检索结果-南通市图书馆

A novel mutation of CYP4V2 gene associated with Bietti crystalline dystrophy complicated by choroidal neovascularization

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2022年第6期15卷 940-946页

作者： Xin-Yao Han Lin-Qi Zhang Ji-Yang tang Lyu-Zhen Huang ran tang Jin-Feng Qu Department of Ophthalmology Peking University People’s HospitalEye Diseases and Optometry InstituteBeijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid DiseasesCollege of OptometryPeking University Health Science CenterBeijing 100044China

AIM: To investigate the clinical characteristics and genetic features of a Bietti crystalline dystrophy(BCD) proband in a Chinese ***: A Chinese female diagnosed with BCD complicated by bilateral choroidal neovascularization(CNV) and her parents underwent complete ophthalmic examinations, including fundus autofluorescence(AF), fundus photography(FP), fundus fluorescein angiography(FFA), visual field testing, full-field electroretinography(ERG), optical coherence tomography(OCT) and optical coherence tomography angiography(OCTA). The sequencing of the CYP4 V2 gene was performed to the whole ***: Bilateral tiny glittering crystal-like deposits and differing extent of atrophy of the retinal pigment epithelium(RPE) were found in the posterior pole of her fundus. The diffuse hypo-fluorescence shown on AF images and window defects shown on FFA both indicated the atrophy of the RPE and choriocapillaris. OCT showed the thinning of the RPE and choriocapillaris layer, ellipsoid zone(EZ) band defect and CNV in both eyes. OCTA images proofed bilateral type 2 CNV. The visual field test showed central and paracentral scotoma. ERG showed a slightly decreased b-wave in scotopic ERG. Gene sequencing identified three mutations of the CYP4 V2 gene, c.802_807 del, c.810 del T, and c.1388 G>A. The mutation c.1388 G>A was a novel substitution ***: The novel mutation c.1388 G>A may be a possible cause that could induce the clinical phenotype of BCD.

关键词： Bietti crystalline dystrophy retinal degeneration CYP4V2 gene choroidal neovascularization

Semantic-aware entity alignment for low resource language knowledge graph

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Computer Science 2024年第4期18卷 97-106页

作者： Junfei tang ran SONG Yuxin HUANG Shengxiang GAO Zhengtao YU Faculty of Information Engineering and Automation Kunming University of Science and TechnologyKunming 650500China Yunnan Key Laboratory of Artificial Intelligence Kunming University of Science and TechnologyKunming 650500China

Entity alignment(EA)is an important technique aiming to find the same real entity between two different source knowledge graphs(KGs).Current methods typically learn the embedding of entities for EA from the structure of KGs for *** EA models are designed for rich-resource languages,requiring sufficient resources such as a parallel corpus and pre-trained language ***,low-resource language KGs have received less attention,and current models demonstrate poor performance on those low-resource ***,researchers have fused relation information and attributes for entity representations to enhance the entity alignment performance,but the relation semantics are often *** address these issues,we propose a novel Semantic-aware Graph Neural Network(SGNN)for entity ***,we generate pseudo sentences according to the relation triples and produce representations using pre-trained ***,our approach explores semantic information from the connected relations by a graph neural *** model captures expanded feature information from *** results using three low-resource languages demonstrate that our proposed SGNN approach out performs better than state-of-the-art alignment methods on three proposed datasets and three public datasets.

关键词： graph neural network knowledge graph entity alignment low-resource language

A Residual Frequency Offset Estimation Method Based on range Migration Fitting

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Beijing Institute of Technology 2024年第2期33卷 103-110页

作者： Liting Zhang Hao Huan ran Tao Xiaogang tang School of Information and Electronics Beijing Institute of Technology School of Aerospace Information Space Engineering University

Recently, researchers have proposed an emitter localization method based on passive synthetic aperture. However, the unknown residual frequency offset(RFO) between the transmitter and the receiver causes the received Doppler signal to shift, which affects the localization accuracy. To solve this issue, this paper proposes a RFO estimation method based on range migration fitting. Due to the high frequency modulation slope of the linear frequency modulation(LFM)-modulation radar signal, it is not affected by RFO in range compression. Therefore, the azimuth time can be estimated by fitting the peak value position of the pulse compression in range ***, the matched filters are designed under different RFOs. When the zero-Doppler time obtained by the matched filters is consistent with the estimated azimuth time, the given RFO is the real RFO between the transceivers. The simulation results show that the estimation error of azimuth distance does not exceed 20 m when the received signal duration is not less than 3 s, the pulse repetition frequency(PRF) of the transmitter radar signal is not less than 1 k Hz, the range detection is not larger than 1 000 km, and the signal noise ratio(SNR) is not less than –5 d B.

关键词： range migration fitting (RMF) passive localization residual frequency offset (RFO)

A High-Performance MoS_(2)-Based Visible-Near-Infrared Photodetector from Gateless Photogating Effect Induced by Nickel Nanoparticles

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Research 2024年第2期6卷 171-179页

作者： ran Duan Weihong Qi Panke Li Kewei tang Guoliang Ru Weimin Liu State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal MaterialsNorthwestern Polytechnical UniversityXi'an 710072China Shandong Laboratory of Yantai Advanced Materials and Green Manufacturing Yantai 265503China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China

Recent advancements in two-dimensional materials have shown huge potential for optoelectronic *** is challenging to achieve highly effective and sensitive broadband photodetection based on MoS_(2)*** engineering,such as introducing vacancies,can narrow the bandgap and boost the separation of photogenerated carriers by defect states but leads to a slow response ***,we propose a nickel nanoparticle-induced gateless photogating effect with a unique energy band structure to enable the application of defect engineering and achieve high optoelectronic *** device based on Ni nanoparticle-decorated MoS_(2)with S vacancies exhibited high responsivities of 106.21 and 1.38 A W^(-1)and detectivities of 1.9×10^(12)and 8.9×10^(9)Jones under 532 and 980 nm illumination(visible to near infrared),respectively,with highly accelerated response *** strategy provides new insight into optimizing defect engineering to design high-performance optoelectronic devices capable of broadband photodetection.

关键词： defect Infrared illumination

Polymerization of Butyl Methacrylate Catalyzed by Salicylaldehyde-Imine Zirconium/Al(i-Bu)_3 System

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2018年第2期33卷 492-499页

作者：程正载 tang ran 谢聪 WANG Yun DING Ling WANG Handing YAN Xiaochao ZHU Sanyong Gauthier Mario School of Chemisty and Chemical Engineering Wuhan University of Science and Technology Hubei Province Key Laboratory of Coal Conversion And Novel Carbon Materials Chemistry Department University of Florida Hubei Collaboration Innovative Center for Non-Power Nuclear Technology Hubei University of Science and Technology

A new kind of zirconium（Zr） complex containing ligand of salicylaldehyde-imine was successfully synthesized with ZrCl_4·2 THF and salicylaldehyde-imine as raw materials. The ligand was characterized by means of ~1HNMR, IR, and GC-MS, and Zr complex was characterized by means of ~1HNMR and IR, respectively. The Zr complex, combined with co-catalyst of Al（i-Bu）_3, was explored to be effective catalytic system for the polymerization of butyl methacrylate（BMA）, to prepare poly-n-butyl methacrylate（PBMA）, which was characterized by IR, ~13C-NMR and GPC. Compared with other double-component（MAO/Cat, AlEt_3/Cat） catalytic systems, catalytic system of Al（i-Bu）_3 and the Zr complex provided the best catalytic activity under the same conditions. The influence of polymerization parameters, such as molar ratio of Al（i-Bu）_3/Cat and BMA/Cat, polymerization temperature and polymerization time, was studied with Zr complex/Al（i-Bu）_3 system. With increasing polymerization time from 4 to 24 hour, the monomer conversion increased from 40.14% to 96.56%. Viscosity-average molecular weight（M_v） of PBMA, detected by the viscosity methodology, increased from 12.67×10~4Da to 44.97×10~4Da and lower molecular weight distribution was obtained. According to these results, the Zr complex contained ligand of salicylaldehyde-imine was a kind of readily, long lifetime and high activity catalyst for BMA polymerization.

关键词： salicylaldehyde-imine zirconium catalyzed polymerization butyl methacrylate

双靶点嵌合抗原受体-T细胞治疗复发难治多发性骨髓瘤患者疗效和安全性的Meta分析

在线全文

学校读者我要写书评

暂无评论

中国全科医学 2024年第8期27卷 985-994页

作者：于海搏张天宇李新张佳佳申曼詹晓凯汤然范斯斌赵凤仪黄仲夏首都医科大学附属北京朝阳医院血液与肿瘤科北京市100020

背景嵌合抗原受体(CAR)-T细胞免疫疗法已在多发性骨髓瘤(MM)中取得较好的疗效,最常见的靶点为B细胞成熟抗原(BCMA)。单靶点CAR-T细胞免疫疗法的缺点是会导致疾病抵抗和复发,可能与抗原逃逸有关。为此,改进开发了双靶点CAR-T细胞治疗复... 详细信息

背景嵌合抗原受体(CAR)-T细胞免疫疗法已在多发性骨髓瘤(MM)中取得较好的疗效,最常见的靶点为B细胞成熟抗原(BCMA)。单靶点CAR-T细胞免疫疗法的缺点是会导致疾病抵抗和复发,可能与抗原逃逸有关。为此,改进开发了双靶点CAR-T细胞治疗复发难治多发性骨髓瘤(RRMM),此方面尚缺乏系统的临床分析。目的对RRMM患者应用双靶点CAR-T细胞免疫疗法治疗的有效性及安全性进行Meta分析。方法计算机检索PubMed、Embase、Cochrane Library、Web of Science、中国知网、万方数据知识服务平台、维普网7个数据库中有关双靶点CAR-T细胞治疗RRMM的单组率研究,检索时限为建库至2023-02-06。由2名研究人员使用自制的数据表单来提取收集数据,并采用非随机对照试验方法学评价指标进行文献质量评价。采用R Studio软件进行数据分析。结果共纳入9篇文献,包括200例既往接受过多线治疗的RRMM患者。双靶点CAR-T细胞疗法根据不同靶点可分为4类:BCMA+CD19、BCMA+CD38,BCMA+跨膜剂与钙调节亲环素配体的相互作用者(TACI)、BCMA+人信号淋巴细胞激活分子家族成员7(CS1),其中BCMA+CD19靶点的研究较多。根据输注形式不同CAR-T细胞疗法可分为4类:双特异性CAR-T细胞、联合或序贯输注两种不同CAR-T细胞、双顺反子结构、共转导。Meta分析显示,双靶点CAR-T细胞治疗RRMM的总缓解率(ORR)为90.0%(95%CI=0.849~0.943),完全缓解率(CRR)为54.6%(95%CI=0.416~0.673),微小残留病(MRD)阴性率为75.6%(95%CI=0.489~0.952),髓外病变(EMD)总缓解率为55.1%(95%CI=0.234~0.851),最后一次随访时的复发率为29.7%(95%CI=0.141~0.454),最后一次随访时的生存率为75.6%(95%CI=0.554~0.915),3~4级细胞释放因子综合征(CRS)发生率为16.4%(95%CI=0.094~0.245),神经毒性(ICANS)发生率为4.0%(95%CI=0~0.120)。敏感性分析提示结果稳定。Egger's检验结果显示,ORR(P=0.03)及EMD总缓解率(P=0.02)提示存在一定的偏倚风险;CRR(P=0.53)、MRD阴性率(P=0.79)、最后一次随访时的复发率(P=0.71)、生存率(P=0.98)、3~4级CRS发生率(P=0.90)、ICANS发生率(P=0.30)提示不存在发表偏倚。结论双靶点CAR-T细胞免疫治疗RRMM显示出良好的疗效和安全性,未来需要多中心、大样本、更长随访期的研究来进一步评估其疗效和安全性。

关键词：多发性骨髓瘤复发难治多发性骨髓瘤双靶点CAR-T细胞免疫疗法 Meta分析

Chilling rather than photoperiod controls budburst for gymnosperm species in subtropical China

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Journal of Plant Ecology 2022年第1期15卷 100-110页

作者： Yuan-Qi Pan Xiu Zeng Wen-De Chen Xin-ran tang Kui Dai Yan-Jun Du Xi-Qiang Song College of Tourism and Urban-Rural Planning Chengdu University of TechnologyChengdu 610059China College of Tropical Crops Hainan UniversityHaikou 570228China Key Laboratory of Genetics and Germplasm Innovation of Tropical Special Forest Trees and Ornamental Plants(Ministry of Education) College of ForestryHainan UniversityHaikou 570228China

The mechanisms regulating spring phenology have been extensively studied in angiosperm ***,given that gymnosperms and angiosperms diverged 300 million years ago,phenology may be triggered by different cues in gymnosperm *** regulatory mechanisms of phenology in subtropical regions remain largely *** combination,it remains untested whether subtropical gymnosperm species have chilling requirements and are *** conducted a climate chamber experiment with three chilling and three photoperiod treatments to investigate budburst during an 8-week forcing *** tested whether budburst of eight gymnosperms species(Cryptomeria japonica,Cunninghamia lanceolata,Cupressus funebris,Ginkgo biloba,Metasequoia glyptostroboides,Pinus massoniana,Pseudolarix amabilis and Podocarpus macrophyllus)was photoperiod sensitive or has strong chilling requirements and whether photoperiod or chilling was more important for advancing *** advanced budburst and increased the percentage of budburst for gymnosperm *** species required moderate chilling days to advance ***,the forcing requirement for gymnosperm species was higher than that for angiosperms in the same forest,suggesting that gymnosperms may need more cumulative forcing to initiate budburst than do *** with temperate gymnosperm species in Germany(194-600℃days),the subtropical species studied here had a much higher forcing requirement(814-1150℃days).The effects of photoperiod were minor,suggesting that chilling outweighs photoperiod in advancing budburst of gymnosperm species in this subtropical *** results reveal that increased winter temperatures with continued global warming may impact not only angiosperms but also gymnosperms,leading to their delayed spring budburst.

关键词： chilling requirement climate change forcing requirement Gutianshan spring phenology twig cutting experiment

Synthesis and Characterization of Novel Hydrolytically Degradable Polyesters

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2023年第2期38卷 467-473页

作者： SUN Xin CHENG Zhengzai DJOUONKEP Lesly Dasilva Wandji LAN Chupeng JIA Ruyan ZENG Sheng CHENG Junpeng tang ran LI Yi YUAN Beibei GAUTHLLER Mario Research Institute of Fine Organic Chemicals&Organic Materials at School of Chemistry and Chemical Engineering Wuhan University of Science and TechnologyWuhan430081China Coal Conversion and New Carbon Materials Hubei Key Laboratory Wuhan University of Science and TechnologyWuhan430081China Yidu High-tech Industrial Park Management Committee Yichang443000China Department of Chemistry University of WaterlooWaterlooOntarioN2L 3G1Canada

Six novel hydrolytically degradable polyesters were synthesized from thiodipropionic acid(TDPA)and five diols by melt polycondensation,and characterized by FT-IR,1H NMR,gel permeation chromatography,differential scanning calorimetry and thermogravimetry *** polystyrene-equivalent number-average(Mn)and weight-average molecular weight(Mw)of these polyesters ranged from 4900-11100 Da and 7900-20879 Da,respectively,with PDI values of *** melting point varied from 62.3-127.9℃,and the 50%mass-loss temperature ranged between 387-417℃.The degradation of these polyesters was studied in terms of relative weight loss in distilled water at different *** losses of 14%-26%were obtained at pH 7.0,26%-38%at pH 6.0,and 32%-43%at pH 8.3 over a 20-week *** ecotoxicity study suggested that safety of the synthesized polyesters for the eisenia *** results indicate that these polyesters have a combination of good thermal and degradability behaviors,which can be tailored through selection of the diol monomers used in the synthesis.

关键词： thiodipropionic acid water-degradable polyester melt polycondensation thermal properties degradability tailoring

在线全文

学校读者我要写书评

暂无评论

红层及其地质灾害研究

岩石力学与工程学报 2023年第1期42卷 28-50页

作者：许强唐然成都理工大学、地质灾害防治与地质环境保护国家重点实验室四川成都610059 成都大学建筑与土木工程学院四川成都610106 成都大学、非饱和土力学特性及工程技术四川省高校工程研究中心四川成都610106

红层是指各地质历史时期沉积的红色岩系的总称,是典型的“易滑地层”,在强降雨过程中很容易产生群发性地质灾害。通过总结国内外红层发育分布和主要特性研究成果发现,红层的性质受控于沉积建造,红层岩石物理力学性质和水理性质等都与其... 详细信息

红层是指各地质历史时期沉积的红色岩系的总称,是典型的“易滑地层”,在强降雨过程中很容易产生群发性地质灾害。通过总结国内外红层发育分布和主要特性研究成果发现,红层的性质受控于沉积建造,红层岩石物理力学性质和水理性质等都与其沉积环境密切相关。红层岩石具有较强的流变性和较强的亲水性,遇水易膨胀、崩解、泥化和软化。分析、总结了红层地区的主要地质灾害类型,重点介绍砂泥岩互层地区平推式滑坡和平缓浅层土质滑坡的成因机制。结果表明,降雨过程中雨水快速进入砂岩中的竖向裂缝形成的静水压力是平推式滑坡的主要驱动力,同时地下水对砂泥岩接触界面或软弱夹层的长期泥化和饱水软化使底滑面强度大幅降低,也是导致大型平推式滑坡发生的主要原因。另外,砂泥岩互层特殊的岩性组合形成的特殊斜坡水文地质条件也是滑坡易发的重要原因。平缓红层区坡残积层中存在大气影响深度和基覆界面存在界面效应,是导致强降雨期间群发性浅层土质滑坡发生的主要原因,并由此决定了滑体的厚度。最后探讨了红层地质灾害的风险防控措施,认为通过数学力学分析结合现场观测与室内试验,建立物理预警模型,是红层滑坡预警的有效途径。而红层地区滑坡则应坚持以排水为主、抗滑支档为辅的治理原则。

关键词：边坡工程红层地质灾害成因机制平推式滑坡浅层土质滑坡风险防控