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A short review of the genes involved in the development and progression of colorectal cancer

BIOCELL 2021年第3期45卷 483-487页

作者： AMAYNA ZAKARIA SYED ABDULLAH IBN ASADUZZAMAN ZOBAYDA NAHAR HAFSA JARIN SNIGDHA taskina murshed RASHED NOOR Department of Life Sciences School of Environment and Life SciencesIndependent UniversityBangladesh(IUB)Dhaka1229Bangladesh

The extent and aggression of colorectal cancer is a worldwide public health *** research has been conducted on the pre-requisites leading to this fatal *** array of genes along with their mutations and the signal transduction pathways leading to the cellular transformation into the cancerous cells have been *** on the knowledge gained so far,present review shortly discussed the role of the major genes especially those are involved in instigating abnormalities in the cellular cycles,cellular proliferation and differentiation.A simple but novel molecular scheme of the colorectal cancer development has also been plotted.

关键词： Colorectal cancer Genes Signal transduction pathways

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Chondroitin sulfate and glucosamine combination in patients with knee and hip osteoarthritis:A long-term observational study in Russia

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World Journal of Orthopedics 2023年第6期14卷 443-457页

作者： Alexander M Lila Lyudmila I Alekseeva Andrey A Baranov Elena A taskina Natalya G Kashevarova Natalia A Lapkina Evgeny A Trofimov Director Research Institute of Rheumatology Named after VA NasonovaMoscow 115522MoscowRussia Bone and Joints Metabolic Diseases Laboratory Research Institute of Rheumatology Named after VA NasonovaMoscow 115522MoscowRussia Department of Therapy Clinical Laboratory Diagnostics and Medical BiochemistryYaroslavl State Medical UniversityYaroslavl 150000YaroslavlRussia Department of Therapy and Rheumatology North-Western State Medical University named after I.I.MechnikovSt.Petersburg 191015St.PetersburgRussia

BACKGROUND Oral treatment of glucosamine(GA) combined with chondroitin sulfate(CS) was reportedly effective for pain relief and function improvement in osteoarthritis patients with moderate to severe knee pain in clinical trials. While the effectiveness of GA and CS on both clinical and radiological findings has been demonstrated, only a few high-quality trials exist. Therefore, controversy regarding their effectiveness in real-world clinical practice *** To investigate the impact of GA + CS on clinical outcomes of patients with knee and hip osteoarthritis in routine clinical *** A multicenter prospective observational cohort study included 1102 patients of both genders with knee or hip osteoarthritis(Kellgren & Lawrence grades Ⅰ-Ⅲ) in 51 clinical centers in the Russian Federation from November 20, 2017, to March 20,2020, who had started to receive oral capsules of glucosamine hydrochloride 500 mg and CS 400mg according to the approved patient information leaflet starting from 3 capsules daily for 3 wk,followed by a reduced dosage of 2 capsules daily before study inclusion(minimal recommended treatment duration is 3-6 mo). Changes in subscale scores [Pain, Symptoms, Function, and Quality of Life(QOL)] of the Knee Injury and Osteoarthritis Outcome Score(KOOS)/Hip Disability and Osteoarthritis Outcome Score(HOOS) questionnaires during the observational period(up to 54-64wk with a total of 4 visits). Patients’ treatment satisfaction, data on the combined oral use of glucosamine hydrochloride and CS, concomitant use of non-steroidal anti-inflammatory drugs(NSAIDs), and adverse events(AEs) were also *** A total of 1102 patients with knee and hip osteoarthritis were included in the study. The mean patient age was 60.4 years, most patients were women(87.8%), and their average body mass index was 29.49 kg/m2. All subscale scores(Pain, Symptoms, Function, and QOL) of the KOOS and HOOS demonstrated clinically and statistically significant im

关键词： Glucosamine Chondroitin sulfate Knee osteoarthritis Hip osteoarthritis Knee injury and osteoarthritis outcome score Hip disability and osteoarthritis outcome score

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