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Cyclosporine treatment in idiopathic membranous nephropathy nephrotic syndrome in adults： a retrospective study spanning 15 years

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Chinese Medical Journal 2011年第21期124卷 3490-3494页

作者： tao jian-ling liu li-li wen yu-bing gao rui-tong li hang li ming-xi li xue-mei li xue-wang Division of Nephrology Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Science Beijing 100730 China

Background Cyclosporine is effective in treating nephrotic syndrome （NS） with idiopathic membranous nephropathy （IMN） in adults. But high relapse rate remains a major concern. The way to manipulate cyclosporine is inconclusive. The aim of this study was to introduce the way how to titrate the cyclosporine to maintain complete remission without relapse. Methods Patients with biopsy-proven IMN with NS treated with cyclosporine for at least 1 month from 1996 to 2011 at Peking Union Medical College Hospital were reviewed. Results Mean age of the 51 eligible patients was 52 years, with 39 men. Mean proteinuria was （7.47±3.14） g/d, serum albumin （24.50±6.29） g/L, and serum creatinine （82.62±21.18） μmol/L. Cyclosporine was commenced at a mean dose of （3.46±0.63） mg·kg^-1·d^-1. Oral prednisone （0.40±0.29） mg·kg^-1·d^-1 was given concomitantly in 38 patients. Cyclosporine was administered for a median of 16 months （range 1-93 months） and stopped in non-responders by month six. By month 3 （n=47）, the number in complete remission （CR） and partial remission （PR） was 3 and 24, which shifted to 12 and 17 by month 6 （n=41）. Male gender, heavy proteinuria, low serum albumin level, and high serum creatinine level were significant determinants in poor response by month six （P 〈0.05 in all variables compared with responders）. There was a significant reversible serum creatinine increase within 25% during month 3 to 12 （P 〈0.05 in all variables compared with baseline value）. Eleven patients maintained cyclosporine for more than 24 months with a cyclosporine dose of （1.04±1.06） mg·kg^-1·d^-1. Nine patients were in CR. Renal function, systolic and diastolic blood pressure remained stable. Renal impairment （〉30% rise of serum creatinine）, secondary infection, hypertension, gingival hyperplasia and liver impairment occurred in 6, 4, 10, 4, and 1 patients, respectively. Conclusions The observation time for cyclosporine to effectively induce CR of NS in IMN adults should be at least six month

关键词： cyclosporine idiopathic membranous nephropathy nephrotic syndrome treatment

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Prediction of energy resolution in the JUNO experiment

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Chinese Physics C 2025年第1期49卷 35-59页

作者： Angel Abusleme Thomas Adam Kai Adamowicz Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Fengpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Joao Pedro Athayde Marcondes de André Didier Auguste Weidong Bai Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Marco Beretta Antonio Bergnoli Daniel Bick Lukas Bieger Svetlana Biktemerova Thilo Birkenfeld Iwan Blake David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Jose Busto Anatael Cabrera Barbara Caccianiga Hao Cai xiao Cai Yanke Cai Zhiyan Cai Stéphane Callier Steven Calvez Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Vanessa Cerrone Jinfan Chang yun Chang Auttakit Chatrabhuti Chao Chen Guoming Chen Pingping Chen Shaomin Chen xin Chen Yiming Chen Yixue Chen yu Chen Zelin Chen Zhangming Chen Zhiyuan Chen Zikang Chen Jie Cheng Yaping Cheng yuChin Cheng Alexander Chepurnov Alexey Chetverikov Davide Chiesa Pietro Chimenti Yen-Ting Chin Po-lin Chou Ziliang Chu Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Marta Colomer Molla Selma Conforti Di Lorenzo Alberto Coppi Daniele Corti Simon Csakli Chenyang Cui Flavio Dal Corso Olivia Dalager Jaydeep Datta Christophe De La Taille Zhi Deng Ziyan Deng xiaoyu Ding xuefeng Ding Yayun Ding Bayu Dirgantara Carsten Dittrich Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko jianmeng Dong Evgeny Doroshkevich Wei Dou Marcos Dracos Frédéric Druillole Ran Du Shuxian Du Katherine Dugas Stefano Dusini Hongyue Duyang Jessica Eck Timo Enqvist Andrea Fabbri Ulrike Fahrendholz Lei Fan jian Fang wenxing Fang Dmitry Fedoseev li-Cheng Feng Qichun Feng Federico Ferraro Amélie Fournier Fritsch Fritsch Haonan Gan Feng gao Feng gao Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Nunzio Giudice Maxim Gonchar Guanghua Gong Hui Gong yuri Gornushkin Marco Grassi Maxim Gromov Vasily Gromov minghao G Yerevan Physics Institute YerevanArmenia Université libre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro Rio de JaneiroBrazil Millennium Institute for SubAtomic Physics at the High-energy Frontier(SAPHIR) ANIDChile Pontificia Universidad Católica de Chile SantiagoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina xi'an Jiaotong University Xi'anChina xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhouChina Institute of Physics National

This paper presents an energy resolution study of the JUNO experiment,incorporating the latest knowledge acquired during the detector construction *** determination of neutrino mass ordering in JUNO requires an exceptional energy resolution better than 3% at 1 *** achieve this ambitious goal,significant efforts have been undertaken in the design and production of the key components of the JUNO *** factors affecting the detection of inverse beta decay signals have an impact on the energy resolution,extending beyond the statistical fluctuations of the detected number of photons,such as the properties of the liquid scintillator,performance of photomultiplier tubes,and the energy reconstruction *** account for these effects,a full JUNO simulation and reconstruction approach is *** enables the modeling of all relevant effects and the evaluation of associated inputs to accurately estimate the energy *** results of this study reveal an energy resolution of 2.95% at 1 ***,this study assesses the contribution of major effects to the overall energy resolution *** analysis serves as a reference for interpreting future measurements of energy resolution during JUNO data ***,it provides a guideline for comprehending the energy resolution characteristics of liquid scintillator-based detectors.

关键词： energy resolution liquid scintillator detector JUNO simulation reconstruction

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Frontiers in high entropy alloys and high entropy functional materials

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Rare Metals 2024年第10期43卷 4639-4776页

作者： wen-tao Zhang xue-Qian wang Feng-Qi Zhang xiao-Ya Cui bing-bing Fan Jia-ming Guo Zhi-Min Guo rui Huang wen Huang Xu-Bo li Meng-Ru li Yan Ma Zhi-Hua Shen Yong-Gang Sun De-Zhuang wang Fei-Yang wang li-Qiang wang Nan wang Tian-li wang Wei wang xiao-Yang wang Yi-Han wang Fu-Jie yu yu-Zhen Yin ling-Kun Zhang Yi Zhang jian-Yang Zhang Qi Zhao yu-Ping Zhao xin-Dong Zhu Yasir Sohail Ya-Nan Chen tao Feng Qi-Long gao Hai-Yan He Yong-jiang Huang Zeng-Bao Jiao Hua Ji Yao jiang Qiang li xiao-ming li Wei-bing liao Huai-Jun lin Hui liu Qi liu Qing-Feng liu Wei-Di liu xiong-Jun liu Yang Lu Yi-Ping Lu wen Ma xue-Fei Miao Jie Pan Qing wang Hong-Hui Wu yuan Wu tao Yang Wei-ming Yang Qian yu Jin-yu Zhang Zhi-Gang Chen liang Mao Yang Ren Bao-Long Shen Xun-li wang Zhe Jia He Zhu Zhen-Duo Wu Si Lan School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China jiangsu Key Laboratory for Advanced Metallic Materials School of Materials Science and EngineeringSoutheast UniversityNanjing 211189China Department of Physics City University of Hong KongHongKong 999077China School of Materials Science and Engineering Tianjin UniversityTianjin 300072China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China Department of Mechanical Engineering Research Institute for Advanced ManufacturingThe Hong Kong Polytechnic UniversityHong Kong 100872China Center of Electron Microscopy and State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory of Solidification Control and Digital Preparation Technology(liaoning Province) School of Materials Science and EngineeringDalian University of TechnologyDalian 116024China Institute of Advanced Wear&Corrosion Resistance and Functional Materials Jinan UniversityGuangzhou 510632China School of Mechanics and Civil Engineering China University of Mining and TechnologyXuzhou 221116China School of Physical Sciences Great Bay UniversityDongguan 523000China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China Beijing Advanced Innovation Center for Materials Genome Engineering Research Institute for Carbon NeutralityUniversity of Science and Technology BeijingBeijing 100083China Department of Mechanical Engineering The University of Hong KongHong Kong 999077China School of Computing Macquarie UniversitySydney 2113Australia Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China State Key Laborato

Owing to their exceptional properties,high-entropy alloys(HEAs)and high-entropy materials have emerged as promising research areas and shown diverse ***,the recent advances in the field are comprehensively reviewed,organized into five *** first section introduces the background of HEAs,covering their definition,significance,application prospects,basic properties,design principles,and *** subsequent section focuses on cutting-edge high-entropy structural materials,highlighting developments such as nanostructured alloys,grain boundary engineering,eutectic systems,cryogenic alloys,thin films,micro-nano-lattice structures,additive manufacturing,high entropy metallic glasses,nano-precipitate strengthened alloys,composition modulation,alloy fibers,and refractory *** the following section,the emphasis shifts to functional materials,exploring HEAs as catalysts,magneto-caloric materials,corrosion-resistant alloys,radiation-resistant alloys,hydrogen storage systems,and materials for ***,the review encompasses functional high-entropy materials outside the realm of alloys,including thermoelectric,quantum dots,nanooxide catalysts,energy storage materials,negative thermal expansion ceramics,and high-entropy wave absorption *** paper concludes with an outlook,discussing future directions and potential growth areas in the *** this comprehensive review,researchers,engineers,and scientists may gain valuable insights into the recent progress and opportunities for further exploration in the exciting domains of high-entropy alloys and functional materials.

关键词： High entropy alloys Cutting-edge structural materials Cutting-edgefunctional materials

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The In-Flight Realtime Trigger and Localization Software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： xiao-yun Zhao Shao-lin xiong xiang-Yang wen xin-Qiao li Ce Cai Shuo xiao Qi Luo wen-xi Peng Dong-Ya Guo Zheng-Hua An Ke Gong Jin-yuan liao Yan-Qiu Zhang yue Huang Lu li xing wen Fei Zhang Jing Duan Chen-Wei wang Dong-li Shi Peng Zhang Qi-Bin Yi Chao-Yang li Yan-bing Xu xiao-Hua liang Ya-Qing liu Da-li Zhang xi-Lei Sun Fan Zhang Gang Chen Huan-yu wang Sheng Yang xiao-Jing liu Min gao Mao-Shun li Jin-Zhou wang xing Zhou Yi Zhao wang-Chen xue Chao Zheng Jia-Cong liu xing-Bo Han Jin-ling Qi Jia Huang Ke-Ke Zhang Can Chen xiong-tao Yang Dong-Jie Hou yu-Sa wang rui Qiao xiang Ma xiao-Bo li Ping wang xin-Ying Song li-ming Song Shi-Jie Zheng bing li Hong-mei Zhang yue Zhu Wei Chen jian-jian He Zhen Zhang Jin Hou Hong-Jun wang Yan-Chao Hao xiang-yu wang Zong-yuan Yang Zhi-Long wen Zhi Chang yuan-yuan Du rui gao xiao-Fei Lan Yan-Guo li Gang li Xu-Fang li Fang-Jun Lu Hong Lu Bin Meng Feng Shi Hui wang Hui-Zhen wang yu-Peng Xu Jia-Wei Yang xue-Juan Yang Shuang-Nan Zhang Chao-yue Zhang Cheng-Mo Zhang Zhi-Cheng Tang Cheng Cheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science College China West Normal UniversityNanchong 637002China Department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China Changchun University of Science and Technology Changchun 130022China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

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Efficacy and safety of Shenyankangfu Tablet,a Chinese patent medicine,for primary glomerulonephritis:A multicenter randomized controlled trial

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Journal of Integrative Medicine 2021年第2期19卷 111-119页

作者： Jie Wu Shu-wei Duan Hong-tao Yang yue-yi Deng Wei li Ya-ni He Zhao-hui Ni Yong-li Zhan Shan lin Zhi-yong Guo Jun Zhu Jing-ai Fang Xu-sheng liu li-hua wang Rong wang Nian-song wang xiao-hong Cheng li-qun He Ping Luo Shi-ren Sun Ji-feng Sun Ai-ping Yin Geng-ru jiang Hong-yu Chen wen-hu liu Hong-li lin Meng liang Lu Ma ming Chen li-qun Song jian Chen Qing Zhu Chang-ying xing yun li Ji-ning gao Rong-shan li Ying li Hao Zhang Ying Lu Qiao-ling Zhou Jun-zhou Fu Qiang He Guang-yan Cai xiang-mei Chen Department of Nephrology Chinese People’s Liberation Army General HospitalChinese People’s Liberation Army Institute of NephrologyState Key Laboratory of Kidney Diseases(2011DAV00088)National Clinical Research Center for Kidney DiseasesBeijing 100853China Department of Nephrology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300192China Department of Nephrology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Nephrology Shandong University of Traditional Chinese Medicine Affiliated HospitalJinan 250011.Shandong ProvinceChina Department of Nephrology Daping HospitalArmy Medical UniversityChongqing 400042China Department of Nephrology Renji HospitalShanghai Jiao Tong UniversityShanghai 200127China Department of Nephrology Guang’anmen HospitalChina Academy of Traditional Chinese Medical SciencesBeijing 100053China Department of Nephrology Tianjin Medical University General HospitalTianjin 300052China Department of Nephrology Changhai Hospital of ShanghaiNaval Medical UniversityShanghai 200433China Department of Nephrology West China HospitalChengdu 610083Sichuan ProvinceChina Department of Nephrology First Affiliated Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Nephrology Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Department of Nephrology Shanxi Medical University Second Affiliated HospitalTaiyuan 030001Shanxi ProvinceChina Department of Nephrology Shandong Provincial HospitalJinan 250021Shandong ProvinceChina Department of Nephrology and Rheumatology Affiliated Sixth People’s HospitalShanghai Jiao Tong UniversityShanghai 200233China Department of Nephrology Shaanxi Traditional Chinese Medicine HospitalXi'an 710003Shaanxi ProvinceChina Department of Nephrology Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 200021China Department of Nephrology Jilin University Se

Background:Shenyankangfu Tablet(SYKFT)is a Chinese patent medicine that has been used widely to decrease proteinuria and the progression of chronic kidney ***:This trial compared the efficacy and safety of SYKFT,for the control of proteinuria in primary glomerulonephritis patients,against the standard drug,losartan ***,setting,participants and intervention:This was a multicenter,double-blind,randomized,controlled clinical *** glomerulonephritis patients,aged 18-70 years,with blood pressure≤140/90 mmHg,estimated glomerular filtration rate(eGFR)>45 mL/min per 1.73 ㎡,and 24-hour proteinuria level of 0.5-3.0 g,were recruited in 41 hospitals across 19 provinces in China and were randomly divided into five groups:SYKFT,losartan potassium 50 mg or 100 mg,SYKFT plus losartan potassium 50 mg or 100 *** outcome measu res:The primary outcome was change in the 24-hour proteinuria level,after 48 weeks of ***:A total of 735 participants were *** percent decline of urine protein quantification in the SYKFT group after 48 weeks was 8.78%±2.56%(P=0.006)more than that in the losartan 50 mg group,which was 0.51%±2.54%(P=1.000)less than that in the losartan 100 mg *** with the losartan potassium 50 mg group,the SYKFT plus losartan potassium 50 mg group had a 13.39%±2.49%(Pline did not change statistically *** average change in TCM syndrome score between the patients who took SYKFT(-3.00[-6.00,-2.00])and who did not take SYKFT(-2.00[-5.00,0])was statistically significant(P=0.003).No obvious adverse reactions were observed in any ***:SYKFT decreased the proteinur

关键词： Herbal medicine,Chinese Shenyankangfu Tablet Primary glomerulonephritis Randomized controlled trial Double blind Double dummy

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High-quality genome assemblies for two Australimusa bananas(Musa spp.)and insights into regulatory mechanisms of superior fiber properties

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Plant Communications 2024年第1期5卷 245-261页

作者： Run Zhou Shuo wang Ni Zhan Weidi He Guiming Deng tongxin Dou xi-tong Zhu wen-Zhao xie yu-yu Zheng Chunhua Hu Fangcheng Bi Huijun gao tao Dong Siwen liu Chunyu li Qiaosong Yang lingqiang wang Jia-ming Song jiangbo Dang Qigao Guo Ganjun Yi ling-ling Chen Ou Sheng Institute of Fruit Tree Research Guangdong Academy of Agricultural SciencesKey Laboratory of South Subtropical Fruit Biology and Genetic Resource UtilizationMinistry of Agriculture and Rural AffairsGuangdong Provincial Key Laboratory of Tropical and Subtropical Fruit Tree ResearchGuangzhou 510640China College of Informatics Huazhong Agricultural UniversityWuhan 430070China State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources College of Life Science and TechnologyGuangxi UniversityNanning 530004China College of Horticulture and Landscape Architecture Southwest UniversityChongqing 400715China

Bananas(Musa spp.)are monocotyledonous plants with high genetic diversity in the Musaceae family that are cultivated mainly in tropical and subtropical *** fruits are a popular food,and the plants themselves have diverse *** genetic groups(genomes)are thought to have contributed to current banana cultivars:Musa acuminata(A genome),Musa balbisiana(B genome),Musa schizocarpa(S genome),and species of the Australimusa section(T genome).However,the T genome has not been effectively ***,we present the high-quality TT genomes of two representative accessions,Abaca(Musa textilis),with high-quality naturalfiber,and Utafun(Musa troglodytarum,Fe’i group),with abundant *** the Abaca and Utafun assemblies comprise 10 pseudochromosomes,and their total genome sizes are 613 Mb and 619 Mb,*** genome analysis revealed that the larger size of the T genome is likely attributable to rapid expansion and slow removal of *** with those of Musa AA or BB accessions or sisal(Agava sisalana),Abacafibers exhibit superior mechanical properties,mainly because of their thicker cell walls with a higher content of cellulose,lignin,and *** of MusaCesA cellulose synthesis genes peaks earlier in Abaca than in AA or BB accessions during plant development,potentially leading to earlier cellulose accumulation during secondary cell wall *** Abaca-specific expressed gene MusaMYB26,which is directly regulated by MusaMYB61,may be an important regulator that promotes precocious expression of secondary cell wall ***,MusaWRKY2 and MusaNAC68,which appear to be involved in regulating expression of MusaLAC and MusaCAD,may at least partially explain the high accumulation of lignin in *** work contributes to a better understanding of banana domestica-tion and the diverse genetic resources in the Musaceae family,thus providing resources for Musa genetic improvement.

关键词： Australimusa bananas T genome Musaceae evolution structural variations fiber

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Timing analysis of the black hole candidate EXO 1846–031 with Insight-HXMT monitoring

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Research in Astronomy and Astrophysics 2021年第3期21卷 193-204页

作者： He-xin liu yue Huang Guang-Cheng xiao Qing-Cui Bu Jin-Lu Qu Shu Zhang Shuang-Nan Zhang Shu-mei Jia Fang-Jun Lu xiang Ma lian tao Wei Zhang li Chen li-ming Song Ti-Pei li yu-Peng Xu xue-Lei Cao Yong Chen Cong-Zhan liu Ce Cai Zhi Chang Gang Chen Tian-xiang Chen Yi-Bao Chen yu-Peng Chen Wei Cui Wei-Wei Cui Jing-Kang Deng Yong-Wei Dong yuan-yuan Du Min-xue Fu Guan-Hua gao He gao Min gao ming-yu Ge yu-Dong Gu Ju Guan Cheng-Cheng Guo Da-Wei Han Jia Huo Lu-Hua jiang Wei-Chun jiang Jing Jin Yong-Jie Jin ling-Da Kong bing li Cheng-Kui li Gang li Mao-Shun li Wei li xian li xiao-Bo li Xu-Fang li Yang-Guo li Zheng-Wei li xiao-Hua liang Jing-yuan liao Bai-Sheng liu Guo-Qing liu Hong-Wei liu xiao-Jing liu Yi-Nong liu Bo Lu xue-Feng Lu Qi Luo tao Luo Bin Meng Yi Nang jian-Yin Nie Ge Ou Na Sai Ren-Cheng Shang xin-Ying Song liang Sun Ying Tan You-li Tuo Chen wang Guo-Feng wang Juan wang ling-Jun wang weng-Shuai wang yu-Sa wang xiang-Yang wen Bai-Yang Wu Bo-bing Wu mei Wu Shuo xiao Shao-lin xiong He Xu Jia-Wei Yang Sheng Yang Yan-Ji Yang Yi-Jung Yang Qi-Bin Yi Qian-Qing Yin yuan You Ai-mei Zhang Cheng-Mo Zhang Fan Zhang Hong-mei Zhang Juan Zhang tong Zhang Wan-Chang Zhang wen-Zhao Zhang Yi Zhang Yi-Fei Zhang Yong-Jie Zhang yuan-hang Zhang yue Zhang Zhao Zhang Zhi Zhang Zi-liang Zhang Hai-Sheng Zhao xiao-Fan Zhao Shi-Jie Zheng Yao-Guang Zheng Deng-Ke Zhou jian-Feng Zhou yu-Xuan Zhu Ren-lin Zhuang yue Zhu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Institut fur Astronomie und Astrophysik Kepler Center for Astro and Particle PhysicsEberhard Karls Universität72076 TubingenGermany Department of Astronomy Beijing Normal UniversityBeijing 100088China Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China College of Physics Sciences&Technology Hebei UniversityBaoding 071002Hebei ProvinceChina

We present the observational results from a detailed timing analysis of the black hole candidate EXO 1846-031 during its outburst in 2019 with the observations of Insight-HXMT,NICER and *** outburst can be classified roughly into four different ***-C quasi-periodic oscillations(QPOs)observed by NICER(about 0.1-6 Hz)and Insight-HXMT(about 0.7-8 Hz)are also reported in this ***,we study various physical quantities related to QPO *** QPO rms-frequency relationship in the energy band 1-10 keV indicates that there is a turning pointing in frequency around2 Hz,which is similar to that of GRS 1915+105.A possible hypothesis for the relationship above may be related to the inclination of the source,which may require a high inclination to explain *** relationships between QPO frequency and QPO rms,hardness,total fractional rms and count rate have also been found in other transient sources,which can indicate that the origin of type-C QPOs is non-thermal.

关键词： X-ray binaries black hole candidate QPO EXO 1846–031

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Major strategies for improving the performance of perovskite solar cells

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iEnergy 2023年第3期2卷 172-199页

作者： lixiu Zhang hang li Kai Zhang wenzhe li Chuantian Zuo George Omololu Odunmbaku Jingde Chen Cong Chen Luozheng Zhang Ru li yuping gao Baomin Xu jiangzhao Chen Yongsheng liu Yang wang Yanlin Song jianxin Tang Feng gao Qing Zhao Yong Peng mingzhen liu Lei tao yuelong li Zhimin Fang ming Cheng Kuan Sun Dewei Zhao Yixin Zhao Shihe Yang Chenyi Yi liming Ding Center for Excellence in Nanoscience(CAS) Key Laboratory of Nanosystem and Hierarchical Fabrication(CAS)National Center for Nanoscience and TechnologyBeijing 100190China State Key Laboratory of Power System Department of Electrical EngineeringTsinghua UniversityBeijing 100084China Shenzhen Graduate School Peking UniversityShenzhen 518055China School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China College of Materials Science and Engineering&Engineering Research Center of Alternative Energy Materials&Devices Sichuan UniversityChengdu 610065China School of Energy&Power Engineer-ing Chongqing UniversityChongqing 400044China Institute for Energy Research Jiangsu UniversityZhenjiang 212013China Institute of New Energy Technology Department of Electronic EngineeringCollege of Information Science and TechnologyJinan UniversityGuangzhou 510631China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China College of Optoelectronic Engineering Chongqing UniversityChongqing 400044China College of Chemistry Nankai UniversityTianjin 300071China Institute of Chemistry Chinese Academy of SciencesBeijing 100190China State Key Lab for Mesoscopic Physics and Frontiers Science Center for Nano-optoelec-tronics School of PhysicsPeking UniversityBeijing 100871China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China Institute of Photoelectronic Thin Film Devices and Technology Nankai UniversityTianjin 300350China School of Materials Science and Engineering Shaanxi Normal UniversityXi’an 710119China

Metal halide perovskite solar cell(PSC)has successfully distinguished itself in optoelectronic field by virtue of the sharp rise in power conversion efficiency over the past *** remarkable efficiency breakthrough at such a fast speed can be mainly attributed to the comprehensive study on film deposition techniques,especially the effective management of surface and interfacial defects in recent ***,we summarized the current trends in performance enhancement for PSCs,with a focus on the generally applicable strategies in high-performance works,involving deposition methods,compositional engineering,additive engineering,crystallization manipulation,charge transport material selection,interfacial passivation,optical coupling effect and constructing tandem solar *** directions and perspectives are also provided.

关键词： Perovskite solar cells efficiency improvement strategies milestones

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Two haplotype-resolved genome assemblies for AAB allotriploid bananas provide insights into banana subgenome asymmetric evolution and Fusarium wilt control

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Plant Communications 2024年第2期5卷 243-260页

作者： wen-Zhao xie yu-yu Zheng Weidi He Fangcheng Bi Yaoyao li tongxin Dou Run Zhou Yi-xiong Guo Guiming Deng wenhui Zhang Min-Hui yuan Pablo Sanz-Jimenez xi-tong Zhu xin-Dong Xu Zu-wen Zhou Zhi-Wei Zhou Jia-Wu Feng Siwen liu Chunyu li Qiaosong Yang Chunhua Hu Huijun gao tao Dong jiangbo Dang Qigao Guo wenguo Cai jianwei Zhang Ganjun Yi Jia-ming Song Ou Sheng ling-ling Chen Institute of Fruit Tree Research Guangdong Academy of Agricultural SciencesKey Laboratory of South Subtropical Fruit Biology and Genetic Resource UtilizationMinistry of Agriculture and Rural AffairsGuangdong Provincial Key Laboratory of Tropical and Subtropical Fruit Tree ResearchGuangzhou 510640China College of Informatics Huazhong Agricultural UniversityWuhan 430070China State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources College of Life Science and TechnologyGuangxi UniversityNanning 530004China College of Horticulture and Landscape Architecture Southwest UniversityChongqing 400715China

Bananas(Musa spp.)are one of the world’s most important fruit crops and play a vital role in food security for many developing *** banana cultivars are triploids derived from inter-and intraspecific hybrid-izations between the wild diploid ancestor species Musa acuminate(AA)and ***(BB).We report two haplotype-resolved genome assemblies of the representative AAB-cultivated types,Plantain and Silk,and precisely characterize ancestral contributions by examining ancestry mosaics across the *** asymmetric evolution is observed in their subgenomes,which can be linked to frequent homol-ogous exchange *** reveal the genetic makeup of triploid banana cultivars and verify that subge-nome B is a rich source of disease resistance *** 58.5%and 59.4%of Plantain and Silk genes,respectively,are present in all three haplotypes,with>50%of genes being differentially expressed alleles in different *** observed that the number of upregulated genes in Plantain is significantly higher than that in Silk at one-week post-inoculation with Fusarium wilt tropical race 4(Foc TR4),which con-firms that Plantain can initiate defense responses faster than ***,we compared genomic and transcriptomic differences among the genes related to carotenoid synthesis and starch metabolism between Plantain and *** study provides resources for better understanding the genomic architecture of culti-vated bananas and has important implications for Musa genetics and breeding.

关键词： bananas Plantain Silk asymmetric evolution homologous exchange Fusarium wilt

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MiR-130 targetssynaptosomal-associated protein 25,which is involved in lead-induced presynaptic vesicle release and attention deficit disorder

MiR-130 targetssynaptosomal-associated protein 25,which is i...

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中国毒理学会第九次全国毒理学大会

作者： wang tao GUAN rui-li SHEN xue-feng CAO Zi-peng YANG rui-hua liu ming-chao DU Ke-jun li xue-hang ZHAO ming-gao CHEN Jing-yuan LUO wen-jing Department of Occupational ＆ Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment School of Public HealthFourth Military Medical University Department of Nutrition ＆ Food Hygiene and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment School of Public Health Fourth Military Medical University Precision Pharmacy ＆Drug Development Center Department of Pharmacy Tangdu Hospital Fourth Military Medical University

Lead（Pb） exposure causes long-term impairment in presynaptic transmitter release in the central nervous ***, the precise underlying mechanisms are unclear. MicroRNAs（miRNAs） regulating gene expression is a vital process for neuronal function. Through miR NA screening,we found that miR-130 was highly expressed in the anterior cingulate cortex（ACC） and hippocampus upon Pb exposure in mice. The dual luciferase assay demonstrated that miR-130 targeted synaptosomalassociated protein 25（SNAP-25） mRNA at nucleotides 555-561. Blocking miR-130 function in vitroor in vivoreversed the Pb-induced decrease in expression of its presynaptic target SNAP-25, leading tothe recovery of presynaptic vesicle release after Pb exposure, as well as the partial recovery of attention deficits in mice. Our study identified a critical target that miR-130 regulate SNAP-25 expression responsible for Pb caused presynaptic function impairment in ACC and mouse attentiondeficit disorder.

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