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糖尿病小型猪三磷酸腺苷结合盒转运体A1.达的变化

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生物化学与生物物理进展 2004年第6期31卷 543-549页

作者：唐朝克席守民尹卫东贺修胜刘德平易光辉杨峻浩王双韦星杨永宗南华大学心血管病研究所衡阳421001 南华大学生物化学与分子生物学教研室衡阳421001 南华大学病理学教研室衡阳421001

用贵州小香猪建立 2型糖尿病动物模型 ,探讨糖尿病小型猪三磷酸腺苷结合盒转运体A1.ABCA1.表达的变化 .采用高脂高蔗糖饲料喂养贵州小香猪 ,建立 2型糖尿病动物模型 .血浆总胆固醇、甘油三酯、高密度脂蛋白胆固醇和葡萄糖的浓度均用氧... 详细信息

用贵州小香猪建立 2型糖尿病动物模型 ,探讨糖尿病小型猪三磷酸腺苷结合盒转运体A1.ABCA1.表达的变化 .采用高脂高蔗糖饲料喂养贵州小香猪 ,建立 2型糖尿病动物模型 .血浆总胆固醇、甘油三酯、高密度脂蛋白胆固醇和葡萄糖的浓度均用氧化酶法测定 ,血浆游离脂肪酸 (FFA)用比色法测定 ,采用逆转录聚合酶链反应、蛋白质印迹和免疫组织化学分别检测ABCA1.RNA和蛋白质的表达 .喂养 6个月后 ,实验组与正常对照组比较 ,空腹血糖值明显升高 ;空腹胰岛素水平在头 3个月轻度升高 ,在第 6个月末其水平降低 ;血清总胆固醇、甘油三酯和游离脂肪酸水平升高 ;肝组织、冠状动脉、肾组织ABCA1.达上调 ,同时观测到糖尿病小型猪肝组织LXRα表达上调 .结果提示高脂高蔗糖饲料可引起小型猪脂质和糖代谢紊乱 ,并导致肝组织、冠状动脉和肾组织ABCA1.达上调以及肝组织LXRα表达上调 .

关键词：三磷酸腺苷结合盒转运体A1 游离脂肪酸糖尿病小型猪

In vivo real-time monitoring delayed administration of M2 macrophages to enhance healing of tendon by NIR-II fluorescence imaging

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Nano Research 2024年第5期17卷 4379-4390页

作者： Yuzhou Chen Mo Chen Chengxuan Yu Huizhu Li Liman Sai Nguyen T.K.Thanh Yueming Wang Yan Wo Jian Zhang xing Yang Evgenii L.Guryev Andrei V.Zvyagin Hao De Min {1. Shiyi Chen Yunxia Li Yuefeng Hao Sijia Feng Jun Chen Sports Medicine Institute of Fudan {1. Department of Sports MedicineHuashan HospitalFudan UniversityShanghai 200040China department of Orthopedic Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China department of Bone and Joint Surgery Department of OrthopedicsRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200001China department of {1. Shanghai Normal UniversityShanghai 200234China Biophysics Group Department of Physics and AstronomyUniversity College LondonLondon WC1E 6BTUK UCL Healthcare Biomagnetic and Nanomaterials Laboratories London W1S 4BSUK department of Anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghai 200025China department of Orthopedics Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou 215500China Institute of Biology and Biomedicine Lobachevsky State University of Nizhny NovgorodNizhny Novgorod 603950Russia Mathematical Institute University of OxfordOxford OX26GGUK Institute of Natural Sciences School of MathematicsShanghai Jiao Tong UniversityShanghai 200240China

The administration time is a critical but long-neglected point in cell therapy based on macrophages because the incorrect time of macrophage administration could result in diverse outcomes regarding the same macrophage *** this work,the second near-infrared(NIR-II)fluorescence imaging in vivo tracking of M2 macrophages during a pro-healing therapy in the mice model of rotator cuff injury revealed that the behavior of administrated macrophages was influenced by the timing of their *** delayed cell therapy(DCT)group had a longer retention time of injected M2 macrophages in the repairing tissue than that in the immediate cell therapy(ICT)*** Keller-Segel model and histological analysis further demonstrated that DCT altered the chemotaxis of M2 macrophages and improved the healing outcome of the repaired structure in comparison with *** results offer a possible explanation of previous conflicting results on reparative cell therapy and provoke reconsideration of the timing of these therapies.

关键词： macrophage cell therapy NIR-II in vivo imaging delayed therapy tendon healing

Biodegradable magnesium alloy as a new connecting material for iodine-1.5 brachytherapy:an initial experimental study in a rabbit VX2 model

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Biodegradable magnesium alloy as a new connecting material f...

中国(第七届)肿瘤微创治疗学术大会暨世界影像导引下肿瘤微创治疗学会成立筹备大会

作者： Dong Chen1.Guang-feng Duan1.Yan-ling Zhang2,Sheng Peng1.Jian-jun Han1.Chuan-xing Li 1.,Fu-jun Zhang 1. 1.{1. of Imaging and Interventional Radiology,Cancer Center of Sun Yat-sen university,guangzhou,51.060,People’s Republic of china 2.School of Biotechnology,southern Medical university,guangzhou 51.51.,People’s Republic of china

Objective To evaluate the in vivo degradation characteristics and tissue compatibility of new I1.5 seed chains connected with the biodegradable magnesium alloy AZ31.in New Zealand rabbits. Methods Thirty New Zealand rabbits were randomly divided into three *** group A,magnesium alloy radioactive I1.5 seeds chains were implanted into VX2 tumors;in group B,magnesium alloy non-radioactive I1.5 seeds chains were implanted into normal muscle;group C served as an untreated control *** mass loss of the AZ31.magnesium alloy connecting material was measured in the two groups at different time points after implantation of the I1.5 seed *** and histological changes at the implantation site and in organs were monitored using light microscopy,and seed displacement was assessed using regular X-ray and computed tomography(CT) *** and urine samples were collected from all experimental animals to measure changes in magnesium ion concentrations. Results The new 1.25 seed chains made with AZ31.magnesium alloy began to degrade during the first week after *** day 21.the degradation rate was 81.in muscle tissue and 83%in tumor tissue;these degradation rates are not statistically *** after implantation,a mild local inflammatory response and gas production were induced;the gas disappeared 21.days after *** magnesium ion concentrations after implantation were relatively stable,but urine magnesium concentrations increased and fluctuated over a larger *** inspection of the liver,kidney,heart,and spleen of all animals implanted with 1.25 seed chains revealed no significant *** 7 days after the implantation of magnesium alloy radioactive 1.25 seed chains into tumors,the connecting material showed good connecting and fixing *** 21.days after implantation,the seeds had separated from each other,displacement had occurred,and the radioactive seeds had aggregated in concordance with

关键词： I1.5 radioactive stranded seeds biodegradable magnesium alloy VX2 tumor biocompatibility

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几种典型混农林业模式的综合评价

西南师范大学学报（自然科学版） 2003年第2期28卷 288-293页

作者：李昌晓李昌阳汤兴华西南师范大学外事处重庆400715 四川省渠县林业局四川渠县635200 西南师范大学学报编辑部重庆400715

应用层次分析模糊评判方法,对黄土高原、秦巴山区不同地域的几种典型混农林业模式进行综合评价,为不同模式地之间相互学习借鉴、共同取长补短,提供了科学的参考依据.文中将农民群众对混农林业模式的理解接受能力纳入评价指标体系范畴,... 详细信息

应用层次分析模糊评判方法,对黄土高原、秦巴山区不同地域的几种典型混农林业模式进行综合评价,为不同模式地之间相互学习借鉴、共同取长补短,提供了科学的参考依据.文中将农民群众对混农林业模式的理解接受能力纳入评价指标体系范畴,这在国内尚属新的尝试.

关键词：混农林业模式综合评价层次分析—模糊评判方法指标体系理解接受能力

CHCHD2 Thr61.le mutation impairs F1.0-ATPase assembly in in vitro and in vivo models of Parkinson's disease

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Neural Regeneration Research 2024年第1期19卷 196-204页

作者： Xiang Chen Yuwan Lin Zhiling Zhang Yuting tang Panghai Ye Wei {1.i Wenlong Zhang Hanqun liu Guoyou Peng Shuxuan Huang Jiewen Qiu Wenyuan Guo Xiaoqin Zhu Zhuohua Wu Yaoyun Kuang Pingyi Xu Miaomiao Zhou department of Neurology The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina department of Neurology The People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina School of Basic Medical Sciences Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina department of Neurology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Mitochondrial dysfunction is a significant pathological alte ration that occurs in Parkinson's disease(PD),and the Thr61.le(T61.)mutation in coiled-coil helix coiled-coil helix domain containing 2(CHCHD2),a crucial mitochondrial protein,has been reported to cause Parkinson's ***-ATPase participates in the synthesis of cellular adenosine triphosphate(ATP)and plays a central role in mitochondrial energy ***,the specific roles of wild-type(WT)CHCHD2 and T61.-mutant CHCHD2 in regulating F1.O-ATPase activity in Parkinson's disease,as well as whether CHCHD2 or CHCHD2 T61. affects mitochondrial function through regulating F1.O-ATPase activity,remain unclea ***,in this study,we expressed WT CHCHD2 and T61.-mutant CHCHD2 in an MPP^(+)-induced SH-SY5Y cell model of *** found that CHCHD2 protected mitochondria from developing MPP^(+)-induced *** normal conditions,ove rexpression of WT CHCHD2 promoted F1.O-ATPase assembly,while T61.-mutant CHCHD2 appeared to have lost the ability to regulate F1.O-ATPase *** addition,mass spectrometry and immunoprecipitation showed that there was an interaction between CHCHD2 and *** weeks after transfection with AAV-CHCHD2 T61.,we intraperitoneally injected 1.methyl-4-phenyl-1.2,3,6-tetrahydropyridine into mice to establish an animal model of chronic Parkinson's disease and found that exogenous expression of the mutant protein worsened the behavioral deficits and dopaminergic neurodegeneration seen in this *** findings suggest that WT CHCHD2 can alleviate mitochondrial dysfunction in PD by maintaining F1.0-ATPase structure and function.

关键词： ATP synthase(F1.0-ATPase) coiled-coil helix coiled-coil helix domain containing 2 dopaminergic neuron mitochondrial dysfunction neurodegeneration oligomycin sensitivity-conferring protein Parkinson's disease T61. mutation tyrosine hydroxylase

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关于花椒林间作年限的研究

西南师范大学学报（自然科学版） 2003年第3期28卷 470-472页

作者：李昌晓李昌阳汤兴华西南师范大学外事处重庆北碚400715 四川省渠县林业局四川渠县6352003 西南师范大学学报编辑部重庆北碚400715

应用花椒林冠覆盖率和林下间作小麦相对减产率之间的线性回归关系,确定出林下小麦间作的理论年限及林分初植密度,为林农复合生产提供直接的参考依据.

关键词：花椒林间作年限小麦冠覆盖率林分初植密度林农复合生产减产率

Interfacial built-in electric field and crosslinking pathways enabling WS_(2)/Ti_(3)C_(2)T_(x) heterojunction with robust sodium storage at low temperature

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Journal of Energy Chemistry 2024年第2期89卷 635-645,I0014页

作者： Jiabao Li Shaocong tang Jingjing Hao Quan Yuan Tianyi Wang Likun Pan Jinliang Li Shenbo Yang Chengyin Wang College of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002JiangsuChina Shanghai Key Laboratory of Magnetic Resonance School of Physics and Electronic Science East China Normal UniversityShanghai 200241China Siyuan Laboratory Guangdong Provincial Engineering Technology Research Center of Vacuum Coating Technologies and New Energy MaterialsGuangdong Provincial Key Laboratory of Nanophotonic ManipulationDepartment of PhysicsJinan UniversityGuangzhou 510632GuangdongChina Hongzhiwei Technology(Shanghai)CO.LTD Shanghai 200241China

Developing efficient energy storage for sodium-ion batteries(SIBs)by creating high-performance heterojunctions and understanding their interfacial interaction at the atomic/molecular level holds promise but is also ***,sluggish reaction kinetics at low temperatures restrict the operation of SIBs in cold ***,cross-linking nanoarchitectonics of WS_(2)/Ti_(3)C_(2)T_(x) heterojunction,featuring built-in electric field(BIEF),have been developed,employing as a model to reveal the positive effect of heterojunction design and BIEF for modifying the reaction kinetics and electrochemical ***,the theoretical analysis manifests the discrepancy in work functions leads to the electronic flow from the electron-rich Ti_(3)C_(2)T_(x) to layered WS_(2),spontaneously forming the BIEF and“ion reservoir”at the heterogeneous ***,the generation of cross-linking pathways further promotes the transportation of electrons/ions,which guarantees rapid diffusion kinetics and excellent structure ***,superior sodium storage performance is obtained for the WS_(2)/Ti_(3)C_(2)T_(x) heterojunction,with only 0.2%decay per cycle at 5.0 A g^(-1.(25℃)up to 1.00 cycles and a high capacity of 293.5 mA h g^(-1.(0.1. g^(-1.after 1.0 cycles)even at-20℃.Importantly,the spontaneously formed BIEF,accompanied by“ion reservoir”,in heterojunction provides deep understandings of the correlation between structure fabricated and performance obtained.

关键词： WS_(2)/Ti_(3)C_(2)T_(x)heterojunction Built-in electric field Ion reservoir Reaction kinetics Sodium storage performance at low temperature

Two-color emissive AIEgens with anti-Kasha property for dual-organelle imaging and phototherapy

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Science china Chemistry 2024年第5期67卷 1740-1752页

作者： Pu Chen Guogang Shan Qingli Nie Yuting Yan Pengfei Zhang Zujin Zhao Hai-Tao Feng Ben Zhong tang AIE Research Center Shaanxi Key Laboratory of PhytochemistryCollege of Chemistry and Chemical EngineeringBaoji University of Arts and SciencesBaoji 721013China Institute of Functional Material Chemistry and National&Local United Engineering Lab for Power Battery Faculty of ChemistryNortheast Normal UniversityChangchun 130024China College of Chemistry&Materials Science Northwest UniversityXi’an 710127China Guangdong Key Laboratory of Nanomedicine CAS-HK Joint Lab of BiomaterialsCAS Key Laboratory of Biomedical Imaging Science and SystemShenzhen Engineering Laboratory of Nanomedicine and NanoformulationsCAS Key Lab for Health InformaticsShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China State Key Laboratory of Luminescent Materials and Devices Key Laboratory of Luminescence from Molecular Aggregates of Guangdong ProvinceSouth China University of TechnologyGuangzhou 510640China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Shenzhen 518172China

Despite the rapid development of probes for targeting single organelle, the construction of robust dual-organelle targeting probes with multicolor emission was rarely reported. Herein, two dual-emissive aggregation-induced emission luminogens(AIEgens)with donor-π-acceptor structures were designed and synthesized, namely QT-1.and QF-2. Both two AIEgens exhibited excitation wavelength-dependence defying the Kasha's rule, and could stain lipid droplets(LDs) and mitochondria in blue and red fluorescence, respectively. Moreover, thanks to the near-infrared emission and abundant reactive oxygen species(ROS) generation efficiency of QT-1. it was chosen as a photodynamic therapy agent to selectively kill cancer cells from {1. cells. Upon light irradiation, an obvious decrease of mitochondrial membrane potential(MMP) and serious change of mitochondrial shape in cells were observed, which corresponded to the efficient inhibition of tumor growth in vivo. This work afforded a promising strategy for the construction of multicolor emission by tuning anti-Kasha behaviors and expanding their application in dualorganelle targeting-based phototheranostics.

关键词： aggregation-induced emission anti-Kasha luminescence fluorescent probe bioimaging photodynamic therapy

CTAB/正丁醇/环己烷/水微乳体系相行为的研究

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山东科学 2002年第2期15卷 35-38页

作者：鲁建军汤兴国山东师范大学化学系山东济南250014 山东寿光一中山东寿光262700

测定了 CTAB/正丁醇 /环己烷 /水三相微乳液体系的“鱼状”相图和单相微乳液体系拟三元相图。从“鱼状”相图的位置考察了 CTAB形成单相微乳液的效能。用电导法确定了单相微乳液体系的结构 (W/ O、B.C.、和 O/ W)。考察了微乳液结构和... 详细信息

测定了 CTAB/正丁醇 /环己烷 /水三相微乳液体系的“鱼状”相图和单相微乳液体系拟三元相图。从“鱼状”相图的位置考察了 CTAB形成单相微乳液的效能。用电导法确定了单相微乳液体系的结构 (W/ O、B.C.、和 O/ W)。考察了微乳液结构和温度对微乳液电导率的影响。

关键词： CTAB 正丁醇环已烷微乳液相图十六烷基三甲基溴化胺电导率表面活性物质