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医疗机构中药制剂开发价值评估评价指标体系构建及内容效度评价

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中国中药杂志 2024年第14期49卷 3971-3976页

作者：唐碧华元唯安张俊华张磊唐健元陈星源李东晓郭继华张霄潇华桦四川省中医药转化医学中心四川成都610000 上海中医药大学附属曙光医院上海201203 天津中医药大学天津300193 上海中医药大学上海201203 成都中医药大学附属医院四川成都610075 四川省中医药科学院四川成都610000 中华中医药学会北京100029

医疗机构中药制剂作为新药“孵化器”获得蓬勃发展,尚缺乏综合评价其开发价值的评估体系。该研究通过文献调研法建立条目池,运用德尔菲专家咨询法确定评价指标内容,利用优序图法确定各指标权重,建立一套2级维度的医疗机构中药制剂开发... 详细信息

医疗机构中药制剂作为新药“孵化器”获得蓬勃发展,尚缺乏综合评价其开发价值的评估体系。该研究通过文献调研法建立条目池,运用德尔菲专家咨询法确定评价指标内容,利用优序图法确定各指标权重,建立一套2级维度的医疗机构中药制剂开发价值评估评价指标体系,包含7个一级条目,36个二级条目,具有科学性。一级条目及权重分别为传承性10.61%、有效性23.22%、安全性22.71%、创新性13.21%、经济性10.00%、适宜性8.57%、可及性11.68%;二级条目权重排名最前的3个指标为开展不良反应监测6.73%、疗效证据5.71%、临床有效率4.75%,排名最后的3个指标为生产优势0.86%、药味剂量0.48%、药品气味(口感)0.18%。进行了内容效度评价,结果证明该指标体系具有可靠性,总体内容效度指数0.47,平均内容效度指数0.90。利用已形成的指标体系对四川省某地级市中医医院的6个院内制剂进行了探索性应用,证明该指标体系具有可操作性。结果表明,该指标体系具有科学性、可靠性和可操作性,可为开发者选择性开发医疗机构中药制剂时提供优选参考。实际应用以该指标体系及权重为基础,根据实际情况做适当调整。

关键词：医疗机构中药制剂开发价值评估评价指标体系德尔菲法优序图法内容效度

SNMS: an intelligent transportation system network architecture based on WSN and P2P network

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The Journal of China Universities of Posts and Telecommunications 2007年第1期14卷 65-70页

作者： LI Li LIU Yuan-an tang bi-hua Wireless Center Beijing University of posts and TelecommunicationsBeijing 100876 China

With the development of city road networks, the question of how to obtain information about the roads is becoming more and more important. In this article, sensor network with mobile station （SNMS）, a novel two-tiered intelligent transportation system （ITS） network architecture based on wireless sensor network （WSN） and peer-to-peer （P2P） network, is proposed to provide significant traffic information about the road and thereby, assist travelers to take optimum decisions when they are driving. A detailed explanation with regard to the strategy of each level as well as the design of two main components in the network, sensor unit （SU） and mobile station （MS）, is presented. Finally, a representative scenario is described to display the operation of the system.

关键词： SNMS WSN P2E SU MS

Capacity analysis of based-regular-topologies cognitive wireless mesh networks with power control

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The Journal of China Universities of Posts and Telecommunications 2013年第5期20卷 71-78页

作者： KOU Ke-hao tang bi-hua LIU Kai-ming MA Tao School of Electronic Engineering Beijing University of Posts and Telecommunications Beijing Key Laboratory of Work Safety Intelligent Monitoring Beijing University of Posts and Telecommunications

Capacity analysis is a fundamental and essential work for evaluating the performance of cognitive wireless mesh network （CWMN） which is considered a promising option for the future network. Power control is an efficient way to avoid interference and improve capacity of wireless mesh networks. In this paper, a quantitative result of the per-node average throughput capacity of CWMN with power control is deduced for the first time, which is much helpful for understanding the limitations of CWMN. Firstly, under the large-scale channel fading model and protocol interference model, a closed-form expression for the maximum channel capacity of each node with power control is presented, under the constraint that the interference tolerated by the primary users （PUs） does not exceed a threshold. And then, with the deduced channel capacity result, the per-node average throughput capacity of CWMN is derived based on two regular topologies, i.e. square topology and triangle topology. The simulation results indicate that the capacity is effectively improved with power control, and affected by topology, tolerated interference threshold, the number of cognitive users （CUs） and primary users （PUs）.

关键词： capacity cognitive wireless mesh networks power control regular topologies

Hierarchical micro-mobility management in high-speed multihop access networks

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The Journal of China Universities of Posts and Telecommunications 2006年第4期13卷 7-12页

作者： tang bi-hua MA Xiao-lei LIU Yuan-an GAO Jin-chun School of Electronic Engineering Beijing University of Posts and Telecommunications Beijing 100876 China

This article integrates the hierarchical micro-mobility management and the high-speed multihop access networks （HMAN）, to accomplish the smooth handover between different access reuters. The proposed soft handover scheme in the high-speed HMAN can solve the micro-mobility management problem in the access network. This article also proposes the hybrid access muter （AR） advertisement scheme and AR selection algorithm, which uses the time delay and stable route to the AR as the gateway selection parameters. By simulation, the proposed micro-mobility,management scheme can achieve high packet delivery fraction and improve the lifetime of network.

关键词： Ad-hoc networks hierarchical micro-mobility management wireless multihop access network

Throughput oriented forwarders selection analysis for opportunistic routing in wireless mesh network

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The Journal of China Universities of Posts and Telecommunications 2013年第2期20卷 73-78页

作者： DU Xiao LIU Yuan-an LIU Kai-ming tang bi-hua CHEN Xing School of Electronic Engineering Beijing University of Posts and Telecommunications

Opportunistic routing explicitly takes advantage of the broadcast nature of wireless communications by using a set of forwarders to opportunistically perform packet forwarding. A key issue in the design of opportunistic routing protocols is the forwarder list selection problem. This paper proposes a novel routing metric which shows the end-to-end throughput and a corresponding throughput oriented opportunistic routing forwarder-selecting algorithm throughput oriented forwarders selection （TOFS） through analyzing forwarding characteristics of forwarders. The algorithm puts forward a constraint mechanism that controls the number of forwarders by constraint of throughput for forwarders selection, achieving a better balance between number of forwarders and effective link stability by introducing the factor of transmission time. Simulation results show that the algorithm can improve the network end-to-end throughput effectively over existing methods.

关键词： wireless mesh networks (WMN) opportunistic routing throughput delivery probability

A Novel Multiuser Detection Algorithm for CDMA-Based MIMO-OFDM System

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The Journal of China Universities of Posts and Telecommunications 2006年第2期13卷 90-94页

作者： LIU Jun-shi tang bi-hua WANG Ya-chen LIU Yuan-an School of Telecommunications Engineering Beijing University of Posts and Telecommunications Beijing 100876 P.R. China School of Electronic and Engineering Beijing University of Posts and Telecommunications Beijing 100876 P. R. China

This paper investigates QR matrix decomposition based successive interference cancellation multiuser detection algorithms in synchronous uplink for code division multiple access based multiple input multiple output orthogonal frequency division multiplexing ,system. The Symbol Error Rate＇（SER） performance of the optimal order and the suboptimal order QR-SIC MUD algorithms are compared with conventional zero forcing and minimum mean ,square error multiuser detection algorithms by Monte Carlo .simulations. Complexity analysis is presented at the end of the paper. Both our .simulation results and complexity analysis show that SER performance of QR-Successive Interference Cancellation （QR-SIC） algorithms is superior to those of zero forcing （ZF） and minimum mean .square error algorithms, and the ,suboptimal order Q-R-SIC algorithm hos a good trade-off between SER performance and computation complexity.

关键词： QR-SIC MUD CDMA MIMO OFDM

Efficient wireless multicast retransmission using network coding

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The Journal of China Universities of Posts and Telecommunications 2011年第6期18卷 59-67,88页

作者： CAO Zhen tang bi-hua LIU Yuan-an XIE Gang LIU Fang DENG Pan-liang School of Electronic Engineering Beijing University of Posts and Telecommunications Beijing 100876 China Key Laboratory of Universal Wireless Communication Ministry of Education Beijing University of Posts and Telecommunications Beijing 100876 China

In wireless multicast, network coding has recently attracted attentions as a substantial improvement to packet retransmission schemes. However, the problem of finding the optimal network code which minimizes the retransmissions is hard to solve or approximate. This paper presents two schemes to reduce the number of retransmissions for reliable multicast efficiently. One is retransmission using network coding based on improved Vandermonde matrix （VRNC）, the other is retransmission using network coding based on adaptive improved Vandermonde matrix （AVRNC）. Using VRNC scheme the sender selects the packets all receivers have lost and encodes them with improved Vandermonde matrix; when receivers receive enough encoded retransmission packets, all the lost packets can be recovered. With AVRNC scheme, the sender can obtain the recovery information from all the receivers after sending out per retransmission packet, and then the improved Vandermonde matrix can be updated, thus reducing the complexity of encoding and decoding. Our proposed schemes can achieve the theoretical lower bound assuming retransmission packets lossless, and approach the theoretical lower bound considering retransmission packets loss. Simulation results show that the proposed algorithms can efficiently reduce the number ofretransmissions, thus improving transmission efficiency.

关键词： reliable multicast network coding (NC) retransmission improved Vandermonde matrix

Distributed interference suppression scheme for multi-cell uplink OFDMA system based on non-cooperative game

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The Journal of China Universities of Posts and Telecommunications 2011年第2期18卷 65-71页

作者： CHANG Ling-jun tang bi-hua XIE Gang ZENG Ling-kang LIU Kai-ming School of Electronic Engineering Beijing University of Posts and Telecommunications Beijing 100876 China School of Information and Communication Engineering Beijing University of Posts and Telecommunications Beijing 100876 China

In this paper,a distributed interference suppression scheme is proposed for multi-cell uplink orthogonal frequency division multiple access（OFDMA） ***,we model resource allocation process as a non-cooperative *** we show the concept of Nash equilibrium（NE） and investigate its existence and uniqueness in *** enhance the performance of multi-cell OFDMA system,the further improvement process based on NE is *** adjustable parameters are set to make the system achieve different tradeoffs between the total capacity and *** results show that the proposed scheme can greatly improve the system performance comparing with conventional scheme.

关键词： multi-cell non-cooperative game OFDMA uplink ICI

Nuclear charge radius predictions by kernel ridge regression with odd-even effects

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Nuclear Science and Techniques 2024年第2期35卷 94-102页

作者： Lu tang Zhen-hua Zhang Mathematics and Physics Department North China Electric Power UniversityBeijing 102206China Hebei Key Laboratory of Physics and Energy Technology North China Electric Power UniversityBaoding 071000China

The extended kernel ridge regression(EKRR)method with odd-even effects was adopted to improve the description of the nuclear charge radius using five commonly used nuclear *** are:(i)the isospin-dependent A^(1∕3) formula,(ii)relativistic continuum Hartree-Bogoliubov(RCHB)theory,(iii)Hartree-Fock-Bogoliubov(HFB)model HFB25,(iv)the Weizsacker-Skyrme(WS)model WS*,and(v)HFB25**** the last two models,the charge radii were calculated using a five-parameter formula with the nuclear shell corrections and deformations obtained from the WS and HFB25 models,*** each model,the resultant root-mean-square deviation for the 1014 nuclei with proton number Z≥8 can be significantly reduced to 0.009-0.013 fm after considering the modification with the EKRR *** best among them was the RCHB model,with a root-mean-square deviation of 0.0092 *** extrapolation abilities of the KRR and EKRR methods for the neutron-rich region were examined,and it was found that after considering the odd-even effects,the extrapolation power was improved compared with that of the original KRR *** strong odd-even staggering of nuclear charge radii of Ca and Cu isotopes and the abrupt kinks across the neutron N=126 and 82 shell closures were also calculated and could be reproduced quite well by calculations using the EKRR method.

关键词： Nuclear charge radius Machine learning Kernel ridge regression method