空分辨率和耗时短的动态监测要求,无人机的最佳飞行参数设定亟待研究。为此,该研究模拟中等规模危险废物填埋场的规模和日填埋量,利用专业级无人机获取模拟区域图像,空三加密处理生成三维点云数据,利用Arcmap叠加分析多期监测数据,从点位坐标、重构尺度、重构体积、体积差分精度4个角度分析重构误差。结果表明:三维重构的坐标精度可以达到米级;重构尺度误差为2~3 cm,重构体积误差为0.16~0.17 m^(3),差分体积误差为0.16~0.17 m^(3);进一步研究发现,高度为25~55 m时,高度越高精度越低,相机倾角为[-53°,-60°]时,精度最高,旁向重叠率大于80%时,误差骤减且基本稳定。考虑到填埋场的填埋作业间隔、无人机续航能力等对飞行时间的约束,为获得最佳精度,建议无人机飞行高度为37 m、相机倾斜角度为[-53°,-60°]、旁向重叠率为80%。

关键词：填埋场库容管理监测无人机飞行参数