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Effect of manipulation on cartilage in rats with knee osteoarthritis based on the Rho-associated protein kinase/LIM kinase 1/Cofilin signaling pathways

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Journal of Traditional Chinese Medicine 2022年第2期42卷 194-199页

作者： GUO Xiao YANG Yunhao LIAO Dongmei PANG Fang YANG Zhixue ZHU zhengwei LUO Ao tang Chenglin College of Traditional Chinese Medicine Chongqing Medical UniversityChongqing 400010China Beibei Traditional Chinese Medicine Hospital Chongqing 400700China

OBJECTIVE:To investigate the effect of manipulation treatment on knee osteoarthritis rats and the effect on Rho-associated protein kinase(ROCK)/LIM-kinase1(LIMK1)/Cofilin signaling ***:Fifty Specific pathogen Free Sprague-Dawley rats were randomly divided into five groups(n=8 each):blank group,model group,manipulation group,celecoxib group,and manipulation combined with celecoxib group(MC group).The osteoarthritis model was established by injecting 0.2 m L 4%papain into the articular disc of the *** successfully establishing the model,we treated the manipulation group with pushing manipulation using one-finger-meditation to the Neixiyan(EX-LE4),Waixiyan(EX-LE5),Xuehai(SP10),Liangqiu(ST34),and Zusanli(ST36)acupoints for 10 min each ***,the celecoxib group was gavaged with 24 mg·kg^(-1)·d^(-1 )celecoxib,while the MC group was treated using both of these two *** four weeks,the cartilage of the right femur was removed for hematoxylin-eosin staining of the cartilage *** expressions of interleukin-1β(IL-1β)and tumor necrosis factor-α(TNF-α)in serum were observed using the enzyme-linked immunosorbent ***,we detected the expressions of ROCK,LIMK1,Phospho-LIM-kinase1(Phospho-LIMK1),Cofilin,and Phospho-Cofilin by Western ***:Compared to the model group,the manipulation group,celecoxib group,and MC group all exhibited superior results concerning pathological morphologic changes of cartilage,as observed by hematoxylin-eosin staining and calculated using the Mankin ***,in contrast to the blank group,the model group exhibited elevated serum levels of IL-1βand TNF-α(P<0.01),while the expression of ROCK,LIMK1,Phospho-LIMK1,Cofilin,and Phospho-Cofilin in cartilage were all higher(P<0.01).Also,the serum levels of IL-1βand TNF-αin each treatment group were lower(P<0.01)than in the model ***,there were lower expressions of ROCK,LIMK1,Phospho-LIMK1,Cofilin,and Phospho-Cofilin in cartilage in the manipulatio

关键词： osteoarthritis knee manipulation cytoskeletal proteins Rho-associated kinases LIM kinases actin depolymerizing factors signal transduction

An AIE probe for long-term plasma membrane imaging and membrane-targeted photodynamic therapy

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Chinese Chemical Letters 2023年第4期34卷 240-245页

作者： Hailing Zhao Nan Li Caixia Ma zhengwei Wei Qiya Zeng Keyi Zhang Na Zhao Ben Zhong tang Key Laboratory of Macromolecular Science of Shaanxi Province Key Laboratory of Applied Surface and Colloid Chemistry of Ministry of Educationand School of Chemistry&Chemical EngineeringShaanxi Normal UniversityXi’an 710119China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen 518172China

Two red-emissive luminogens(TPTH and TPTB) with typical aggregation-induced emission characteristics were developed. By introducing the heavy atom of Br at the end of alkyl chain, TPTB exhibited higher reactive oxygen species generation efficiency through both types I and II pathways. Due to its excellent biocompatibility and proper lipophilicity, TPTB could be used for long-term cell membrane staining and this staining ability was independent of the change of plasma membrane potential. Furthermore, TPTB could ablate the cancer cells through cell membrane-targeted photodynamic therapy.

关键词： Aggregation-induced emission Plasma membrane Fluorescent probe Long-term imaging Photodynamic therapy

程潮矿业公司链篦机-回转窑-环冷机系统平衡考察与分析

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鞍钢技术 2024年第4期 21-25页

作者：汤启宙李正威周晓军何东黄雯武钢资源集团程潮矿业有限公司湖北鄂州436051 武汉开圣工程设计研究有限责任公司湖北黄石435000

为了了解程潮矿业公司球团厂链篦机-回转窑-环冷机系统三大主机的热工状态,对系统的物料、风量及热量平衡进行了考察与分析,并为优化现场热工制度提出了合理建议。结果表明,链篦机机漏风率为10.86%,链篦机、回转窑和环冷机热损失率分别... 详细信息

为了了解程潮矿业公司球团厂链篦机-回转窑-环冷机系统三大主机的热工状态,对系统的物料、风量及热量平衡进行了考察与分析,并为优化现场热工制度提出了合理建议。结果表明,链篦机机漏风率为10.86%,链篦机、回转窑和环冷机热损失率分别为5.38%、12.09%和1.87%,需针对风箱和烟罩密封性进行检修,降低漏风率和热损失,对回转窑内耐火砖进行实时监测,定期更换破损耐火砖,降低窑内散热。

关键词：链篦机-回转窑-环冷机物料平衡风量平衡热量平衡

“一站式”手工大鞘吸栓清除方案对急性下肢深静脉血栓的治疗效果分析

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血管与腔内血管外科杂志 2024年第4期10卷 494-497,509页

作者：刘潇龙昊李修红宋正伟唐昊胡云龙重庆市大足区人民医院肝胆血管外科重庆402360

目的探讨“一站式”手工大鞘吸栓清除方案对急性下肢深静脉血栓(DVT)的治疗效果。方法收集2021年7月至2022年9月重庆市大足区人民医院收治的51例急性下肢DVT患者的临床资料,均行“一站式”手工大鞘吸栓清除方案治疗,且采用溶栓和抗凝治... 详细信息

目的探讨“一站式”手工大鞘吸栓清除方案对急性下肢深静脉血栓(DVT)的治疗效果。方法收集2021年7月至2022年9月重庆市大足区人民医院收治的51例急性下肢DVT患者的临床资料,均行“一站式”手工大鞘吸栓清除方案治疗,且采用溶栓和抗凝治疗。评价患者溶栓疗效、手术时间、住院时间情况、静脉通畅情况、治疗前后患肢周径情况,随访6个月下肢深静脉血栓后综合征(PTS)发生率和支架内血流通畅情况。结果51例患者治疗总有效率为100%,手术时间(105.52±21.34)min,住院时间(5.98±1.46)d。治疗后静脉通畅评分低于治疗前,患肢膝上20 cm周径和膝下15 cm周径均小于治疗前,差异均有统计学意义(P﹤0.05)。随访6个月,51例患者髂静脉和下肢深静脉支架内血流通畅,且均未发生PTS情况。结论“一站式”手工大鞘吸栓清除方案对急性下肢DVT患者疗效显著,可明显改善患者静脉通畅情况,未发生PTS,安全性良好,值得临床推广应用。

关键词： “一站式”手工大鞘吸栓急性下肢深静脉血栓治疗效果

A novel sprayable thermosensitive hydrogel coupled with zinc modified metformin promotes the healing of skin wound

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Bioactive Materials 2023年第2期20卷 610-626页

作者： zhengwei Liu Wanze tang Jiayi Liu Yingying Han Qinnan Yan Yuechao Dong Xiaomei Liu Dazhi Yang Guixing Ma Huiling Cao Department of Biochemistry School of MedicineSouthern University of Science and TechnologyGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease ResearchShenzhen Key Laboratory of Cell MicroenvironmentShenzhen518055China Southern University of Science and Technology Shenzhen518055China Department of Biomedical Engineering Southern University of Science and TechnologyShenzhen518055China The First Affiliated Hospital Southern University of Science and TechnologyShenzhen518055China

A novel sprayable adhesive is established(ZnMet-PF127)by the combination of a thermosensitive hydrogel(Pluronic F127,PF127)and a coordination complex of zinc and metformin(ZnMet).Here we demonstrate that ZnMet-PF127 potently promotes the healing of traumatic skin defect and burn skin injury by promoting cell proliferation,angiogenesis,collagen ***,we find that ZnMet could inhibit reactive oxygen species(ROS)production through activation of autophagy,thereby protecting cell from oxidative stress induced damage and promoting healing of skin *** complex exerts better effects on promoting skin wound healing than ZnCl2 or metformin *** complex also displays excellent antibacterial activity against Staphylococcus aureus or Escherichia coli,which could reduce the incidence of skin wound ***,we demonstrate that sprayable PF127 could be used as a new drug delivery system for treatment of skin *** advantages of this sprayable system are obvious:(1)It is convenient to use;(2)The hydrogel can cover irregular skin defect sites evenly in a liquid *** combination with this system,we establish a novel sprayable adhesive(ZnMet-PF127)and demonstrate that it is a potential clinical treatment for traumatic skin defect and burn skin injury.

关键词： Thermosensitive hydrogel Skin wound ZnMet-PF127 Reactive oxygen species(ROS) Autophagy

The structure and magnetic properties of β-(Ga_(0.96)Mn_(0.04))_2O_3 thin film

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Journal of Semiconductors 2018年第5期39卷 16-20页

作者： Yuanqi Huang zhengwei Chen Xiao Zhang Xiaolong Wang Yusong Zhi Zhenping Wu Weihua tang Laboratory of Optoelectronics Materials and Devices School of Science Beijing University of Posts and Telecommunications State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and Telecommunications

High quality epitaxial single phase（Ga_（0.96）Mn_（0.04））_2O_3 and Ga_2O_3 thin films have been prepared on sapphire substrates by using laser molecular b（eam）epitaxy（L-MBE）. X-ray diffraction results indicate that the thin films have the monoclinic structure with a 201 preferable orientation. Room temperature（RT） ferromagnetism appears and the magnetic properties of β-（Ga_（0.96）Mn_（0.04））_2O_3 thin film are enhanced compared with our previous works. Experiments as well as the first principle method are used to explain the role of Mn dopant on the structure and magnetic properties of the thin films. The ferromagnetic properties are explained based on the concentration of transition element and the defects in the thin films.

关键词： L-MBE epitaxial growth Mn doped Ga2O3 thin film RT ferromagnetism

川西南公路顺层边坡桩锚组合结构加固分析——以乐西高速ZK9+352~ZK9+526边坡为例

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科技和产业 2024年第5期24卷 271-279页

作者：刘正威邬凯罗晓龙闵祥陈沛唐爽李涛四川公路桥梁建设集团有限公司成都610041 四川省公路规划勘察设计研究院有限公司成都610041 西南交通大学土木工程学院成都610031

四川盆地周边地形地质条件复杂,公路建设中顺层边坡的工程病害频现。通过工程地质分析和数值计算,基于滑面损伤本构模型,研究顺层边坡支护前后滑面应力、位移和边坡稳定性系数等特征量的变化规律,验证桩锚组合结构加固顺层边坡的适用性... 详细信息

四川盆地周边地形地质条件复杂,公路建设中顺层边坡的工程病害频现。通过工程地质分析和数值计算,基于滑面损伤本构模型,研究顺层边坡支护前后滑面应力、位移和边坡稳定性系数等特征量的变化规律,验证桩锚组合结构加固顺层边坡的适用性;通过施工全周期现场监测,获取边坡深部位移、抗滑桩桩身弯矩和锚索应力的时效特征。结果表明:开挖扰动下顺层边坡具渐进性失稳破坏特征;自坡脚沿滑面向后缘,位移呈指数型平滑递减,剪应力先增大后降低,滑面损伤变量自剪应力峰值位置开始同频衰减;采用桩锚组合结构加固顺层边坡后,滑面位移最大值降低88.62%,最大损伤变量降低84.75%,稳定系数提高25.20%;坡体深部位移、抗滑桩桩身弯矩、锚索应力等监测验证了桩锚组合结构加固的有效作用。

关键词：公路顺层边坡桩锚组合结构有限元现场监测

The human leukocyte antigen and genetic susceptibility in human diseases

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Journal of Bio-X Research 2019年第3期2卷 112-120页

作者： Jinping Gao Caihong Zhu zhengwei Zhu Lili tang Lu Liu Leilei Wen Liangdan Sun Department of Dermatology the First Affiliated Hospital of Anhui Medical UniversityAnhui ProvinceChina Institute of Dermatology Anhui Medical UniversityAnhui ProvinceChina Key Laboratory of Dermatology(Anhui Medical University) Ministry of EducationAnhui ProvinceChina State Key Laboratory Incubation Base of Dermatology Anhui Medical UniversityAnhui ProvinceChina Key Laboratory of Major Autoimmune Diseases Anhui ProvinceHefeiAnhui ProvinceChina

The human leukocyte antigen(HLA)complex is involved in immunity,belongs to a highly polymorphic family of genes,and is found in a disease-associated region of the human *** HLA region of the genome has been associated with more than hundreds of diseases,including autoimmune diseases,cancer,and infectious *** of its extensive linkage disequilibrium,HLA represents one of the most attractive and valuable regions that have been discovered in numerous feasibility ***,despite its critical role,attempts to apply comprehensive and traditional strategies towards the characterization of the HLA locus have been *** recent development of genotyping arrays and sequencing technologies has resulted in the development of technologies that are capable of addressing the extreme polymorphism nature of *** this review,we summarized the current approaches being used to capture,sequence,and analyze HLA genes and *** addition,we discussed the new methodologies being used for these applications,including HLA genotyping,population genetics,and disease-association studies.

关键词： allele genetic susceptibility genome-wide association study human diseases human leukocyte antigen

激素浓度组合对成熟油梨枝条伸长和生根的影响

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热带农业科学 2024年第3期44卷 15-22页

作者：成镜汤倩黄天带顾晓川徐正伟彭素娜海南天然橡胶与热带林木研究院海南海口571101 中国热带农业科学院橡胶研究所/农业农村部橡胶树生物学与遗传资源利用重点实验室/省部共建国家重点实验室培育基地/海南省热带作物栽培生理学重点实验室/热带林木种子种苗工程中心/海口市热带植物种苗创新重点实验室海南海口571101 海南大学林学院海南儋州571737

为了建立抗根腐病成熟油梨砧木的快繁技术体系,通过设置不同浓度(0.1、0.5、1.0、1.5、2.0、2.5、3.0 mg/L)的细胞分裂素(meta-topolin,MT)与不同浓度(0.1、0.5、1.0、1.5 mg/L)的赤霉素(gibberellin,GA3)的组合试验,研究适宜于成熟油... 详细信息

为了建立抗根腐病成熟油梨砧木的快繁技术体系,通过设置不同浓度(0.1、0.5、1.0、1.5、2.0、2.5、3.0 mg/L)的细胞分裂素(meta-topolin,MT)与不同浓度(0.1、0.5、1.0、1.5 mg/L)的赤霉素(gibberellin,GA3)的组合试验,研究适宜于成熟油梨外植体伸长的培养条件;同时设置不同浓度(0.5、1.0、1.5、2.0、2.5、3.0 mg/L)的吲哚-3-丁酸(indole-3-butyric acid,IBA)的生根培养基,探究最适油梨外植体生根的培养条件。研究发现,伸长试验30 d时(D30)油梨外植体株高增量和茎粗增量的效应量依次是MT浓度×GA_(3)浓度>MT浓度>GA_(3)浓度;对D30叶片增量的效应量依次是MT浓度>MT浓度×GA_(3)浓度>GA_(3)浓度。结果表明,在该研究的测试范围内,最适于伸长的激素浓度组合是MT 2 mg/L、GA_(3)(0.5~1.0)mg/L,而在测试的IBA浓度范围内均没有观察到根系的生长。通过显微结构观察发现,MT浓度为1 mg/L处理的油梨外植体茎木质部(木质部厚度为171.6μm)生长优于MT浓度为0.1 mg/L的处理(木质部厚度为95.3μm),这对后期的成功驯化有一定积极作用。本研究结果可为成熟油梨快繁体系建立提供借鉴。

关键词：成熟油梨激素抗根腐病砧木伸长生根驯化