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“三师共管”模式对社区高血压性心脏病的管理效果

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潍坊医学院学报 2023年第3期45卷 189-191页

作者：牟鸿宽邱宗玉刘爱强陶宇昊郑世良潍坊医学院附属医院全科医学科山东潍坊261031

目的探讨“三师共管”模式对社区高血压性心脏病的管理效果。方法选择2020年10月~2020年12月在潍坊市奎文区大虞社区确诊的高血压性心脏病患者为研究对象,随机分为实验组和对照组。实验组采用“三师共管”模式,对照组采用常规管理。每... 详细信息

目的探讨“三师共管”模式对社区高血压性心脏病的管理效果。方法选择2020年10月~2020年12月在潍坊市奎文区大虞社区确诊的高血压性心脏病患者为研究对象,随机分为实验组和对照组。实验组采用“三师共管”模式,对照组采用常规管理。每月随访1次,共12个月。评估两组患者1年后治疗依从性、血压控制率及心血管相关危险指标的变化。结果1年后,实验组治疗依从性和血压控制率显著高于对照组(P<0.01);吸烟率、BMI下降,运动人数增加,降压药联合使用率增加(P<0.05);总胆固醇、低密度脂蛋白降低(P<0.05);心电图和心脏超声结果好转(P<0.05)。结论“三师共管”模式能提高高血压性心脏病患者治疗依从性和血压控制率,降低心血管病发生危险,改善心脏功能。

关键词：高血压高血压性心脏病三师共管心血管危险因素

人乳头瘤病毒16型E6和E7细胞毒性T淋巴细胞表位的预测与筛选

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中华肿瘤防治杂志 2024年第19期31卷 1163-1169页

作者：崔湘杰苏羽豪朱兰芳史磊史荔陶玉芬中国医学科学院医学生物学研究所史荔实验室

目的以人乳头瘤病毒16型（HPV16）E6和E7癌蛋白为靶抗原，通过生物信息学方法及小鼠体内实验，筛选出能被人与鼠主要组织相容性复合体（MHC）共呈递的细胞毒性T淋巴细胞（CTL）优势表位。方法在美国国家生物技术信息中心（NCBI）网站... 详细信息

目的以人乳头瘤病毒16型（HPV16）E6和E7癌蛋白为靶抗原，通过生物信息学方法及小鼠体内实验，筛选出能被人与鼠主要组织相容性复合体（MHC）共呈递的细胞毒性T淋巴细胞（CTL）优势表位。方法在美国国家生物技术信息中心（NCBI）网站上获取HPV16 E6和E7的参考蛋白序列，通过免疫表位数据库（IEDB）网站中的MHC-Ⅰ加工和MHC-Ⅰ结合方法，预测出人类白细胞抗原（HLA）-A*02:01、HLA-A*11:01、HLA-A*24:02限制性和C57BL/6小鼠H-2b限制性的CTL表位，根据评分筛选出两者共同呈递的CTL表位。同时，构建表达HPV16 E6和E7的DNA疫苗（pVAX1-E6E7Com）,免疫小鼠后分离脾淋巴细胞，以预测得到的CTL表位作为抗原，与小鼠脾淋巴细胞共培养40 h后，通过酶联免疫斑点法来评估各CTL表位诱导的特异性T细胞免疫应答的能力。所有实验数据均通过单因素方差分析和Dunnett t检验进行组间比较。结果预测筛选获得10条人鼠共呈递的抗原肽。酶联免疫斑点法检测结果表明，实验组的每种表位均能诱导小鼠淋巴细胞产生特异性免疫应答，与阳性参考肽(E7-49RAHYNIVTF57)相比，实验组中每种表位差异均无统计学意义（均P>0.05）,其中E6-38VYCKQQLL45（175.60±52.88）、E6-49VYDFAFRDL57（202.20±108.50）、E6-86YCYSLYGTTL95（157.00±44.46）和E7-77RTLEDLLMGTL87（162.20±49.35）激发的特异性斑点数比阳性参考肽E7-49RAHYNIVTF57（156.20±97.40）的斑点数量多。结论通过这种生物信息学方法预测和筛选得到的10个CTL表位均具有一定的免疫原性，可作为HPV16型治疗性疫苗的优势候选表位。

关键词：人乳头瘤病毒16型 E6 E7 细胞毒性T淋巴细胞表位

Mechanical properties,thermal conductivity and defect formation energies of samarium immobilization in Gd_(2)Zr_(2)O_(7):First-principles study and irradiation experiment

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Journal of Rare Earths 2023年第3期41卷 422-433,I0004页

作者： yuhao Wang Jiahu Ouyang tao Wei Gui Cao Zhanguo Liu Zhaoying Ding Yujin Wang Yaming Wang Key Laboratory of Advanced Structural-Functional Integration Materials&Green Manufacturing Technology School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin 150001China Nuclear Fuel Cycle Research Theme Australian Nuclear Science and Technology OrganisationLocked Bag 2001Kirrawee DCNSW2232Australia

A density functional theory(DFT)study was employed to investigate the mechanical property,thermal conductivity,Debye temperature,electronic structure and defect chemistry of(Gd_(1-x)Sm_(x))_(2)Zr_(2)O_(7).All the(Gd_(1-x)Sm_(x))_(2)Zr_(2)O_(7) compounds exhibit an excellent structural and mechanical stability(Gd_(0.25)Sm_(0.75))_(2)Zr_(2)O_(7) has the lowest Young’s modulus of 213.7 GPa,the largest Possion’s ratio of 0.292,the lowest Debye temperature of 491.8 K and the lowest thermal *** calculated thermal conductivities of(Gd_(1-x)Sm_(x))_(2)Zr_(2)O_(7) are 1.17-1.21 W/(m·K)by the Clark’s model and 1.32-1.36 W/(m·K)by the Cahall’s model,*** formation energies of O vacancies at 48f site are negative,which increase with the Sm content,however,the formation energies of O vacancies at 8b site are almost *** addition,Sm partly occupying the Gd-site reduces distinctly the formation energies of defects such as A-site vacancies,cation antisite defects,anion Frenkel pairs of oxygen at 8b site and cation interstitials,which suggests that Sm-doped Gd_(2)Zr_(2)O_(7),especially equimolar GdSmZr_(2)O_(7),has a better irradiation *** the 16 MeVTa-ion irradiation at a fluence of 1×10^(14) or 2×10^(14) ions/cm^(2),the crystal structure of GdSmZr_(2)O_(7) transforms from pyrochlore to a defect fluorite without obvious amorphous phase.

关键词： Pyrochlores First-principles calculations Mechanical properties Defect formation energies Ion irradiation Rare earths

Pushing the limits of microwave absorption capability of carbon fiber in fabric design based on genetic algorithm

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Journal of Advanced Ceramics 2023年第2期12卷 329-340页

作者： yuhao LIU Xiaoxiao HUANG Xu YAN Long XIA tao ZHANG Jiahao SUN Yanan LIU Yu ZHOU State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China Beijing Institute of Radio Measurement China Aerospace Science and Industry Corporation LimitedBeijing 100854China School of Materials Science and Engineering Harbin Institute of TechnologyWeihaiWeihai 264209China

The field of electromagnetic wave absorption(EWA)requires the adaptability,tenability,and multifunction of high-performance materials in the *** design and preparation of EWA materials aiming at performance requirements is the latest research ***,a performancedriven strategy for simultaneously coordinating different target performances was proposed to optimize the structure of the periodical long continuous carbon/glass fiber fabric(PCGF)materials through algorithm and *** optimized structure of the PCGF not only improves the impedance matching,but also introduces the induced orientation effect for a high cooperative loss of conductivity,resonance,and periodic *** flexible PCGF shows a broad effective absorption bandwidth(EAB)of 32.7 GHz covering a part of the C-band and the whole X-,Ku-,K-,and Ka-bands with a thickness(d)of only 0.92 mm and a density of 5.6×10^(−4) kg·cm^(−3).This highly designable fabric is promising for the EWA practical application owing to integrating the characteristics of good flexibility,acid and alkali resistance,bending resistance,excellent mechanical properties,and easy large-scale preparation.

关键词： broadband microwave absorption carbon fiber impedance matching periodical long continuous carbon/glass fiber fabric(PCGF) multiple loss mechanism

酸雨类型转变对杉木林地土壤和细根生长的影响

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南京林业大学学报（自然科学版） 2024年第3期48卷 90-98页

作者：丁咏刘鑫张金池王宇浩陈美玲李涛刘孝武周悦湘孙连浩廖艺南京林业大学林草学院、水土保持学院南方现代林业协同创新中心江苏省水土保持与生态修复重点实验室江苏南京210037

【目的】探究酸雨类型转变对杉木细根生长和土壤养分含量的影响,为改善酸雨胁迫地区杉木人工林土壤酸化提供依据。【方法】在江苏南京铜山林场进行了为期1 a的野外模拟酸雨试验,设置了3种酸雨酸度(pH为4.5,3.5和2.5)和3种酸雨类型[硫酸... 详细信息

【目的】探究酸雨类型转变对杉木细根生长和土壤养分含量的影响,为改善酸雨胁迫地区杉木人工林土壤酸化提供依据。【方法】在江苏南京铜山林场进行了为期1 a的野外模拟酸雨试验,设置了3种酸雨酸度(pH为4.5,3.5和2.5)和3种酸雨类型[硫酸型酸雨,SO_(4)^(2-)与NO_(3)^(-)的浓度比(硫氮比)5∶1。混合型酸雨,硫氮比1∶1。硝酸型酸雨,硫氮比1∶5],并设置对照CK(pH为6.6,利用当地自然溪水),共10个试验处理。分别测定酸雨胁迫后杉木林地土壤化学性质、细根生理特性及细根元素含量,利用相关性及结构方程模型分析方法,探究酸雨类型转变对杉木细根生长的直接及间接影响。【结果】随着酸雨pH和硫氮比的降低,杉木细根生物量和根系活力均减少。所有强酸雨处理(pH 2.5)杉木根系的过氧化氢酶活性均低于其他酸雨处理,且当酸雨类型转变为硝酸型酸雨时,过氧化氢酶活性逐渐降低并低于CK;另外,细根镁、铝含量及钙铝比(含量比,下同)和镁铝比在不同的硫氮比处理之间均存在差异。与CK相比,所有酸雨处理均增加了细根钙和铝含量,钾含量随着酸雨胁迫逐渐减少。然而,土壤养分总碳、总氮、碳氮比、总硫、有效磷和速效钾在不同硫氮比和不同pH之间不存在显著差异。通过相关性分析可知:土壤pH与镁铝比、根系生物量和根系活力呈极显著正相关(P<0.01),并且根系生物量与过氧化物酶、过氧化氢酶之间均呈显著正相关(P<0.05),却与铝含量呈极显著负相关(P<0.01)。【结论】酸雨酸度对杉木细根和土壤均有较大影响,酸雨类型对细根的影响要强于土壤。其中,酸雨类型对根系活力和钙铝比均有直接影响。随着硫氮比值的降低,酸雨对杉木细根生长的抑制作用更明显。

关键词：杉木酸雨硫氮比细根生物量土壤养分

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财政紧约下Ⅱ型小城市公交都市建设策略探讨

交通与港航 2024年第4期11卷 40-45页

作者：孙玉浩郑猛钟燕刘涛朱刚郭杜杜新疆大学交通运输工程学院武汉市规划研究院(武汉市交通发展战略发展研究院) 博乐市交通运输局

Ⅱ型小城市在我国城镇化进程中发挥着重要的生力军和基础性作用,同时也面临着人口规模小、财政紧约和基础设施不完善等多重挑战,公共交通发展举步维艰。在资金受限条件下,探讨Ⅱ型小城市如何制定有效的公交都市建设策略,以实现可持续发... 详细信息

Ⅱ型小城市在我国城镇化进程中发挥着重要的生力军和基础性作用,同时也面临着人口规模小、财政紧约和基础设施不完善等多重挑战,公共交通发展举步维艰。在资金受限条件下,探讨Ⅱ型小城市如何制定有效的公交都市建设策略,以实现可持续发展和提高市民出行品质。通过对Ⅱ型小城市公交都市建设现状和面临的挑战进行分析,提出了一系列切实可行的策略,包括以运营为导向优化资源配置、引入多元化的融资渠道以及动态评估响应和公众参与等。研究结果旨在为决策者提供理论依据和实践指导,促进Ⅱ型小城市公交系统的优化升级。

关键词： Ⅱ型小城市财政紧约公交都市建设策略探讨

A tetrahedral framework nucleic acid based multifunctional nanocapsule for tumor prophylactic mRNA vaccination

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Chinese Chemical Letters 2023年第7期34卷 169-175页

作者： yuhao Liu Songhang Li Shiyu Lin Sirong Shi taoran Tian Bowen Zhang tao Zhang Yunfeng Lin State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan University Chengdu 610041China Key Laboratory of Oral Biomedical Research of Zhejiang Province Zhejiang UniversityHangzhou 31000China Guanghua School of Stomatology Guangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhou 510055China

Synthetic antigen-encoding mRNA plays an increasingly significant role in tumor vaccine technology owing to its antigen-specific immune-activation. However, its immune efficacy is challenged by inferior delivery efficiency and demand for suitable adjuvants. Here, we develop a novel mRNA nanovaccine based on a multifunctional nanocapsule, which is a dual-adjuvant formulation composed of cytosine-phosphateguanine motifs loaded tetrahedral framework nucleic acid(CpG-tFNA) and an immunopeptide murine β-defensin 2(mDF2β). This m RNA nanovaccine successfully achieves intracellular delivery, antigen expression and presentation of dendritic cells, and proliferation of antigen-specific T cells. In a tumor prophylactic vaccination model, it exerts an excellent inhibitory effect on lymphoma occurrence through cellular immunity. This mRNA nanovaccine has promising prophylactic applications in tumors and many other diseases.

关键词： Tetrahedral framework nucleic acid(tFNA) RNA nanovaccine Cytosine-phosphate-guanine(CpG)motifs Murineβ-defensin 2(mDF2β) Tumor immunotherapy

Hysteresis-Free, High-Performance Polymer-Dielectric Organic Field-Effect Transistors Enabled by Supercritical Fluid

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Research 2020年第1期2020卷 1079-1088页

作者： yuhao Shi Yingkai Zheng Jialiang Wang Ran Zhao tao Wang Changbin Zhao Kuan-Chang Chang Hong Meng Xinwei Wang School of Advanced Materials Shenzhen Graduate SchoolPeking UniversityShenzhen 518055China School of Electronic and Computer Engineering Shenzhen Graduate SchoolPeking UniversityShenzhen 518055China

Organic field-effect transistors(OFETs)are of the core units in organic electronic circuits,and the performance of OFETs replies critically on the properties of their dielectric *** to the intrinsic flexibility and natural compatibility with other organic components,organic polymers,such as poly(vinyl alcohol)(PVA),have emerged as highly interesting dielectric materials for ***,unsatisfactory issues,such as hysteresis,high subthreshold swing,and low effective carrier mobility,still considerably limit the practical applications of the polymer-dielectric OFETs for high-speed,low-voltage flexible organic *** work develops a new approach of using supercritical CO_(2) fluid(SCCO_(2))treatment on PVA dielectrics to achieve remarkably high-performance polymer-dielectric *** SCCO_(2) treatment is able to completely eliminate the hysteresis in the transfer characteristics of OFETs,and it can also significantly reduce the device subthreshold slope to 0._(2)5 V/dec and enhance the saturation regime carrier mobility to 30.2 cm^(2) V^(-1) s^(-1),of which both the numbers are remarkable for flexible polymer-dielectric *** is further demonstrated that,coupling with an organic light-emitting diode(OLED),the SCCO_(2)-treated OFET is able to function very well under fast switching speed,which indicates that an excellent switching behavior of polymer-dielectric OFETs can be enabled by this SCCO_(2) *** the broad and essential applications of OFETs,we envision that this SCCO_(2) technology will have a very broad spectrum of applications for organic electronics,especially for high refresh rate and low-voltage flexible display devices.

关键词： dielectric hysteresis eliminate

基于离散元方法的RDX-Al颗粒混合数值模拟分析

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爆破器材 2017年第5期46卷 13-17页

作者：李世伟王鹏程王正宏王彩玲赵省向陶宇浩李建良辽宁庆阳特种化工有限公司辽宁庆阳111002 南京理工大学化工学院江苏南京210094 西安近代化学研究所陕西西安710065

基于离散元方法,以旋转筒内RDX-Al二元颗粒体系的搅拌过程为研究对象进行模拟。采用离散元软件(EDEM),首先研究RDX-Al二元颗粒各自随转速的变化趋势,并进一步得出二元颗粒变化率的特点,做出分布上的拟合,得出最吻合模拟试验的函数为指... 详细信息

基于离散元方法,以旋转筒内RDX-Al二元颗粒体系的搅拌过程为研究对象进行模拟。采用离散元软件(EDEM),首先研究RDX-Al二元颗粒各自随转速的变化趋势,并进一步得出二元颗粒变化率的特点,做出分布上的拟合,得出最吻合模拟试验的函数为指数函数。然后,将旋转筒细分为多个单元空间,考察旋转轴与单元空间之间的距离对二元颗粒混合效果的影响。结果表明:单元空间离旋转轴越远,即旋转半径越大,颗粒之间的变化率也就越快,越容易达到均匀状态。最后,考察加入抄板的影响,结果表明:RDX-Al二元颗粒趋于的稳定值分别发生了改变。

关键词：离散元方法二元颗粒变化率抄板