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中华内分泌代谢杂志 2009年第3期25卷 278-279页

作者：李玉姝于晓会滕晓春关海霞范晨玲单忠艳滕卫平中国医科大学附属第一医院内分泌科暨内分泌研究所沈阳110001

从转基因小鼠分离表达主要组织相容性复合体（MHC）Ⅱ类分子的甲状腺细胞与小鼠自身T细胞共同培养，结果甲状腺细胞未能刺激T细胞的增殖和活化，相反，促进了自身CD4^＋T细胞凋亡。

关键词：甲状腺细胞主要组织相容性复合体Ⅱ类分子 T淋巴细胞

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小鼠甲状腺球蛋白的提取、纯化和鉴定

中国现代医学杂志 2007年第12期17卷 1467-1469页

作者：滕晓春贾秀坤范晨玲王红郭锐滕卫平中国医科大学附属第一医院内分泌科辽宁沈阳110001 中国医科大学实验技术中心一部辽宁沈阳110001

目的进行小鼠甲状腺球蛋白的纯化和鉴定。方法小鼠甲状腺组织匀浆后进行盐析和Sphadex G-200凝胶层析2次纯化,纯化后的蛋白质产物经十二烷基磺酸钠—聚丙烯酰胺凝胶电泳(SDS-PAGE)和Western免疫印迹鉴定。结果经纯化的蛋白产物为高纯度... 详细信息

目的进行小鼠甲状腺球蛋白的纯化和鉴定。方法小鼠甲状腺组织匀浆后进行盐析和Sphadex G-200凝胶层析2次纯化,纯化后的蛋白质产物经十二烷基磺酸钠—聚丙烯酰胺凝胶电泳(SDS-PAGE)和Western免疫印迹鉴定。结果经纯化的蛋白产物为高纯度的甲状腺球蛋白。结论Sphadex G-200凝胶层析和Western免疫印迹是进行甲状腺球蛋白纯化和鉴定的一种较好的方法。

关键词：小鼠甲状腺球蛋白纯化免疫印迹

Prediction of fracture initiation in cohesive soils based on data mining modelling and large-scale laboratory verification

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Underground Space 2024年第6期19卷 279-300页

作者： Weiping Luo Dajun Yuan Yannick Choy Hing Ng Dalong Jin Ping Lu teng Wang Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai 200092China Key Laboratory of the Ministry of Education for Urban Underground Engineering Beijing Jiaotong UniversityBeijing 100044China Department of Civil and Environmental Engineering National University of SingaporeSingapore 119077Singapore

Many empirical and analytical methods have been proposed to predict fracturing pressure in cohesive *** of them take into account three to four specific influencing factors and rely on the assumption of a failure *** this study,a novel data-mining approach based on the XGBoost algorithm is investigated for predicting fracture initiation in cohesive *** has the advantage of handling multiple influencing factors simultaneously,without pre-determining a failure mode.A dataset of 416 samples consisting of 14 distinct features was herein collected from past studies,and used for developing a regressor and a classifier model for fracturing pressure prediction and failure mode classification *** results show that the intrinsic characteristics of the soil govern the failure mode while the fracturing pressure is more sensitive to the stress *** XGBoost-based model was also tested against conventional approaches,as well as a similar machine learning algorithm namely random forest ***,several large-scale triaxial fracturing tests and an in-situ case study were carried out to further verify the generalization ability and applicability of the proposed data mining approach,and the results indicate a superior performance of the XGBoost model.

关键词： Fracturing pressure Failure mode Cohesive soil Data-mining Large-scale tests

TRβ基因M442T点突变所致甲状腺激素抵抗综合征1例报告

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中国实用内科杂志 2016年第1期36卷 84-86页

作者：滕晓春金婷王冉冉张涵袆何雪单忠艳滕卫平中国医科大学附属第一医院内分泌与代谢病科内分泌研究所辽宁省内分泌疾病重点实验室辽宁沈阳110001

甲状腺激素抵抗综合征（RTH）是由于甲状腺激素受体（TR）基因突变，导致靶器官对甲状腺激素（TH）的敏感性降低，使得TH对全身组织器官作用障碍的一种罕见综合征。根据突变受体亚型不同，分为TRα基因突变致RTH（RTHd）和TRB基因突变致... 详细信息

甲状腺激素抵抗综合征（RTH）是由于甲状腺激素受体（TR）基因突变，导致靶器官对甲状腺激素（TH）的敏感性降低，使得TH对全身组织器官作用障碍的一种罕见综合征。根据突变受体亚型不同，分为TRα基因突变致RTH（RTHd）和TRB基因突变致RTH（RTHB）。

关键词：甲状腺激素抵抗甲状腺激素受体β 基因突变

Dynamic characteristics of nonlinear vibration isolator for gas turbine

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International Journal of Mechanical System Dynamics 2024年第3期4卷 374-383页

作者： teng Wang Linhan Feng Lei Zhang chunhui Zhang Yue Wu Naval Research Institute BeijingChina

In this study,a theoretical model of the vibration isolation system of the gas turbine is developed and numerically solved.A simplified finite element(FE)model was also established to determine the response under the shock *** results of the FE model are used to verify the effectiveness of the theoretical model and the numerical *** influence of isolator stiffness,vibration isolator damping,and vibration isolator nonlinear stiffness coefficient on the shock response of the vibration isolation system is studied using the controlled-variable *** parameters(stiffness,damping,and nonlinear coefficient)enter into the shock resistance design of gas turbine vibration isolators.

关键词： gas turbine vibration isolator theoretical model damping dynamic characteristics

Experimental and Three-Dimensional Numerical Simulation of Phenomena Induced by Submerged Oblique Jet Scouring

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Fluid Dynamics & Materials Processing 2024年第8期20卷 1799-1821页

作者： Hao Chen Xianbin teng Faxin Zhu Zhibin Zhang Jie Wang School of Naval Architecture and Maritime Zhejiang Ocean UniversityZhoushan316022China School of Marine Engineering Guangzhou Maritime UniversityGuangzhou510725China

Scouring experiments were conducted using a three-dimensional laser scanning technology for angles of the jet spanning the interval from 0°to 30°,and the characteristics of the scour hole in equilibrium conditions were investigated *** results indicate that the optimal scouring effects occur when the jet angle is in the ranges between 15°and 20°.Moreover,the dimensionless profiles of the scour hole exhibit a high degree of similarity at different jet *** simulations conducted using the Flow-3D software to investigate the bed shear stress along the jet impingement surface have shown that this stress is influenced by both the resultant force and the jet impingement surface *** reaches its maximum value when the jet is vertical,decreases rapidly as the jet starts to tilt,then increases slightly,and decreases again significantly when the angle exceeds 20°.

关键词： Submerged jet jet angle experimental study numerical simulation bed shear stress

MAVEN observation of magnetosonic waves in the Martian magnetotail region

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Earth and Planetary Physics 2024年第2期8卷 317-325页

作者： Shangchun teng JiCheng Sun JiaWei Gao Y.Harada Markus Fraenz DeSheng Han State Key Laboratory of Marine Geology School of Ocean and Earth ScienceTongji UniversityShanghai 200092China MNR Key Laboratory for Polar Science Polar Research Institute of ChinaShanghai 200136China Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Department of Geophysics Kyoto UniversityKyotoJapan Max-Planck-Institute for Solar System Research GoettingenGermany

Magnetosonic waves are an important medium for energy transfer in collisionless space *** waves have been widely investigated in the upstream of the bow shock at *** waves are believed to originate from pickup ions or reflected *** utilizing MAVEN spacecraft data,we have observed the occurrence of quasi-perpendicularly propagating magnetosonic emissions near the proton gyrofrequency in the Martian magnetotail *** plasma waves are associated with a significant enhancement of proton and oxygen *** excited magnetosonic waves could possibly heat the protons through resonance and facilitate the ionospheric plasma *** results could be helpful to better understand the Mars’magnetospheric dynamics and offer insights into possible energy redistribution between waves and plasma in the Martian nightside magnetosphere.

关键词： Martian magnetotail region magnetosonic waves proton escape

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辽宁地区代谢综合征的患病率及城乡差异

中华内分泌代谢杂志 2010年第3期26卷 209-210页

作者：刘赫单忠艳滕晓春赖亚新陈彦彦中国医科大学附属第一医院内分泌科沈阳110001

采用多阶段分层整群随机抽样方法调查辽宁地区18岁以上3431人。按照中华医学会糖尿病分会2004年的标准，代谢综合征（MS）的患病率为19．50％（男性19．79％，女性18．44％）。女性患病率农村〉城镇〉城市；同等收入水平MS患病率男女均... 详细信息

采用多阶段分层整群随机抽样方法调查辽宁地区18岁以上3431人。按照中华医学会糖尿病分会2004年的标准，代谢综合征（MS）的患病率为19．50％（男性19．79％，女性18．44％）。女性患病率农村〉城镇〉城市；同等收入水平MS患病率男女均农村〉城镇〉城市。辽宁地区MS的患病率高发正转向发展中的贫穷地区。

关键词：辽宁地区性别经济状况代谢综合征患病率

水-空气耦合介质中冰载荷对闸墩的撞击影响研究

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工程力学 2024年第6期41卷 177-187页

作者：贡力杨腾腾靳春玲贾治元董洲全兰州交通大学土木工程学院甘肃兰州730070 兰州交通大学调水工程及输水安全研究所甘肃兰州730070

西北干寒地区长距离输水工程中河道修建的闸墩受到冰载荷撞击破坏,为确保冬季安全稳定供水,需进行冰载荷对闸墩撞击破坏力学特性研究。该文采用任意拉格朗日-欧拉(arbitrary Lagrangian-Eulerian, ALE)流固耦合(fluid structure interac... 详细信息

西北干寒地区长距离输水工程中河道修建的闸墩受到冰载荷撞击破坏,为确保冬季安全稳定供水,需进行冰载荷对闸墩撞击破坏力学特性研究。该文采用任意拉格朗日-欧拉(arbitrary Lagrangian-Eulerian, ALE)流固耦合(fluid structure interaction, FSI)方法模拟不同碰撞工况下冰体楔入闸墩碰撞过程,并通过对比实验,验证了冰材料模型参数和ALE算法的适用性,分析了网格尺寸对撞击力的影响。研究结果表明:计算得到冰载荷对闸墩撞击力极值与实验值具有良好的吻合性,表明该模拟所采用的冰材料模型参数、ALE算法和网格尺寸能够较准确模拟冰载荷对闸墩的作用力;闸墩损伤变形与冰排破损主要集中在碰撞接触区,接触区撞击力大小受到“水垫效应”的影响,空气介质对撞击力影响较小;不同冰厚和冰速工况下撞击力时程曲线呈现“Sawtooth”(上下波动)现象,撞击力加载-卸载时间较短;冰排楔入闸墩的过程中,撞击力极值出现在0°正碰接触区,在冰速1.2 m/s~3.0 m/s范围内,撞击力逐渐减小,在不改变冰速工况下,随着冰厚的增加,墩体结构响应越大,冰速和冰厚两种影响工况下闸墩顶端位移均为周期性振动。其仿真结果拟为西北干寒地区冰期河道中墩体结构安全提供指导。

关键词：数值模拟流固耦合任意拉格朗日-欧拉冰载荷撞击力闸墩

NHE-1反义基因对胃癌细胞的酸化作用及其意义

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第三军医大学学报 2007年第3期29卷 240-242页

作者：滕小春刘海峰房殿春杨仕明王国安陈刚第三军医大学西南医院全军消化内科中心重庆400038 武警总医院消化内科北京100039

目的探讨Na+-H+交换泵-1(Na+-H+exchanger1,NHE-1)反义基因转染对人胃癌细胞内pH值(intracellu-larpH,pHi)的调节作用及其在肿瘤基因治疗中的价值。方法构建人NHE-1基因反义真核表达载体,采用脂质体法将其转染至SGC-7901胃癌细胞中,采... 详细信息

目的探讨Na+-H+交换泵-1(Na+-H+exchanger1,NHE-1)反义基因转染对人胃癌细胞内pH值(intracellu-larpH,pHi)的调节作用及其在肿瘤基因治疗中的价值。方法构建人NHE-1基因反义真核表达载体,采用脂质体法将其转染至SGC-7901胃癌细胞中,采用荧光探针检测转染前后细胞内pH值的变化以及对细胞增殖和凋亡的影响。结果转染反义基因的细胞pHi明显降低,增殖能力降低,细胞凋亡率增加。结论NHE-1基因的表达在肿瘤细胞pHi及增殖和凋亡调节中起重要作用。

关键词： NHE1基因真核表达载体反义基因治疗胃癌