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PSA density improves the rate of prostate cancer detection in Chinese men with a PSA between 2.5-1..0 ng ml-1.and 1..1.20.0 ng ml-1. a multicenter study

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Asian Journal of Andrology 2015年第3期17卷 503-507页

作者： Yu-Rong Lin xing-Hua Wei Matthew Uhlman Xuan-Ting Lin Si-Feng Wu Peng-Fei Diao Hai-Qing Xie Ke-Ji Xie Ping {1. department of Urology Guangzhou First People's Hospital Guangzhou Medical University Guangzhou 510180 China department of Urology Jieyang People's Hospital Jieyang 522000 China department of Urology University of Iowa Iowa City IA 52242 USA

Chinese men should have a higher prostate-specific antigen （PSA）＂gray zone＂ than the traditional value of 2.5-1..0 ng ml-1.since the incidence of prostate cancer （PCa） in Chinese men is relative low. We hypothesized that PSA density （PSAD） could improve the rate of PCa detection in Chinese men with a PSA higher than the traditional PSA ＂gray zone.＂ A total of 461.men with a PSA between 2.5 and 20.0 ng ml-1. who had undergone prostatic biopsy at two Chinese centers were included in the analysis. The men were then further divided into groups with a PSA between 2.5-1..0 ng ml-1.and 1..1.20.0 ng ml-1. Receiver operating characteristic （ROC） curve was used to evaluate the efficacy of PSA and PSAD for the diagnosis of PCa. In men with a PSA of 2.5-1..0 ng ml-1.or 1..1.20.0 ng ml-z, the areas under the ROC curve were higher for PSAD than for PSA. This was consistent across both centers and the cohort overall. When the entire cohort was considered, the optimal PSAD cut-off for predicting PCa in men with a PSA of 2.5-1..0 ng m1.1.was 0.1. ng ml-2 ml-2, with a sensitivity of 64.4% and specificity of 64.6%. The optimal cut-off for PSAD in men with a PSA of 1..1.20.0 ng m1.1.was 0.33 ng ml-1.ml-1. with a sensitivity of 60.3% and specificity of 82.7%. PSAD can improve the effectiveness for PCa detection in Chinese men with a PSA of 2.5-1..0 ng ml-1.（traditional Western PSA ＂gray zone＂） and 1..1.20.0 ng ml-2 （Chinese PSA ＂gray zone＂）.

关键词： area under the receiver operating characteristic curve prostate cancer prostate-specific antigen prostate-specificantigen density

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富血小板凝胶联合腔内血管成形术治疗缺血性糖尿病足的研究

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中华介入放射学电子杂志 2024年第1期12卷 27-32页

作者：黄晨庄炜钊刘合祝李永生王倩唐郁宽广州市番禺区中心医院微创介入科广东广州511400 华南师范大学生命科学学院广东广州510631 广东省脐带血造血干细胞库广东广州510663

目的探索富血小板凝胶(platelet-rich gel,PRG)联合腔内血管成形术促进糖尿病足溃疡修复及血管生成的效果,为糖尿病足寻找一种长期有效的治疗方法。方法将2020年至2023年期间在广州市番禺区中心医院就诊的符合入组条件的271.患者随机分... 详细信息

目的探索富血小板凝胶(platelet-rich gel,PRG)联合腔内血管成形术促进糖尿病足溃疡修复及血管生成的效果,为糖尿病足寻找一种长期有效的治疗方法。方法将2020年至2023年期间在广州市番禺区中心医院就诊的符合入组条件的271.患者随机分为3组,对照组采用常规消毒及普通辅料覆盖;介入组采用常规消毒溃疡及普通辅料覆盖的基础上联合腔内血管成形术治疗糖尿病足;PRG+介入组将PRG均匀敷到表浅溃疡表面,同时采用腔内血管成形术治疗血管闭塞。观察比较3组患者治疗前后的Rutherford分级、Wagner分级、足部皮肤颜色、皮温、踝肱指数、溃疡修复面积等指标。结果本研究共纳入患者271.,其中对照组97例,介入组92例,PRG+介入组82例。3组性别、年龄、Rutherford分级、Wagner分级、足部皮肤颜色、皮温、踝肱指数、血管闭塞数目及程度、溃疡面积等指标比较,差异无统计学意义(P>0.05)。治疗后1.6个月后,PRG+介入组均显著下调了患者的Rutherford分级及Wagner分级,患者的足部皮肤颜色、皮温相比对照组、介入组,差异均有统计学差异(P2)cm^(2)、溃疡愈合率(68.3%)与其他两组相比差异有统计学意义(P<0.05)。结论PRG联合腔内血管成形术治疗糖尿病足溃疡的效果明显,可达到改善下肢缺血区域微循环,促进组织修复的作用。该方法是一种长期有效、安全可靠的治疗糖尿病足的新模式。

关键词：糖尿病足腔内血管成形术富血小板凝胶下肢动脉闭塞组织修复

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The effect of urbanization and exposure to multiple environmental factors on life-history traits and breeding success of Barn Swallows(Hirundo rustica)across china

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Avian Research 2022年第3期13卷 301-310页

作者： Yanyan Zhao Emilio Pagani-Nú~nez Yu liu Xiaoying {1. Zhiqiang Zhang Guangji Pan Luting Song Xiang Li Zhuoya Zhou Yanqiu Chen Donglai Li Yang liu Rebecca J.Safran State Key Laboratory of Biocontrol School of EcologySun Yat-sen UniversityGuangzhou510006China Institute of Eco-Environmental Research Guangxi Academy of SciencesNanning530007China department of Health and Environmental Sciences Xi’an Jiaotong-Liverpool UniversitySuzhou215028China Key Laboratory for Biodiversity Science and Ecological Engineering Ministry of EducationCollege of Life SciencesBeijing Normal UniversityBeijing100091China College of Wildlife and Protected Area Northeast Forestry UniversityHarbin150006China Institute of Wildlife Conservation Central South University of Forestry and TechnologyChangsha410004China College of Life Science Liaoning UniversityShenyang110036China department of Ecology and Evolutionary Biology University of ColoradoBoulderUSA

In addition to landscape changes,urbanization also brings about changes in environmental factors that can affect *** the common referral in the published literature to multiple environmental factors such as light and noise pollution,there is a gap in knowledge about their combined *** developed a multidimensional environmental framework to assess the effect of urbanization and multiple environmental factors(light,noise,and temperature)on life-history traits and breeding success of Barn Swallows(Hirundo rustica)across rural to urban gradients in four locations spanning over 2500 km from North to south *** a single breeding season,we measured these environmental factors nearby nests and quantified landscape urbanization over a 1.m~*** then analysed the relationships between these multiple environmental factors through a principal component analysis and conducted spatially explicit linear-mixed effects models to assess their effect on lifehistory traits and breeding *** were particularly interested in understanding whether and how Barn Swallows were able to a{1.pt to such environmental conditions associated with *** results show that there is significant variation in the exposure to environmental conditions experienced by Barn Swallows breeding across urbanization gradients in *** changes and their effects are complex due to the behavioural responses ameliorating potential negative effects by selecting nesting sites that minimize exposure to environmental ***,significant relationships between landscape urbanization,exposure to environmental factors,and life-history traits such as laying {1.te and clutch size were ***,the impact on breeding success was,at least in our sample,negligible,suggesting that Barn Swallows are extremely a{1.ptable to a wide range of environmental features.

关键词： Fitness Heat-island effect Latitude Light pollution Noise pollution Parental investment

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Expert consensus on management principles of orthopedic emergency in the epidemic of coronavirus disease 201.

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Chinese Medical Journal 2020年第9期133卷 1096-1098页

作者： Pei-Fu tang Zhi-Yong Hou Xin-Bao Wu Chang-Qing Zhang Jun-Wen Wang Xin {1. Zeng-Wu Shao Ai-Xi Yu Gang Wang Bin Chen Ping Zhang Yan-Jun Hu Bo-Wei Wang Xiao-Dong Guo Xin tang Dong-Sheng Zhou Fan liu Ai-Mi Chen Kun Zhang Kai-Nan Li Yan-Bin Zhu 无 department of Orthopedics Department of OrthopedicsThe First Medical CenterChinese PLA General HospitalBeijing 100853China Emergency Center of Trauma Third Hospital of Hebei Medical UniversityShijiazhuangHebei 050051China department of Traumatology and Orthopedics Beijing Jishuitan HospitalBeijing 100035China department of Orthopedics The Sixth People’s Hospital Affiliated to Shanghai Jiaotong UniversityShanghai 200233China department of Orthopedics Wuhan Fourth HospitalWuhanHubei 430034China department of Orthopedics Union Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhanHubei 430022China department of Trauma Microsurgery Zhongnan Hospital of Wuhan UniversityWuhanHubei 430071China department of Orthopedics and Traumatology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China department of Orthopedics The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning 116011China department of Orthopedics Shandong Provincial HospitalJinanShandong 25002China department of Orthopedics Affiliated Hospital of Nantong UniversityNantongJiangsu 226001China department of Orthopedics Changzheng Hospital Affiliated to Naval Military Medical UniversityShanghai 200003China department of Orthopedics Honghui Hospital Affiliated to Medical College of Xi’an Jiaotong UniversityXi’an Shaanxi 710054China department of Orthopedics Affiliated Hospital of Chengdu UniversityChengduSichuan 610081China Orthopedic Trauma Branch of Chinese Orthopedic Association External Fixation and Limb Reconstruction Branch of Chinese Orthopedic Association Trauma Expert Committee of Chinese Association of Orthopedic Surgeons

Since December 201.,many patients in Wuhan sustained pneumonia with unknown causes.[1.2]A part of severe patients developed acute respiratory distress syndrome or septic shock,and even *** January 7,2020,Chinese researchers have for the first time detected a new *** January 20,2020,the National Health Commission issued Announcement No.1.of 2020,which included the new coronavirus pneumonia as a Class B infectious disease,and conducted epidemic prevention and control according to the Class A infectious *** new kind of pneumonia has been named coronavirus disease 201.(COVID-1.).The sixth edition of"Diagnosis and Treatment Scheme for New Coronavirus Infected Pneumonia"points out that the main transmission routes include respiratory droplets and close contact *** is a possibility of aerosol transmission in a relatively closed environment with prolonged exposure to high concentrations of *** coronavirus pneumonia has a certain incubation period.

关键词： prevention sustained aerosol

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初始可切除型胃癌肝转移不同治疗方式预后情况及其影响因素分析的全国多中心临床研究

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中华消化外科杂志 2024年第1期23卷 114-124页

作者：李力高云鹤商亮唐兆庆薛侃余江梁延锐何子锐柯彬郑华龙黄华熊建平何中原李佶阳卢婷婷宋奇赢刘诗贺郗洪庆唐云乔治梁寒季加孚陈凛解放军医学院研究生院北京100853 解放军总医院第一医学中心普通外科医学部北京100853 山东第一医科大学附属省立医院胃肠外科济南250021 复旦大学附属中山医院普通外科上海200032 南方医科大学南方医院普通外科广州510515 北京大学肿瘤医院胃肠外科北京100142 上海交通大学医学院附属瑞金医院普通外科上海200025 天津医科大学肿瘤医院胃部肿瘤科天津300060 福建医科大学附属协和医院胃外科福州350001 复旦大学附属肿瘤医院胃外科上海200032 中国医学科学院肿瘤医院胰胃外科北京100021 南京医科大学第一附属医院普通外科南京210029

目的探讨初始可切除型胃癌肝转移(GCLM)不同治疗方式的预后情况,分析预后的影响因素。方法采用回顾性队列研究方法。收集201.年1.至201.年1.月基于真实世界数据的GCLM诊疗全国多中心回顾性队列研究数据库中327例初始可切除型GCLM患者... 详细信息

目的探讨初始可切除型胃癌肝转移(GCLM)不同治疗方式的预后情况,分析预后的影响因素。方法采用回顾性队列研究方法。收集201.年1.至201.年1.月基于真实世界数据的GCLM诊疗全国多中心回顾性队列研究数据库中327例初始可切除型GCLM患者的临床病理资料;男267例,女60例;年龄为61.54,68)岁。根据患者具体情况分别行根治性手术联合系统治疗、姑息性手术联合系统治疗、单纯系统治疗。观察指标:(1.不同治疗方式患者临床特征情况。(2)不同治疗方式患者预后情况。(3)初始可切除型GCLM患者预后的影响因素分析。(4)根治性手术联合系统治疗和姑息性手术联合系统治疗潜在获益人群筛选。正态分布的计量资料以x±s表示,组间比较采用独立样本t检验。偏态分布的计量资料以M(Q1.Q3)表示,组间比较采用秩和检验。计数资料以绝对数或百分比表示,组间比较采用χ2检验。采用Kaplan-Meier法计算生存率并绘制生存曲线,Log-Rank检验进行生存分析。采用COX风险比例回归模型进行单因素和多因素分析。倾向评分匹配按1.1.近邻匹配法匹配,卡钳值为0.1.采用森林图筛选不同手术联合系统治疗的潜在获益人群。结果 (1.不同治疗方式患者临床特征情况。327例患者中,行根治性手术联合系统治疗1.8例,行姑息性手术联合系统治疗1.4例,行单纯系统治疗45例;3者吸烟、饮酒、胃原发肿瘤部位和肿瘤最大径、肝转移肿瘤部位、转移时限比较,差异均有统计学意义(P2)不同治疗方式患者预后情况。327例患者的中位总生存时间为1..9个月(95%可信区间为1..9~24.9个月),1.3年总生存率分别为61.3%、32.7%。行根治性手术联合系统治疗、姑息性手术联合系统治疗、单纯系统治疗患者的1.总生存率分别为68.3%、63.1.、30.6%,3年总生存率分别为41.1.、29.9%、1..9%,3者总生存率比较,差异有统计学意义(χ2=1..46,P26~0.61.P2~0.71.P1.20,1.70,1.20,2.06,95%可信区间为1.1.~1.27,1.25~2.31.1.04~1.42,1.45~2.92,P2~0.87,0.25~0.60,0.30~0.70,P21.0.42,95%可信区间为0.09~0.48,0.23~0.78,P<0.05)。结论与行单纯系统治疗比较,行根治性手术联合系统治疗或姑息性手术联合系统治疗可以改善初始可切除型GCLM患者预后。胃原发肿瘤越大、肿瘤分化程度为低分化、肝转移肿瘤越大、肝转移肿瘤数目为多发是影响初始可切除型GCLM患者预后的独立危险因素;免疫或靶向治疗、根治性手术联合系统治疗、姑息性手术联合系统治疗是影响初始可切除型GCLM患者预后的独立保护因素。

关键词：胃肿瘤肝转移手术治疗系统治疗预后影响因素

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Human cytomegalovirus DNA and immediate early protein 1.2 are highly associated with glioma and prognosis

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Protein & Cell 2020年第7期11卷 525-533页

作者： Le Wen Fei Zhao Yong Qiu Shuang Cheng Jin-Yan Sun Wei Fang Simon Rayner Michael A.McVoy xing-Jun Jiang Qiyi {1. Fang-Cheng Li Fei Hu Min-Hua Luo Joint Center of Translational Precision Medicine Guangzhou Institute of PediatricsGuangzhou Women and Children's Medical CenterGuangzhou 510623China State Key Laboratory of Virology CAS Center for Excellence in Brain Science and Itelligence TechnologyWuhan Instute of VirologyWuhan 430071China Chinese Institute for Brain Research Beijing 102206China Wuhan Brain Hospital Ministry of TransportationWuhan 430010China Depatment of Medical Genetics Oslo University Hospital and University of OsloOsloNorway department of Pediatrics Virginia Commonwealth University School of MedicineRichmondVirginiaUSA department of Neurosurgery Xiangya HospitalCentral South UniversityChangha 410008China department of Microbiology Howard University College of MedicineWashingtonDCUSA university of Chinese Academy of Sciences Bejing 100049China

Dear Editor,Gliomas are the most common brain tumors in adults which encompass all primary central nervous system(CNS)tumors of glial cell *** World Health Organization(WHO)classifies gliomas into four grades based on the histologic/prognostic *** of the unclear etiol-ogy and pathogenesis,therapeutic efficacy and prognosis is poor.

关键词： glioma prognosis pathogenesis

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A NOTE ON JACOBI SPECTRAL-COLLOCATION METHODS FOR WEAKLY SINGULAR VOLTERRA INTEGRAL EQUATIONS WITH SMOOTH SOLUTIONS

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Journal of Computational Mathematics 2013年第1期31卷 47-56页

作者： Yanping Chen Xianjuan Li Tao tang School of Mathematical Sciences South China Normal University Guangzhou 510631 China College of Mathematics and Computer Science Fuzhou University Fuzhou 350108 China department of Mathematics Hong Kong Baptist University Kowloon Tong Hong Kong

This work is concerned with spectrM Jacobi-collocation methods for Volterra integral equations of the second kind with a weakly singular of the form （t - s）-a When the underlying solutions are sufficiently smooth, the convergence analysis was carried out in [Chen ＆ tang, J. Comput. Appl. Math., 233 （2009）, pp. 938-950]; due to technical reasons 1.In this work, we will improve the results to the the results are restricted to 0 〈 μ 〈 1.2. general case 0 〈 μ 〈 1.and demonstrate that the numericl errors decay exponentially in the infinity and weighted norms when the smooth solution is involved.

关键词： Volterra integral equations Convergence analysis Spectral-collocation meth-ods.

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IGF-1./β-catenin signaling axis is involved in type 2 diabetic osteoporosis

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Journal of Zhejiang university-Science B(Biomedicine & Biotechnology) 2019年第10期20卷 838-848页

作者： Zhi-da ZHANG Hui REN Wei-xi WANG Geng-yang SHEN Jin-jing HUANG Mei-qi ZHAN Jing-jing {1. Xiang YU Yu-zhuo ZHANG De LIANG Zhi-dong YANG Xiao-bing JIANG The First Clinical School Guangzhou University of Chinese MedicineGuangzhou 510405China department of Spinal Surgery the First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510405China School of Basic Medicine Guangzhou University of Chinese MedicineGuangzhou 510006China Lingnan Medical Research Center of guangzhou {1. of Chinese Medicine Guangzhou 510405China

Insulin-like growth factor-1.receptor(IGF-1.R)is involved in both glucose and bone ***-1.R signaling regulates the canonical Wnt/β-catenin signaling *** this study,we investigated whether the IGF-1.R/β-catenin signaling axis plays a role in the pathogenesis of diabetic osteoporosis(DOP).Serum from patients with or without DOP was collected to measure the IGF-1.R level using enzyme-linked immunosorbent assay(ELISA).Rats were given streptozotocin following a four-week high-fat diet induction(DOP group),or received vehicle after the same period of a normal diet(control group).Dual energy X-ray absorption,a biomechanics test,and hematoxylin-eosin(HE)staining were performed to evaluate bone mass,bone strength,and histomorphology,respectively,in *** real-time polymerase chain reaction(qRT-PCR)and western blotting were performed to measure the total and phosphorylation levels of IGF-1.R,glycogen synthase kinase-3β(GSK-3β),andβ-*** serum IGF-1.R level was much higher in patients with DOP than in *** rats exhibited strikingly reduced bone mass and attenuated compression strength of the vertebrae compared with the control *** staining showed that the histomorphology of DOP vertebrae was seriously impaired,which manifested as decreased and thinned trabeculae and increased lipid droplets within *** analysis demonstrated that IGF-1.R mRNA expression was significantly up-regulated,and western blotting detection showed that phosphorylation levels of IGF-1.R,GSK-3β,andβ-catenin were enhanced in DOP rat *** results suggest that the IGF-1.R/β-catenin signaling axis plays a role in the pathogenesis of *** may contribute to development of the underlying therapeutic target for DOP.

关键词： Diabetic osteoporosis Insulin-like growth factor-1.receptor(IGF-1.) Signaling axis Pathogenesis

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新型四元硫族化合物光伏特性的高通量筛选和第一性原理研究

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物理学报 2024年第17期73卷 75-84页

作者：康家兴严全河曹浩宇孟威威徐飞洪峰上海大学理学院上海市高温超导重点实验室上海200444 华南师范大学华南先进光电子研究院广州510006 复旦大学物理系应用表面物理国家重点实验室上海200433

本工作提出了一种对Cu_(2)ZnSnS_(4)中Zn元素异价取代策略,探讨了新型四元硫族化合物A_(2)M_(2)M'Q_(4)(A=Na,K,Rb,Cs,In,Tl;M=Cu,Ag,Au;M'=Ti,Zr,Hf,Ge,Sn;Q=S,Se,Te)作为新型太阳能电池吸收层材料的应用潜力.利用第一性原理高通量计算,评估了1.50种A_(2)M_(2)M'Q_(4)化合物热力学稳定性、带隙、光谱极限最大效率和声子色散谱等特性.结果表明,有1.种热力学和动力学稳定的候选材料,它们表现出合适的带隙,并展现出高的光吸收性能,光谱极限最大效率的理论值均超过30%.它们的电子结构和光学性质类似于Cu_(2)ZnSnS_(4),有望应用于高效单结薄膜太阳能电池.本文数据集可在https://***/1..57760/sciencedb.j0021..00006中访问获取.

关键词：第一性原理高通量筛选四元硫族化合物光伏应用

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Comparative study on the anti-tuberculous effect and mechanism of the traditional Chinese medicines NiuBeiXiao He extract and JieHeWan

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Military Medical Research 2022年第2期9卷 164-183页

作者： Li-Yao Duan Yan Liang Wen-Ping Gong Yong Xue Jie Mi Jie Wang Lan Wang Zai-xing Jia Hong Lei Yu-Mei Liang Jun {1. Yue Zheng Xue-Qiong Wu Tuberculosis Prevention and Control Key Laboratory Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and TreatmentTuberculosis Research Institutethe 8th Medical CenterChinese PLA General HospitalBeijing 100091China Hebei North university Zhangjiakou 075000HebeiChina Clinical Laboratory the 8th Medical CenterChinese PLA General HospitalBeijing 100091China Pathology department the 8th Medical CenterChinese PLA General HospitalBeijing 100091China Guangdong Qifang Pharmaceutical Co. LtdGuangzhou 510075China

Background:The traditional Chinese medicine NiuBeiXiaoHe(NBXH)extract and Chinese medicine preparation JieHeWan(JHW)exhibit anti-tuberculosis(TB)*** anti-TB effect of NBXH was compared with that of JHW to elucidate the mechanism of action of ***:BALB/c mice aged 6-8 weeks were randomly divided into a {1. control group,TB model group,JHW treatment group,and NBXH treatment *** 3 and 1. weeks of treatment,the therapeutic effect in each group was evaluated by comparing lung histopathology,lung and liver colony counts,the number of spots representing effector T cells secreting IFN-γin an enzyme-linked immunospot assay(ELISPOT),and the levels of Th1.Th2,and Th1. cytokines,which were measured by a cytometric bead array(CBA).Mouse RNA samples were subjected to transcriptome ***:After 1. weeks of treatment,the mean histopathological lesion area of the NBXH group was significantly smaller than that of the TB model group(P2 and IL-4 levels in the NBXH group were significantly increased(Pdamage caused by *** infection by regulating immune-related pathways,which clarified the mechanism of action of NBXH.

关键词： Traditional Chinese medicine Tuberculosis NiuBeiXiaoHe extract JieHeWan Therapeutic effect

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