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Exploring cerebral structural and functional abnormalities in a mouse model of post-traumatic headache induced by mild traumatic brain injury

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Zoological Research 2024年第3期45卷 648-662页

作者： Dan Yang Bin-Bin Nie Jin-Gang He Zong-Qiang Lv Feng-Feng Mo Si-Yi Ouyang Jie Wang Ju-Xiang Chen tao tao Department of Anesthesiology Central People’s Hospital of ZhanjiangZhanjiangGuangdong 524045China Key Laboratory of Nuclear Radiation and Nuclear Energy Technology Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Key Laboratory of Magnetic Resonance in Biological Systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsNational Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences-Wuhan National Laboratory for OptoelectronicsWuhanHubei 430071China Department of Neurosurgery Changhai HospitalNaval Medical UniversityShanghai 200082China Department of Nutrition and Food Hygiene Faculty of Naval MedicineNaval Medical UniversityShanghai 200433China Department of Anesthesiology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Institute of Neuroscience and Brain Diseases/Xiangyang Central Hospital Affiliated Hospital of Hubei University of Arts and ScienceXiangyangHubei 441021China Songjiang Hospital and Songjiang Research Institute Shanghai Jiao Tong University School of MedicineShanghai 201600China Department of Anesthesiology Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China

Mild traumatic brain injury(mTBI)-induced post-traumatic headache(PTH)is a pressing public health concern and leading cause of disability worldwide.Although PTH is often accompanied by neurological disorders,the exact underlying mechanism remains largely unknown.Identifying potential biomarkers may prompt the diagnosis and development of effective treatments for mTBI-induced PTH.In this study,a mouse model of mTBI-induced PTH was established to investigate its effects on cerebral structure and function during short-term recovery.Results indicated that mice with mTBI-induced PTH exhibited balance deficits during the early post-injury stage.Metabolic kinetics revealed that variations in neurotransmitters were most prominent in the cerebellum,temporal lobe/cortex,and hippocampal regions during the early stages of PTH.Additionally,variations in brain functional activities and connectivity were further detected in the early stage of PTH,particularly in the cerebellum and temporal cortex,suggesting that these regions play central roles in the mechanism underlying PTH.Moreover,our results suggested that GABA and glutamate may serve as potential diagnostic or prognostic biomarkers for PTH.Future studies should explore the specific neural circuits involved in the regulation of PTH by the cerebellum and temporal cortex,with these two regions potentially utilized as targets for non-invasive stimulation in future clinical treatment.

关键词： Post-traumatic headache(PTH) Mild traumatic brain injury(mTBI) Metabolic kinetics fMRI Cerebellum

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An Overview of Sequential Approximation in Topology Optimization of Continuum Structure

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 43-67页

作者： Kai Long Ayesha Saeed Jinhua Zhang Yara Diaeldin Feiyu Lu tao tao Yuhua Li Pengwen Sun Jinshun Yan State Key Laboratory of Alternate Electrical Power Systemwith Renewable Energy Sources North China Electric Power UniversityBeijing102206China Faculty of Materials and Manufacturing Beijing University of TechnologyBeijing100124China New Energy and Energy Storage Division China Southern Power Grid Technology Co.Ltd.Guangzhou510080China School of Mechanical Engineering Inner Mongolia University of TechnologyHohhot010051China College of Energy and Power Engineering Inner Mongolia University of TechnologyHohhot010051China

This paper offers an extensive overview of the utilization of sequential approximate optimization approaches in the context of numerically simulated large-scale continuum structures.These structures,commonly encountered in engineering applications,often involve complex objective and constraint functions that cannot be readily expressed as explicit functions of the design variables.As a result,sequential approximation techniques have emerged as the preferred strategy for addressing a wide array of topology optimization challenges.Over the past several decades,topology optimization methods have been advanced remarkably and successfully applied to solve engineering problems incorporating diverse physical backgrounds.In comparison to the large-scale equation solution,sensitivity analysis,graphics post-processing,etc.,the progress of the sequential approximation functions and their corresponding optimizersmake sluggish progress.Researchers,particularly novices,pay special attention to their difficulties with a particular problem.Thus,this paper provides an overview of sequential approximation functions,related literature on topology optimization methods,and their applications.Starting from optimality criteria and sequential linear programming,the other sequential approximate optimizations are introduced by employing Taylor expansion and intervening variables.In addition,recent advancements have led to the emergence of approaches such as Augmented Lagrange,sequential approximate integer,and non-gradient approximation are also introduced.By highlighting real-world applications and case studies,the paper not only demonstrates the practical relevance of these methods but also underscores the need for continued exploration in this area.Furthermore,to provide a comprehensive overview,this paper offers several novel developments that aim to illuminate potential directions for future research.

关键词： Topology optimization sequential approximate optimization convex linearization method ofmoving asymptotes sequential quadratic programming

Developing a diagnostic model for predicting prostate cancer: a retrospective study based on Chinese multicenter clinical data

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Asian Journal of Andrology 2024年第1期26卷 34-40页

作者： Chang-Ming Wang Lei Yuan Xue-Han Liu Shu-Qiu Chen Hai-Feng Wang Qi-Fei Dong Bin Zhang Ming-Shuo Huang Zhi-Yong Zhang Jun Xiao tao tao Department of Urology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Radiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Core Facility Center for Medical Sciences The First Affiliated Hospital of USTcDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Urology Affiliated Zhongda Hospital of Southeast UniversityNanjing 210009China Department of Urology Shanghai East HospitalTongji University School of MedicineShanghai 200120China Department of Urology Shanghai Changhai HospitalSecond Military Medical UniversityShanghai 200000China Department of Urology Affiliated Anhui Provincial Hospital of Anhui Medical UniversityHefei 230001China

The overdiagnosis of prostate cancer(PCa)caused by nonspecific elevation serum prostate-specific antigen(PSA)and the overtreatment of indolent PCa have become a global problem that needs to be solved urgently.We aimed to construct a prediction model and provide a risk stratification system to reduce unnecessary biopsies.In this retrospective study,clinical data of 1807 patients from three Chinese hospitals were used.The final model was built using stepwise logistic regression analysis.The apparent performance of the model was assessed by receiver operating characteristic curves,calibration plots,and decision curve analysis.Finally,a risk stratification system of clinically significant prostate cancer(csPCa)was created,and diagnosis-free survival analyses were performed.Following multivariable screening and evaluation of the diagnostic performances,a final diagnostic model comprised of the PSA density and Prostate Imaging-Reporting and Data System(PI-RADS)score was established.Model validation in the development cohort and two external cohorts showed excellent discrimination and calibration.Finally,we created a risk stratification system using risk thresholds of 0.05 and 0.60 as the cut-off values.The follow-up results indicated that the diagnosis-free survival rate for csPCa at 12 months and 24 months postoperatively was 99.7%and 99.4%,respectively,for patients with a risk threshold below O.05 after the initial negative prostate biopsy,which was significantly better than patients with higher risk.Our diagnostic model and risk stratification system can achieve a personalized risk calculation of csPCa.It provides a standardized tool for Chinese patients and physicians when considering thenecessity of prostatebiopsy.

关键词： nomogram prostate biopsy prostate cancer Prostate Imaging-Reporting and Data System prostate-specific antigen density

Review of Fault-tolerant Control for Motor Inverter Failure with Operational Quality Considered

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CES Transactions on Electrical Machines and Systems 2024年第2期8卷 202-215页

作者： Yuxuan Du Wenxiang Zhao Yihua Hu Jinghua Ji tao tao School of Electrical and Information Engineering Jiangsu University Department of Engineering King’s College London

In recent years,motor drive systems have garnered increasing attention due to their high efficiency and superior control performance.This is especially apparent in aerospace,marine propulsion,and electric vehicles,where high performance,efficiency,and reliability are crucial.The ability of the drive system to maintain long-term fault-tolerant control(FTC)operation after a failure is essential.The likelihood of inverter failures surpasses that of other components in the drive system,highlighting its critical importance.Long-term FTC operation ensures the system retains its fundamental functions until safe repairs or replacements can be made.The focus of developing a FTC strategy has shifted from basic FTC operations to enhancing the post-fault quality to accommodate the realities of prolonged operation post-failure.This paper primarily investigates FTC strategies for inverter failures in various motor drive systems over the past decade.These strategies are categorized into three types based on post-fault operational quality:rescue,remedy,and reestablishment.The paper discusses each typical control strategy and its research focus,the strengths and weaknesses of various algorithms,and recent advancements in FTC.Finally,this review summarizes effective FTC techniques for inverter failures in motor drive systems and suggests directions for future research.

关键词： Fault-tolerant Motor drive Operation quality Inverter failure

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Growth of ablative Rayleigh-Taylor instability induced by time-varying heat-flux perturbation

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Matter and Radiation at Extremes 2024年第1期9卷 85-93页

作者： Yang Liu De-Hua Zhang Jing-Fei Xin Yudong Pu Jun Li tao tao Dejun Sun Rui Yan Jian Zheng Department of Modern Mechanics University of Science and Technology of ChinaHefei 230026China Deep Space Exploration Laboratory Hefei 230026China Laser Fusion Research Center China Academy of Engineering PhysicsMianyang 621900China Institute of Applied Physics and Computational Mathematics Beijing 100094China Department of Plasma Physics and Fusion Engineering University of Science and Technology of ChinaHefeiAnhui 230026China Collaborative Innovation Center of IFSA(CICIFSA) Shanghai Jiao Tong UniversityShanghai 200240China CAS Center for Excellence in Ultra-intense Laser Science Shanghai 201800China

The evolution of ablative Rayleigh–Taylor instability(ARTI)induced by single-mode stationary and time-varying perturbations in heat flux is studied numerically in two dimensions.Compared with the stationary case,time-varying heat-flux perturbation mitigates ARTI growth because of the enhanced thermal smoothing induced by the wave-like traveling heat flux.A resonance is found to form when the phase velocity of the heat-flux perturbation matches the average sound speed in the ablation region.In the resonant regime,the coherent density and temperature fluctuations enhance the electron thermal conduction in the ablation region and lead to larger ablation pressure and effective acceleration,which consequently yield higher linear growth rate and saturated bubble velocity.The enhanced effective acceleration offers increased implosion velocity but can also compromise the integrity of inertial confinement fusion shells by causing faster ARTI growth.

关键词： perturbation stationary acceleration

Localization of q-form fields on a de Sitter brane in chameleon gravity

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Frontiers of physics 2024年第3期19卷 11-18页

作者： Yi Zhong tao-tao Sui School of Physics and Electronics Science Hunan UniversityChangsha 410082China Lanzhou Center for Theoretical Physics Key Laboratory of Theoretical Physics of Gansu Provinceand Key Laboratory of Quantum Theory and Applications of MoELanzhou UniversityLanzhou 730000China College of Physics Nanjing University of Aeronautics and AstronauticsNanjing 211106China

Recently,it was found that the vector field can be naturally localized on the thick brane in chameleon gravity.In this work,we extend this study to encompass de Sitter brane scenario.We focus on the localization of q-form fields.The scalar and vector fields can be localized on the de Sitter brane,while the KR field cannot be localized.The condition for localization of the scalar and vector fields is obtained.Furthermore,we investigate the localization characteristics in two examples with given conformal factor b(ϕ).In the first case,the effective potentials and KK modes of the matter fields are obtained asymmetric even though the de Sitter brane has Z2 symmetry.In the second case,volcano-like effective potentials are generated in the de Sitter brane model.

关键词： brane q-form field chameleon gravity

Predictive value of machine learning models for lymph node metastasis in gastric cancer: A two-center study

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 85-94页

作者： Tong Lu Miao Lu Dong Wu Yuan-Yuan Ding Hao-Nan Liu tao-tao Li Da-Qing Song Department of Emergency Medicine Jining No.1 People’s HospitalJining 272000Shandong ProvinceChina Wuxi Mental Health Center Wuxi 214000Jiangsu ProvinceChina Department of Gastroenterology Jining No.1 People’s HospitalJining 272000Shandong ProvinceChina Department of Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221002Jiangsu ProvinceChina

BACKGROUND Gastric cancer is one of the most common malignant tumors in the digestive system,ranking sixth in incidence and fourth in mortality worldwide.Since 42.5%of metastatic lymph nodes in gastric cancer belong to nodule type and peripheral type,the application of imaging diagnosis is restricted.AIM To establish models for predicting the risk of lymph node metastasis in gastric cancer patients using machine learning(ML)algorithms and to evaluate their pre-dictive performance in clinical practice.METHODS Data of a total of 369 patients who underwent radical gastrectomy at the Depart-ment of General Surgery of Affiliated Hospital of Xuzhou Medical University(Xuzhou,China)from March 2016 to November 2019 were collected and retro-spectively analyzed as the training group.In addition,data of 123 patients who underwent radical gastrectomy at the Department of General Surgery of Jining First People’s Hospital(Jining,China)were collected and analyzed as the verifi-cation group.Seven ML models,including decision tree,random forest,support vector machine(SVM),gradient boosting machine,naive Bayes,neural network,and logistic regression,were developed to evaluate the occurrence of lymph node metastasis in patients with gastric cancer.The ML models were established fo-llowing ten cross-validation iterations using the training dataset,and subsequently,each model was assessed using the test dataset.The models’performance was evaluated by comparing the area under the receiver operating characteristic curve of each model.RESULTS Among the seven ML models,except for SVM,the other ones exhibited higher accuracy and reliability,and the influences of various risk factors on the models are intuitive.CONCLUSION The ML models developed exhibit strong predictive capabilities for lymph node metastasis in gastric cancer,which can aid in personalized clinical diagnosis and treatment.

关键词： Machine learning Prediction model Gastric cancer Lymph node metastasis

Degradation of organics using LaFeO_(3)as a persulfate activator under low-intensity ultra-violet-light irradiation:Catalytic performance and mechanism

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Journal of Rare Earths 2022年第7期40卷 1043-1052页

作者： Yumei Li Jian Fan Xiaonan Feng tao tao School of Environment Huazhong University of Science and TechnologyWuhan 430074China School of Energy and Environment Inner Mongolia University of Science and TechnologyBaotou 014010China

ABO_(3)-type perovskite oxides with abounding defect structures and diverse physical chemistry attributes have been extensively studied in heterogeneous catalysis.Semiconductor LaFeO_(3)perovskites fabricated via the sol-gel method were used as peroxydisulfate(PDS)activators for methylene blue(MB)degradation under low-intensity ultra-violet(UV)-light to evaluate the degradation efficiency of organic pollutants and mechanism.The results indicate that under low-intensity UV irradiation,the developed UV/LaFeO_(3)/PDS system shows excellent degradation ability of organic pollutants in a wide pH range.Electron spin resonance and radical quenching experiments verify that SO_(4)^(·-),·OH,h^(+)and ^(1)O_(2)are generated during the activation process,and ^(1)O_(2)plays a dominant role in MB degradation.Reduction of low oxidation state Fe(Ⅱ)and O_(2)^(2-)/O^(-)on the LaFeO_(3)surface shows that oxygen vacancy,as the electron transfer mediator,enhances the redox cycle efficiency of Fe(Ⅱ)/Fe(Ⅲ).Photogenerated electrons of LaFeO_(3)involved in the cyclic transformation of Fe(Ⅱ)/Fe(Ⅲ)and PDS activation further increase the number of active radicals and thus promote the synergistic effect of photocatalytic coupled with sulfate radicalbased advanced oxidation processes.

关键词： LaFeO_(3) Peroxydisulfate Singlet oxygen Low-intensity UV-light Rare earths

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Epigenetic combined with transcriptomic analysis of the m6A methylome after spared nerve injury-induced neuropathic pain in mice

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Neural Regeneration Research 2023年第11期18卷 2545-2552页

作者： Fanning Zeng Jun Cao Zexuan Hong Yitian Lu Zaisheng Qin tao tao Department of Anesthesiology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Anesthesiology Central People’s Hospital of ZhanjiangZhanjiangGuangdong ProvinceChina Department of Anesthesiology Shenzhen Maternity&Child Healthcare HospitalSouthern Medical UniversityShenzhenGuangdong ProvinceChina

Epigenetic changes in the spinal cord play a key role in the initiation and maintenance of nerve injury-induced neuro pathic pain.N6-methyladenosine(m6A)is one of the most abundant internal RNA modifications and plays an essential function in gene regulation in many diseases.However,the global m6A modification status of mRNA in the spinal cord at different stages after neuropathic pain is unknown.In this study,we established a neuropathic pain model in mice by preserving the complete sural nerve and only damaging the common peroneal nerve.High-throughput methylated RNA immunoprecipitation sequencing res ults showed that after spared nerve injury,there were 55 m6A methylated and diffe rentially expressed genes in the spinal cord.Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway results showed that m6A modification triggered inflammatory responses and apoptotic processes in the early stages after spared nerve injury.Over time,the diffe rential gene function at postoperative day 7 was enriched in "positive regulation of neurogenesis" and "positive regulation of neural precursor cell prolife ration." These functions suggested that altered synaptic morphological plasticity was a turning point in neuropathic pain formation and maintenance.Results at postoperative day 14 suggested that the persistence of neuropathic pain might be from lipid metabolic processes,such as "very-low-density lipoprotein particle clearance," "negative regulation of choleste rol transport" and "membrane lipid catabolic process." We detected the expression of m6A enzymes and found elevated mRNA expression of Ythdf2 and Ythdf3 after spared nerve injury modeling.We speculate that m6A reader enzymes also have an important role in neuropathic pain.These results provide a global landscape of mRNA m6A modifications in the spinal cord in the spared nerve injury model at diffe rent stages after injury.

关键词： epigenetic m6A reader m6A MeRIP-Seq Nlrp1b neuropathic pain RNA methylation spared nerve injury Ythdf2

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