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An Assisted Diagnosis of Alzheimer’s Disease Incorporating Attention Mechanisms Med-3D Transfer Modeling

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Computers, materials & Continua 2024年第1期78卷 713-733页

作者： Yanmei Li Jinghong tang Weiwu Ding Jian Luo Naveed Ahmad Rajesh Kumar school of Artificial Intelligence Chongqing University of TechnologyChongqing400054China Computer school China West Normal UniversityNanchong637009China Department of Computer science Prince Sultan UniversityRiyadh11586Saudi Arabia Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou313001China

Alzheimer’s disease(AD)is a complex,progressive neurodegenerative *** subtle and insidious onset of its pathogenesis makes early detection of a formidable challenge in both contemporary neuroscience and clinical *** this study,we introduce an advanced diagnostic methodology rooted in theMed-3D transfermodel and enhanced with an attention *** aim to improve the precision of AD diagnosis and facilitate its early ***,we employ a spatial normalization technique to address challenges like clarity degradation and unsaturation,which are commonly observed in imaging ***,an attention mechanism is incorporated to selectively focus on the salient features within the imaging *** upon this foundation,we present the novelMed-3D transfermodel,designed to further elucidate and amplify the intricate features associated *** proposedmodel has demonstrated promising results,achieving a classification accuracy of 92%.To emphasize the robustness and practicality of our approach,we introduce an adaptive‘hot-updating’auxiliary diagnostic *** system not only enables continuous model training and optimization but also provides a dynamic platform to meet the real-time diagnostic and therapeutic demands of AD.

关键词： Alzheimer’s disease channel attention Med-3D hot update

Complexes of cupric ion and tartaric acid enhanced calcium peroxide Fenton-like reaction for metronidazole degradation

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Chinese Chemical Letters 2024年第7期35卷 183-187页

作者： Shiyu Pan Bo Cao Deling Yuan Tifeng Jiao Qingrui Zhang Shoufeng tang State Key Laboratory of Metastable materials science and Technology Hebei Key Laboratory of Heavy Metal Deep-Remediation in Water and Resource ReuseSchool of Environmental and Chemical EngineeringYanshan UniversityQinhuangdao 066004China

To surmount the obstacles of traditional Fenton method and synchronously utilize Cu^(2+)and polyphenol in water,an improved Fenton-like reaction applying calcium peroxide(CaO_(2))as H_(2)O_(2)source and regulating by the complex of Cu^(2+)-tartaric acid(TA,a representative of polyphenol)was constructed.A typical antibiotic,metronidazole(MTZ)could be effectively eliminated by the Cu^(2+)/TA/CaO_(2)system,and the optimized parameters were as follows:0.1 mmol/L Cu^(2+),2 mmol/L TA,2 mmol/L CaO_(2),and initial *** spectrum confirmed the formation of Cu^(2+)-TA complex,which promoted the Cu^(2+)/Cu+circulation through decreasing the Cu^(2+)/Cu^(+) couple redox potential,which further enhanced the H_(2)O_(2)decomposition and the formation of reactive *** radical was dominant for MTZ degradation,followed by oxygen and superoxide *** degradation intermediates of MTZ were detected and their evolution way was ***,the ternary process showed a wide p H tolerance(3–8)for removing MTZ and broad applicability for eliminating other dyes and *** work provided a reference for Cu-based Fenton-like strategy for organic wastewater settlement.

关键词： Cupric ion Tartaric acid Complexation Calcium peroxide Metronidazole removal

A DNA micro-complex containing polyaptamer for exosome separation and wound healing

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Chinese Chemical Letters 2024年第9期35卷 257-261页

作者： Jingwen Zhao Jianpu tang Zhen Cui Limin Liu Dayong Yang Chi Yao Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalTianjin Institute of Digestive DiseaseTianjin Key Laboratory of Digestive DiseasesTianjin 300052China Frontiers science Center for Synthetic Biology Key Laboratory of Systems Bioengineering(MOE)School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300350China

Exosomes(EXOs)have showed great potential in regenerative *** separation of EXOs from complex biological media is essential for the down-stream ***,we report a deoxyribonucleic acid(DNA)-based micro-complex(DMC)containing polyaptamers,which realized the specific separation of EXOs from cell culture media and the significant promotion of wound *** synthesis of DMCs was based on a biomineralization process via rolling circle amplification(RCA)under the catalysis of phi29 DNA *** endow DMCs with the ability to capture EXOs,the DNA template of RCA was integrated with complementary sequence of aptamer that specifically recognized the CD63 proteins on *** obtained DMCs contained polyaptamers that can specifically capture the EXOs in cell culture *** EXOs-capturing DMCs were collected by centrifugation,achieving the separation of *** stem cell(MSC)-derived EXOs(MSC-EXOs)were separated by this DMC-based strategy,and the separated MSC-EXOs significantly enhanced the migration ability of *** particular,the significant therapeutic efficacy of the DMCs with MSC-EXOs was verified in full-thickness wound excision mouse models,in which the wounds completely healed in 10 *** envision that this DMC-based separation strategy can be a promising route to promote the development of EXOs in biomedicine.

关键词： DNA nanotechnology DNA materials Aptamer Exosomes Wound healing

Delayed Fluorescence and Amplified Chirality via Modified Substitution Position for Deep-red Circularly Polarized Organic Light Emitting-diodes

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Chemical Research in Chinese Universities 2024年第4期40卷 657-663页

作者： ZHU Lixun LIU Dan WU Kaiwen XIE Guohua ZHAO Zheng tang Ben Zhong school of science and engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Shenzhen518172P.R.China Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionThe Hong Kong University of Science and TechnologyHongkong999077P.R.China The Institute of Flexible Electronics(Future Technologies) Xiamen UniversityXiamen361005P.R.China

Developing easily accessible deep-red/near-infrared circularly polarized emitters for practical organic light-emitting diodes remains a significant ***,a practical strategy has been proposed for developing deep-red circularly polarized delayed fluorescent emitters based on a novel chiral acceptor *** changing triphenylamine(TPA)substitution position from para to meta,R/S-M-TBBTCN demonstrated thermally activated delayed fluorescence(TADF)properties with a delayed lifetime of 6.6µs that R/S-P-TBBTCN doesn’t ***,R/S-M-TBBTCN showed a 65 nm red-shift in emission and a 10-fold enhancement in asymmetry factor(glum),compared with R/*** solution-processed nondoped circularly polarized organic light-emitting diodes(CP-OLEDs)based on R-M-TBBTCN display deep-red emission and 2.2%external quantum efficiency.

关键词： Amplified chirality Deep-red circularly polarized organic light emitting-diode Binaphthol based chiral acceptor

Morphological design and tunable mechanical properties of 3D spinodal membrane structures:adaptive coarse-grained modelling

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Acta Mechanica Sinica 2024年第8期40卷 166-178页

作者： Yujie Xiang Jie Tian Keke tang Xianqiao Wang Zheng Zhong school of Aerospace engineering and Applied Mechanics Tongji UniversityShanghai200092China Key Laboratory of AI-aided Airworthiness of Civil Aircraft Structures Civil Aviation Administration of ChinaTongji UniversityShanghai200092China school of school of Environmental CivilAgricultural and Mechanical EngineeringUniversity of GeorgiaAthensGA30602USA school of science Harbin Institute of TechnologyShenzhen518055China

The spinodal decomposition method emerges as a promising methodology,showcasing its potential in exploring the design space for metamaterial ***,spinodal structures design is still largely limited to regular structures,due to their relatively easy parameterization and *** predicting the mechanical properties of 3D spinodal membrane structure remains a challenge,given that the features of the membrane necessitate adaptive mesh through the modelling *** paper proposes an integrated approach for morphological design with customized mechanical properties,incorporating the spinodal decomposition method and adaptive coarse-grained modeling,which can produce various morphologies such as lamellar,columnar,and cubic ***-periodic parameterβand orientational parameterΘ(θ_(1),θ_(2),θ_(3))are identified to achieve the optimal goal of anisotropic mechanical *** analysis is conducted to reveal the correlation between the customized spinodal structure and mechanical *** work provides an integrated approach for morphological variation and tuning mechanical properties,paving the way for the design and development of customized functional materials similar to 3D spinodal membrane structures.

关键词： Morphological design Spinodal decomposition Adaptive coarse-grained modeling Mechanical properties Parametric design

Method for the extraction of circulating nucleic acids based on MOF reveals cell-free RNA signatures in liver cancer

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National science Review 2024年第1期11卷 94-106页

作者： Yuqing Sun Haixin Yu Shaoqing Han Ruoxi Ran Ying Yang Yongling tang Yuhao Wang Wenhao Zhang Heng tang Boqiao Fu Boshi Fu Xiaocheng Weng Song-Mei Liu Hexiang Deng Shuang Peng Xiang Zhou College of Chemistry and Molecular sciences Key Laboratory of Biomedical Polymers-Ministry of Education Wuhan University Department of Digestive Surgical Oncology Union Hospital Tongji Medical College Huazhong University of Science and Technology Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Clinical Laboratory Center for Gene Diagnosis and Program of Clinical Laboratory Zhongnan Hospital of Wuhan University College of Chemistry and materials science Hubei Engineering University Department of Pharmacology School of Pharmacy China Medical University Taikang Center for Life and Medical sciences Wuhan University Department of Hematology Zhongnan Hospital of Wuhan University

Cell-free RNA(cf RNA) allows assessment of health, status, and phenotype of a variety of human organs and is a potential biomarker to non-invasively diagnose numerous diseases. Nevertheless, there is a lack of highly efficient and bias-free cf RNA isolation technologies due to the low abundance and instability of cf ***, we developed a reproducible and high-efficiency isolation technology for different types of cell-free nucleic acids(containing cf RNA and viral RNA) in serum/plasma based on the inclusion of nucleic acids by metal-organic framework(MOF) materials, which greatly improved the isolation efficiency and was able to preserve RNA integrity compared with the most widely used research kit method. Importantly, the quality of cf RNA extracted by the MOF method is about 10-fold that of the kit method, and the MOF method isolates more than three times as many different RNA types as the kit method. The whole transcriptome mapping characteristics of cf RNA in serum from patients with liver cancer was described and a cf RNA signature with six cf RNAs was identified to diagnose liver cancer with high diagnostic efficiency(area under curve = 0.905 in the independent validation cohort) using this MOF method. Thus, this new MOF isolation technique will advance the field of liquid biopsy, with the potential to diagnose liver cancer.

关键词： MOF circulating cell-free RNA biomarker liver cancer diagnosis

Adsorption Kinetics of Water onto Collagen Fibers

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Adsorption Kinetics of Water onto Collagen Fibers

Mitigating the Reconstruction of Metal Sulfides for Ultrastable Oxygen Evolution at High Current Density

2007年全国高分子学术论文报告会

作者： Keyong tang Lianmei TU school of materials science and engineering,Zhengzhou university,450052

＜正＞The adsorption kinetics of water onto untanned and tanned collagen fibersunder batch equilibrium experimental ntal conditions at 20+2℃ was *** results have shown that water uptake was rapid in the first 6h andt... 详细信息

关键词： collagen fibers water adsorption kinetics

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CCS Chemistry 2024年第1期6卷 137-148页

作者： Shuai Niu tang tang Yuanju Qu Yuyun Chen Hao Luo Hui Pan Wen-Jie Jiang Jianan Zhang Jin-Song Hu Beijing National Laboratory for Molecular sciences CAS Key Laboratory of Molecular Nanostructure and NanotechnologyInstitute of ChemistryChinese Academy of SciencesBeijing 100190 Joint Key Laboratory of the Ministry of Education Institute of Applied Physics and Materials EngineeringUniversity of MacaoMacao SAR 999078 Department of Chemical engineering University of MelbourneParkvilleVictoria 3010 College of materials science and engineering Zhengzhou UniversityZhengzhou 450001 school of Chemical sciences University of Chinese Academy of SciencesBeijing 100049 Dalian National Laboratory for Clean Energy Dalian 116023

Metal sulfides are emerging highly active electrocatalysts for the oxygen evolution reaction(OER),but still suffer from the instability caused by their inevitable reconstruction,especially at industrial-level current ***,it is discovered that Fe-incorporated Ni3S2 nanowires can deliver extraordinary durability with an ultralow potential degradation rate of 0.006 mV/h in alkaline electrolytes made with fresh water and seawater at a benchmark of 500 mA cm^(-2) while meeting the industrial activity requirement for overpotential less than 300 mV(290 mV).Systematic experiments and theoretical simulations suggest that after forming the S-doped NiFeOOH shell to boost intrinsic activity,Fe incorporation effectivelymitigates the reconstruction of the Ni_(3)S_(2) nanowire core by restraining Ni oxidation and S dissolution,justifying the *** work highlights the significance of circumventing reconstruction and provides a strategy to explore practical chalcogenides-based OER electrocatalysts.

关键词： oxygen evolution reaction sulfur-doped NiFeOOH NiFe sulfides nanowire ultrastable high current density

A Self-Healing Elastomer with Extremely High Toughness Achieved by Acylsemicarbazide Hydrogen Bonding and Cu^(2+)-Neocuproine Coordination Interactions

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Chinese Journal of Polymer science 2024年第10期42卷 1425-1434,I0007页

作者： Xiao-Ming An Yi-Ping Wang tang-Song Zhu Chong Xing Xu-Dong Jia Qiu-Hong Zhang Key Laboratory of High Performance Polymer Material and Technology of MOE Department of Polymer Science and EngineeringSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing210093China State Key Laboratory of Coordination Chemistry Nanjing UniversityNanjing210093China

Elastomers with high mechanical toughness can guarantee their durability during service ***-healing ability,as well as recyclability,can also extend the life of materials and save the consuming cost of the *** efforts have been dedicated to promoting the mechanical toughness as well as the self-healing capability of elastomers at the same time,while it remains a challenge to balance the trade-off between the above properties in one *** we proposed a molecular design driven by dual interactions of acylsemicarbazide hydrogen bonding and Cu^(2+)-neocuproine coordination *** introducing the reversible multiple hydrogen bonds and strong coordination bonds,we successfully fabricated an extremely tough and self-healing *** elastomer can achieve an impressive top-notch toughness of 491 MJ/m^(3).Furthermore,it boasted rapid elastic restorability within 10 min and outstanding crack tolerance with high fracture energy(152.6kJ/m^(2)).Benefiting from the combination of dynamic interactions,the material was able to self-repair under 80℃conveniently and could be reprocessed to restore the exceptional mechanical properties.

关键词： Metal-ligand coordination Hydrogen bond Ultra-tough elastomer Self-healing