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Research and Realization of Medical Image Fusion Based on Three-Dimensional Reconstruction

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Chinese Journal of Biomedical Engineering(English Edition) 2007年第3期16卷 117-122页

作者： tao ling QIAN Zhi-yu CHEN Chun-xiao College of Automation Engineering Nanjing University of Aeronautics ＆ Astronautic Nanjing 210016 China

A new medical image fusion technique is *** method is based on three-dimensional *** reconstruction,the three-dimensional volume data is normalized by three-dimensional coordinate conversion in the same way and intercepted through setting up cutting plane including anatomical structure,as a result two images in entire registration on space and geometry are obtained and the images are fused at *** with traditional two-dimensional fusion technique,three-dimensional fusion technique can not only resolve the different problems existed in the two kinds of images,but also avoid the registration error of the two kinds of images when they have different scan and imaging *** research proves this fusion technique is more exact and has no registration,so it is more adapt to arbitrary medical image fusion with different equipments.

关键词： medical image volume data three-dimensional reconstruction image cutting image fusion

Sleep quality in middle-aged and elderly hemodialysis patients:Impact of a structured nursing intervention program

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World Journal of Clinical Cases 2024年第25期12卷 5713-5719页

作者： ling-ling tao Cai-Hua Zeng Wen-Juan Mei Yan-Li Zou Blood Purification Room The First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Poor sleep quality is common among hemodialysis patients and can significantly impact their *** study aimed to evaluate the effectiveness of a structured nursing intervention program in improving sleep quality in middleaged and elderly hemodialysis *** To evaluate the impact of nursing intervention on sleep quality in hemodialysis *** This cross-sectional study was conducted in a tertiary hospital,the First Affiliated Hospital of Nanchang University,in *** study included 105 middle-aged and elderly hemodialysis patients aged≥45 years who underwent maintenance hemodialysis for at least 3 mo,utilizing the Pittsburgh Sleep Quality Index(PSQI)to identify poor *** identified underwent a 12-wk nursing intervention program focusing on education,relaxation techniques,and ***-intervention,sleep quality was reassessed using the *** The study found that 68.6%of hemodialysis patients were poor *** the 12-wk nursing intervention program,there was a significant decrease in the mean global PSQI score from 8.9±3.2 to 5.1±2.7(Pling effectively improved sleep quality among middle-aged and elderly hemodialysis *** significant decrease in the mean global PSQI score post-intervention indicates the positive impact of tailored nursing interventions in addressing poor sleep quality in this patient *** findings emphasize the importance of implementing targeted nursing interventions to enhance the quality of life for hemodialysis patients by addressing the prevalent issue of poor sleep quality.

关键词： Hemodialysis patients Nursing intervention Sleep quality Elderly Pittsburgh Sleep Quality Index Patient wellbeing

分级结构的AdaBoost入侵检测方法研究

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西安电子科技大学学报 2008年第2期35卷 345-350,361页

作者：王勇陶晓玲桂林电子科技大学网络中心

针对目前智能入侵检测方法存在不能同时满足检测精度和检测速度的要求问题,提出一种分级结构的智能入侵检测方法.该方法将改进的AdaBoost算法用于入侵特征的选择及构造每一级的Ada-域值分类器,并通过级连多个分类器来共同完成检测任务.... 详细信息

针对目前智能入侵检测方法存在不能同时满足检测精度和检测速度的要求问题,提出一种分级结构的智能入侵检测方法.该方法将改进的AdaBoost算法用于入侵特征的选择及构造每一级的Ada-域值分类器,并通过级连多个分类器来共同完成检测任务.设计并实现了Linux实时入侵检测实验平台,在此平台上训练和测试分级结构的智能入侵检测器.实验结果表明,该方法降低了运算复杂度;在保证高的检测率的同时,降低了虚警率;提高了处理速度,更适合入侵检测系统的实时处理要求.

关键词：入侵检测 AdaBoost算法特征选择 Ada-域值分类器分级结构

Strontium Substituted Nanohydroxyapatite Incorporated 3D Printing Scaffold for Bone Tissue Engineering

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Journal of Donghua University(English Edition) 2018年第1期35卷 18-23页

作者： LIU Dinghua NIL Wei CHEN Liang WANG Weizhong tao ling DU Haibo HE Chuanglong College of Chemistry Chemical Engineering and Biotechnology Donghua University Shanghai 201620 China

The customized implants which are composed of polycaprolactone( PCL) and strontium substituted nanohydroxyapatite( SrHA) were fabricated successfully by using fused deposition modeling( FDM),which is a simple 3 D printing technology for fabricating personalized products. The physical and chemical properties of composite scaffolds were characterized by transmission electron microscopy( TEM), Fourier transform infrared spectroscopy( FTIR), X-Ray diffraction( XRD) and inductively coupled plasma-atomic emission spectroscopy( ICPAES). The results suggested that strontium element was successfully doped into nanohydroxyapatite and all scaffolds showed the homogeneous network structure. Furthermore, the in vitro biocompatibility of the scaffolds was evaluated by cell counting kit-8( CCK-8) assay. The data indicated that the prepared scaffolds exhibited excellent biocompatibility to bone marrow mesenchymal stem cells( BMSCs). Besides,strontium element can be released from PCL-SrHA scaffolds in a sustained manner. Therefore,the 3 D printing PCL-SrHA scaffolds hold great potential for bone tissue engineering.

关键词： 3D printing strontium hydroxyapatite polycaprolactone(PCL) bone tissue engineering

An adaptive smoothed particle hydrodynamics for metal cutting simulation

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Acta Mechanica Sinica 2022年第10期38卷 125-144页

作者： YiJin Cheng Yan Li ling tao Pierre Joli Zhi-Qiang Feng School of Mechanics and Aerospace Engineering Southwest Jiaotong UniversityChengdu611756China LMEE Univ EvryUniversitéParis-SaclayEvry91020France

Normally large amounts of particles are required to accurately simulate the metal cutting process,which consumes a lot of computing time and *** techniques can help decrease the number of particles,hence reducing the *** paper presents a novel adaptive smoothed particle hydrodynamics(SPH)method for the metal cutting *** spatial resolution changes adaptively according to the distance to the tool tip by the particle splitting and *** particles are selected in the region where the workpiece and the tool are in *** the contact region constantly changes during the cutting process,two quadrilateral frames are adopted in the adaptive algorithm to dynamically change the distribution of *** frame for the refinement,the other for the *** frames move at the same speed as the *** test the computational efficiency,the metal cutting process is simulated by using SPH with three different adaptive *** results show that the proposed adaptive algorithm with dynamic refinement and coarsening can significantly optimize the runtime.

关键词： Smoothed particle hydrodynamics Metal cutting simulation Dynamic adaptive Refinement Coarsening

Stress-induced growth-differentiation factor 15 plays an intriguing role in cardiovascular diseases

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Chinese Medical Journal 2013年第7期126卷 1350-1354页

作者： LIU Hai-tao WANG Hai-chang tao ling LI Cheng-xiang LI Fei ZHANG Yu-yang LIU Bo-wu Department of Cardiology Xijing Hospital Fourth Military Medical University Xi'an Shaanxi 710032 China

Objective To provide an overview of the current knowledge of growth-differentiation factor 15 （GDF-15） in heart disease. Data sources To identify relevant publications, we searched PubMED database combining the textual terms of heart, cardiac, cardiovascular disease with GDF-15. Study selection Well-controlled, relatively large-scale, retrospective studies as well as meaningful individual cases were all selected as materials. Results GDF-15 is a distant member of the transforming growth factor-13 cytokine superfamily. In myocardium, GDF-15 is weakly expressed under physiological conditions. However, its expression level is increased in response to pathological stress. Growing evidence indicate that elevated levels of GDF-15 is a promising prognostic biomarker in cardiovascular diseases. Moreover, GDF-15 exhibits the properties of endogenous anti-hypertrophy of cardiomyocytes and protecting the heart suffering from ischemia and reperfusion insult. Conclusion Ve GDF-15 may be a promising biomarker for evaluation and management of patient with cardiovascular diseases, and have potential protective properties on myocardium.

关键词： growth-differentiation factor 15 biomarker cardiovascular disease

Thermo-mechanical analysis and design of the extraction grids for negative ion source at ASIPP

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Thermo-mechanical analysis and design of the extraction grid...

Degradation of WTAP Blocks Antiviral Responses by Reducing the m6A Levels of IRF3 and IFNAR1 mRNA

第十八届全国等离子体科学技术会议

作者： ling tao Chundong Hu Yuanlai Xie Jianglong Wei Institute of Plasma Physics Chinese Academy of Sciences

A new negative ion source with accelerator is under developing in the Institute of Plasma Physics Chinese Academy Of Scieneces(ASIPP) for the future research of Neutral Beam Injection(NBI)system of China Fusion Engineering Test Reactor(CFETR).For the NBI system,the extraction system is one of the key components to obtain the negative ions,which is designed as three grids: the plasma grid,the extraction grid and the grounded grid,and it must fulfill several operational requirements and satisfy the fatigue *** grid is impacted by different heat loads especially the extraction *** this paper,the fluid-solid coupling model is established for the extraction grid and its internal cooling fluid,and the corresponding heat flux boundary conditions are proposed according to the power deposition *** the temperature profile of the grid,temperature rising of the internal water and the flow characteristics of the cooling water is analyzed,and the stress distribution and deformation characteristics of the grid are obtained.d on these results,the cooling circuit is designed and optimized to satisfy the grid requirements of temperature(under423.1573.15 K) and pressure drop(less than 0.5 Mpa),and the stability of the extraction gird could be *** paper provides an important reference for the analysis and design of other grids structures in the extraction system,and is of great significance to the engineering realization and experimental condition of accelerator for NBI system in the future.

关键词： neutral beam injection system extraction system thermo-mechanical analysis temperature control

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Degradation of WTAP Blocks Antiviral Responses by Reducing t...

Advances in the effects of supplementation vitamin D on metabolic syndrome

第十四届全国免疫学学术大会

作者： Yong Ge tao ling Shaochun Yuan Anlong Xu School of Life Sciences Sun Yat-Sen University School of Life Sciences Beijing University of Chinese Medicine

N-methyladenosine(mA) is a chemical modification present in multiple RNA species and is added to mRNA by a multisubunit ‘writer’ complex composed of the METTL3/METTL14/WTAP heterotrimer and numerous additional adaptor proteins. Studies on mA reveal its comprehensive roles in almost every aspect of mRNA metabolism and mA has emerged as a widespread regulatory mechanism that controls gene expression in diverse physiological processes. Type I IFNs are important for host defence against viruses. To avoid excessive or dysregulated IFN responses, the host has developed sophisticated mechanisms at multiple-levels to maintain appropriate IFN responses and ensure the most favorable outcome. Some recent discoveries indicate that mA can affect the life cycles of numerous viruses as well as the cellular antiviral immune response. However, the specific mechanisms, especially whether and how mA modification regulate the production of type I IFNs and ISGs, are still largely unknown. Here, we reveal that WT1-associated protein(WTAP), one of the mA ‘writers’, is degraded via the ubiquitination-proteasome pathway upon activation of IFN-I signaling. By screening the key components involved in IFN-I signaling after knocking down WTAP, we find that degradation of WTAP can block antiviral responses by reducing the protein abundance of IFN-regulatory factor 3(IRF3) and interferon alpha/beta receptor subunit 1(IFNAR1). Further tests show that the mA levels of IRF3 and IFNAR1 mRNAs are reduced with the degradation of WTAP, leading to translational suppression of IRF3 and instability of IFNAR1 mRNAs. Thus, the WTAP-IRF3/IFNAR1 axis may serve as negative feedback pathway to fine-tune the activation of IFN-I signaling to protect the host from immunopathology of overreactive and harmful IFN-I production, which highlights the sophisticated regulatory mechanisms of antiviral responses at post-transcriptional level and the roles of mA in the antiviral responses by dictating the fate of mRNAs assoc

关键词： antiviral responses IFNAR1 IRF3 m~6A modification WTAP

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Journal of Hainan Medical University 2021年第5期27卷 71-74页

作者： Ya-ling tao Xu-Lei Tang Cong-Hui Guan First Hospital of Lanzhou University Lanzhou CityGansu Province730000

Metabolic syndrome is a syndrome of central obesity,diabetes or impaired glucose metabolism,dyslipidemia,hypertension,hyperuricemia and a series of metabolic *** incidence of terminal events is high,especially cardiovascular and cerebrovascular events have been among the top three causes of death,which seriously threatens human *** D is a fat-soluble vitamin with many *** relationship between its deficiency and metabolic syndrome has attracted attention at home and *** supplementation vitamin D can improve the state of metabolic syndrome is inconsistent with the existing research *** paper mainly discusses the relationship between vitamin D deficiency and various components of metabolic syndrome(obesity,diabetes,hypertension,dyslipidemia),and the effect of vitamin supplementation D on these metabolic diseases.

关键词： Metabolic Syndrome Vitamin D Research progress