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An Underwater Image Bubble Noise Removal Method Based on Optical Flow

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Journal of Harbin Institute of Technology(New Series) 2019年第1期26卷 11-16页

作者： Hao Li jianguo tao Yang Luo Liping Deng Zongquan Deng State Key Laboratory of Robotics and System Harbin Institute of Technology

It is very important for underwater robots to accurately detect and locate target objects. However,under many circumstances,it is difficult to clearly observe the target object due to the existence of bubble noise. In this paper,we proposed a method to solve this problem. First,we used the LK optical flow algorithm to calculate the motion vector of the image background and compensate for the background ***,the optical flow field of the bubbles was calculated by the HS optical flow algorithm,and the area where the bubble existed was obtained by binarizing the image. Finally,we used the adjacent frame image to repair the bubble area. We carried out a bubble noise removal experiment. The results show that this method can effectively remove the bubble noise in the image.

关键词： bubble noise optical flow background motion image repair

Acellular nerve grafts supplemented with induced pluripotent stem cell-derived exosomes promote peripheral nerve reconstruction and motor function recovery

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Bioactive Materials 2022年第9期7卷 272-287页

作者： Jianfeng Pan Meng Zhao Xiangjiao Yi jianguo tao Shaobo Li Zengxin Jiang Biao Cheng Hengfeng Yuan Feng Zhang Department of Orthopedics Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai200072China Diseases&Population Geninfo Lab School of Life SciencesWestlake UniversityHangzhouZhejiang310024China Institute of Orthopaedics and Traumatology Zhejiang Chinese Medical University Affiliated First Affiliated HospitalHangzhouZhejiang310024China Department of Orthopaedics Shanghai Jiaotong University Affiliated Sixth People’s HospitalShanghai200233China Institute of Microsurgery On Extremities Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai200233China Joseph M.Still Burn and Reconstructive Center JacksonMS39204USA

Peripheral nerve injury is a great challenge in clinical work due to the restricted repair gap and weak regrowth ***,we selected induced pluripotent stem cells(iPSCs)derived exosomes to supplement acellular nerve grafts(ANGs)with the aim of restoring long-distance peripheral nerve *** fibroblasts were reprogrammed into iPSCs through non-integrating transduction of Oct3/4,Sox2,Klf4,and *** obtained iPSCs had highly active alkaline phosphatase expression and expressed Oct4,SSEA4,Nanog,Sox2,which also differentiated into all three germ layers in vivo and differentiated into mature peripheral neurons and Schwann cells(SCs)in *** isolation and biological characteristics of iPSCs-derived exosomes,we found that numerous PKH26-labeled exosomes were internalized inside SCs through endocytotic pathway and exhibited a proliferative effect on SCs that were involved in the process of axonal regeneration and *** that,we prepared ANGs via optimized chemical extracted process to bridge 15 mm long-distance peripheral nerve gaps in *** to the promotion of iPSCs-derived exosomes,satisfactory regenerative outcomes were achieved including gait behavior analysis,electrophysiological assessment,and morphological analysis of regenerated ***,motor function was restored with comparable to those achieved with nerve autografts and there were no significant differences in the fiber diameter and area of reinnervated muscle *** together,our combined use of iPSCs-derived exosomes with ANGs demonstrates good promise to restore long-distance peripheral nerve defects,and thus represents a cell-free strategy for future clinical applications.

关键词： Induced pluripotent stem cells Exosomes Acellular nerve grafts Peripheral nerve reconstruction Motor function recovery

miR-150在套细胞淋巴瘤中的表达及意义

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中国肿瘤临床 2013年第13期40卷 763-766页

作者：张新伟王芳任秀宝 tao jianguo 天津医科大学附属肿瘤医院生物治疗科天津市肿瘤防治重点实验室天津市300060 美国莫菲特肿瘤中心研究所血液肿瘤科

目的:探讨套细胞淋巴瘤(mantle cell lymphoma,MCL)中miR-150的表达情况及其临床意义。方法:通过定量RT-PCR检测29例初治MCL患者及7例正常人外周血B细胞中miR-150和c-Myc的表达水平,探索miR-150和c-Myc表达之间的关系;利用RNAi阻断MCL... 详细信息

目的:探讨套细胞淋巴瘤(mantle cell lymphoma,MCL)中miR-150的表达情况及其临床意义。方法:通过定量RT-PCR检测29例初治MCL患者及7例正常人外周血B细胞中miR-150和c-Myc的表达水平,探索miR-150和c-Myc表达之间的关系;利用RNAi阻断MCL细胞系Mino和HBL-2中c-Myc表达后,检测miR-150的变化,确定c-Myc是否参与miR-150的表达调控;抑制P493-6细胞表达c-Myc后,观察miR-150的变化,进一步明确miR-150是否受c-Myc调节;将pre-miR-150电转HBL-2细胞系,通过集落形成试验明确miR-150对细胞增殖的影响,Western blot检测c-Myb蛋白的变化。结果:与正常人外周血B细胞相比,MCL患者低表达miR-150、过表达c-Myc,两者的表达呈负相关;阻断c-Myc后,Mino和HBL-2细胞的miR-150表达增加;抑制c-Myc表达后,P493-6细胞的miR-150表达增高;过表达miR-150后,HBL-2的c-Myb蛋白表达水平和集落形成能力下降。结论:MCL患者低表达miR-150的原因可能与其c-Myc过表达有关。miR-150能够抑制MCL的增殖,在MCL的治疗中具有潜在价值。

关键词：套细胞淋巴瘤 miR-150 c-Myc

Shared genetic architecture highlights the bidirectional association between major depressive disorder and fracture risk

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General Psychiatry 2024年第3期37卷 352-363页

作者： Pianpian Zhao Zhimin Ying Chengda Yuan Haisheng Zhang Ao Dong jianguo tao Xiangjiao Yi Mengyuan Yang Wen Jin Weiliang Tian David Karasik Geng Tian Houfeng Zheng The Affiliated Hangzhou First People’s Hospital School of MedicineWestlake UniversityHangzhouZhejiangChina Westlake Laboratory of Life Sciences and Biomedicine HangzhouZhejiangChina Diseases&Population(DaP)Geninfo Lab School of Life SciencesWestlake UniversityHangzhouZhejiangChina Institute of Basic Medical Sciences Westlake Institute for Advanced StudyHangzhouZhejiangChina Department of Orthopedic Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina Department of Dermatology Hangzhou Hospital of Traditional Chinese MedicineHangzhouZhejiangChina Department of Global Statistics Eli Lilly and CompanyBranchburgNew JerseyUSA Azrieli Faculty of Medicine Bar-Ilan UniversitySafedIsrael Binzhou Medical University YantaiShandongChina

Background There is limited evidence suggesting that osteoporosis might exacerbate depressive symptoms,while more studies demonstrate that depression negatively affects bone density and increases fracture *** To explore the relationship between major depressive disorder(MDD)and fracture *** We conducted a nested case-control analysis(32670 patients with fracture and 397017 individuals without fracture)and a matched cohort analysis(16496 patients with MDD and 435492 individuals without MDD)in the same prospective UK Biobank data ***,we investigated the shared genetic architecture between MDD and fracture with linkage disequilibrium score regression and the MiXeR statistical *** used the conditional/conjunctional false discovery rate approach to identify the specific shared *** calculated the weighted genetic risk score for individuals in the UK Biobank and logistic regression was used to confirm the association observed in the prospective *** We found that MDD was associated with a 14%increase in fracture risk(hazard ratio(HR)1.14,95%CI 1.14 to 1.15,p<0.001)in the nested case-control analysis,while fracture was associated with a 72%increase in MDD risk(HR 1.72,95%CI 1.64 to 1.79,p<0.001)in the matched cohort analysis,suggesting a longitudinal and bidirectional ***,genetic summary data suggested a genetic overlap between MDD and ***,we identified four shared genomic loci,with the top signal(rs7554101)near *** protein encoded by SGIP1 is involved in cannabinoid receptor type 1 *** found that genetically predicted MDD was associated with a higher risk of fracture and vice *** addition,we found that the higher expression level of SGIP1 in the spinal cord and muscle was associated with an increased risk of fracture and *** The genetic pleiotropy between MDD and fracture highlights the bidirectional association observed in the epidemiological *** shared ge

关键词： fracture matched osteoporosis

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新型主-被动悬架式星球车垂直越障性能分析

宇航学报 2023年第8期44卷 1127-1138页

作者：户三峰陶建国哈尔滨工业大学机器人技术与系统国家重点实验室哈尔滨150080

针对现有星球车移动系统因摩擦系数需求较大而制约其越障能力的问题,提出一种摩擦系数需求较小、越障能力强大的新型主-被动悬架式六轮移动系统构型。该移动系统采用双差动连杆悬架机构连接前后两节的三对车轮,具有被动、半主动和主动... 详细信息

针对现有星球车移动系统因摩擦系数需求较大而制约其越障能力的问题,提出一种摩擦系数需求较小、越障能力强大的新型主-被动悬架式六轮移动系统构型。该移动系统采用双差动连杆悬架机构连接前后两节的三对车轮,具有被动、半主动和主动三种行驶运动模式。建立星球车的运动学和准静力学模型,对三种模式的垂直越障性能进行了分析,获得了实现越障车轮所需的摩擦系数,并以此作为评价指标,对所设计的星球车移动系统和其它典型星球车移动系统的越障性能进行了对比讨论。建立了所设计的星球车移动系统的虚拟样机模型,校验了其半主动和主动模式的垂直越障性能。计算与仿真结果表明,所设计的新型主-被动悬架式星球车半主动模式的垂直越障能力与摇臂-转向架式悬架星球车相当,主动模式的垂直越障能力相较于摇臂-转向架式悬架星球车有显著提升。

关键词：星球车主-被动悬架准静力学分析垂直越障

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日本校园欺凌事件中教育机构的调查报告义务

比较教育研究 2021年第4期43卷 36-42页

作者：陶建国河北大学法学院河北保定071002

在日本,教育机构在校园欺凌事件中对家长负有调查报告义务,违反这一义务时,教育机构设置者将承担损害赔偿责任。教育机构负有调查报告义务的理论学说包括教育委托关系说、教育权上的信息请求权说、接受教育的权利说和知情权说等。2013年... 详细信息

在日本,教育机构在校园欺凌事件中对家长负有调查报告义务,违反这一义务时,教育机构设置者将承担损害赔偿责任。教育机构负有调查报告义务的理论学说包括教育委托关系说、教育权上的信息请求权说、接受教育的权利说和知情权说等。2013年,日本颁布《欺凌预防对策推进法》,从立法上确立了教育机构的调查报告义务,文部科学省根据法律授权出台了建构调查报告机制的指导性规定。相关立法和政策就调查报告制度确立了详细的内容,包括调查条件、调查组织、调查程序和方法、调查报告的利用和个人信息的保护等。在司法实践方面,教育机构如果依据程序规范能够积极对学生家长履行调查报告义务,法院一般不会作出其行为违法的认定。

关键词：教育机构校园欺凌调查报告义务

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韩国幼儿园教育评价制度研究

外国教育研究 2014年第11期41卷 47-53页

作者：陶建国河北大学政法学院河北保定071002

为提高幼儿园教育质量,确保幼儿园教育符合国家制定的标准,韩国通过制定《幼儿教育法》建立了幼儿园教育评价制度。评价每三年进行一次,实施对象为韩国全部国立、公立和私立幼儿园。为确保评价结果的客观性和公正性,韩国制定了详细的评... 详细信息

为提高幼儿园教育质量,确保幼儿园教育符合国家制定的标准,韩国通过制定《幼儿教育法》建立了幼儿园教育评价制度。评价每三年进行一次,实施对象为韩国全部国立、公立和私立幼儿园。为确保评价结果的客观性和公正性,韩国制定了详细的评价指标体系。负责评价的机构是由教育专家和幼儿园教师组成的评价委员会,评价方法基本上使用书面评价、现场评价和综合评价方式。幼儿园评价制度对推动幼儿园完善教育环境、提高教育质量发挥了积极作用,但制度运行过程中也显现出一些需要进一步完善的问题。

关键词：韩国幼儿园幼儿教育教育评价

描述变胞机构构态变换的一种新方法及其在构型综合中的应用

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机械工程学报 2011年第15期47卷 1-8页

作者：杨飞陶建国邓宗全哈尔滨工业大学机器人技术与系统国家重点实验室哈尔滨150001

通过分析变胞机构的拓扑构态变换过程,提出一种能描述杆件减少过程中任意杆件合并的矩阵表达新方法,此方法不需要进行行列变换就可得到简洁的终态矩阵,且不影响原机构杆件的编号。以此方法为基础,阐述杆件数增加或不变的变胞机构拓扑构... 详细信息

通过分析变胞机构的拓扑构态变换过程,提出一种能描述杆件减少过程中任意杆件合并的矩阵表达新方法,此方法不需要进行行列变换就可得到简洁的终态矩阵,且不影响原机构杆件的编号。以此方法为基础,阐述杆件数增加或不变的变胞机构拓扑构态变换的数学描述和实现方法。根据变胞机构构态变化规律和平面机构构型综合的拓扑相关性,提出基于变胞机构拓扑构态变换的数学描述进行平面闭链机构构型综合的新方法,给出单自由度闭链构型综合的实现方法和步骤,并以8杆机构构型综合为例进行应用说明。

关键词：变胞机构构态变换图论邻接矩阵构型综合

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韩国雇用法制和政策的最新发展状况考察

中国人力资源开发 2014年第17期31卷 92-96,102页

作者：陶建国河北大学政法学院副教授

2013年至2014年期上半年,韩国先后出台了非正规雇佣转换为正式雇佣、时间选择制雇佣;延长退休年龄等政策或法制,这些立法或政策促使韩国劳动市场发生重大变化。韩国政府近几年对雇用法制或政策的不断完善,目的是实现2010年颁布的《国家... 详细信息

2013年至2014年期上半年,韩国先后出台了非正规雇佣转换为正式雇佣、时间选择制雇佣;延长退休年龄等政策或法制,这些立法或政策促使韩国劳动市场发生重大变化。韩国政府近几年对雇用法制或政策的不断完善,目的是实现2010年颁布的《国家雇用战略2020》设立的目标,构建世界先进的劳动市场。当然,韩国社会在对劳动市场的变化感到惊喜的同时,也在反思其中存在的问题。

关键词：雇佣法制劳动者退休年龄工资