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Chinese Journal of Natural Medicines 2019年第1期17卷 50-58页

作者： FENG Shu-Jun tang zhi-han WANG Ying tang Xin-Ying LI Tao-Hua tang Wei KUANG Ze-Min Department of Cardiology The First People's Hospital of ChenzhouUniversity of South China Institute of Cardiovascular Disease Key Lab for Arteriosclerology of Hunan ProvinceUniversity of South China Department of Biochemistry and Molecular Biology The Libin Cardiovascular Institute of AlbertaThe University of CalgaryHealth Sciences Center3330 Hospital Drive NW Department of Cardiology The Second Affiliated Hospital of Henan University of Science and Technology Class 2014 Medical CollegeUniversity of South China Department of Hypertension Beijing Anzhen Hospital of Capital Medical University

Atherosclerotic cardiovascular disease(ASCVD) is the deadliest disease in the world, with endothelial injury occurring throughout the course of the disease. Therefore, improvement in endothelial function is of essential importance in the prevention of ASCVD. Red yeast rice(RYR), a healthy traditional Chinese food, has a lipid modulation function and also plays a vital role in the improvement of endothelial reactivity and cardiovascular protection; thus, it is significant in the prevention and treatment of ASCVD. This article reviews the molecular mechanisms of RYR and its related products in the improvement of endothelial function in terms of endothelial reactivity, anti-apoptosis of endothelial progenitor cells, oxidative stress alleviation and anti-inflammation.

关键词： Red yeast rice Xuezhikang Atherosclerotic cardiovascular disease Endothelial cells Molecular mechanism

Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo Qi han tang Jianian Hu Siying Kang Song Qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

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几何结构保持非负矩阵分解的数据表达方法

信息与控制 2017年第1期46卷 53-59,64页

作者：李冰锋唐延东韩志中国科学院沈阳自动化研究所国家重点实验室辽宁沈阳110016 河南理工大学电气工程与自动化学院河南焦作454000 中国科学院大学北京100049

作为一种线性降维方法,非负矩阵分解(NMF)算法在多个场合均有应用;但NMF算法只能在欧氏空间上进行语义分解,当输入数据是嵌入在高维空间的低维流形时,NMF会引入较大的分解误差.为解决此问题,本文提出了一种基于几何结构保持的非负矩阵... 详细信息

作为一种线性降维方法,非负矩阵分解(NMF)算法在多个场合均有应用;但NMF算法只能在欧氏空间上进行语义分解,当输入数据是嵌入在高维空间的低维流形时,NMF会引入较大的分解误差.为解决此问题,本文提出了一种基于几何结构保持的非负矩阵分解算法(SPNMF).在SPNMF算法中,我们将局部近邻样本点间的相似性关系的保持和远距离非近邻样本点间的互斥性关系的保持引入到NMF框架;并把非负矩阵分解的求解问题转化为数值优化问题,然后用交替优化的方法对SPNMF算法进行了求解.相对于NMF,SPNMF算法拥有更多的数据分布的先验知识,因此SPNMF算法可以获得一种更好低维数据表达方式.在人脸数据库上的试验结果表明,相对于NMF及其它的改进算法,SPNMF算法具有更高的聚类精度.

关键词：非负矩阵分解结构保持图正则化补空间图像聚类

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu tang Chun-Mao Yuan Jun-Bo Yang zhi-Li Zuo han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids

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杜仲叶提取物对清醒大鼠血压的影响

中国医院药学杂志 2007年第7期27卷 901-903页

作者：唐志晗彭娟姜金兰南华大学医学院湖南衡阳421001 永州市第三人民医院药剂科湖南永州425006

目的:观察杜仲叶提取物急慢性降压作用。方法:以间接测压法测量清醒大鼠尾动脉血压:(1)测量自发性高血压大鼠(SHR)多次灌胃杜仲叶提取物的血压变化,观察其慢性降压作用。(2)测量肾性高血压大鼠1次灌胃杜仲提取物后1,2,4,6,8h的血压,以... 详细信息

目的:观察杜仲叶提取物急慢性降压作用。方法:以间接测压法测量清醒大鼠尾动脉血压:(1)测量自发性高血压大鼠(SHR)多次灌胃杜仲叶提取物的血压变化,观察其慢性降压作用。(2)测量肾性高血压大鼠1次灌胃杜仲提取物后1,2,4,6,8h的血压,以观察提取物急性降压作用。结果:(1)连续18d灌胃杜仲叶提取物***-1或***-1均明显降低SHR血压。(2)一次性灌杜仲叶提取物***-1或***-1均明显降低肾性高血压大鼠血压。结论:杜仲叶提取物有明显的降低急慢性血压作用。

关键词：杜仲叶提取物血压大鼠

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马祖常文风革新之功刍议

西安建筑科技大学学报（社会科学版） 2018年第5期37卷 95-100页

作者：唐值瀚四川师范大学文学院四川成都610066

文章至元,承宋季庸沓骫骳之文弊,马祖常踵武前贤,力求复古以革新。举其大端,为文法先秦两汉,推扬宗经载道、修辞立诚的文章创作宗旨,重视作者的道德树立,重构文章的刚健骨力,此其一。其二,文尚质实,不事藻饰,蕴含鲜明的现实品格,以具体... 详细信息

文章至元,承宋季庸沓骫骳之文弊,马祖常踵武前贤,力求复古以革新。举其大端,为文法先秦两汉,推扬宗经载道、修辞立诚的文章创作宗旨,重视作者的道德树立,重构文章的刚健骨力,此其一。其二,文尚质实,不事藻饰,蕴含鲜明的现实品格,以具体的文章实践反拨宋季骫骳文风。其三,两知贡举的文化行为对于马祖常推进复古革新的文学实践有着重要意义。马祖常发挥主持科试的便宜条件,使复古革新的文学主张付诸铨选人才的具体行为之中,取录与自身文学主张相契合的进士文人,传播复古革新思想,导引元代文章步入雅正宏大之境。

关键词：元代马祖常宋季文风革新

槲皮素抑制诱导型一氧化氮合酶减轻脓毒症大鼠的心肌损伤

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中国药理学通报 2011年第11期27卷 1586-1589页

作者：张弛黄靓屈顺林唐志晗韦星南华大学心血管病研究所湖南衡阳421001 南华大学机能学实验中心湖南衡阳421001 南华大学外科学总论教研室湖南衡阳421001

目的初步探讨槲皮素对脓毒症心肌损伤的影响及其机制。方法将30只SPF级♂SD大鼠分为槲皮素预处理组、脓毒症组和假手术组,每组10只。采用盲肠结扎穿刺法制备脓毒症大鼠模型。盲肠结扎穿刺术后12 h经右颈总动脉左心室内插管监测各组大鼠... 详细信息

目的初步探讨槲皮素对脓毒症心肌损伤的影响及其机制。方法将30只SPF级♂SD大鼠分为槲皮素预处理组、脓毒症组和假手术组,每组10只。采用盲肠结扎穿刺法制备脓毒症大鼠模型。盲肠结扎穿刺术后12 h经右颈总动脉左心室内插管监测各组大鼠MAP、LVSP、LVEDP、±dp/dtmax等血流动力学指标,免疫印迹法测定心肌组织iNOS蛋白表达,酶法测定心肌组织匀浆中iNOS活力及NO含量。结果脓毒症组大鼠LVSP降低、LVEDP升高、+dp/dtmax与-dp/dtmax均有所下降,而槲皮素预处理组以上各项指标均有不同程度改善;脓毒症组大鼠左心室心肌组织iNOS的表达上调,iNOS的活力升高,NO的含量增加,而槲皮素预处理组以上指标的增加幅度较小。结论槲皮素通过降低心肌组织iNOS的表达及活力,抑制脓毒症时心肌组织中过量的NO产生,减轻脓毒症心肌损伤。

关键词：槲皮素脓毒症心肌损伤血流动力学诱导型一氧化氮合酶一氧化氮

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南京国际会议展览中心屋盖钢结构吊装技术

施工技术 2000年第6期29卷 18-19页

作者：于晓光唐植汉中国石化第二建设公司江苏南京210046

介绍跨度 75 m、悬挑 1 5 m的钢管拱架整体吊装技术。

关键词：屋盖拱架吊装钢结构南京国际会议展览中心

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泵站技术改造工程建设要把好“四关”

排灌机械 2005年第3期23卷 49-51页

作者：汤汉志安徽省天长市水利局安徽天长239300

针对泵站技术改造工程的特点,结合从事泵站建设和管理工作经验,提出泵站技术改造工程在各个工作阶段应把握的重点:前期工作阶段要重点抓好土建和机电设备检测工作;设计阶段要搞好工程设计参数的复核和设备选型工作;工程施工阶段要严格... 详细信息

针对泵站技术改造工程的特点,结合从事泵站建设和管理工作经验,提出泵站技术改造工程在各个工作阶段应把握的重点:前期工作阶段要重点抓好土建和机电设备检测工作;设计阶段要搞好工程设计参数的复核和设备选型工作;工程施工阶段要严格按照基建程序管理,搞好设备采购和设备安装工作;竣工验收阶段要搞好工程、财务审计和竣工验收资料的整理归档工作。

关键词：工程建设技术改造工程工程施工阶段工作阶段工作经验泵站建设检测工作机电设备设备选型设计参数设计阶段程序管理安装工作设备采购竣工验收归档工作验收资料土建

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僧传文学视域下元代塔铭文的高僧角色

德州学院学报 2018年第5期34卷 18-22页

作者：唐值瀚四川师范大学文学院成都610066

元代塔铭以高僧大德为传述对象,同时有着虚构和想象的成分,可视为僧传文学的类型之一,是深具史传叙事传统的佛教传记文学。史传叙事的现实性与尚实品格以及僧传文学的宗教性与写作意图,使元代塔铭中的高僧具有神人同体的形象特征。读者... 详细信息

元代塔铭以高僧大德为传述对象,同时有着虚构和想象的成分,可视为僧传文学的类型之一,是深具史传叙事传统的佛教传记文学。史传叙事的现实性与尚实品格以及僧传文学的宗教性与写作意图,使元代塔铭中的高僧具有神人同体的形象特征。读者是塔铭的接受主体,也是塔铭撰写的最终指向。元代塔铭撰者在撰文过程中采取修辞策略以明高僧神异之不诬,有助于读者在阅读中获得真实感,达到对高僧崇高形象的心理认同,进而在读者接受的维度实现塔铭文的写作意图。

关键词：元代塔铭僧传文学高僧形象修辞策略