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Natural Products and Antiviral Resistance

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Advances in Microbiology 2024年第7期14卷 366-388页

作者： Erute magdalene Adongbede Janak Raj Khatiwada Rishipal Rastrapal Bansode Leonard Lamont Williams Department of Botany University of Lagos Lagos Nigeria Center for Excellence in Post-Harvest Technologies North Carolina A & T State University Kannapolis North Carolina USA

Viral diseases are minacious with the potential for causing pandemics and treatment is complicated because of their inherent ability to mutate and become resistant to drugs. Antiviral drug resistance is a persistent problem that needs continuous attention by scientists, medical professionals, and government agencies. To solve the problem, an in-depth understanding of the intricate interplay between causes of antiviral drug resistance and potential new drugs specifically natural products is imperative in the interest and safety of public health. This review delves into natural product as reservoir for antiviral agents with the peculiar potentials for addressing the complexities associated with multi-drug resistant and emerging viral strains. An evaluation of the mechanisms underlying antiviral drug activity, antiviral drug resistance is addressed, with emphasis on production of broad-spectrum antiviral agents from natural sources. There is a need for continued natural product-based research, identification of new species and novel compounds.

关键词： Drug Resistance Resistance Mechanisms Phytochemicals Broad-Spectrum Drugs Antiviral Agents

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Coinfection with Malaria in Selected States in Nigeria

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Advances in Infectious Diseases 2024年第2期14卷 442-455页

作者： Oluwagbemiga Olanrewaju Aina Olufemi Samuel Amoo Kazeem Adewale Osuolale Adewale Kayode Ojogbede Azuka Patrick Okwuraiwe David Ayoola Oladele Adesola Zaidat Musa Tajudeen Akanji Bamidele Celestina Onyinye Okoyenta Abideen Olurotimi Salako Toyosi Yekeen Raheem Ifeoma Eugenia Idigbe Fehintola Anthonia Ige Joseph Ojonugwa Shaibu Gregory Aigbe Ohihoin Kikelomo Wright Bisola Adebayo Hussein Abdu-Razzaq Abdulrahman Ahmad Mustapha Imam Bashir Bello Tambuwal Muhammad Shuaibu Gobir Richard Ikwuogu Christian Tetsola Gloria Patrick-Ferife Nathaniel Enamuotor Mildred Okowa William Nwachukwu Cornelius Ohonsi magdalene Egede Chinwe Ochu Ehimario Igumbor Oliver Chukwujekwu Ezechi Babatunde Lawal Salako Rosemary Ajuma Audu Biochemistry and Nutrition Department Nigerian Institute of Medical Research Lagos Nigeria Centre for Human Virology and Genomics Microbiology Department Nigerian Institute of Medical Research Lagos Nigeria Monitoring and Evaluation Unit Nigerian Institute of Medical Research Lagos Nigeria Public Health and Epidemiology Department Nigerian Institute of Medical Research Lagos Nigeria Clinical Sciences Department Nigerian Institute of Medical Research Lagos Nigeria Molecular Biology and Biotechnology Department Nigerian Institute of Medical Research Lagos Nigeria Department of Community Health & Primary Health Care Lagos State University College of Medicine Lagos State University Teaching Hospital Lagos Nigeria Research Unit Lagos State Ministry of Health Lagos Nigeria Sokoto State Ministry of Health Sokoto Nigeria Department of Medical Biochemistry Usmanu Danfodiyo University Sokoto Nigeria Centre for Advanced Medical Research and Training Usmanu Danfodiyo University Sokoto Nigeria Delta State Ministry of Health Asaba Nigeria Nigeria Centre for Disease Control Abuja Nigeria Center for Infectious Disease Research Nigerian Institute of Medical Research Lagos Nigeria

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Plasmodium species are the causative agents of coronavirus disease 2019 (COVID-19) and malaria respectively with similar clinical presentations. The objective of this study is to determine the burden of co-infection of SARS-CoV-2 and malaria in the general population. Five (5 mLs) of blood samples were collected for SARS-CoV-2 and malaria parasite test. The malaria test was performed using a commercially available one-step malaria antigen Plasmodium falciparum histidine-rich protein 2 (Pf HRP-II) rapid test kit. The results of the study showed that the participants that were coinfected with SARS-CoV-2 IgG and malaria were 13 (2.5%) in Lagos, 1114 (39.1%) in Delta and 49 (2.3%) in Sokoto States. The prevalence of coinfection of SARS-CoV-2 and malaria in urban areas in Lagos, Delta and Sokoto States were 7 (2.2%), 1373 (48.1%), and 5 (0.2%) respectively. In rural areas, the prevalence of coinfection of SARS-CoV-2 and malaria in Lagos, Delta and Sokoto States were 6 (0.3%), 365 (12.8%), and 44 (2.1%) respectively in this study. This suggests that participants in the urban areas were more prone to co-infections than the rural areas in Lagos and Delta states, while it was otherwise in Sokoto State. In conclusion, the co-infection of SARS-CoV-2 and malaria was very high in Delta State compared to the other States. It is important for clinics to screen for both diseases when patients present with symptoms of malaria. This is because the infections have similar symptoms and the public is quick to assume malaria infection without diagnosing for COVID-19 and vice versa.

关键词： SARS-CoV-2 Malaria Coinfection

Double Tragedy: Examining the Effects of Mental Health Stigma on Help Seeking Behaviour among Deaf People in Ghana

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Open Journal of Psychiatry 2023年第3期13卷 153-174页

作者： Juventus Duorinaah Wisdom Kwadwo Mprah Lyla Adwan-Kamara magdalene Mawugbe Ghana National Association of the Deaf Accra Ghana Department of Health Promotion and Disability Studies Kwame Nkrumah University of Science and Technology Kumasi Ghana Ghana Somubi Dwumadie (Ghana Participation Programme) Accra Ghana

Background: Globally, mental health is recognized as one of the major public health issues, and mental health stigma is one of the main barriers to mental healthcare. While several studies have been conducted on the stigma associated with mental health, very little is known about the mental health stigma experienced by deaf persons with mental health conditions in Ghana. This study examines the experiences of double stigmatization by deaf people with mental health conditions in Ghana. Methodology: A descriptive, mixed method data collection was used for seventy-nine (79) participants. The paper presents findings from the only qualitative component of the study. Results: The findings from the study showed that deaf people with mental illness experienced double stigma, namely being stigmatized for being deaf and for having mental illness. This hindered access to mental health services for deaf people with mental health condition. Conclusion: Deaf people with mental health conditions experience double stigmatization which discourages them from seeking professional psychiatric care. This implies that efforts to reduce mental health stigma and create awareness on deafness should be improved upon. It is recommended that, in view of the impact of stigma on the provision and use of mental health care services, strategies to improve access to mental health care, should seriously consider concerns about stigma.

关键词： Accessibility Deaf People Mental Health Interventions Stigma

Outcomes of early hospital readmission after kidney transplantation: Perspectives from a Canadian transplant centre

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World Journal of Transplantation 2023年第6期13卷 357-367页

作者： Olusegun Famure Esther DKim Yanhong Li Johnny WHuang Roman Zyla magdalene Au Pei XuanChen Heebah Sultan Monika Ashwin Michelle Minkovich S Joseph Kim Department of Nephrology Kidney TransplantToronto General HospitalToronto M5G 2N2OntarioCanada Department of Kidney Transplant Toronto General HospitalToronto M5G 2N2OntarioCanada

BACKGROUND Early hospital readmissions(EHRs)after kidney transplantation range in incidence from 18%-47%and are important and substantial healthcare quality *** can adversely impact clinical outcomes such as graft function and patient mortality as well as healthcare *** have been extensively studied in American healthcare systems,but these associations have not been explored within a Canadian *** to significant differences in the delivery of healthcare and patient outcomes,results from American studies cannot be readily applicable to Canadian populations.A better understanding of EHR can facilitate improved discharge planning and long-term outpatient management post kidney *** To explore the burden of EHR on kidney transplant recipients(KTRs)and the Canadian healthcare system in a large transplant *** This single centre cohort study included 1564 KTRs recruited from January 1,2009 to December 31,2017,with a 1-year *** defined EHR as hospitalizations within 30 d or 90 d of transplant discharge,excluding elective *** Cox and linear regression models were used to examine EHR,late hospital readmissions(defined as hospitalizations within 31-365 d for 30-d EHR and within 91-365 d for 90-d EHR),and outcomes including graft function and patient *** In this study,307(22.4%)and 394(29.6%)KTRs had 30-d and 90-d EHRs,*** such as having previous cases of rejection,being transplanted in more recent years,having a longer duration of dialysis pretransplant,and having an expanded criteria donor were associated with EHR *** cumulative probability of death censored graft failure,as well as total graft failure,was higher among the 90-d EHR group as compared to patients with no *** multivariable models found no significant association between EHR and patient mortality,patients with EHR were at an increased risk of late hospital readmissions,poorer kidney fun

关键词： Kidney Transplantation Early hospital readmissions Incidence and trends Post-transplant outcomes

Hidden heterogeneity and its influence on dengue vaccination impact

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Infectious Disease Modelling 2020年第1期5卷 783-797页

作者： magdalene Walters T.Alex Perkins Department of Biological Sciences and Eck Institute for Global Health University of Notre DameNotre DameIN46556USA

The CYD-TDV vaccine was recently developed to combat dengue,a mosquito-borne viral disease that afflicts millions of people each year throughout the tropical and subtropical *** rollout has been complicated by recent findings that vaccinees with no prior exposure to dengue virus(DENV)experience an elevated risk of severe disease in response to their first DENV infection subsequent to *** a result of these findings,guidelines for use of CYD-TDV now require serological screening prior to vaccination to establish that an individual does not fall into this high-risk *** complications mean that the public health impact of CYD-TDV vaccination is expected to be higher in areas with higher *** important practical difficulty with tailoring vaccination policy to local transmission contexts is that DENV transmission is spatially heterogeneous,even at the scale of neighborhoods or blocks within a *** raises the question of whether models based on data that average over spatial heterogeneity in transmission could fail to capture important aspects of CYD-TDV impact in spatially heterogeneous *** explored this question with a deterministic model of DENV transmission and CYD-TDV vaccination in a population comprised of two communities with differing transmission *** to the full model,a version of the model based on the average of the two communities failed to capture benefits of targeting the intervention to the high-transmission community,which resulted in greater impact in both communities than we observed under even *** addition,the model based on the average of the two communities substantially overestimated impact among vaccinated individuals in the low-transmission *** the event that the specificity of serological screening is not high,this result suggests that models that ignore spatial heterogeneity could overlook the potential for harm to this segment of the population.

关键词： Dengue Vector borne disease Dengvaxia CYD-TDV Computational modeling SIR R Spatial heterogeneity

Future Science Prize goes to non-invasive prenatal testing

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Science China(Life Sciences) 2017年第4期60卷 429-431页

作者： Kang Li Yaou Duan magdalene Yin Lin Ting Zhiying Ou Li Liu Kang Zhang Xin Fu Molecular Medicine Research Center Department of Ophthalmology West China Hospital Sichuan University Sichuan 610041 China Guangzhou Elite Health Biological Pharmaceutical Technology Company Ltd. Guangzhou 510005 China Institute for Genomic Medicine and Shiley Eye Institute University of California San Diego La JoUa CA 92328 USA Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou 510623 China

The Future Forum,a non-profit organization established last year in Beijing,announced that pathologist Dennis Ming Yuk Lo from the Chinese University of Hong Kong won the life sciences Future Science Prize for the discovery of fetal cell-free DNA(cfDNA)in maternal plasma in 1997(Lo et al.,1997).By detecting male fetus-derived Y sequences in maternal plasma,Lo et *** proved the presence of fetal cfDNA in maternal plasma and serum(Lo et al.,1997).This discovery has opened up a tremendous breadth of

关键词： Future Science Prize goes to non-invasive prenatal testing

Apoptosis in Retinal Degeneration—Recent Developments

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Open Journal of Apoptosis 2014年第1期3卷 1-3页

作者： magdalene J. Seiler Anatomy & Neurobiology UC Irvine School of Medicine Irvine USA

Apoptosis in Retinal Degeneration—Recent

关键词： Apoptosis

政府透明度与社交在加强公民信任不同层面中的运用：来自加纳的经验证

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政府透明度与社交在加强公民信任不同层面中的运用：来自加纳的经...

作者： magdalene Zeinab Akosua Adams 中国科学技术大学

学位级别：硕士

政府的透明度吸引了来自不同层面的大量研究,透明度质量和背景得到改善。通过加纳的理论亮点和分析调查,这项研究有助于持续辩论透明度,并进一步评估政府如何建立对加纳公民的信任,以信任他们的日常运作。通过研究总结了文献中的概念,... 详细信息

政府的透明度吸引了来自不同层面的大量研究,透明度质量和背景得到改善。通过加纳的理论亮点和分析调查,这项研究有助于持续辩论透明度,并进一步评估政府如何建立对加纳公民的信任,以信任他们的日常运作。通过研究总结了文献中的概念,提出了六个不同的维度,以促进透明度指标,解决公共问责制,服务提供,城乡发展,政府效率和社交媒体使用等领域的透明度提升问题。信息披露。但是,提供的维度在提供公民和政府信息的潜在用户需要听取的信息,增强对公民的服务以及影响公民信任方面得到了令人满意的解决。此外,来自加纳的实证结果验证了所提出的模型的准确性,并根据公民在拟议区域内鼓励加强的频率来检查这些变量的变化。实证结果支持了我们的假设,并表明在每个方面都有很好的尺寸和可接受的负荷。对分析的调查结果显示,社会媒体利用各方面与公民沟通,以影响对政府的信任,这是一个重要的预测。该研究表明,大多数公民更愿意选择通过社交媒体在政府中使用的方式,来信息来覆盖大多数公民。

关键词：政府透明度政府效力公民信任社交媒体使用加纳

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视网膜移植后结构和功能的重建

视网膜移植后结构和功能的重建