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Targeted gene sequencing and bioinformatics analysis of patients with gallbladder neuroendocrine carcinoma:A case report

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 239-251页

作者： Yun-Chuan Yang zhi-tao Chen Da-Long Wan Hui Tang Mu-Lin Liu Department of Medical College Jinan UniversityGuangzhou 510000Guangdong ProvinceChina Department of General Surgery The First Affiliated Hospital of Bengbu Medical UniversityBengbu 233000Anhui ProvinceChina Department of Hepatobiliary Surgery Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Department of Pathology The First Affiliated Hospital of Medical School of Zhejiang UniversityHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Gallbladder neuroendocrine carcinoma(NEC)represents a subtype of gallbladder malignancies characterized by a low incidence,aggressive nature,and poor *** its clinical severity,the genetic alterations,mechanisms,and signaling pathways underlying gallbladder NEC remain *** SUMMARY This case study presents a rare instance of primary gallbladder NEC in a 73-year-old female patient,who underwent a radical cholecystectomy with hepatic hilar lymphadenectomy and resection of liver segments IV-B and *** gene sequencing and bioinformatics analysis tools,including STRING,GeneMANIA,Metascape,TRRUST,Sangerbox,cBioPortal and GSCA,were used to analyze the biological functions and features of mutated genes in gallbladder *** mutations(APC,ARID2,IFNA6,KEAP1,RB1,SMAD4,TP53,BTK,GATA1,GNAS,and PRDM3)were identified,and the tumor mutation burden was determined to be 9.52 muts/Mb via targeted gene sequencing.A protein-protein interaction network showed significant interactions among the twelve mutated *** Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were used to assess mutation functions and *** results revealed 40 tumor-related pathways.A key regulatory factor for gallbladder NEC-related genes was identified,and its biological functions and features were compared with those of gallbladder *** Gallbladder NEC requires standardized *** with other gallbladder carcinomas revealed clinical phenotypes,molecular alterations,functional characteristics,and enriched pathways.

关键词： Gallbladder neuroendocrine carcinoma Targeted-gene sequencing Bioinformatics analysis case report Immunocytochemistry Case report

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Modified Moving Particle Semi-Implicit Meshless Method for Incompressible Fluids

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Journal of Thermal Science 2004年第3期13卷 226-234页

作者： Jun Guo zhi tao Beijing Univ Aeronaut & Astronaut Div 402 Dept Jet Prop Beijing 100083 Peoples R China

A modified moving particle semi-implicit method (MPS) is presented for incompressible fluids. Modification is on the removal of imaginary nodes to enforce the boundary conditions. Comparison with the original imaginary-node scheme has proved the validity of the proposed method. Performance of MPS method in general is also investigated by comparing the results of Lid-driven and natural convection problems with finite volume method (FVM). It is found that MPS method shows relatively strong numerical diffusion, and for convection problems, MPS method appears to be less robust than FVM. Though better results could be obtained with different kernel functions, such improvement is quite limited.

关键词： meshless method incompressible fluids numerical diffusion kernel function.

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Computational Research on Rotating Channel by a Modified Anisotropic Turbulence Model

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Journal of Thermal Science 2011年第5期20卷 385-393页

作者： Jianqin Zhu zhi tao Chaoqun Nie Institute of Engineering Thermophysics Chinese Academy of Science Beijing 100190 China National Key Lab. on Aero-Engines School of Jet Propulsion Beihang University Beijing 100191.China

Based on the simplified format of the Reynolds stress equations, a fire-new rotational-modification method for the anisotropic turbulence model has been presented. A three-dimensional Navier-Stokes code with this new rotational modified k-ω turbulence models （β=0.1 and β=1） and the standard k-ω turbulence model have been used for the prediction of flow and heat transfer characteristics in a rotating smooth square channel. The Reynolds number Re based on the inlet velocity of the cooling air and hydraulic diameter is 6000 .The rotating speed are 300, 600, 900, 1200rpm respectively. The calculations results of using three turbulence models have been compared with the experimental data. The research results show that （1） the rotational modification coefficient Rf13 used in the new anisotropic k-ω model would increased/decreased the predictions of heat transfer on the trailing surface/leading surface compared to the standard k-ω model. And this tendency would be increased with the increased ft. （2） The simulation performance of the standard k-ω model was well on the leading surface. However, on the trailing surface it under-predicted the heat transfer at high rotating speed. （3） The calculation results of the new anisotropic k-ω model with β=0.1 proposed by the present paper agreed well with experimental data, both on the leading and trailing surfaces. Besides, compared to 1, 0.1 is a more appropriate magnitude of βat conditions in the present paper.

关键词： anisotropy turbulence model rotation heat transfer

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QSAR of Estrogen of Bisphenol A with 3D Vector of Atomic Property Correlation

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Chinese Journal of Structural Chemistry 2007年第8期26卷 988-994页

作者： CHEN zhi-tao ZHOU Peng HE Liu LI zhi-Liang College of Chemistry and Chemical Engineering Chongqing University Chongqing 400044 China College of Biomedical Engineering Chongqing University Chongqing 400044 China

Considering atomic property vector and atomic correlative function, the 3-dimensional structural vector of atomic property correlation （3D-VAPC）, a novel descriptor,is defined to characterize a 3-dimensional molecular structure by introducing self-adaptability regulation mechanism and the idea of orientating to customers. Characterizing the structures of 25 bisphenol A compounds by this vector, the QSAR models of three kinds of estrogen activities （ER affinities, gene induction and cell proliferation） have high multiple correlation coefficient （Rcum^2=0.933, 0.813, 0.959） and cross verification coefficient （Qcum^2=0.847, 0.953, 0.798） by support vector machine （SVM）, which suits for nonlinear circumstances. The above results show that the models successfully express the correlation between structure and three kinds of estrogen activities. Therefore, 3D-VAPC exactly reflects the molecular structural information and SVM method correctly describes the correlation between information and property of the compounds.

关键词： 3D vector of atomic property correlation (3D-VAPC) support vector machine (SVM) quantitative structure-activity relationship (QSAR) bisphenol A estrogen

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The Same Distribution of Limit Cycles in a Hamiltonian System with Nine Seven-order Perturbed Terms

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Acta Mathematicae Applicatae Sinica 2008年第1期24卷 167-176页

作者： tao Jiang zhi-yan Yang School of Information Beijing Wuzi University Beijing 101149 China

Using qualitative analysis and numerical simulation, we investigate the number and distribution of limit cycles for a cubic Hamiltonian system with nine different seven-order perturbed terms. It is showed that these perturbed systems have the same distribution of limit cycles. Furthermore, these systems have 13, 11 and 9 limit cycles for some parameters, respectively. The accurate positions of the 13, 11 and 9 limit cycles are obtained by numerical exploration, respectively. Our results imply that these perturbed systems are equivalent in the sense of distribution of limit cycles. This is useful for studying limit cycles of perturbed systems.

关键词： Limit cycles bifurcation

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Wavelets with Differential Relation

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Acta Mathematica Sinica,English Series 2011年第5期27卷 1011-1022页

作者： zhi-tao CHUANG Youming LIU Department of Applied Mathematics Beijing University of Technology Beijing 100124 P. R. China

Divergence-free wavelets are successfully applied to numerical solutions of Navier-Stokes equation and to analysis of incompressible flows. They closely depend on a pair of one-dimensional wavelets with some differential relations. In this paper, we point out some restrictions of those wavelets and study scaling functions with the differential relation; Wavelets and their duals are discussed; In addition to the differential relation, we are particularly interested in a class of examples with the interpolatory property; It turns out there is a connection between our examples and Micchelli＇s work.

关键词： Differential relation interpolation wavelets scaling functions symmetry

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Catalytic asymmetric synthesis of 1,4-enynes

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Chinese Chemical Letters 2023年第8期34卷 18-27页

作者： Han-Yu Lu zhi-tao He CAS Key Laboratory of Synthetic Chemistry of Natural Substances Shanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesShanghai 200032China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China

1,4-Enyne units are ubiquitous skeletons in biologically active molecules and natural ***,they represent versatile building blocks for abundant downstream derivatizations via controllable modifications of both alkene and alkyne units ***,great efforts have been made to establish efficient protocols to achieve optically active 1,*** the enormous application potential of enantioenriched 1,4-enyne units but no related review on this topic has been described,here we aim to provide a comprehensive summary on the catalytic methods established for enantioselective constructions of these intriguing *** to the reaction types,this review is divided into five parts,including asymmetric allylic substitution,asymmetric propargylic substitution,asymmetric alkynylallylic substitution,asymmetric hydroalkynylation and asymmetric 1,2-addition of alkynes to conjugated imines or ketones.

关键词： 1,4-Enynes Catalytic reaction Asymmetric synthesis

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Experimental Investigation of the Secondary Flow in a Rotating Smooth Channel Subjected to Thermal Boundary Conditions

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Journal of Thermal Science 2020年第6期29卷 1463-1474页

作者： LI Haiwang YOU Haoliang YOU Ruquan tao zhi National Key Laboratory of Science and Technology on Aero-Engines Aero-thermodynamics Beihang UniversityBeijing 100191China

In the current study,thermal boundary conditions are considered in a rotating smooth channel with a square cross-section to investigate the secondary flow and compare it to that of the same channel without *** measurement is conducted at three streamwise planes(X=445 mm,525 mm,605 mm).The flow parameters are the Reynolds number(Re=4750,which was based on the average longitudinal or primary velocity U and the hydraulic diameter D of the channel cross-section),the rotation number(Ro=?D/U,where?is the rotational velocity,ranging from 0 to 0.26),and the aspect ratio of the channel cross-section(AR=1,which is calculated by dividing the channel height by the channel width).The leading and trailing walls are heated under a constant heat flux qw=380 W/m^2,and the top and bottom walls are isothermal at room *** work is in a series with our previous work without thermal boundary *** on the experimental data,we obtained a four-vortex *** is a counter-rotating vortex pair near the leading side and the trailing *** the leading and trailing walls are heated,the buoyancy force increases the relative vertical position of the vortex pair near the trailing side from 5%to 12.5%of the hydraulic *** moving upstream along the streamwise direction,the upper vortex near the trailing wall becomes weaker,whereas the lower vortex becomes *** the rotational speed increases,the vortex pair near the trailing side is inhibited by the Coriolis *** heated thermal boundary conditions,the vortex pair near the trailing side reappears due to the effect of buoyancy *** results indicate that the buoyancy force has a substantial effect on the secondary flow regime under thermal boundary conditions.

关键词： flow dynamic rotating smooth channel secondary flow buoyancy force

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Existence and Multiplicity of Solutions for Nonlocal Systems with Kirchhoff Type

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Acta Mathematicae Applicatae Sinica 2016年第1期32卷 35-54页

作者： zhi-tao ZHANG Yi-min SUN Academy of Mathematics and Systems Science Chinese Academy of Sciences School of Mathematics Northwest University

Firstly,we use Nehari manifold and Mountain Pass Lemma to prove an existence result of positive solutions for a class of nonlocal elliptic system with Kirchhoff *** a multiplicity result is established by cohomological index of Fadell and *** also consider the critical case and prove existence of positive least energy solution when the parameter β is sufficiently large.

关键词： Critical point Nehari manifold cohomological index

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Existence of Positive Solutions for a General Nonlinear Eigenvalue Problem

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Acta Mathematicae Applicatae Sinica 2011年第3期27卷 367-372页

作者： Xi-you Chengt zhi-tao Zhang Academy of Mathematics and Systems Science Institute of Mathematics Chinese Academy of Sciences Beijing 100190 China Department of Applied Mathematics Nanjing Audit University Nanjing 210029 China

Let Ω R n be a bounded domain, H = L 2 （Ω）, L ： D（L） H → H be an unbounded linear operator, f ∈ C（ × R, R） and λ∈ R. The paper is concerned with the existence of positive solutions for the following nonlinear eigenvalue problem Lu = λf （x, u）, u ∈ D（L）, which is the general form of nonlinear eigenvalue problems for differential equations. We obtain the global structure of positive solutions, then we apply the results to some nonlinear eigenvalue problems for a second-order ordinary differential equation and a fourth-order beam equation, respectively. The discussion is based on the fixed point index theory in cones.

关键词： unbounded linear operator fixed point index positive solution

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