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Primary myelofibrosis with thrombophilia as first symptom combined with thalassemia and Gilbert syndrome:A case report

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World Journal of Clinical Cases 2022年第13期10卷 4161-4170页

作者： Guzailinuer Wufuer Kaisaer Wufuer Tu Ba tao Cui ling tao ling Fu Ming Mao Ming-Hui Duan Department of Hematology People's Hospital of Xinjiang Uygur Autonomous RegionUrumqi 830001Xinjiang Uygur Autonomous RegionChina Department of Thoracic Surgery The Eighth Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830001Xinjiang Uygur Autonomous RegionChina Department of Pathology People's Hospital of Xinjiang Uygur Autonomous RegionUrumqi 830001Xinjiang Uygur Autonomous RegionChina Department of Radiology People's Hospital of Xinjiang Uygur Autonomous RegionUrumqi 830001Xinjiang Uygur Autonomous RegionChina Department of Hematology Peking Union Medical College HospitalBeijing 100730China

BACKGROUND A 46-year-old Han man first had sigmoid sinus and transverse sinus venous thrombosis at the age of *** the age of 44,he once again developed *** testing showed heterozygous SERPINC1 mutation,bone marrow biopsy showed fibrosis grade 1(MF-1),and JAK2 V617F mutation was positive,accompanied by UGT1A1 mutation andβ-thalassemia gene *** SUMMARY A 46-year-old Han man was first found to have sigmoid sinus and transverse sinus venous thrombosis at the age of 42 but had no individual or family thrombosis history,and he had been regularly taking warfarin anticoagulant therapy for a long period of *** the age of 44,venous thrombosis reappeared in parts of the intrahepatic vein,main portal vein,splenic vein,and superior mesenteric vein,and his spleen was obviously *** had a history of jaundice for many years,and genetic testing revealed that he carried a heterozygous SERPINC1 *** marrow biopsy showed multifocal fibrous tissue hyperplasia among trabeculae and focal *** was positive for the JAK2 V617F *** the same time,UGT1A1 andβ-thalassemia gene mutations existed,and a SERPINC1 mutation and UGT1A1 mutation were both found in his *** The patient in this case had thrombophilia as the primary symptom,JAK2V617-positive myeloproliferative neoplasm(MPN)was the main potential cause,and hereditary AT-III deficiency may have been one of multiple secondary *** remains to be determined whether UGT1A1 andβ-thalassemia gene mutations are related to ***,the clinical features of MPN in this patient were hidden,and the relevant clinical features of coexisting thalassemia and hereditary Gilbert syndrome,reported here for the first time domestically and abroad,were complicating factors,causing great difficulties for a clear ***,when thrombophilia has been determined,it is necessary to screen the relevant latent problems *** the clinical features cannot be perfect

关键词： Thrombophilia Prefibrotic myelofibrosis Negative family thrombosis history Case report

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Estimating index of population trend by re-sampling techniques （jackknife and bootstrap） and its application to the life table study of rice leaf roller, Cnaphalocrocis medinalis （Lepidoptera： Pyralidae）

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Insect Science 2008年第2期15卷 153-161页

作者： Fang-ling tao Shi-Fan Min Wei-Jian Wu Guang-Wen Liang ling Zeng Laboratory of Insect Ecology South China Agriculture University Guangzhou Department of Food Science Jiangxi AgriculturalUniversity Nanchang China

Taking a published natural population life table of rice leaf roller, Cnaphalocrocis medinalis （Lepidoptera： Pyralidae）, as an example, we estimated the population trend index, I, via re-sampling methods （jackknife and bootstrap）, determined its statistical properties and illustrated the application of these methods in determining the control effectiveness of bio- agents and chemical insecticides. Depending on the simulation outputs, the smoothed distribution pattern of the estimates of I by delete-1 jackknife is visually distinguishable from the normal density, but the smoothed pattern produced by delete-d jackknife, and logarithm- transformed smoothed patterns produced by both empirical and parametric bootstraps, matched well the corresponding normal density. Thus, the estimates of I produced by delete-1 jackknife were not used to determine the suppressive effect of wasps and insecticides. The 95% percent confidence intervals or the narrowest 95 percentiles and Z-test criterion were employed to compare the effectiveness of Trichogrammajaponicum Ashmead and insecticides （powder, 1.5% mevinphos ＋ 3% alpha-hexachloro cyclohexane） against the rice leaf roller based on the estimates of I produced by delete-d jackknife and bootstrap techniques. At a = 0.05 level, there were statistical differences between wasp treatment and control, and between wasp and insecticide treatments, if the normality is ensured, or by the narrowest 95 percentiles. However, there is still no difference between insecticide treatment and control. By Z-test criterion, wasp treatment is better than control and insecticide treatment with P-value 〈 0.01. Insecticide treatment is similar to control with P-value 〉 0.2 indicating that 95% confidence intervals procedure is more conservative. Although similar conclusions may be drawn by re-sampling techniques, such as the delta method, about the suppressive effect of trichogramma and insecticides, the normality of the estimates can be checked and guarante

关键词： index of population trend life table re-sampling (jackknife bootstrap) riceleaf roller ( Cnaphalocrocis medinalis)

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Technical factors affecting the performance of anion exchange membrane water electrolyzer

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International Journal of Minerals,Metallurgy and Materials 2023年第11期30卷 2259-2269页

作者： Xun Zhang Yakang Li Wei Zhao Jiaxin Guo Pengfei Yin tao ling Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education Institute of New-EnergySchool of Materials Science and EngineeringTianjin UniversityTianjin 300072China School of Materials Science and Engineering Tianjin Chengjian UniversityTianjin 300384China

Anion exchange membrane(AEM)electrolysis is a promising membrane-based green hydrogen production ***,AEM electrolysis still remains in its infancy,and the performance of AEM electrolyzers is far behind that of well-developed alkaline and proton exchange membrane ***,breaking through the technical barriers of AEM electrolyzers is *** the basis of the analysis of the electrochemical performance tested in a single cell,electrochemical impedance spectroscopy,and the number of active sites,we evaluated the main technical factors that affect AEM *** factors included catalyst layer manufacturing(e.g.,catalyst,carbon black,and anionic ionomer)loadings,membrane electrode assembly,and testing conditions(e.g.,the KOH concentration in the electrolyte,electrolyte feeding mode,and operating temperature).The underlying mechanisms of the effects of these factors on AEM electrolyzer performance were also *** irreversible voltage loss in the AEM electrolyzer was concluded to be mainly associated with the kinetics of the electrode reaction and the transport of electrons,ions,and gas-phase products involved in *** on the study results,the performance and stability of AEM electrolyzers were significantly improved.

关键词： hydrogen production anion exchange membrane water electrolyzer catalyst membrane electrode assembly

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铁碳填料耦合生物膜法对生活污水的处理研究

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水处理技术 2025年第1期51卷 90-96,113页

作者：任珺武潮辉杨埴王若安杨莉萍陶玲兰州交通大学环境与市政工程学院甘肃兰州730070 甘肃瀚兴环保科技有限公司甘肃兰州730070 甘肃创恒环保工程有限公司甘肃兰州730070

在700~1000℃的高温下烧结制备了不同种类的铁碳微电解填料,通过静态实验表明,掺杂铝粉的铁碳微电解填料投加到生活污水中有显著的处理效果,NH_(4)^(+)-N、COD和TN分别达到了6.18%、44.18%和6.86%,去除效果优于其他填料。掺杂铝粉的铁... 详细信息

在700~1000℃的高温下烧结制备了不同种类的铁碳微电解填料,通过静态实验表明,掺杂铝粉的铁碳微电解填料投加到生活污水中有显著的处理效果,NH_(4)^(+)-N、COD和TN分别达到了6.18%、44.18%和6.86%,去除效果优于其他填料。掺杂铝粉的铁碳填料在TP的去除率为33.45%,低于掺杂碳酸镁的铁碳微电解填料35.53%的去除率。但是,根据综合处理效果来看,处理生活污水最佳的填料为掺杂铝粉的铁碳微电解填料。将掺杂铝粉的铁碳微电解填料投加到挂膜成功的生物膜反应器中,结果表明,投加铁碳微电解填料的生物膜在NH_(4)^(+)-N、COD、TN和TP的平均出水去除率分别达到了85%、89%、79%和81%。

关键词：生活污水生物膜铁碳微电解填料

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Sodium 4-phenylbutyrate Attenuates High-fat Diet-induced Impaired Spermatogenesis

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Biomedical and Environmental Sciences 2018年第12期31卷 876-882页

作者： WANG Er Hui YAO San Qiao tao ling XI Jin Yan Department of Nutrition and Food Hygiene College of Public Health Xinxiang Medical University Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine Xinxiang Medical University

Objective To determine the mitigating effects of sodium 4-phenylbutyrate(4-PBA) on high-fat diet(HFD)-induced spermatogenesis dysfunction. Methods Male rats(n = 30) were randomly divided into three groups: control, HFD, and 4-PBA(HFD +4-PBA). After 13 weeks, rats were euthanized. Testes and epididymis were harvested for further analysis. Sex hormones were detected, and hematoxylin and eosin staining was performed to examine the histological changes in the testes. Semen samples were collected to evaluate sperm quality. Spermatogenic cell apoptosis was detected by TUNEL assay. Results Compared with the control group, the final body weight and body weight gain were significantly higher in HFD-fed rats, while the testicle/body weight ratios were lower(P < 0.05). In HFD-fed rats, obvious pathological changes in the testicular tissue were observed. Treatment with 4-PBA attenuated HFD-induced histological damage, ameliorated the HFD-induced decrease in serum testosterone(T), and reduced the rate of testicular cell apoptosis(P < 0.05) in obese male rats. Finally, 4-PBA significantly improved semen parameters in HFD rats(P < 0.05). Conclusion HFD exposure induced detrimental effects on spermatogenesis, semen quality, serum T level, and testicular cell apoptosis in rats. Treatment with 4-PBA ameliorated HFD-induced impaired spermatogenesis via inhibition of apoptosis in rats. 4-PBA may have therapeutic value in the treatment of obesity-related impairment of spermatogenesis.

关键词： Male infertility Sodium 4-phenylbutyrate Obesity Spermatogenesis Semen Testis

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Influence of spinal cord injury on core regions of motor function

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Neural Regeneration Research 2021年第3期16卷 567-572页

作者： Xiao-Yan Shen Chun-ling tao Lei Ma Jia-Huan Shen Zhi-ling Li Zhi-Gong Wang Xiao-Ying Lü School of Information Science and Technology Nantong UniversityNantongJiangsu ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Institute of RF and OE-ICs Southeast UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Bioelectronics Southeast UniversityNanjingJiangsu ProvinceChina

Functional electrical stimulation is an effective way to rebuild hindlimb motor function after spinal cord ***,no site map exists to serve as a reference for implanting stimulator *** this study,rat models of thoracic spinal nerve 9 contusion were established by a heavy-impact method and rat models of T6/8/9 spinal cord injury were established by a transection *** microstimulation was performed to record motion types,site coordinates,and threshold currents induced by *** transection(complete injury),the core region of hip flexion migrated from the T13 to T12 vertebral segment,and the core region of hip extension migrated from the L1 to T13 vertebral *** was affected by post-transection time,but not transection ***,the longer the post-transection time,the longer the distance of *** study provides a reference for spinal electrode implantation after spinal cord *** study was approved by the Institutional Animal Care and Use Committee of Nantong University,China(approval No.20190225-008)on February 26,2019.

关键词： model motor neurological function rat recovery repair spinal cord injury

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Romipeptides A and B, two new romidepsin derivatives isolated from Chromobacterium violaceum No.968 and their antitumor activities in vitro

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Chinese Journal of Natural Medicines 2019年第2期17卷 155-160页

作者： XIONG Lei CHEN Chang-Fa MIN tao-ling HU Hai-Feng State Key Lab of New Drug&Pharmaceutical Process Shanghai Institute of Pharmaceutical Industry China State Institute of Pharmaceutical Industry

Romipeptides A and B(1 and 2),two new romidepsin derivatives,and three known compounds,chromopeptide A(3),romidepsin(4)and valine-leucine dipeptide(5)were isolated from the fermentation broth of Chromobacterium violaceum *** structures were elucidated by interpretation of their UV,HR-ESI-MS and NMR *** absolute configuration of compound 1 and 2 were established by single crystal X-ray diffraction *** 1–5 were evaluated for their anti-proliferative activities against three human cancer cell lines,SW620,HL60,and *** results showed most of these compounds exhibited antitumor activities in vitro,in which compound 2 displayed potent cytotoxicity to SW620,HL60 and A549 cell lines,with IC_(50) of 12.5,6.7 and 5.7 nmol·L^(–1),respectively.

关键词： Chromobacterium violaceum Romidepsin derivatives Cytotoxicity

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Secure Content Based Image Retrieval Scheme Based on Deep Hashing and Searchable Encryption

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Computers, Materials & Continua 2023年第6期75卷 6161-6184页

作者： Zhen Wang Qiu-yu Zhang ling-tao Meng Yi-lin Liu School of Computer and Communication Lanzhou University of TechnologyLanzhou730050China

To solve the problem that the existing ciphertext domain image retrieval system is challenging to balance security,retrieval efficiency,and retrieval *** research suggests a searchable encryption and deep hashing-based secure image retrieval technique that extracts more expressive image features and constructs a secure,searchable encryption ***,a deep learning framework based on residual network and transfer learn-ing model is designed to extract more representative image deep ***,the central similarity is used to quantify and construct the deep hash sequence of *** Paillier homomorphic encryption encrypts the deep hash sequence to build a high-security and low-complexity searchable ***,according to the additive homomorphic property of Paillier homomorphic encryption,a similarity measurement method suitable for com-puting in the retrieval system’s security is ensured by the encrypted *** experimental results,which were obtained on Web Image Database from the National University of Singapore(NUS-WIDE),Microsoft Common Objects in Context(MS COCO),and ImageNet data sets,demonstrate the system’s robust security and precise retrieval,the proposed scheme can achieve efficient image retrieval without revealing user *** retrieval accuracy is improved by at least 37%compared to traditional hashing *** the same time,the retrieval time is saved by at least 9.7%compared to the latest deep hashing schemes.

关键词： Content-based image retrieval deep supervised hashing central similarity quantification searchable encryption Paillier homomorphic encryption

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Test factors affecting the performance of zinc–air battery

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Journal of Energy Chemistry 2020年第5期29卷 1-7页

作者： Dian Jiao Ziang Ma Jisi Li Yajing Han Jing Mao tao ling Shizhang Qiao Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education School of Materials Science and EngineeringTianjin UniversityTianjin 300072China School of Chemical Engineering The University of AdelaideAdelaideSA 5005Australia

Zinc-air batteries provide a great potential for future large-scale energy *** assess the test factors that mainly affect the measured power density of the zinc-air *** fitting the polarization curves of the zinc-air batteries,we reveal the effect of testing parameters(electrode distance,electrolyte concentration,and oxygen flux)and preparation of catalysts ink on the activation,ohm,and concentration polarizations of the zinc-air ***,recommendations on evaluating the potentials of non-noblemetal electrocatalysts for applications in zinc-air batteries were given.

关键词： Zinc-air battery Power density Oxygen reduction reaction Non-noble metal catalysts

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Correlation-driven threefold topological phase transition in monolayer OsBr_(2)

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Frontiers of physics 2023年第3期18卷 121-130页

作者： San-Dong Guo Yu-ling tao Wen-Qi Mu Bang-Gui Liu School of Electronic Engineering Xi’an University of Posts and TelecommunicationsXi’an 710121China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190China

Spin–orbit coupling(SOC)combined with electronic correlation can induce topological phase transition,producing novel electronic ***,we investigate the impact of SOC combined with correlation effects on physical properties of monolayer OsBr_(2),based on first-principles calculations with generalized gradient approximation plus U(GGA+U)*** intrinsic out-of-plane magnetic anisotropy,OsBr_(2)undergoes threefold topological phase transition with increasing U,and valleypolarized quantum anomalous Hall insulator(VQAHI)to half-valley-metal dxy dx2−y2 dz2¯6m2(HVM)to ferrovalley insulator(FVI)to HVM to VQAHI to HVM to FVI transitions can be *** topological phase transitions are connected with sign-reversible Berry curvature and band inversion between/and *** to symmetry,piezoelectric polarization of OsBr_(2)is confined along the in-plane armchair direction,and only one d11 is *** a given material,the correlation strength should be fixed,and OsBr_(2)may be a piezoelectric VQAHI(PVQAHI),piezoelectric HVM(PHVM)or piezoelectric FVI(PFVI).The valley polarization can be flipped by reversing the magnetization of Os atoms,and the ferrovalley(FV)and nontrivial topological properties will be suppressed by manipulating out-of-plane magnetization to in-plane *** considered reasonable U range,the estimated Curie temperatures all are higher than room *** findings provide a comprehensive understanding on possible electronic states of OsBr_(2),and confirm that strong SOC combined with electronic correlation can induce multiple quantum phase transition.

关键词： correlation SOC phase transition piezoelectricity

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