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First experimental constraints on WIMP couplings in the effective field theory framework from CDEX

Science china({1.,Mechanics & Astronomy) 2021年第8期64卷 15-22页

作者： Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui {1. YanDong {1. Yu {1. YuanYuan {1. ZhongZhi {1. Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian tang WeiYou tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu Key Laboratory of Particle and Radiation Imaging(Ministry of Education) Department of Engineering PhysicsTsinghua UniversityBeijing 100084China department of {1. Tsinghua UniversityBeijing 100084China Institute of physics Academia SinicaTaipei 11529China NUCTECH Company Beijing 100084China YaLong River Hydropower Development Company Chengdu 610051China College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875China College of physics Sichuan UniversityChengdu 610065China School of physics Peking UniversityBeijing 100871China Sino-French Institute of Nuclear and Technology Sun Yet-sen UniversityZhuhai 519082China department of Nuclear {1. China Institute of Atomic EnergyBeijing 102413China department of {1. Banaras Hindu UniversityVaranasi 221005India department of {1. Beijing Normal UniversityBeijing 100875China School of physics Nankai UniversityTianjin 300071China

We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the china {1.rk Matter Experiment(CDEX), based on the {1.ta from both CDEX-1. and CDEX-1. stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, {1.ta from CDEX-1. were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)2) region.

关键词： WIMP EFT CDEX dark matter annual modulation

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Curcumin protects against interleukin-6-induced rapid Ca～(2+) influx in rat hippocampal neurons

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Neural Regeneration Research 2011年第24期6卷 1850-1854页

作者： Qinying Deng Tao Huang Hongmei tang {1.ming Zhong Sujian Xia Xiangcai Wei Jun Dong department of Pathophysiology Key Laboratory of State Administration of Traditional Chinese Medicine Medical College of Jinan University Guangzhou 510632 Guangdong Province China Institute of Brain Research Medical College of Jinan University Guangzhou 510632 Guangdong Province China Joint Laboratory for Brain Function and Health of Jinan university and the university of Hongkong Guangzhou 510632 Guangdong Province China Family Planning Research Institute of Guangdong Guangzhou 510600 Guangdong Province China department of Medical Statistics Medical College of Jinan University Guangzhou 510632 Guangdong Province China

The current study sought to investigate the potential protective action of curcumin against interleukin-6-induced injury in rat hippocampal neurons. The results revealed that interleukin-6 induced typical cellular injury, such as the swelling of cell bodies and increased Ca^2＋ concentration. After administration of curcumin, interleukin-6-induced neurons recovered to a normal state, and the fluorescence intensity of Ca^2＋ gradually returned to normal. These findings suggest that curcumin exerts a protective effect on hippocampal neurons of rats. In addition, our results suggest that the protective effect of curcumin involves prevention of the rapid Ca^2＋ influx induced by interleukin-6, which maintains Ca^2＋ homeostasis.

关键词： curcumin interleukin-6 hippocampus neurons Ca^2+ channel

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Amplitude analysis of the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)

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Chinese physics C 2024年第8期48卷 6-33页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban H.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang W.L.Chang G.R.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.S.Chen M.L.Chen S.J.Chen S.L.Chen S.M.Chen T.Chen X.R.Chen X.T.Chen Y.B.Chen Y.Q.Chen Z.J.Chen Z.Y.Chen S.K.Choi X.Chu G.Cibinetto F.Cossio J.J.Cui H.L.dai J.P.dai A.Dbeyssi R.E.de Boer D.Dedovich C.Q.Deng Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Fang S.S.Fang W.X.Fang Y.Fang Y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng Y.T.Feng K.Fischer M.Fritsch C.D.Fu J.L.Fu Y.W.Fu H.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia P.T.Ge Z.W.Ge C.Geng E.M.Gersabeck B.Ding X.X.Ding Y.Ding Y.Ding J.Dong L.Y.Dong M.Y.Dong X.Dong M.C.Du S.X.Du Z.H.Duan P.Egorov Y.H.Fan J.Fang JA.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna M.Greco M.H.Gu Y.T.Gu C.Y.Guan Z.L.Guan A.Q.Guo L.B.Guo M.J.Guo R.P.Guo Y.P.Guo A.Guskov J.Gutierrez K.L.Han T.T.Han X.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz Y.K.Heng C.Herold T.Holtmann P.C.Hong G.Y.Hou X.T.Hou Y.R.Hou Z.L.Hou B.Y.Hu H.M.Hu J.F.Hu T.Hu Y.Hu G.S.Huang K.X.Huang L.Q.Huang X.T.Huang Y.P.Huang T.Hussain F.H\"olzken N.H\"usken N.in der Wiesche M.Irshad J.Jackson S.Janchiv J.H.Jeong Q.Ji Q.P.Ji W.Ji X.B.Ji X.L.Ji Y.Y.Ji X.Q.Jia Z.K.Jia D.Jiang H.B.Jiang P.C.Jiang S.S.Jiang T.J.Jiang X.S.Jiang Y.Jiang J.B.Jiao J.K.Jiao Z.Jiao S.Jin Y.Jin M.Q.Jing X.M.Jing T.Johansson S.Kabana N.Kalantar-Nayestanaki X.L.Kang X.S.Kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kuessner X.Kui A.Kupsc W.K\"uhn J.J.Lane P.Larin L.Lavezzi T.T.Lei Z.H.Lei H.Leithoff M.Lellmann T.Lenz C.Li C.Li C.H.Li Cheng Li D.M.Li F.Li G.Li H.Li H.B.Li H.J.Li H.N.Li Hui Li J.R.Li J.S.Li K.Li L.J.Li L.K.Li Lei Li M.H.Li P.R.Li Q.M.Li Q.X.Li R.Li S.X.Li T.Li W.D.Li W.G.Li X.Li X.H.Li X.L.Li X.Y.Li Y Institute of High Energy physics Chinese Academy of SciencesBeijing 100049China Beihang university Beijing 100191China Bochum Ruhr-university D-44780 BochumGermany Budker Institute of Nuclear physics SB RAS(BINP) Novosibirsk 630090Russia Carnegie Mellon university PittsburghPennsylvania 15213USA Central china {1. university Wuhan 430079China Central south {1. Changsha 410083China china Center of Advanced Science and Technology Beijing 100190China china {1. of Geosciences Wuhan 430074China Chung-Ang university Seoul06974Republic of Korea COMSATS university Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan {1. Shanghai 200433China GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi normal {1. Guilin 541004China Guangxi university Nanning 530004China Hangzhou normal {1. Hangzhou 310036China Hebei university Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan normal {1. Xinxiang 453007China Henan university Kaifeng 475004China Henan university of Science and Technology Luoyang 471003China Henan university of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan normal {1. Changsha 410081China Hunan university Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana university BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Inner Mongolia university Hohhot 010021China Institute of Modern physics Lanzhou 730000China Institute of physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity of 2.93 fb^(−1.taken at the center-of-mass energy√s=3.773 GeV with the BESIII detector,a joint amplitude analysis is performed on the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).The fit fractions of individual components are obtained,and large interferences among the dominant components of the decays D^(0)→a_(1.(1.60)π,D^(0)→π(1.00)π,D^(0)→ρ(770)ρ(770),and D^(0)→2(ππ)_(S)are observed in both *** the obtained amplitude model,the CP-even fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2±1.1.(stat).±1.5_(syst.))%and(68.9±1.5_(stat).±2.4_(syst.))%,*** branching fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.01._(stat.)±0.01._(syst.))%and(0.951.0.025_(stat.)±0.021.(syst.))%,*** amplitude analysis provides an important model for the binning strategy in measuring the strong phase parameters of D^(0)→4πwhen used to determine the CKM angleγ(ϕ_(3))via the B^(−)→DK^(−)decay.

关键词： BESIII D^(0)meson decays amplitude analysis CP-even fraction

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Ultrathin organic polymer with p-πconjugated structure for simultaneous photocatalytic disulfide bond generation and CO_(2)reduction

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Journal of Energy Chemistry 2023年第1期76卷 639-647,I0016页

作者： Linquan Hou Zhunyun tang Guojiang Mao Shiheng Yin Bei Long Tao Ouyang Guo-Jun Deng Atif Ali Ting Song Key Laboratory for Green Organic Synthesis and Application of Hunan Province Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of EducationCollege of ChemistryXiangtan UniversityXiangtan 411105HunanChina Hunan Key Laboratory for Micro-Nano Energy Materials and Device School of Physics and OptoelectronicsXiangtan UniversityXiangtan 411105HunanChina School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007HenanChina Analytical and Testing Center South China University of TechnologyGuangzhou 510640GuangdongChina department of Chemistry and State Key Laboratory of Synthetic Chemistry The University of Hong KongPokfulam RoadHong Kong 999077China

Combining photocatalytic organic reactions with CO_(2)reduction is an efficient solar energy utilization mode,but it is still limited by the organic species that can be matched and the low ***,ultrathin organic polymer with p-πconjugated structure(TPP)was rationally designed and prepared,and showed a high yield of CO(1..2 mmol g^(-1.)and conversion of SAS coupled products(1.0%),far exceeding the organic polymer with P=O *** enhanced photoredox activity of TPP is ascribed to the orbital interaction between the p-orbital on phosphorus and theπ-orbitals of aromatic,which can accelerate the photoinduced charge carrier separation and improve the CO_(2)adsorption *** can also be used for the dehydrocoupling of various benzyl mercaptans to the corresponding SAS bond *** work provides a new concept for the efficient synthesis of disulfide bonds combined with CO_(2)reduction in a photoreaction system.

关键词： Photocatalytic coupled reaction Disulfide bond CO_(2)reduction High activity Organic polymer

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Coastal blue carbon in china as a nature-based solution toward carbon neutrality

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The Innovation 2023年第5期4卷 109-123页

作者： Faming Wang Jihua liu Guoming Qin Jingfan Zhang Jinge Zhou Jingtao Wu Lulu Zhang Poonam Thapa Christian J.Sanders Isaac R.Santos Xiuzhen Li Guanghui Lin Qihao Weng Jianwu {1. Nianzhi Jiao Hai Ren Xiaoliang Research Station of Tropical Coastal Ecosystems Key Laboratory of Vegetation Restoration and Management of Degraded Ecosystemsand the CAS Engineering Laboratory for Ecological Restoration of lsland and Coastal EcosystemsSouth China Botanical GardenChinese Academy of SciencesGuangzhou 510650China southern Marine Science and Engineering Guangdong Laboratory({1.) Guangzhou 510650China Marine Research Institute Shandong UniversityQingdao 266237China university of Chinese Academy of Sciences Beijing 100049China National Marine Science Centre Faculty of Science and EngineeringSouther Cross UniversityCoffs HarbourNSW 2450Australia department of Marine Sciences University of Gothenburg41319 GothenburgSweden State Key Laboratory of Estuarine and Coastal Research and Instiute of Eco-Chongming East China Normal UniversityShanghai 201100China Key Laboratory for Earth System Modeling Ministry of EducationDepartment of Earth System ScienceTsinghua UniversityBejing 100084China Laboratory of Stable Isotope and Gulf Ecology Institute of Ocean EngineeringTsinghua's Shenzhen International Graduate SchoolShenzhen 518055China department of Land Surveying and Geo-nformatics The Hong Kong Polytechnic UniversiyHongkong 99077China Innovative Research Center for Carbon Neutralization Global ONCE ProgramXiamen 361005China

To achieve the Paris Agreement,china pledged to become“Carbon Neutral”by the *** addition to massive decarbonization,this would require significant changes in ecosystems toward negative CO_(2)*** ability of coastal blue carbon ecosystems(BCEs),including mangrove,salt marsh,and seagrass meadows,to sequester large amounts of CO_(2)makes their conservation and restoration an important“nature-based solution(NbS)”for climate a{1.ptation and *** this review,we examine how BCEs in china can contribute to climate *** the national scale,the BCEs in china store up to 1.8 Tg C across a total area of 1.440,377 ha,including over 75%as unvegetated ti{1.l *** annual sedimental C burial of these BCEs reaches up to 2.06 Tg C year^(−1.,of which most occurs in salt marshes and ti{1.l *** lateral C flux of mangroves and salt marshes contributes to 1.1. Tg C year^(−1.along the Chinese *** and restoration of BCEs benefit climate change mitigation and provide other ecological services with a value of$32,000 ha^(−1.year^(−1..The potential practices and technologies that can be implemented in china to improve BCE C sequestration,including their constraints and feasibility,are also *** directions are suggested to improve blue carbon estimates on aerial extent,carbon stocks,sequestration,and mitigation *** and preserving BCEs would be a cost-effective step to achieve Carbon Neutral by 2060 in china despite various barriers that should be removed.

关键词： tidal coastal carbon

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Gravitational wave astronomy: the current status

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Science china({1.,Mechanics & Astronomy) 2015年第12期58卷 3-43页

作者： BLAIR david JU Li ZHAO ChunNong WEN LinQing CHU Qi FANG Qi CAI RongGen GAO JiangRui LIN XueChun {1. Dong WU Ling-An ZHU ZongHong REITZE david H. ARAI Koji ZHANG Fan FLAMINIO Raffaele ZHU xingJiang HOBBS George MANCHESTER Richard N. SHANNON Ryan M. BACCIGALUPI Carlo GAO Wei XU Peng BIAN xing CAO ZhouJian CHANG ZiJing DONG Peng GONG XueFei HUANG ShuangLin JU Peng LUO ZiRen QIANG Li'E tang WenLin WAN XiaoYun WANG Yue XU ShengNian ZANG YunLong ZHANG HaiPeng LAU Yun-Kau NI Wei-Tou School of physics The University of Western Australia State Key Laboratory of Theoretical physics Institute of Theoretical Physics Chinese Academy of Sciences The School of physics & Electronic Engineering Shanxi University Laboratory of All-Solid-State Light Sources Institute of Semiconductors Chinese Academy of Science State Key Laboratroy of Modern Optical Instrumentation Department of Optical Engineering Zhejiang University Laboratory of Optical physics Institute of Physics Chinese Academy of Sciences Gravitational Wave and Cosmology Laboratory Department of Astronomy Beijing Normal University LIGO Laboratory California Institute of Technology department of {1. University of Florida department of {1. West Virginia University National Astronomical Observatory of Japan CSIRO Astronomy and Space Science International Centre for Radio Astronomy Research Curtin University SISSA Astrophysics Sector Institute of Applied Mathematics Academy of Mathematics and Systems Science Chinese Academy of Sciences university of Chinese Academy of Sciences Morningside Center of Mathematics Chinese Academy of Sciences State Key Laboratory of Scientific and Engineering Computing Academy of Mathematics and Systems ScienceChinese Academy of Sciences department of Mathematics Henan University department of Mathematics Capital Normal University department of Geo{1. College of the Geology Engineering and Geomatics Chang'an University QUEST Centre of Quantum Engineering and Space-Time Research Leibniz Universitt Hannover Max-Planck-Institut für Gravitationsphysik(Albert Einstein Institut) Aerospace Flight Dynamics Laboratory Beijing Aerospace Control Center Qian Xuesen Laboratory of Launch Vehicle Technology Center for Gravitation and Cosmology Department of Physics Tsing Hua University

In the centenary year of Einstein's General Theory of Relativity, this paper reviews the current status of gravitational wave astronomy across a spectrum which stretches from attohertz to kilohertz frequencies. Sect. 1.of this paper reviews the historical development of gravitational wave astronomy from Einstein's first prediction to our current understanding the spectrum. It is shown that detection of signals in the audio frequency spectrum can be expected very soon, and that a north-south pair of next generation detectors would provide large scientific benefits. Sect. 2 reviews the theory of gravitational waves and the principles of detection using laser interferometry. The state of the art Advanced LIGO detectors are then described. These detectors have a high chance of detecting the first events in the near future. Sect. 3 reviews the KAGRA detector currently under development in Japan,which will be the first laser interferometer detector to use cryogenic test masses. Sect. 4 of this paper reviews gravitational wave detection in the nanohertz frequency band using the technique of pulsar timing. Sect. 5 reviews the status of gravitational wave detection in the attohertz frequency band, detectable in the polarisation of the cosmic microwave background, and discusses the prospects for detection of primordial waves from the big bang. The techniques described in sects. 1.5 have already placed significant limits on the strength of gravitational wave sources. Sects. 6 and 7 review ambitious plans for future space based gravitational wave detectors in the millihertz frequency band. Sect. 6 presents a roadmap for development of space based gravitational wave detectors by{1. while sect. 7 discusses a key enabling technology for space interferometry known as time delay interferometry.

关键词： gravitational waves ground based detectors pulsar timing spaced based detectors CMB

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Bevacizumab biosimilar LY01.08 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial

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Cancer Communications 2021年第9期41卷 889-903页

作者： Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke liu Zhongliang Guo Yong liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang tang Yan Wang Puyuan xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted DrugsBeijing 100021P.R.China department of Oncology Yibin Second People’s HospitalYibinSichuan 644000P.R.China department of Oncology Liuzhou People’s HospitalLiuzhouGuangxi 545006P.R.China department of Thoracic Oncology Fujian Provincial Cancer HospitalFuzhouFujian 350014P.R.China Oncology department the First Affiliated Hospital of Bengbu Medical CollegeBengbuAnhui 233030P.R.China department of Oncology the First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhouGuangdong 510030P.R.China department of Internal medicine Linyi Cancer HospitalLinyiShandong 276002P.R.China department of Thoracic Surgery the Affiliated Cancer Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510095P.R.China department of Internal Medicine-Oncology/department of thoracic oncology Henan Chest HospitalZhengzhouHenan 450003P.R.China The Second department of Radiotherapy Wuwei Cancer Hospital of Gansu ProvinceWuweiGansu 730000P.R.China department of Oncology the People’s Hospital of Jiangsu ProvinceNanjingJiangsu 210000P.R.China Respiratory Medicine department Shanghai East HospitalShanghai 200120P.R.China The Second department of Internal Medicine-Oncology Xuzhou Central HospitalXuzhouJiangsu 221009P.R.China Oncology department Tangshan People’s HospitalTangshanHebei 063001P.R.China Respiratory Medicine department West China Hospital of Sichuan UniversityChengduSichuan 610041P.R.China Thoracic Surgery the Second Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong 515051P.R.China Internal Medicine-Oncology Hunan Cancer HospitalChangshaHunan 410013P.R.China department of Oncology Xiangyang Central HospitalXiangyangHubei 441021P.R.China Respiratory department Lishui Central HospitalLishuiZ

Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01.08 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01.08 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across china were randomized in a ratio of 1.1.to receive LY01.08 or Avastin 1. mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01.08 until disease progression,intolerable toxicity,or *** primary endpoint was objective response rate(ORR)in accor{1.nce with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1.confirmed by independent radiological review committees(IRRC).Secon{1.ry endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and *** study was registered in Clinical ***(NCT035331.7).Results:Between December 1.^(th),201.,and May 1.^(th),201.,a total of 649 patients were randomized to the LY01.08(n=324)or Avastin(n=325)*** of September 25th,201. for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1.6)andmedian duration of treatment of 3.0(range 0.0-5.1.*** responseevaluable patients in the LY01.08 and Avastin groups were 48.5% and 53.0%,*** stratified ORR ratio was 0.91.90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 1.^(th),2020,with a median follow-up of 1..6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1.year OS rate were observed between the LY01.

关键词： anti-angiogenesis anti-VEGF monoclonal antibody avastin bevacizumab biosimilar nonsmall cell lung cancer LY01.08 vascular endothelial growth factor

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劈离式肝移植右侧供肝肝内胆管的解剖分型与胆道重建

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中华消化外科杂志 2024年第2期23卷 272-279页

作者：韦金铭傅斌生杨卿张彤冯啸曾凯宁姚嘉唐晖陈规划杨扬易述红中山大学附属第三医院肝脏外科暨肝移植中心广州510600

目的探讨劈离式肝移植(SLT)右侧供肝肝内胆管的解剖分型与胆道重建。方法采用回顾性描述性研究方法。收集201.年7月至2022年1.中山大学附属第三医院收治的85例行SLT患者的临床资料;男65例,女20例;年龄为45(1.82)岁。观察指标:(1.手术... 详细信息

目的探讨劈离式肝移植(SLT)右侧供肝肝内胆管的解剖分型与胆道重建。方法采用回顾性描述性研究方法。收集201.年7月至2022年1.中山大学附属第三医院收治的85例行SLT患者的临床资料;男65例,女20例;年龄为45(1.82)岁。观察指标:(1.手术情况。(2)右侧供肝肝内胆管解剖情况。(3)胆道重建情况。(4)术后胆道并发症情况。(5)随访情况。正态分布的计量资料以x±s表示;偏态分布的计量资料以M(范围)或M(Q1.Q3)表示。计数资料以绝对数或百分比表示,组间比较采用χ2检验或Fisher确切概率法。结果(1.手术情况。85例供肝中,采用左右半肝劈离方式1.例,采用经典的右三叶和左外叶劈离方式74例。85例供肝冷缺血时间为291.273,354)min;受者手术时间为(497±97)min,无肝期时间为51.40,80)min,输血量为8(7,1.)U。(2)右侧供肝肝内胆管解剖情况。85例供肝中,经典胆管解剖模型(1.)47例,占比为55.3%(47/85),解剖变异型38例,占比为44.7%(38/85)。38例解剖变异型分别为:2型7例,3a型1.例,3b型2例,3c型2例,4型1.,5a型3例,5b型4例,6型3例。85例供肝的胆管劈离方式中,84例为保留肝总管主干于右半肝或右三叶,1.行完全左右半肝劈离将肝总管主干保留于左半肝,右半肝保留右肝管(1.);84例仅有1.胆管开口,1.有2个胆管开口(3c型)。(3)胆道重建情况。85例受者胆道重建方案为供肝胆总管-受者胆总管端端吻合69例(1.38例、2型5例、3a型1.例、3b型2例、4型1.、5a型3例、5b型4例、6型2例),供肝胆总管-受者空肠吻合1.例(1.7例、2型2例、3c型1.、6型1.),供肝肝总管-受者空肠吻合3例(1.1.、3a型2例),供肝右肝管-受者空肠吻合1.(1.),供肝右后支-受者肝总管端端吻合+供肝肝总管-受者空肠Roux-en-Y吻合1.(3c型)。(4)术后胆道并发症情况。85例受者中,6例发生胆道并发症,发生率为7.1.(6/85)。6例发生胆道并发症受者中,5例为1.,1.为3b型。5例发生胆道并发症的1.受者中,3例为术后胆道狭窄合并胆漏,2例为术后胆管吻合口狭窄。1.发生胆道并发症的3b型受者术后出现胆管吻合口狭窄合并肝断面胆漏。47例经典胆管解剖模型和38例解剖变异型受者发生胆道并发症分别为5例和1.,两者比较,差异无统计学意义(P>0.05)。(5)随访情况。83例受者获得随访,随访时间为52(1.,96)个月。随访期间,2例受者因非胆道并发症因素死亡(1.1.,3a型1.)。结论SLT右侧供肝肝内胆管解剖分型主要为经典胆管解剖模型,胆道重建方案主要为供肝胆总管-受者胆总管端端吻合。

关键词：肝肿瘤劈离式肝移植肝内胆管解剖分型胆道造影胆道重建

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脑灰质异位相关癫痫^(1.)F-FDG PET/MRI表现

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中国医学影像技术 2024年第2期40卷 203-207页

作者：黎颖昕凌雪英唐勇进程勇徐浩暨南大学附属第一医院核医学科广东广州510630

目的观察脑灰质异位(GMH)相关癫痫的1. F-FDG PET/MRI表现。方法回顾性分析27例经MRI诊断GMH癫痫患者,观察其颅脑1. F-FDG PET/MRI表现、有无其他颅脑畸形并进行分型。结果27例中,1.例室管膜下GMH、2例皮质下GMH、2例层状(带状)GMH、8... 详细信息

目的观察脑灰质异位(GMH)相关癫痫的1. F-FDG PET/MRI表现。方法回顾性分析27例经MRI诊断GMH癫痫患者,观察其颅脑1. F-FDG PET/MRI表现、有无其他颅脑畸形并进行分型。结果27例中,1.例室管膜下GMH、2例皮质下GMH、2例层状(带状)GMH、8例混合型GMH;相比病灶周围或对侧镜像区脑白质,22例糖代谢增高、3例糖代谢减低,2例糖代谢未见明显异常;相比中央前回灰质,8例糖代谢增高、1.例糖代谢减低,3例糖代谢未见明显异常。27例中,6例合并脑裂畸形,6例合并双侧小脑半球体积缩小,合并透明隔缺如及穹隆低位、胼胝体发育异常、多微小脑回畸形各1.。结论GMH相关癫痫1. F-FDG PET/MRI表现具有一定特征性,有助于临床诊断。

关键词：神经系统畸形脑灰质癫痫正电子发射断层显像磁共振成像

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维普期刊数据库

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交叉异位融合肾影像学表现

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中国医学影像技术 2024年第2期40卷 261-265页

作者：张流柳伏文皓孙梦雅唐广磊关键吉安市第一人民医院影像科江西吉安343000 中山大学附属第一医院医学影像科广东广州510080

目的观察交叉异位融合肾影像学表现。方法回顾性分析1.例交叉异位融合肾资料,分析该病影像学表现。结果 1.例交叉异位融合肾包括L型5例,下异位型(Ii型)、S型及块状型(O型)各2例,甜甜圈型或盘状型(C-C型)1.;均表现为一侧肾窝空虚而对... 详细信息

目的观察交叉异位融合肾影像学表现。方法回顾性分析1.例交叉异位融合肾资料,分析该病影像学表现。结果 1.例交叉异位融合肾包括L型5例,下异位型(Ii型)、S型及块状型(O型)各2例,甜甜圈型或盘状型(C-C型)1.;均表现为一侧肾窝空虚而对侧肾形态、位置大致正常,异位肾跨过中线与对侧肾融合,8例右向左、4例左向右融合;异位肾输尿管均跨过中线,1.例开口于对侧膀胱三角区、1.异位开口于前列腺。3例合并生殖系统畸形,其中单角子宫、双角子宫、隐睾各1.;2例合并下腔静脉异常,包括双下腔静脉、左下腔静脉各1.。结论交叉异位融合肾具有特征性影像学表现;完整显示肾融合、输尿管走行及开口有助于准确诊断及分型。

关键词：肾先天畸形体层摄影术,X线计算机磁共振成像

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