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Metabolic profiling of endogenous bile acids:a novel method to assess hepatoprotective effect of Tanreqing capsule on carbon-tetrachloride-induced liver injury in rats

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Chinese Journal of Natural Medicines 2018年第4期16卷 271-283页

作者： XU Ying ZHONG Ping-Ping tao yan-yan Shanghai Kaibao Pharmaceutical Co. Ltd.Shanghai 201401China School of Pharmacy Shanghai University of Traditional Chinese MedicineShanghai 201203China Institute of Liver Diseases Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai201203China Shanghai Clinical Key Laboratory of Traditional Chinese Medicine Shanghai 201203China

Tanreqing(TRQ), a traditional Chinese medicine(TCM) formula, can alleviate liver injury and improve liver function. Its pharmacological mechanisms of actions are still unclear due to its complex components and multi-target natures. Metabolomic study is an effective approach to investigating drug pharmacological actions, new diagnostic markers, and potential mechanisms of actions. In the present study, a new strategy was used to evaluate the protective effect of TRQ capsule against carbon tetrachloride(CCl_4)-induced hepatotoxicity in rats, by analyzing metabolic profiling of endogenous bile acids(BAs) along with biochemical and histological analyses. BAs concentrations were determined by ultra-performance liquid chromatography coupled with quadrupole mass spectrometry(UPLC-MS). Principal component analysis and partial least squares discriminant analysis were then employed to analyze the UPLC-MS results and compare the hepatoprotective effect of TRQ capsule in different groups at the doses of 0.36, 1.44, and 2.88 g·kg^(-1) body weight, respectively. Moreover, our results suggested that taurocholic acid(TCA) and taurohyodesoxycholic acid(THDCA) were the most important biochemical markers, which were indicative of CCl_4-induced acute hepatic damage and hepatoprotective effect of TRQ capsule. Therefore, this new strategy would be an excellent alternative method for evaluating hepatoprotective effect and proposing potential mechanisms of action for other drugs as well.

关键词： Metabolic profiling Bile acids Hepatoprotective effect Tanreqing capsule UPLC-MS

Salvianolate Reduces Glucose Metabolism Disorders in Dimethylnitrosamine-Induced Cirrhotic Rats

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Chinese Journal of Integrative Medicine 2018年第9期24卷 661-669页

作者： TANG Li-rui tao yan-yan LIU Cheng-hai WANG Hai-nan Institute of Liver Diseases Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai 2201203 China Department of Emergency Medicine Putuo Hospital affiliated to Shanghai University of Traditional Chinese Medicine Shanghai 2200062 China Shanghai Key Laboratory of Traditional Chinese Medicine Shanghai 2201203 China E-Institute of Traditional Chinese Medicine Internal Medicine Shanghai Municipal Education Commission Shanghai 2201203 China China Food and Drug Administration Beijing 2100053 China

Objective： To evaluate the preventive effect of salvianolate （Sal B） on glucose metabolism disorders of dimethylnitrosamine （DMN）-induced cirrhotic rats. Methods： Fiffy-five Wistar rats were randomly divided into a control group （n=10） and a cirrhotic group （n=45） according to a random number table. Liver cirrhosis was induced by intraperitoneal administration of DMN. The cirrhotic rats were divided into model, Sal B and metformin groups （n=15）, respectively. Rats in the model group were given saline, two treatment groups were given Sal B （50 mg/kg）, metformin （150 mg/kg） respectively for 28 consecutive days, while rats in the control group were injected 0.9% saline with same volume of vehicle. Body weight was measured everyday. Insulin sensitivity was determined by euglycemic hyperinsulinemic clamp. Organ index, glucose tolerance test （OGTT）, and fasting plasma glucose （FPG）, fasting insulin （FINS）, hepatic glycogen, hydroxyproline （HYP） and liver function were detected at the end of the treatment. Area under the curve （AUC） for OG3-1 was calculated. Liver and pancreas histology were determined by histopathological examination with hematoxylin and eosin staining （HE）, Sirius Red staining and Masson＇s trichrome staining, respectively. Hepatic expression of α-smooth muscle actin （oL-SMA） and collagen （Col I ） were evaluated by immunohistochemical staining. Results： Compared with the model group, Sal B significantly increased body and liver weight, liver-body ratio, glucose infusion rate （GIR）, FPG, FINS levels and hepatic glycogen at the end of administration （P〈0.05 or P〈0.01）. Meanwhile, Sal B significantly decreased AUC for OGI-I＇, spleen weight, spleen-body ratio, aminotransferase and HYP level （P〈0.05 or P〈0.01）. Sal B was also effective in alleviating necrosis of liver tissue, suppressing fibrosis progression and inhibiting the expression of oL-SMA and Col I in liver. Compared with the metformin group, Sal B had advantages in ameliorating FPG, hepatic glycogen,

关键词： salvianolate fibrosis cirrhosis insulin resistance glycogen metformin

Fouling in offshore areas southeast of the Zhujiang(Pearl)River Delta,the northern South China Sea

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Acta Oceanologica Sinica 2003年第2期22卷 201-212页

作者： yan tao, yan Wenxia, Dong Yu, Liang Guanhe, yan yan, Wang Huajie South China Sea Institute of Oceanology,Chinese Academy of Sciences,Guangzhou 510301,China. Chinese Acad Sci S China Sea Inst Oceanol Guangzhou 510301 Peoples R China

In order to understand the type and extent of marine fouling in offshore areas southeast ofthe Zhujiang (Pearl) River delta, within the period form May 1986 to June 1987, two biological buoys were deployed at water depths of 95 m and 113 m located in 114 km and 160 km off the coast of Hong Kong, respectively. Moreover, the fouling community of a Marex hydrological buoy located in 115 m depth water 172 km off Hong Kong was also surveyed. The results show that a total of 78 species were collected and identified. The panels exposed for 3 months were mainly dominated by stalked barnacles Conchoderma hunteri and Lepas anatifera and hydroids Orthopyxis sp. As for the buoys, including the subsurface buoy, and their mooring systems exposed for 6 and 12 months, respectively, some hard foulers such as common oysters, pearl oysters, acorn barnacles and bryozoans were also found. The compositions of fouling communities also varied greatly with depth.

关键词： Biofouling offshore structures the South China Sea

Distributed Minimum-Energy Containment Control of Continuous-Time Multi-Agent Systems by Inverse Optimal Control

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1533-1535页

作者： Fei yan Xiangbiao Liu tao Feng School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China National Engineering Laboratory of Integrated Transportation Big Data Application Technology Chengdu 611756China

Dear Editor,This letter focuses on the distributed optimal containment control of continuous-time multi-agent systems(CTMASs)with respect to the minimum-energy performance index over fixed *** achieve this,we firstly investigate the optimal containment control problem using the inverse optimal control method,where all states of followers asymptotically converge to the convex hull spanned by the leaders while some quadratic performance indexes get minimized.A sufficient condition for existence of the distributed optimal containment control protocol is *** introducing the parametric algebraic Riccati equation(PARE),it is strictly proved that the global performance index can be used to approximate the standard minimumenergy performance index as the parameters tends to *** consequence,the standard minimum-energy cooperative containment control can be solved by local steady state feedback protocols.

关键词： optimal infinity algebraic

Resilient performance of self-centering hybrid rocking walls with curved interface under pseudo-static loading

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Earthquake Engineering and Engineering Vibration 2024年第1期23卷 65-85页

作者： Su Xing yan Shi Sun Xianglei Wang tao School of Civil Engineering Shenyang Jianzhu UniversityShenyang 110168China PetroChina East China Design Institute Co. Ltd.Qingdao 266000China Qingdao Country Garden Bolin Real Estate Co. Ltd.Qingdao 266100China

Frame and rocking wall(FRW)structures have excellent resilient performance during ***,the concrete at interfacial corners of rocking walls(RWs)is easily crushed due to local extreme compression during the rocking *** innovative RW with a curved interface is proposed to prevent interfacial corners from producing local damage,enhancing its earthquake resilient performance(ERP).The precast wall panel with a curved interface is assembled into an integral self-centering hybrid rocking wall(SCRW)by two post-tensioned unbonded prestressed ***,two ordinary energy dissipation steel rebars and two shear reinforcements are arranged to increase the energy dissipation capacity and lateral *** SCRW specimens and one monolithic reinforced concrete(RC)shear wall(SW)were tested under pseudo-static loading to compare the ERPs of the proposed SCRW and the SW,focusing on studying the effect of the curved interface on the *** key resilient performance of rocking effects,failure modes,and hysteretic properties of the SCRW were *** results show that nonlinear deformations of the SCRW are concentrated along the interface between the SCRW and the foundation,avoiding damage within the *** restoring force provided by the prestressed tendons can effectively realize self-centering capacity with small residual deformation,and the resilient performance of the SCRW is better than that of monolithic *** addition,the curved interface of the SCRW makes the rocking center change and move inward,partially relieving the stress concentration and crush of *** rocking range of the rocking center is about 41.4%of the width of the SCRW.

关键词： self-centering hybrid rocking wall(SCRW) monolithic shear wall(SW) earthquake resilient performance(ERP) curved interface rocking center

Clustering for Bivariate Functional Data

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 613-629页

作者： Shi-yun CAO yan-qiu ZHOU yan-ling WAN tao ZHANG School of Science Guangxi University of Science and TechnologyLiuzhou 545006China School of Marxism Guangxi University of Science and TechnologyLiuzhou 545006China Key Laboratory of Intelligent Information Processing and Graph Processing Guangxi University of Science and TechnologyLiuzhou 545006China

In this paper,we consider the clustering of bivariate functional data where each random surface consists of a set of curves recorded repeatedly for each *** k-centres surface clustering method based on marginal functional principal component analysis is proposed for the bivariate functional data,and a novel clustering criterion is presented where both the random surface and its partial derivative function in two directions are *** addition,we also consider two other clustering methods,k-centres surface clustering methods based on product functional principal component analysis or double functional principal component *** results indicate that the proposed methods have a nice performance in terms of both the correct classification rate and the adjusted rand *** approaches are further illustrated through empirical analysis of human mortality data.

关键词： bivariate functional data -centres surface clustering functional principal component analysis partial derivative function

Carbon efficiency modeling and optimization of solar-powered cellular networks

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Science China(Information Sciences) 2024年第5期67卷 228-243页

作者： Yuxi ZHAO Xiaohu GE Wen yan tao HAN Yi ZHONG School of Electronic Information and Communications Huazhong University of Science and Technology Huawei Technology Co. Ltd.

As wireless communication traffic experiences rapid growth, the carbon emissions caused by the communication industry are also on the rise. To achieve “carbon neutrality”, researchers are considering the use of renewable energy sources to power cellular networks, thereby reducing carbon emissions. However, a challenge arises when using renewable energy, specifically owing to the unpredictable nature of both the energy consumption of the cellular network and the power generation from renewable sources. This inconsistency results in low renewable energy utilization and reduced carbon efficiency. Herein, we construct a carbon efficiency model of solar-powered cellular networks using practical data from solar radiation. We propose a mechanism that alternately optimizes the performance of the renewable energy network and the cellular network. This approach is based on convex optimization theory and the Dinkelback algorithm, and it leads to the design of a carbon efficiency optimization algorithm. This algorithm aims to improve the carbon efficiency of cellular networks and reduce their carbon emissions. Simulation results demonstrate that our optimization scheme yields a maximum improvement of 2.56 × 108bps/g in the carbon efficiency of the cellular network as compared to conventional power allocation schemes such as the traditional water filling method and heuristic energy sharing and charge/discharge algorithms.

关键词： cellular networks renewable energy carbon efficiency convex optimization theory dinkelbach

Game-theoretical Model for Dynamic Defense Resource Allocation in Cyber-physical Power Systems Under Distributed Denial of Service Attacks

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 41-51页

作者： Bingjing yan Pengchao Yao tao yang Boyang Zhou Qiang yang the College of Electrical Engineering Zhejiang UniversityHangzhou 310027China Zhejiang Lab Hangzhou 311100China

Electric power grids are evolving into complex cyber-physical power systems(CPPSs)that integrate advanced information and communication technologies(ICTs)but face increasing cyberspace threats and *** study considers CPPS cyberspace security under distributed denial of service(DDoS)attacks and proposes a nonzero-sum game-theoretical model with incomplete information for appropriate allocation of defense resources based on the availability of limited *** time delay is applied to quantify the expected utility as CPPSs have high time requirements and incur massive damage DDoS *** resource allocation strategies are adopted by attackers and defenders under the three cases of attack-free,failed attack,and successful attack,which lead to a corresponding consumption of resources.A multidimensional node value analysis is designed to introduce physical and cybersecurity *** experiments and numerical results demonstrate the effectiveness of the proposed model for the appropriate allocation of defense resources in CPPSs under limited resource availability.

关键词： Game theory complex cyber-physical power system(CPPS) multidimensional evaluation distributed denial of service(DDoS)attack

Prediction and validation of diffusive uptake rates for indoor volatile organic compounds in axial passive samplers

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Energy and Built Environment 2024年第1期5卷 24-31页

作者： yan Wang tao Yu Jinhan Mo Department of Building Science Tsinghua UniversityBeijing 100084China Beijing Key Laboratory of Indoor Air Quality Evaluation and Control Beijing 100084China Wuhan Second Ship Design and Research Institute Wuhan 430205China School of Energy and Power Engineering Beihang UniversityBeijing 100191China Key Laboratory of Eco Planning&Green Building Ministry of Education(Tsinghua University)Beijing 100084China

The diffusive uptake rate is essential for using passive samplers to measure indoor volatile organic compounds(VOCs).The traditional theoretical model of passive samplers requires available regression formulas of uptake rates and physicochemical properties of adsorbents to predict the uptake ***,it is difficult to obtain the uptake rates of different VOCs under different sampling periods,and it is also difficult to obtain the physical parameters of adsorbents accurately and *** study provides a reliable numerical prediction method of diffusive uptake rates of *** modeling was based on the standard automated thermal desorption(ATD)tubes packed with Tenax TA and the mass transfer process during *** experimental determinations of toluene uptake rate are carried out to verify the prediction *** uptake rates of typical indoor VOCs are obtained from the literature to calibrate the key apparent parameters in the model by statistical regression *** predicted model can provide the VOC diffusive uptake rates under different sampling duration with an average deviation of less than 5%.This study can provide the basis for fast and accurate prediction of diffusive uptake rates for various VOC pollutants in built environments.

关键词： Indoor air quality Diffusive uptake rate Prediction model Sampling Adsorption