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Novel SNP markers on ginsenosides biosynthesis functional gene for authentication of ginseng herbs and commercial products

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Chinese Journal of Natural Medicines 2020年第10期18卷 770-778页

作者： WU Wen-Ru CHENG Chun-Song CHENG Qi-Qing LAO Chi-Chou CUI Hao tang zi-yu OUYANG yue LIU Liang ZHOU Hua State Key Laboratory of Quality Research in Chinese Medicine Faculty of Chinese MedicineMacao University o f Science and TechnologyMacao 999078China School of Chinese Pharmaceutical Sciences Guangzhou University of Chinese MedicineGuangzhou 510006China Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China Macao University of Science and TechnologyMacao 999078China

Panax ginseng and Panax quinquefolius have similar bioactive components and morphological characteristics, but they are known to have different medicinal values, high-sensitive and accurate method is expected to identify the sources of ginseng products and evaluate the quality, but with a huge challenge. Our established UHPLC-TOF/MS method coupled with orthogonal partial least squares discriminant analysis(OPLS-DA) model based on 18 ginsenosides was applied to discriminate the sources of raw medicinal materials in ginseng products, and nested PCR strategy was used to discover 6 novel single nucleotide polymorphism(SNP)sites in functional dammarenediol synthase(DS) gene for genetic authentication of P. ginseng and P. quinquefolius for the first ***-DA model could identify the sources of raw ginseng materials are real or not. SNP markers were applied to identify ginseng fresh samples as well as commercial products, and proved to be successful. This established molecular method can tell exact source information of adulterants, and it was highly sensitive and specific even when total DNA amount was only 0.1 ng and the adulteration was as low as 1%. Therefore, this study made an attempt at the exploration of new type SNP marker for variety authentication and function regulation at the same time, and the combination of chemical and molecular discrimination methods provided the comprehensive evaluation and authentication for the sources of ginseng herbs and products.

关键词： Panax ginseng Panax quinquefolius UHPLC-TOF/MS Dammarenediol synthase Nested PCR SNP

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Characteristic Analysis of Power Oscillations Caused by Disharmony Among Voltage-source-controlled Units in Three-terminal Local Power Grid

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Journal of Modern Power Systems and Clean Energy 2024年第4期12卷 1295-1308页

作者： Qiyi yu Yi tang School of Electrical Engineering Southeast UniversityNanjing 210018China

Previous studies have demonstrated that disharmo-ny among voltage-source-controlled units(VSCUs)may occur on an alternating current(AC)transmission or distribution line under steady-state operating conditions(SSOCs)or quasi-static operating conditions(QSSOCs).As the studies on frequency dis-harmony have been expanded to multiple disharmonized vS-CUs in the local power grid,its adverse effects on AC lines and equivalent load(EL)at the bus without active voltage control ability(non-active bus)need to be investigated ***-ering the locality of disharmony and common topological con-nections among VSCUs,this paper adopts a Y-type three-termi-nal local power grid(LPG)as the research *** dishar-mony among the three VSCUs is ***,for the load at non-active bus,the formulas for single-phase instantaneous voltage,load current,load power,as well as average power un-der disharmony operating conditions(DOCs)are *** characteristic indicators of the above electrical quantities are defined,which can measure the amplification and reduction de-grees of the above electrical quantities before and after ***,for the line directly connected to VSCUs,the formulas for single-phase instantaneous line current and power and the average power under DOCs are *** character-istic indicators of power flow are defined,which can be used to quantify the peak amplification impact of oscillation before and after ***,the case study on the Y-type three-terminal LPG under the single-disharmony and the multi-dis-harmony switching scenarios indicates that the long-period pow-er oscillation caused by disharmony may occur in the load flow at the non-active bus and the line *** oscillation causes a serious decrease in load capability and a significant amplifica-tion of the peak of line power oscillation.

关键词： New power system power oscillation disharmony voltage-source-controlled unit(VSCU) characteristic analysis

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Data-driven modeling on anisotropic mechanical behavior of brain tissue with internal pressure

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Defence Technology（防务技术） 2024年第3期33卷 55-65页

作者： Zhiyuan tang yu Wang Khalil I.Elkhodary Zefeng yu Shan tang Dan Peng State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentDalian University of Technology116023DalianPR China The Department of Mechanical Engineering The American University in CairoNew Cairo11835Egypt Department of Neurology The Second Hospital of Dalian Medical UniversityDalian116023PR China

Brain tissue is one of the softest parts of the human body,composed of white matter and grey *** mechanical behavior of the brain tissue plays an essential role in regulating brain morphology and brain ***,traumatic brain injury(TBI)and various brain diseases are also greatly influenced by the brain's mechanical *** white matter or grey matter,brain tissue contains multiscale structures composed of neurons,glial cells,fibers,blood vessels,etc.,each with different mechanical *** such,brain tissue exhibits complex mechanical behavior,usually with strong nonlinearity,heterogeneity,and directional *** a constitutive law for multiscale brain tissue using traditional function-based approaches can be very ***,this paper proposes a data-driven approach to establish the desired mechanical model of brain *** focus on blood vessels with internal pressure embedded in a white or grey matter matrix material to demonstrate our *** matrix is described by an isotropic or anisotropic nonlinear elastic model.A representative unit cell(RUC)with blood vessels is built,which is used to generate the stress-strain data under different internal blood pressure and various proportional displacement loading *** generated stress-strain data is then used to train a mechanical law using artificial neural networks to predict the macroscopic mechanical response of brain tissue under different internal ***,the trained material model is implemented into finite element software to predict the mechanical behavior of a whole brain under intracranial pressure and distributed body *** with a direct numerical simulation that employs a reference material model,our proposed approach greatly reduces the computational cost and improves modeling *** predictions made by our trained model demonstrate sufficient ***,we find that the level of internal blood pressur

关键词： Data driven Constitutive law Anisotropy Brain tissue Internal pressure

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Cronkhite-Canada syndrome with esophagus involvement and sixyear follow-up:A case report

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World Journal of Gastroenterology 2024年第8期30卷 984-990页

作者： yu-Chen tang Department of Endocrinology The First Affiliated Hospital of Ningbo UniversityNingbo 315000Zhejiang ProvinceChina

BACKGROUND Cronkhite-Canada syndrome(CCS)is a rare,noninherited disease characterized by gastrointestinal polyposis with diarrhea and ectodermal *** polyps are distributed through the whole digestive tract,and they are common in the stomach and colon but very uncommon in the *** SUMMARY Here,we present a case of a 63-year-old man with skin hyperpigmentation accompanied by diarrhea,alopecia,and loss of his *** data indicated anemia,hypoalbuminemia,hypocalcemia,hypokalemia,and positive fecal occult *** showed numerous polyps scattered throughout the digestive tract,including the *** was treated with nutritional support and glucocorticoids with remission of his *** Comprehensive treatment led by hormonal therapy can result in partial or full remission of clinical *** should be individualized for each patient according to their therapy *** endoscopy is necessary for assessing mucosal disease activity and detecting malignant transformation.

关键词： Cronkhite-Canada syndrome Gastrointestinal polyposis Hormonal therapy Prognosis Case report

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Inheritance of the exciton geometric structure from Bloch electrons in two-dimensional layered semiconductors

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Frontiers of physics 2024年第4期19卷 25-35页

作者： Jianju tang Songlei Wang Hongyi yu Guangdong Provincial Key Laboratory of Quantum Metrology and Sensing&School of Physics and Astronomy Sun Yat-sen University(Zhuhai Campus)Zhuhai 519082China State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat-sen University(Guangzhou Campus)Guangzhou 510275China

We theoretically studied the exciton geometric structure in layered semiconducting transition metal *** on a three-orbital tight-binding model for Bloch electrons which incorporates their geometric structures,an effective exciton Hamiltonian is constructed and solved perturbatively to reveal the relation between the exciton and its electron/hole *** show that the electron−hole Coulomb interaction gives rise to a non-trivial inheritance of the exciton geometric structure from Bloch electrons,which manifests as a valley-dependent center-of-mass anomalous Hall velocity of the exciton when two external fields are applied on the electron and hole constituents,*** obtained center-of-mass anomalous velocity is found to exhibit a non-trivial dependence on the fields,as well as the wave function and valley index of the *** findings can serve as a general guide for the field-control of the valley-dependent exciton transport,enabling the design of novel quantum optoelectronic and valleytronic devices.

关键词： transition metal dichalcogenides exciton geometric structure Berry curvature van der Waals stacking

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A Numerical Calculation Algorithm of the Inclination Function Based on the Representation of SO(3) Group

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 137-148页

作者： yu-xiao Wei Wen-lin tang Department of Geophysics School of Geology Engineering and GeomaticsChang’An UniversityXi’an710064China Key Laboratory of Electronics and Information Technology for Space Systems National Space Science CenterChinese Academy of SciencesBeijing100190China

In the determination of the Earth gravity field in satellite geodesy, the inclination functions represent the projection of data observed along the orbital plane of a satellite orbit into the sphere in the terrestial reference frame. The inclination functions in this work is studied from a group theoretical perspective. The inclination functions are proved to generate a representation of the SO(3) group. An orthogonal relation of the inclination functions is derived and some recurrence relations for the inclination functions are given, based on which an algorithm to calculate the inclination functions is proposed.

关键词： SO(3)group inclination function satellite geodesy representation of SO(3)

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Antiviral treatment standards for hepatitis B:An urgent need for expansion

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World Journal of Gastroenterology 2024年第4期30卷 418-420页

作者： zi-Hong Bao Zhi-Kun Dai Hao-Xian tang Department of Infectious Diseases The First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Medical College Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of Cardiology The First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The present letter to the editor is related to the review with the title“Past,present,and future of long-term treatment for hepatitis B virus.”Chronic hepatitis B(CHB)represents an important and pressing public health *** identification and effective antiviral therapy hold the potential to reduce liver-related mortality attributable to chronic infection with hepatitis B virus(HBV)***,the current global treatment rates for CHB remain conspicuously low,with the excessively stringent treatment criteria advocated by national CHB guidelines being a contributing factor to these low ***,recent strides in comprehending this malady and the emergence of novel antiviral agents prompt the imperative re-evaluation of treatment standards to extend the sphere of potential *** impending need arises for a novel paradigm for the classification of patients with CHB,the expansion of antiviral treatment eligibility for HBV-infected individuals,and even the streamlining of the diagnostic process for CHB to amplify cost-effectiveness and augment survival prospects.

关键词： Hepatitis B virus Chronic hepatitis B Antiviral treatment criteria Serum alanine aminotransferase Liver-related mortality Letter to the Editor

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A flat-foldable equiangular spiral folding pattern inspired by sunflowers for deployable structures

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Chinese Journal of Aeronautics 2024年第6期37卷 425-438页

作者： Shuangqing yu Jinguo LIU Pengyuan ZHAO Yingying tang State Key Laboratory of Robotics Shenyang Institute of AutomationChinese Academy of SciencesShenyang 110016China Institutes for Robotics and Intelligent Manufacturing Chinese Academy of SciencesShenyang 110169China University of Chinese Academy of Sciences Beijing 100049China

Flasher origami pattern has been widely utilized to improve the stowage efficiency of deployable ***,flasher origami cannot be folded fully flat,and they still have great potential for optimization in terms of storage volume and folding *** this paper,a flat foldable equiangular spiral folding pattern inspired by the sunflower disk is ***,a parametric design method for this equiangular spiral crease diagram is introduced in ***,a kinematic model of the equiangular spiral folding pattern is established based on the kinematic equivalence between rigid origami and spherical linkages.A simulation of the developed model demonstrates that the equiangular spiral folding pattern can be folded *** the folded ratio as an evaluation index,the calculated results and experiments show that the equiangular spiral crease pattern can yield fewer creases and improve stowage efficiency in comparison to flasher origami *** spiral folding pattern can save a considerable amount of space and provide a new approach to spatially deployable structures.

关键词： Flasher origami Sunflower-inspired Deployable structures Flat-foldability Equiangular spiral folding pattern

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Photo-induced grease/oil switched lubricant for friction regulation

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Friction 2024年第8期12卷 1696-1706页

作者： Zheng ZHANG Shuangxi tang Liran MA yu TIAN State Key Laboratory of Tribology in Advanced Equipment Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China

Controllable friction regulation has drawn much interest in both scientific and industrial *** there have been many researches on friction regulation by many physical fields and chemical ***-sensitive materials are promising because it is relatively easy to change their properties compared with ***,a new kind of photo-induced grease/oil switched lubricant is designed and shows great reversibility under ultraviolet(UV)and visible(Vis)*** viscosity can change more than 50 times under different irradiation,and the coefficients of friction(COFs)obviously increase under Vis irradiation and decrease under UV irradiation,which performs better than those of the common *** to the experimental results,the phenomena are contributed to the break and reconstruction of the three-dimensional network inside the *** a switchable grease/oil state under different irradiation,this work provides a new principle for designing a smart lubricant with controllable friction regulation.

关键词： photo-induced spiropyran switched lubricant friction regulation

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Capillary Property of Entangled Porous Metallic Wire materials and Its Application in Fluid Buffers:Theoretical Analysis and Experimental Study

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Defence Technology（防务技术） 2024年第1期31卷 400-416页

作者： yu tang Yiwan Wu Hu Cheng Rong Liu Engineering Research Center for Metal Rubber School of Mechanical Engineering and AutomationFuzhou UniversityFuzhou 350156China AECC Guizhou Liyang Aviation Power Co. LTDGuiyang 550014China College of Computer and Information Sciences Fujian Agriculture and Forestry UniversityFuzhou 350156China

Strong impact does serious harm to the military industries so it is necessary to choose reasonable cushioning material and design effective buffers to prevent the impact of *** on the capillary property entangled porous metallic wire materials(EPMWM),this paper designed a composite buffer which uses EPMWM and viscous fluid as cushioning materials under the low-speed impact of the recoil force device of weapon equipment(such as artillery,mortar,etc.).Combined with the capillary model,porosity,hydraulic diameter,maximum pore diameter and pore distribution were used to characterize the pore structure characteristics of *** calculation model of the damping force of the composite buffer was *** low-speed impact test of the composite buffer was *** parameters of the buffer under low-speed impact were identified according to the model,and the nonlinear model of damping force was *** test results show that the composite buffer with EPMWM and viscous fluid can absorb the impact energy from the recoil movement effectively,and provide a new method for the buffer design of weapon equipment(such as artillery,mortar,etc.).

关键词： Entangled porous metallic wire materials Capillary property Viscousfluid Low-speed impact Damping force

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