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Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

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World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-Zheng Lan Zheng Wu Wen-jia Chen Xin-Ning yu Hua-tao Wu Jing liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

Adaptive detection of range-spread targets in homogeneous and partially homogeneous clutter plus subspace interference

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Journal of Systems Engineering and Electronics 2024年第1期35卷 43-54页

作者： jian tao HE jia WANG Bencai liu yu XU Congan XIE Zikeng Research Institute of Information Fusion Naval Aviation UniversityYantai 264001China Air Force Early Warning Academy Wuhan 430019China

Adaptive detection of range-spread targets is considered in the presence of subspace interference plus Gaussian clutter with unknown covariance *** target signal and interference are supposed to lie in two linearly independent subspaces with deterministic but unknown *** on the two-step criteria,two adaptive detectors based on Gradient tests are proposed,in homogeneous and partially homogeneous clutter plus subspace interference,*** of the proposed detectors exhibit theoretically constant false alarm rate property against unknown clutter covariance matrix as well as the power *** results show that,the proposed detectors have better performance than their existing counterparts,especially for mismatches in the signal steering vectors.

关键词： adaptive detection subspace interference constant false alarm rate Gradient test partially homogeneous environment

Microstructure and Properties of an Advanced Nickel-base PM Superalloy

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Journal of Iron and Steel Research International 2014年第12期21卷 1152-1157页

作者： Chao-jie WU yu tao jian jia Central Iron and Steel Research Institute

The need for nickel-base powder metallurgy （PM） superalloy turbine discs is becoming increasingly evi dent. With the eventual aim of improving thrust-to-weight ratio of aeroengines for power generation, well integration of significantly high strength, high damage tolerance and high-temperature capability would be reasonably required. An advanced PM superalloy, which was designed for applications up to 815- 8 5 0 ℃, was experimentally investigated. Emphasis was primarily put on microstructure and mechanical properties. The results indicated the measured phases in the sample were composed of γ,γ＇, MC, and Ma B2. With uniform coarse grain microstruc ture （ASTM 5-6）, the sample appeared to exhibit overwhelming superiority over the prior art materials FGH95, FGH96, FGH97 and FGH98. The dominant embodiments consisted of high tensile strength （Rm = 1000 MPa and Rp0.2 800 MPa at 850℃）, strong creep resistance （ξp 0.12% at 815 ℃/400 MPa/50 h）, and considerable stressrupture life （τ=457.4 h at 815 ℃/450 MPa）. The technical practicability of applications up to 815-850 ℃ of this alloy was conclusively proved.

关键词： PM superalloy microstructure mechanical property

Persymmetric adaptive detection of range-spread targets in subspace interference plus Gaussian clutter

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Science China(Information Sciences) 2023年第5期66卷 271-282页

作者： tao jian jia HE yu liu You HE Congan XU Zikeng XIE Research Institute of Information Fusion Naval Aviation University

In this paper, we consider the adaptive detection problem of range-spread targets embedded in subspace interference plus structured Gaussian clutter. The target signal and interference are assumed to lie in two linearly independent subspaces with unknown coordinates. The clutter component is modeled as a complex Gaussian vector with an unknown persymmetric covariance matrix. We leverage the persymmetric structure to design a two-step detector according to the Rao test criterion. The theoretical results show that the proposed detector possesses the constant false alarm rate property with respect to the clutter covariance matrix. Furthermore, the numerical results show that the proposed detector exhibits better detection performance than the existing unstructured subspace detectors, particularly under a limited training data size. In addition, the proposed detector outperforms the existing persymmetric subspace detectors.

关键词： adaptive detection persymmetry structured interference constant false alarm rate Rao test

Research progress on advanced rail materials for electromagnetic railgun technology

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Defence Technology（防务技术） 2021年第2期17卷 429-439页

作者： Hong-bin Xie Hui-ya Yang jian yu Ming-yu Gao jian-dong Shou You-tong Fang jia-bin liu Hong-tao Wang School of Materials Science and Engineering Zhejiang UniversityHangzhou310027China Center for X-mechanics Faculty of EngineeringZhejiang UniversityHangzhou310027China

Electromagnetic railgun attracts more and more attention due to its advantage in speed,cost,and *** is found that the rail should withstand huge mechanical and thermal shocks during the launching *** forms of rail failure are accompanied by gouge,grooving,transition,and arc ablation,*** service life of the rail has become a bottleneck restricting the development of electromagnetic railgun technology.A series of researches are carried out to solve rail failure,including analysing the failure mechanism and using various advanced rail *** paper provides a comprehensive review of rail materials,including material composition,preparation,microstructure,and *** begin from a short background of the requirement of the rail *** a detailed investigation of rail materials is described,and the performances of those materials are ***,further development prospect of rail material is discussed.

关键词： Strength Conductivity Electromagnetic railgun Copper alloys Rai

Energy-efficient collaborative target tracking algorithm using cost-reference particle filtering in wireless acoustic sensor networks

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The Journal of China Universities of Posts and Telecommunications 2009年第1期16卷 9-15,43页

作者： yu Zhi-jun WEI jian-ming liu Hai-tao Wireless Sensor Network Research and Development Center Shanghai Institute of Microsystem and Information Technology Shanghai 200050 China

Target tracking is one of the most important applications of wireless sensor networks. Optimized computation and energy dissipation are critical requirements to save the limited resource of sensor nodes. A new robust and energy-efficient collaborative target tracking framework is proposed in this article. After a target is detected, only one active cluster is responsible for the tracking task at each time step. The tracking algorithm is distributed by passing the sensing and computation operations from one cluster to another. An event-driven cluster reforming scheme is also proposed for balancing energy consumption among nodes. Observations from three cluster members are chosen and a new class of particle filter termed cost-reference particle filter （CRPF） is introduced to estimate the target motion at the cluster head. This CRPF method is quite robust for wireless sensor network tracking applications because it drops the strong assumptions of knowing the probability distributions of the system process and observation noises. In simulation experiments, the performance of the proposed collaborative target tracking algorithm is evaluated by the metrics of tracking precision and network energy consumption.

关键词： target tracking cost-reference particle filtering energy-efficient wireless sensor networks (WSNs)

The Photocatalytic Oxidation of As（Ⅲ） Enhanced by Surface Alkalinized g-C3N4

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Transactions of Tianjin University 2020年第1期26卷 40-48页

作者： tao yu Zhen liu jian Ma Xin Tan School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin 300072China School of Environmental Science and Engineering Tianjin UniversityTianjin 300350China

A new,facile,and efficient way to prepare alkalinized g-C3N4 is *** calcined a mixture of KCl and melamine to obtain g-C3N4,whose in-plane structure was K+doped so that alkalinized samples could be obtained by treatment with different concentrations of *** different samples were used to oxidize As(Ⅲ)in both visible light and natural *** sample treated with 10 mol/L KOH showed the highest efficiency,converting all As(Ⅲ)into As(Ⅴ)within 120 min in both visible light and natural light,as the oxidative capacity of the As(Ⅲ)in the alkalinized samples was significantly higher than that of the original samples.K+doping improved the electron transport capacity of the samples,while the alkalinized samples could destroy their edge structures,so as to improve the separation efficiency of the photogenerated *** experiment confirmed that alkalinized g-C3N4 significantly improves the oxidation ability of As(Ⅲ)and plays an important role in the photocatalytic treatment of refractory nonmetallic ions.

关键词： Photocatalysis g-C3N4 Alkalization K^+doping As(Ⅲ)

Effect of Mn Modification on the Corrosion Susceptibility of Mg–Mn Alloys by Magnesium Scrap

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Acta Metallurgica Sinica(English Letters) 2021年第1期34卷 1-11页

作者： Dong-Dong Gu jian Peng jia-Wen Wang Zheng-tao liu Fu-Sheng Pan State Key Laboratory of Mechanical Transmission College of Materials Science and EngineeringChongqing UniversityChongqing 400044China Chongqing Research Center for Advanced Materials Chongqing Academy of Science and TechnologyChongqing 401123China

The microstructure and anti-corrosion behavior of Mg–Mn alloys by magnesium scrap have been investigated in this *** results show that the size of the Fe-rich particles in magnesium scrap decreases but the quantity increases with the Mn *** the presence of Mn-containing Fe-rich particles with unique symbiotic structure can eff ectively weaken the micro-galvanic corrosion,the presence of more free Fe(Fe-rich particles)does not necessarily lead to severe corrosion of the *** corrosion susceptibility of Mg–Mn–Fe alloy primarily depends on the solubility of iron in the Mg matrix,while it can be significantly reduced by suitable Mn ***,the tolerance limit of the Fe impurity can be expressed as Femax=0.0083 Mn(relative to the iron solubility).Only when the Fe/Mn ratio is below 0.0083 can the alloy have excellent corrosion resistance,with the corrosion rate changing in the scope of 0.38±0.09 to 0.54±0.15 mg/cm^(2) day and icorr from 3 to 9×10^(–4) A/cm^(2).

关键词： Magnesium scrap Mn modification Fe impurity Corrosion susceptibility Corrosion resistance

Influence of Al/Cu content on grain boundary diffusion in Nd-Fe-B magnet via in-situ observation

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Journal of Rare Earths 2019年第4期37卷 398-403页

作者： Xinghua Cheng jian Li Lei Zhou tao liu Xiaojun yu Bo Li China Iron & Steel Research Institute Croup Functional Materials Division Advanced Technology & Materials Co. Ltd.

The influence of aluminum and copper content in the starting Nd-Fe-B magnet on grain boundary diffusion process(GBDP) was studied by observing the phase transformation behaviors of the magnets in-situ at high temperature. A higher coercivity increment is discovered in the sample with higher AI/Cu despite the fact that its Dy diffusion amount is the same as the other. DSC analysis shows an evident melting behavior in the higher Al/Cu sample. Laser scanning confocal microscopy(LSCM) in-situ characterization shows a large amount of melted intergranular phase spills out to the surface simultaneously at around 600 ℃ in the high Al/Cu sample, while the phase spills out gradually one after another in the range between 623 and680 ℃ in the other sample, which indicates that the intergranular phase can be more easily melted in the sample containing more AI/Cu. The area fraction of matrix phase remarkably shrinks while that of intergranular phase enlarges after LSCM heating, which demonstrates the outer region of the Nd_2 Fe_(14)B grains melt at the temperature of 900 ℃. Electron probe microanalyzer result(EPMA) shows that the Nd and Dy concentrate in edge regions and subsequently mix into the intergranular phase with the melting of the grain edge, while a large amount of AI and Cu in the intergranular phase spill out. Nevertheless, the sample with higher starting AI/Cu still remains higher residual contents after LSCM experiments, and that could probably be the main reason why the high AI/Cu magnet shows smaller coercivity decrement after LSCM experiment. Overall, the increase of AI/Cu in the starting magnet optimizes the Dy distribution and the wettability of intergranular phase, enhancing coercivity increment effect further.

关键词： Nd-Fe-B sintered magnet Grain boundary diffusion process In-situ LSCM Melting behavior Copper Aluminum