检索结果-南通市图书馆

世界核心医学期刊文摘（妇产科学分册） 2006年第4期2卷 43-44页

作者： testa A.C. Fruscella E. Ludovisi M. 朱晓明 Department of Obstetrics and Gynecology Catholic University of Sacred Heart L.go A. Gemelli 8 00168 Rome Italy

Objective. The role and type of procedures of follow-up in patients with gynecological tumors are still a debatable issue. We prospectively analyzed the role of routine transabdominal and transvaginal ultrasound examination (US) in the detection of recurrent disease in gynecologic cancer patients. Methods. Among 552 patients who underwent surgery for gynecological cancer, 385 were available for the analysis. Follow-up examinations included clinical examination, serum tumor marker assay, transvaginal and transabdominal sonography and CT scan/MRI. Results. Positive US examination was documented in 83/385 patients (21.5%). In the overall series, the positive predictive value (PPV) of US examination was 100%, while the negative predictive value (NPV) was 92.7%failing to identify 22 cases of recurrences. When considering the subgroup of patients with positive clinical examination or abnormal tumor marker, positive US analysis was able to identify 66/66 cases of recurrence (PPV = 100%), but exhibited an NPV of 22.2%, with 21/27 (77.8%) false negative cases. Conversely, in cases without clinical/serological signs of disease, positive US recognized all cases of recurrences (17/17, PPV = 100%), and exhibited a very high NPV, with only 1 false negative case out of 275 (0.4%). The US detected recurrences appeared as a solitary lesion in 38/75 (50.6%) patients and in 28/75 (37%) appeared located centrally in the pelvis. The sonographic pattern of the ovarian recurrences was a solid lesion in most (33/40, 82%) cases. In the other gynecological tumors, the lesions appeared as solid masses in 33/35 (94%) cases. Conclusions. We showed that routine US might play a role in the follow-up of gynecologic malignancies, especially in the group of asymptomatic patients, while CT/MRI imaging might be more properly applied to patients with clinical or serological signs of disease.

关键词：妇科肿瘤声像图检查血清肿瘤标记物阴道超声检查随访检查实质性病变阴性预测值阳性预测值疾

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

体系建筑

体系建筑

引用

丛书名：英文原名:Systems building

1980年

作者：（瑞士）施米德（T. Schmid）（意）泰斯塔（C. testa）陈琬译

来源：汇雅图书（南通市图书馆... 评论

在线全文

汇雅图书（南通市图书馆）

学校读者我要写书评

暂无评论

灵长类动物神经压迫致面瘫模型：小型非人类灵长类动物的新型面瘫模型

引用

临床耳鼻咽喉头颈外科杂志 2013年第8期27卷 429-431页

作者： FELIPE COSTA NEIVA ANDREI BORIN SIMONE CININI LUIZ EUGENIO A.M MELLO OSWALDO LARCIO M.CRUZ JOS RICARDO G.testa 张甦琳周柳青孔维佳 Otorhinolaryngology and Head and Neck Surgery Department Federal University of Sao Paulo / UNIFESPSao PauloBrazil Physiology Department Federal University of Sao Paulo / UNIFESPSao PauloBrazil 华中科技大学同济医学院附属协和医院耳鼻咽喉科武汉430022

目的:推广一种面神经损伤模型(绒猴)。方法:将各个非人类灵长类动物绒猴进行3种不同的面神经损伤处理,术后均观察27d,通过图像记录面部运动。结果:两种神经压迫后严重面瘫的模型能够在预估的时间内逐渐恢复到正常水平,而切除神经后则完... 详细信息

目的:推广一种面神经损伤模型(绒猴)。方法:将各个非人类灵长类动物绒猴进行3种不同的面神经损伤处理,术后均观察27d,通过图像记录面部运动。结果:两种神经压迫后严重面瘫的模型能够在预估的时间内逐渐恢复到正常水平,而切除神经后则完全失去了面部运动恢复的可能。结论:我们认为压迫所致面神经损伤可以在一个合理的观察窗(4周)内,进行神经营养效果的可能分析。此外,没有迹象表明半面的肌肉有来自于对侧神经的交叉支配,或者其他伴行的神经支配。

关键词：面神经神经再生动物模型神经学脑神经病脑神经神经退化

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

儿童期发生的癫痫死亡率

引用

世界核心医学期刊文摘（儿科学分册） 2005年第6期1卷 24-25页

作者： Berg A. T. Shinnar S. testa F. M. 郭战宏 Neuroepidemiology Group Department of Biological Sciences Northern Illinois University DeKalb IL 60115 United States Dr

Objectives: To evaluate mortality in children with newly diagnosed epilepsy, to determine the risk of death, and to identify predictors of death from the point of diagnosis. Design: Prospective community-based cohort of 613 children with newly diagnosed epilepsy. The outcome measure was death, χ2 Tests were used for bivariate analyses and the Cox proportional hazards model for multivariable analyses. Standardized mortality ratios were used to quantify the excess mortality in the cohort relative to the population. Results: Thirteen deaths occurred during 4733 person-years of follow-up, for a crude death rate of 2.7 per 1000 person-years (0.52 per 1000 person-years in those with nonsymptomatic epilepsy and 12.6 per 1000 person-years in those with symptomatic epilepsy). Ten deaths were associated with the underlying cause of the seizures, 2 were associated with the occurrence or probable occurrence of seizures, and 1 was unrelated to seizures or the underlying disorder. On multivariable analysis, symptomatic etiology (rate ratio, 10.2; 95%con-fidence interval [CI], 2.1-49.6) and epileptic encephalopathy (rate ratio, 13.3; 95%CI, 3.4-51.7) were independently associated with mortality. The overall standardized mortality ratio for the cohort was 7.54 (95%CI, 4.38-12.99). In children with symptomatic epilepsy, the standardized mortality ratio was 33.46 (95%CI, 18.53-60.43), and in those with nonsymptomatic epilepsy, it was 1.43 (95%CI, 0.36-5.73). Conclusions: Children with epilepsy have an increased risk of death. Most deaths occur in children with severe underlying conditions and are not directly related to the occurrence of seizures.

关键词：症状性癫痫童期癫痫性癫痫患儿双变量分析前瞻性队列研究潜在疾病脑病死亡风险多元分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

应用雷贝拉唑、克拉霉素和甲硝唑三联根治幽门螺杆菌1周对^(13)C-氨基比林呼气试验的影响

引用

世界核心医学期刊文摘（胃肠病学分册） 2005年第12期1卷 7-8页

作者： Giannini E.G. Malfatti F. Botta F. R. testa 郝筱倩 Gastroenterology Unit Department of Internal Medicine University of Genoa Viale Benedetto XV No. 6 16132 Genoa Italy Dr.

Helicobacter pylori eradication therapy is commonly prescribed in the general population. Treatment consists of drugs that are mainly metabolized by the liver cytochrome P- 450 (CYP) enzymatic pool. Most H. pylori- infected patients often take drugs for comorbid illnesses, therefore increasing the potential for drug- drug interactions. We aimed to evaluate the interactions of rabeprazole, clarithromycin, and metronidazole 1- week H. pylori eradication therapy with CYP- dependent liver metabolic function in clinical practice. Ten patients referred to our unit for H. pylori infection underwent 1- week eradication therapy with rabeprazole (20 mg, b.i.d.), clarithromycin (500 mg, b.i.d.), and metronidazole (500 mg, b.i.d.). We chose the 13C- aminopyrine breath test (13C- ABT) to evaluate CYP- dependent liver function since it is noninvasive and nonharmful. All patients underwent 13C- ABT at three time points: before therapy (t0), at the end of therapy (t8), and after 1 month of follow- up (t38). Mean 13C- ABT dose/hr (t0 = 14.0 ± 5.4, t8 = 13.5 ± 4.0, t38 = 16.1 ± 5.6) as well as 13C- ABT cumulative dose (t0 = 2.4 ± 1.1, t 8 = 2.4 ± 0.8, t38 = 2.6 ± 1.0) were not statistically different at the three time points of the study. These results did not seem to be influenced by drugs being administered concomitantly. In everyday clinical practice rabeprazole- based H. pylori eradication therapy does not seem to display any significant interactions with CYP- dependent liver function, even in patients on multiple drugs.

关键词：雷贝拉唑呼气试验药物相互作用治疗法细胞色素肝脏代谢临床实践平均剂量菌根酶体系

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Subclinical carotid atherosclerosis predicts all-cause mortality and cardiovascular events in obese patients with negative exercise echocardiography

引用

World Journal of Cardiology 2019年第1期11卷 24-36页

作者： Rafael Vidal-Perez Raúl Franco-Gutiérrez Alberto J Pérez-Pérez Virginia Franco-Gutiérrez Alberto Gascón-Vázquez Andrea López-López Ana María testa-Fernández Carlos González-Juanatey Department of Cardiology Hospital Universitario Lucus Augusti Department of Otolaryngology Hospital Carmen y Severo Ochoa Faculty of Medicine University of Santiago de Compostela

BACKGROUND Obesity is a major health problem due to its high prevalence. The relationship between obesity and cardiovascular disease is unclear. Some studies agree that certain conditions associated with obesity, such as physical inactivity or cardiovascular risk factors, are responsible for cardiovascular risk excess among obese people. Carotid intima-media thickness and carotid plaques(CP) have been associated with cardiovascular adverse events in healthy populations, and recent data suggest a higher prevalence of subclinical carotid atherosclerosis in obese and metabolically unhealthy patients. However, there are no studies correlating subclinical atherosclerosis and adverse events(AE) in obese *** To determine the association between carotid disease and AE in obese patients with negative exercise echocardiography(EE).METHODS From January 1, 2006 to December 31, 2010, 2000 consecutive patients with a suspicion of coronary artery disease were submitted for EE and carotid ultrasonography. Exclusion criteria included previous vascular disease, left ventricular ejection fraction < 50%, positive EE, significant valvular heart disease and inferior to submaximal EE. An AE was defined as all-cause mortality,myocardial infarction and cerebrovascular accident. Subclinical atherosclerosis was defined as CP presence according to Manheim and the American Society of Echocardiography *** Of the 652 patients who fulfilled the inclusion criteria, 226(34.7%) had body mass indexes ≥ 30 kg/m2, and 76 of them(33.6%) had CP. During a mean follow-up time of 8.2(2.1) years, 27 AE were found(11.9%). Mean event-free survival at 1, 5 and 10 years was 99.1%(0.6), 95.1%(1.4) and 86.5%(2.7), respectively. In univariate analysis, CP predicted AE [hazard ratio(HR) 2.52, 95% confidence interval(CI) 1.17-5.46; P = 0.019]. In multivariable analysis, the presence of CP remained a predictor of AE(HR 2.26, 95%CI 1.04-4.95, P = 0.041). Other predictors identified were glomerular

关键词： Carotid intima media thickness Carotid plaque Carotid disease Myocardial infarction Mortality Stroke Exercise stress echocardiography

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

体系建筑

体系建筑

引用

作者： T.·施米德(T. Schmid) C.·泰斯塔(C. testa)

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

Serum SCCA-IgM as a predictor of hepatocellular carcinoma in patients with liver cirrhosis

引用

Open Journal of Gastroenterology 2012年第2期2卷 56-61页

作者： Daniela Buccione Gianluca Fatti Andrea Gallotta Elisabetta Loggi Roberto Di Donato Lilia testa Carlo Saitta Valentina Santi Antonio Di Micoli Virginia Erroi Marta Frigerio Valentina Fazio Antonino Picciotto Alessandra Biasiolo Francoise Degos Patrizia Pontisso Giovanni Raimondo Franco Trevisani APHP Hopital Beaujon INSERM U 773 Clichy France Dipartimento di Medicina Clinica e Sperimentale “G. Patrassi” Università di Padova Padova Italia Dipartimento di Medicina Clinica Alma Mater Studiorum-Università di Bologna Bologna Italia Dipartimento di Medicina Interna Policlinico Universitario di Messina Messina Italia Dipartimento di Medicina Interna Università di Genova Genova Italia Xeptagen S.p.A. Venezia Italia

Aberrant Squamous Cell Carcinoma Antigen (SCCA) expression is an early hepatocarcinogenetic event and circulating SCCA-IgM complexes are elevated in most HCC patients. We evaluated whether serum SCCA-IgM levels can identify HCV +ve cirrhotic patients at low HCC risk. In this retrospective study we enrolled 29 cirrhotic patients in whom serum SCCA-IgM was measured 8 - 69 months (median 31) before HCC diagnosis, and 28 cirrhotic patients who remained HCC- free, with SCCA-IgM measured 15 - 68 months (median 48) before the study end. The best discriminating value of SCCA-IgM was calculated and tested in predicting HCC diagnosis within 12, 24 and 36 months. Sensitivity analysis, considering different HCC incidence, was conducted to identify the patient subgroup with an annual cancer risk below the threshold of a cost-effective semiannual surveillance with ultrasound. Cumulative HCC incidence at 12, 24 and 36 months was 7.0%, 15.7% and 26.3%, respectively. SCCA-IgM levels were higher in HCC than in cirrhotic patients [median: 381 (95% C.I.: 50 - 5289) vs. 100 (70 - 493) AU/mL, P = 0.005]. The SCCA-IgM value ≤ 200 AU/mL accurately identified patients at low risk of HCC development in the subsequent year (sensitivity 75%, specificity 62%, positive predictive value 13% and negative predictive value 97%). Considering an annual HCC incidence ≤ 3%, patients with SCCA-IgM ≤ 200 AU/mL (60% of the whole patients) had an HCC risk below the accepted threshold of a cost-effective surveillance (1.5%). In conclusion, provided that our provocative results are confirmed in larger studies, SCCA-IgM serum measurement could permit implementation of a two step (with different costs) surveillance: an initial serological surveillance, based on the annual monitoring of this biomarker, and the conventional surveillance by semiannual US when SCCA-IgM becomes >200 AU/mL. This could improve the cost/effectiveness of surveillance of HCV infected patients at risk of HCC.

关键词： SCCA-IgM HCC Risk Assessment Surveillance Cost/Effectiveness

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

非数字,非物理——南加州建筑学院机器人工作室

引用

城市建筑 2018年第19期15卷 40-44页

作者：彼得.特斯塔张润泽南加州建筑学院机器人工作室特斯塔&怀瑟工作室南加州建筑学院

南加州建筑学院机器人工作室从2010年以非制造模式开始探讨,开创性地利用机器人技术建设全新的平台装置来探讨虚构性、美学及相关论述。本文介绍了一个不同的视角,它可以确定主题,并将机器人工作室定位为当代理论中的前瞻性设计装置。

关键词：南加州建筑学院机器人工作室

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

前瞻性多模态成像评估局部晚期宫颈癌病人放化疗后行根治手术——“宫颈癌的前瞻性影像学及新辅助治疗”研究2:常规序列和DW-MRI扫描的作用

引用

国际医学放射学杂志 2019年第3期 379-379页

作者：于子川 B.Gui M.Miccò A.L.Valentini F.Cambi T.Pasciuto A.testa Radiologia Diagnostica e Interventistica Generale Area Diagnosticaper ImmaginiDipartimento Diagnostica per ImmaginiRadioterapia Oncologica ed EmatologiaFondazione Policlinico Universitario A.Gemelli IRCCS

摘要目的评价常规和DW-MRI检查对局部晚期宫颈癌(LACC)行新辅助放化疗(nCRT)及根治性手术后病人肿瘤残留的诊断价值。方法在2010年10月—2014年6月

关键词：常规序列特异度局部晚期宫颈癌 DW-MRI

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：