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Perspectives of DNA microarray and next-generation DNA sequencing technologies

Science china(Life Sciences) 2009年第1期52卷 7-16页

作者： teng xiaokun1 & xiao huasheng1,2 1 national engineering center for biochip at shanghai,shanghai 2.12.3,china 2 shanghai-most key laboratory of health and disease genomics,chinese national human genome center,shanghai 2.12.3,china national engineering center for biochip at shanghai Shanghai 201203 China shanghai-most key laboratory of health and disease genomics Chinese National Human Genome Center Shanghai 201203 China

DNA microarray and next-generation DNA sequencing technologies are important tools for high-throughput genome research,in revealing both the structural and functional characteristics of *** the past decade the DNA microarray technologies have been widely applied in the studies of functional genomics,systems biology and *** next-generation DNA sequencing method was first introduced by the 454 Company in 2003,immediately followed by the establishment of the Solexa and Solid techniques by other biotech *** it has not been long since the first emergence of this technology,with the fast and impressive improvement,the application of this technology has extended to almost all fields of genomics research,as a rival challenging the existing DNA microarray *** paper briefly reviews the working principles of these two technologies as well as their application and perspectives in genome research.

关键词： DNA microarray next generation DNA sequencing genome

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genome-wide Analysis of Smad Targets Reveals the Role of BMP Signaling in Embryonic Stem Cell Fate Determination

Genome-wide Analysis of Smad Targets Reveals the Role of BMP...

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第十一次中国生物物理学术大会暨第九届全国会员代表大会

作者： teng Fei 1# ,Kai Xia 2# ,Zhang Chen 2 ,Hua Chen 1 ,Zhongwei Li 1 ,Jianping Zhang 1 ,Bing Zhou 2 ,huasheng xiao 3 ,Jing-Dong J.Han 2* ,Ye-Guang Chen 1* 1The State key laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology,Tsinghua University,Beijing 100084,china 2CAS key laboratory of Molecular Developmental Biology and center for Molecular Systems Biology,Institute of Genetics and Developmental Biology,the chinese Academy of Sciences,Beijing 100101,china 3national engineering center for biochip at shanghai,Zhangjiang Hi-Tech Park, shanghai,2.12.3,china

＜正＞Embryonic stem（ES）cells are under precise control of both intrinsic self-renewal gene regulatory network and extrinsic growth factor-triggered signaling *** external

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Different developmental potential of pluripotent stem cells generated by different reprogramming strategies

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分子细胞生物学报:英文版 2011年第3期3卷 197-199页

作者： Jing Jiang Guohui Ding Jiangwei Lin Man Zhang Linyu Shi Wenjian Lv Hui Yang huasheng xiao Gang Pei Yixue Li Jiarui Wu Jinsong Li laboratory of Molecular Cell Biology Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China key laboratory of Systems Biology Shanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China national engineering center for biochip at shanghai Zhangjiang Hi-Tech ParkShanghai 201203China shanghai key laboratory of Signaling and disease Research School of Life Sciences and TechnologyTongji UniversityShanghai 200092China State key laboratory of Molecular Biology Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China

Dear Editor,Recent studies show that induced pluripotent stem cells(iPSCs)generated through ectopic expression of transcription factors retain an epigenetic memory of their original somatic cells(Kim et al.,2010;Polo et al.,2010)or aberrant silencing of a single imprinted gene cluster(Liu et al.,2010;Stadtfeld et al.,2010),which affects their developmental and differentiation potentials.

关键词： programming potential

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genome-wide Analysis of Smad Targets Reveals the Role of BMP Signaling in Embryonic Stem Cell Fate Determination

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生物物理学报 2009年第S1期25卷 28-28页

作者： teng Fei Kai Xia Zhang Chen Hua Chen Zhongwei Li Jianping Zhang Bing Zhou huasheng xiao Jing-Dong JHan Ye-Guang Chen The State key laboratory of Biomembrane and Membrane Biotechnology Department of Biological Sciences and BiotechnologyTsinghua UniversityBeijing 100084China CAS key laboratory of Molecular Developmental Biology and center for Molecular Systems Biology Institute of Genetics and Developmental Biologythe Chinese Academy of SciencesBeijing 100101China national engineering center for biochip at shanghai Zhangjiang Hi-Tech ParkShanghai201203China

Embryonic stem (ES) cells are under precise control of both intrinsic self-renewal gene regulatory network and extrinsic growth factor-triggered signaling cascades.

关键词： genome-wide Analysis of Smad Targets Reveals the Role of BMP Signaling in Embryonic Stem Cell Fate Determination BMP

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