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Science China Chemistry 2012年第5期55卷 726-734页

作者： WU Hui SU ZhaoHui terayama Yuki TAKAHARA Atsushi Institute for Materials Chemistry and Engineering Kyushu University Fukuoka 819-0395 Japan State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China Graduate School of Engineering Kyushu University Fukuoka 819-0395 Japan

The polystyrene-based polymer blends, partially miscible poly(bisphenol A carbonate)/polystyrene (PC/PS) and completely miscible poly(2,6-dimethylphenylene oxide)/polystyrene (PPO/PS), in nanorods with gradient composition distribution were discussed. The polymer blend nanorods were prepared by infiltrating the polymer blends into nanopores of anodic aluminum oxide (AAO) templates via capillary action. Their morphology was investigated by micro-Fourier transform infrared spectroscopy (micro-FTIR) and nano-thermal analysis (nano-TA) with spatial resolution. The composition gradient of polymer blends in the nanopores is governed by the difference of viscosity and miscibility between the two polymers in the blends and the pore diameter. The capillary wetting of porous AAO templates by polymer blends offers a unique method to fabricate functional nanostructured materials with gradient composition distribution for the potential application to nanodevices.

关键词： nanorods gradient composition distribution polymer blends anodic aluminum oxide micro-FTIR nano-TA

Fine-grained optimization method for crystal structure prediction

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npj Computational Materials 2018年第1期4卷 379-386页

作者： Kei terayama Tomoki Yamashita Tamio Oguchi Koji Tsuda Graduate school of Frontier Sciences the University of Tokyo5-1-5Kashiwa-no-haKashiwaChibaJapan RIKEN Center for Advanced Intelligence Project 1-4-1 NihonbashiChuo-kuTokyo 103-0027Japan Graduate school of Medicine Kyoto UniversityYoshida-Konoe-choSakyo-kuKyoto 606-8507Japan Center for Materials research by Information Integration Research and ServicesDivision of Materials Data and Integrated SystemNational Institute for MaterialsScience1-2-1 SengenTsukubaIbaraki 305-0047Japan Institute of Scientific and Industrial Research Osaka University8-1 MihogaokaIbarakiOsaka 567-0047Japan

Crystal structure prediction based on first-principles calculations is often achieved by applying relaxation to randomly generated initial *** a structure requires multiple optimization *** is time consuming to fully relax all the initial structures,but it is difficult to figure out which initial structure leads to the optimal solution in *** this paper,we propose a optimization method for crystal structure prediction,called Look Ahead based on Quadratic Approximation,that optimally assigns optimization steps to each candidate *** allows us to identify the most stable structure with a minimum number of total local optimization *** simulations using known systems Si,NaCl,Y_(2)Co_(17),Al_(2)O_(3),and GaAs showed that the computational cost can be reduced significantly compared to random *** method can be applied for controlling all kinds of local optimizations based on first-principles calculations to obtain best results under restricted computational resources.

关键词： structure grain optimization

Left testicular artery arching over the ipsilateral renal vein

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Asian Journal of Andrology 2006年第1期8卷 107-110页

作者： Munekazu Naito Hayato terayama Yoichi Nakamura Shogo Hayashi Takayoshi Miyaki Masahiro Itoh Department of Anatomy Tokyo Medical UniversityTokyo 160-8402Japan

Aim： To report two cases of the left testicular artery arching over the left renal vein （LRV） before running downward to the testis. Methods： The subjects were obtained from two Japanese cadavers. During the student course of gross-anatomical dissection, the anatomical relationship between the testicular vessels and the renal vein was specifically observed. Results： The arching left testicular artery arose from the aorta below the LRV and made a loop around the LRV, which appeared to be mildly compressed between the arching artery and the psoas major muscle. Conclusion： Clinically, compression of the LRV between the abdominal aorta and the superior mesenteric artery occasionally induces LRV hypertension, resulting in varicocele, orthostatic protenuria and hematuria. Considering that the incidence of a left arching testicular artery is higher than that of a right one, an arching left artery could be an additional cause of LRV hypertension. （Asian J Androl 2006 Jan; 8： 107-110）

关键词： anatomy testis blood vessels

Specific acupuncture stimulation of Shenshu(BL23)affects sympathetic nervous activity-associated plasma renin concentration changes

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Journal of Traditional Chinese Medicine 2022年第2期42卷 250-255页

作者： Kanae Umemoto Tomoya Hayashi Kaori Fukushige Shuichi Hirai Hayato terayama Kou Sakabe Munekazu Naito Graduate School of Acupuncture and Moxibustion Meiji University of Integrative MedicineNantanKyoto 629-0392Japan Department of Anatomy Division of Basic Medical Sc+ienceTokai University School of MedicineIseharaKanagawa 259-1193Japan Department of Anatomy Aichi Medical University School of MedicineNagakuteAichi 480-1195Japan Graduate School of Acupuncture and Moxibustion Meiji University of Integrative MedicineNantanKyoto629-0392Japan Department of Physiology Meiji University of Integrative MedicineNantanKyoto 629-0392Japan Division of Anatomical Science Department of Functional MorphologyNihon University School of MedicineItabashi-kuTokyo 173-0032Japan Department of Anatomy Division of Basic Medical ScienceTokai University School of MedicineIseharaKanagawa 259-1193Japan

OBJECTIVE:To examine whether specific stimulation of Shenshu(BL23)affects sympathetic nervous activity(SNA)-associated plasma renin concentration(PRC).METHODS:Eight healthy volunteers participated in three pattern conditions in random order:control(Cont),stimulation of Shenshu(BL23),and stimulation of sham point(Sham).All participants were initially in the supine position for>60 min,and then remained in the standing position during the experimental procedure to increase *** electrocardiogram was used to calculate low frequency/high frequency(LF/HF)ratio;blood was collected to analyze ***:The LF/HF ratio was significantly increased in the standing position when compared with the supine position(P<0.01).There was no difference in LF/HF ratio during or after stimulation of Shenshu(BL23)in the standing position when compared with before the stimulation in the supine position;however,the LF/HF ratio was significantly increased in Cont and Sham conditions(P<0.01).There was no difference in PRC after stimulation of Shenshu(BL23)in the standing position when compared with before the stimulation in the supine position;however,there was a significant increase in PRC in the Cont and Sham conditions(Cont P<0.05,Sham P<0.01).CONCLUSION:Our results demonstrated that specific acupuncture stimulation of Shenshu(BL23)in the standing position decreased SNA-associated PRC,which was not observed during acupuncture stimulation of the sham point.

关键词： Acupuncture Point BL23(Shenshu) Sympathetic nervous activity Plasma renin concentration

Surgical anatomy of innervation of the gallbladder in humans and Suncus murinus with special reference to morphological understanding of gallstone formation after gastrectomy

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World Journal of Gastroenterology 2007年第14期13卷 2066-2071页

作者： Shuang-Qin Yi Tetsuo Ohta Akihiko Tsuchida Hayato terayama Munekazu Naito Jun Li Heng-Xiao Wang Nozomi Yi Shigenori Tanaka Masahiro Itoh Department of Anatomy Tokyo Medical University 6-1-1 Shinjuku Shinjukuku Tokyo 160-8402 Japan Department of Gastroenterologie Surgery Kanazawa University 13-1 Takara-Machi Kanazawa 920-8420Japan Third Department of Surgery Tokyo Medical Kanazawa University 13-1 Takara-Machi Kanazawa 920-8420Japan Department of Anatomy and Neuroembryology Kanazawa University 13-1 Takara-Machi Kanazawa 920-8420Japan

AIM： To clarify the innervation of human gallbladder,with special reference to morphological understanding of gallstone formation after gastrectomy.METHODS： The liver, gallbladder and surrounding structures were immersed in a 10 mg/L solution of alizarin red S in ethanol to stain the peripheral nerves in cadavers （n = 10）. Innervation in the areas was completely dissected under a binocular microscope. Similarly,innervation in the same areas of 10 Suncus murinus （S. murinus） was examined employing whole mount immunohistochemistry.RESULTS： Innervation of the gallbladder occurred predominantly through two routes. One was from the anterior hepatic plexus, the innervation occurred along the cystic arteries and duct. Invariably this route passed through the hepatoduodenal ligament. The other route was from the posterior hepatic plexus, the innervation occurred along the cystic duct ventrally. This route also passed through the hepatoduodenal ligament *** results were obtained in S. murinus.CONCLUSION： The route from the anterior hepatic plexus via the cystic artery and/or duct is crucial for preserving gallbladder innervation. Lymph node dissection specifically in the hepatoduodenal ligament may affect the incidence of gallstones after ***, the route from the posterior hepatic plexus via the common bile duct and the cystic duct to the gallbladder should not be disregarded. Preservation of the plexus may attenuate the incidence of gallstone formation after gastrectomy.

关键词： Innervation Gallstone Hepatoduodenalligament Gastrectomy Whole mount immunohistochemistry

Short-term effects of di-（2-ethylhexyl） phthalate on testes,liver, kidneys and pancreas in mice

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Asian Journal of Andrology 2007年第2期9卷 199-205页

作者： Yumi Miura Munekazu Naito Maira Ablake Hayato terayama Shuang-Qin Yi Ning Qu Lin-Xian Cheng Shigeru Suna Fumihiko Jitsunari Masahiro Itoh Department of Anatomy Tokyo Medical University Tokyo 160-8402 Japan Department of Histology and Embryology Xin Jiang Medical University Xinjiang 830001 China Department of Hygiene and Public Health Faculty of Medicine Kagawa University Kagawa 761-0783 Japan

Aim： To determine the biochemical effect of di-（2-ethylhexyl） phthalate （DEHP） on testes, liver, kidneys and pancreas on day 10 in the process of degeneration of the seminiferous epithelium. Methods： Diets containing 2% DEHP were given to male Crlj：CDI（ICR） mice for 10 days. The dose of DEHP was 0.90±0.52 mg/mouse/day. Their testes, livers, kidneys and pancreata were examined for detection of mono-（2-ethylhexyl） phthalate （MEHP）, nitrogen oxides （NOx） produced by peroxidation of nitric oxide （NO） with free radicals, and lipid peroxidation induced by the chain reaction of free radicals. Results： Histological observation and serum analysis showed the presence of severe sperrnatogenic disturbance, Leydig cell dysfunction, liver dysfunction and dehydration. Unexpectedly, the concentration of MEHP in the testes was extremely low compared with that in the liver. However, the concentration of the NOx in the testes was as high as the hepatic concentration. Furthermore, free radical-induced lipid peroxidation was histochemically detected in the testes but not in the liver. Conclusion： The results indicate that DEHP-induced aspermatogenesis is caused by the high sensitivity of the testicular tissues to MEHP rather than the specific accumulation or uptake of circulating MEHP into the testes.

关键词： phthalatc nitrogen oxide free radical testis

Deep-learning-based quality filtering of mechanically exfoliated 2D crystals

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npj Computational Materials 2019年第1期5卷 57-62页

作者： Yu Saito Kento Shin Kei terayama Shaan Desai Masaru Onga Yuji Nakagawa Yuki M.Itahashi Yoshihiro Iwasa Makoto Yamada Koji Tsuda RIKEN Center for Advanced Intelligence Project(AIP) Tokyo 103-0027Japan Department of Computational Biology and Medical Sciences Graduate School of Frontier SciencesThe University of TokyoKashiwa 277-8561Japan Graduate School of Medicine Kyoto UniversityKyoto 606-8501Japan Quantum-Phase Electronics Center(QPEC)and Department of Applied Physics The University of TokyoTokyo 113-8656Japan RIKEN Center for Emergent Matter Science(CEMS) Wako 351-0198Japan Department of Intelligence Science and Technology Kyoto UniversityKyoto 606-8501Japan PRESTO Japan Science and Technology Agency(JST)4-1-8HonchoKawaguchi-shiSaitama 332-0012Japan National Institute for Materials Science(NIMS) Center for Materials Research by Information IntegrationTsukuba 305-0047Japan California NanoSystems Institute University of California at Santa BarbaraSanta BarbaraCA 93106USA

Two-dimensional(2D)crystals are attracting growing interest in various research fields such as engineering,physics,chemistry,pharmacy,and biology owing to their low dimensionality and dramatic change of properties compared to the bulk counter *** the various techniques used to manufacture 2D crystals,mechanical exfoliation has been essential to practical applications and fundamental ***,mechanically exfoliated crystals on substrates contain relatively thick flakes that must be found and removed manually,limiting high-throughput manufacturing of atomic 2D crystals and van der Waals ***,we present a deep-learning-based method to segment and identify the thickness of atomic layer flakes from optical microscopy *** carefully designing a neural network based on U-Net,we found that our neural network based on Unet trained only with the data based on realistically small number of images successfully distinguish monolayer and bilayer MoS2 and graphene with a success rate of 70–80%,which is a practical value in the first screening process for choosing monolayer and bilayer flakes of all flakes on substrates without human *** remarkable results highlight the possibility that a large fraction of manual laboratory work can be replaced by AI-based systems,boosting productivity.

关键词： crystals filtering attracting

Optimal resection of gastric bronchogenic cysts based on anatomical continuity with adherent gastric muscular layer: A case report

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World Journal of Gastrointestinal Surgery 2023年第6期15卷 1216-1223页

作者： Masayoshi terayama Koshi Kumagai Hiroshi Kawachi Rie Makuuchi Masaru Hayami Satoshi Ida Manabu Ohashi Takeshi Sano Souya Nunobe Department of Gastroenterological Surgery Gastroenterological CenterCancer Institute HospitalJapanese Foundation for Cancer ResearchTokyo 135-8550Japan Department of Pathology Cancer Institute HospitalJapanese Foundation for Cancer ResearchTokyo 135-8550Japan

BACKGROUND Bronchogenic cysts are congenital lesions requiring radical resection because of malignant ***,a method for the optimal resection of these cysts has not been completely *** SUMMARY Herein,we presented three patients with bronchogenic cysts that were located adjacent to the gastric wall and resected *** cysts were detected incidentally with no symptoms and the preoperative diagnosis was challenging to obtain via radiological *** on laparoscopic findings,the cyst was attached firmly to the gastric wall and the boundary between the gastric and cyst walls was difficult to ***,resection of cysts alone caused cystic wall injury in Patient ***,the cyst was resected completely along with a part of the gastric wall in Patient *** examination revealed the final diagnosis of bronchogenic cyst and revealed that the cyst wall shared the muscular layer with the gastric wall in Patients 1 and *** Patient 3,the cyst was located adjacent to the gastric wall but histopathologically originated from diaphragm rather than *** the patients were free from *** The findings of this study state that a safe and complete resection of bronchogenic cysts required the adherent gastric muscular layer or full-thickness dissection,if bronchogenic cysts are suspected via pre-and/or intraoperative findings.

关键词： Bronchogenic cysts Laparoscopic resection Gastric wall Muscular layer Case report

Surgical anatomy of the innervation of pylorus in human and Suncus murinus, in relation to surgical technique for pylorus-preserving pancreaticoduodenectomy

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World Journal of Gastroenterology 2006年第14期12卷 2209-2216页

作者： Shuang-Qin Yi Fei Ru Tetsuo Ohta Hayato terayama Munekazu Naito Shogo Hayashi Sichen Buhe Nozomi Yi Takayoshi Miyaki Shigenori Tanaka Masahiro Itoh Department of Anatomy Tokyo Medical University 6-1-1 Shinjuku Shinjuku-ku Tokyo 160-8402 Japan Department of Medicine Johns Hopkins Medical Institutions 600 North Wolfe Street Baltimore Maryland 21287 United States Department of Gastroenterologic Surgery Kanaza- wa University 13-1 Takara-Machi Kanazawa 920-8420 Japan Department of Anatomy and Neuroembryology Kanazawa University 13-1 Takara-Machi Kanazawa 920-8420 Japan

AIM： To clarify the innervation of the antro-pyloric region in humans from a clinico-anatomical perspective. METHODS： The stomach, duodenum and surrounding structures were dissected in 10 cadavers, and immersed in a 10mg/L solution of alizarin red S in ethanol to stain the peripheral nerves. The distribution details were studied to confirm innervations in the above areas using a binocular microscope. Similarly, innervations in 10 Suncus murinus were examined using the method of whole-mount imm unohistochemistry. RESULTS： The innervation of the pyloric region in humans involved three routes： One arose from the anterior hepatic plexus via the route of the suprapyloric/supraduodenal branch of the right gastric artery; the second arose from the anterior and posterior gastric divisions, and the third originated from the posterior-lower region of the pyloric region, which passed via the infrapyloric artery or retroduodenal branches and was related to the gastroduodenal artery and right gastroepiploic artery. For Suncus murinus, results similar to those in humans were observed. CONCLUSION： There are three routes of innervation of the pyloric region in humans, wherein the route of the right gastric artery is most important for preserving pyloric region innervation. Function will be preserved by more than 80% by preserving the artery in pylorus-preserving pancreaticoduodenectomy （PPPD）. However, the route of the infrapyloric artery should not be disregarded. This route is related to several arteries （the right gastroepiploic and gastroduodenal arteries）, and the preserving of these arteries is advantageous for preserving pyloric innervation in PPPD. Concurrently, the nerves of Latarjet also play an important role in maintaining innervation of the antro-pyloric region in PPPD. This is why pyloric function is not damaged in some patients when the right gastric artery is dissected or damaged in PPPD.

关键词： Innervation Quality of life Pylorus-preserving pancreaticoduodenectomy Suncus murinus Whole mount immunohistochemistry