检索结果-南通市图书馆

CEPC Technical Design Report

在线全文

学校读者我要写书评

暂无评论

Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya subash Chandra Behera Alexander Belyaev Michele Bertucci xiao-Jun Bi yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai yuchen Cai haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen xiang Chen xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen yukai Chen Zelin Chen Zilin Chen gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

Identification of antimalarial targets of chloroquine by a combined deconvolution strategy of ABPP and MS-CETSA

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Military Medical Research 2023年第1期10卷 64-77页

作者： Peng Gao Yan-Qing liu Wei xiao Fei xia Jia-yun Chen Li-Wei Gu Fan Yang liu-hai Zheng Jun-Zhe zhang Qian zhang Zhi-Jie Li yu-Qing Meng Yong-Ping Zhu Huan tang Qiao-Li Shi Qiu-Yan Guo Ying zhang Cheng-Chao Xu Ling-yun Dai Ji-gang Wang Artemisinin Research Center Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China Department of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515China Department of Geriatrics the Second Clinical Medical College of Jinan Universitythe First Affiliated Hospital of Southern University of Science and TechnologyShenzhen People’s HospitalShenzhen 518020GuangdongChina Institute of Molecular and Cell Biology Agency for ScienceTechnology and Research(A*STAR)Singapore 138673Singapore Department of Biological Sciences National University of SingaporeSinga‑pore 117543Singapore

Background: Malaria is a devastating infectious disease that disproportionally threatens hundreds of millions of people in developing countries. In the history of anti-malaria campaign, chloroquine(CQ) has played an indispensable role, however, its mechanism of action(MoA) is not fully ***: We used the principle of photo-affinity labeling and click chemistry-based functionalization in the design of a CQ probe and developed a combined deconvolution strategy of activity-based protein profiling(ABPP) and mass spectrometry-coupled cellular thermal shift assay(MS-CETSA) that identified the protein targets of CQ in an unbiased manner in this study. The interactions between CQ and these identified potential protein hits were confirmed by biophysical and enzymatic ***: We developed a novel clickable, photo-affinity chloroquine analog probe(CQP) which retains the antimalarial activity in the nanomole range, and identified a total of 40 proteins that specifically interacted and photocrosslinked with CQP which was inhibited in the presence of excess CQ. Using MS-CETSA, we identified 83 candidate interacting proteins out of a total of 3375 measured parasite proteins. At the same time, we identified 8 proteins as the most potential hits which were commonly identified by both ***: We found that CQ could disrupt glycolysis and energy metabolism of malarial parasites through direct binding with some of the key enzymes, a new mechanism that is different from its well-known inhibitory effect of hemozoin formation. This is the first report of identifying CQ antimalarial targets by a parallel usage of labeled(ABPP)and label-free(MS-CETSA) methods.

关键词： Chloroquine Antimalaria Activity-based protein profiling(ABPP) Cellular thermal shift assay(CETSA) Quantitative proteomics

在线全文

学校读者我要写书评

暂无评论

深海系泊系统动力特性研究进展

海洋工程 2008年第1期26卷 120-126页

作者：唐友刚张素侠张若瑜刘海笑天津大学建筑工程学院天津300072

系泊系统设计是深海平台开发的关键问题之一。由于深海环境载荷和系泊材料物理特性及系缆构型影响,系泊系统分析涉及流固耦合非线性、非线性流体动力及整个系泊系统的运动稳定性。总结深海系泊系统关键理论和技术研究的前沿问题,包括系... 详细信息

系泊系统设计是深海平台开发的关键问题之一。由于深海环境载荷和系泊材料物理特性及系缆构型影响,系泊系统分析涉及流固耦合非线性、非线性流体动力及整个系泊系统的运动稳定性。总结深海系泊系统关键理论和技术研究的前沿问题,包括系泊系统系缆建模、系泊系统耦合动力分析的理论和方法等,重点分析系泊系统非线性动力学问题的研究进展,并且提出了深海系泊系统需要深入研究的若干动力学问题。

关键词：深海系泊深海平台动力响应运动稳定性

The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST)

在线全文

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2012年第9期12卷 1197-1242页

作者： xiang-Qun Cui Yong-Heng Zhao Yao-Quan Chu Guo-Ping Li Qi Li Li-Ping zhang Hong-Jun su Zheng-Qiu Yao Ya-Nan Wang xiao-Zheng Xing Xin-Nan Li Yong-Tian Zhu gang Wang Bo-Zhong Gu A-Li Luo Xin-Qi Xu Zhen-Chao zhang Gen-Rong liu Hao-Tong zhang De-Hua Yang Shu-yun Cao hai-yuan Chen Jian-Jun Chen Kun-Xin Chen Ying Chen Jia-Ru Chu Lei Feng Xue-Fei Gong Yong-Hui Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Lei Jia Fang-Hua Jiang xiang Jiang Zi-Bo Jiang Ge Jin Ai-Hua Li Yan Li Ye-Ping Li Guan-Qunliu Zhi-gang liu Huo-Ming Shi Zheng-Hong tang Qing-Sheng Tao xiang-Yan yuan Chao Zhai Jing zhang Yan-xia zhang Yong zhang Ming Zhao Fang Zhou Guo-Hua Zhou Jie Zhu Si-Cheng Zou National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China yzhao @ *** Nanjing Institute of Astronomical Optics and Technology National Astronomical ObservatoriesChinese Academy of Sciences Nanjing 210042 China University of Science and Tecfinologyof China Hefei 230026 China Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China Institute of Architecture Design and Research Chinese Academy of Sciences Beijing 100190China

The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST, also called the Guo Shou Jing Telescope) is a special reflecting Schmidt telescope. LAMOST’s special design allows both a large aperture (effective aperture of 3.6 m–4.9 m) and a wide field of view (FOV) (5°). It has an innovative active reflecting Schmidt configuration which continuously changes the mirror’s surface that adjusts during the observation process and combines thin deformable mirror active optics with segmented active optics. Its primary mirror (6.67m×6.05 m) and active Schmidt mirror (5.74m×4.40 m) are both segmented, and composed of 37 and 24 hexagonal sub-mirrors respectively. By using a parallel controllable fiber positioning technique, the focal surface of 1.75 m in diameter can accommodate 4000 optical fibers. Also, LAMOST has 16 spectrographs with 32 CCD cameras. LAMOST will be the telescope with the highest rate of spectral acquisition. As a national large scientific project, the LAMOST project was formally proposed in 1996, and approved by the Chinese government in 1997. The construction started in 2001, was completed in 2008 and passed the official acceptance in June 2009. The LAMOST pilot survey was started in October 2011 and the spectroscopic survey will launch in September 2012. Up to now, LAMOST has released more than 480 000 spectra of objects. LAMOST will make an important contribution to the study of the large-scale structure of the Universe, structure and evolution of the Galaxy, and cross-identification of multiwaveband properties in celestial objects.

关键词： techniques: wide field telescope - active optics - multi fiber - spectroscopy survey - data reduction

The first data release(DR1) of the LAMOST regular survey

在线全文

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-Li Luo Yong-Heng Zhao gang Zhao Li-Cai Deng xiao-Wei liu Yi-Peng Jing gang Wang Hao-Tong zhang Jian-Rong Shi xiang-Qun Cui Yao-Quan Chu Guo-Ping Li Zhong-Rui Bai yue Wu Yan Cai Shu-yun Cao Zi-Huang Cao Jeffrey L.Carlin hai-yuan Chen Jian-Jun Chen Kun-Xin Chen Li Chen Xue-Lei Chen xiao-Yan Chen Ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui Yi-Qiao Dong Bing Du Dong-Wei Fan Lei Feng Jian-Ning Fu Peng Gao Xue-Fei Gong Bo-Zhong Gu Yan-Xin Guo Zhan-Wen Han Bo-Liang He Jin-Liang Hou Yong-Hui Hou Wen Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Zhi-Ying Huo Lei Jia Fang-Hua Jiang xiang Jiang Zhi-Bo Jiang Ge Jin xiao Kong Xu Kong Ya-Juan Lei Ai-Hua Li Chang-Hua Li Guang-Wei Li hai-Ning Li Jian Li Qi Li Shuang Li Sha-Sha Li Xin-Nan Li Yan Li Yin-Bi Li Ye-Ping Li yuan Liang Chien-Cheng Lin Chao liu Gen-Rong liu Guan-Qun liu Zhi-gang liu Wen-Zhi Lu yu Luo Yin-Dun Mao Heidi Newberg Ji-Jun Ni Zhao-xiang Qi Yong-Jun Qi Shi-Yin Shen Huo-Ming Shi Jing Song Yi-Han Song Ding-Qiang su Hong-Jun su Zheng-Hong tang Qing-Sheng Tao yuan Tian Dan Wang Da-Qi Wang Feng-Fei Wang Guo-Min Wang hai Wang Hong-Chi Wang Jian Wang Jia-Ning Wang Jian-Ling Wang Jian-Ping Wang Jun-xian Wang Lei Wang Meng-Xin Wang Shou-Guan Wang Shu-Qing Wang xia Wang Ya-Nan Wang you Wang yue-Fei Wang you-Fen Wang Peng Wei Ming-Zhi Wei Hong Wu Ke-Fei Wu Xue-Bing Wu yu-Zhong Wu xiao-Zheng Xing Ling-Zhe Xu Xin-Qi Xu Yan Xu Tai-Sheng Yan De-Hua Yang hai-Feng Yang Hui-Qin Yang Ming Yang Zheng-Qiu Yao Yong yu Hui yuan hai-Bo yuan hai-Long yuan Wei-Min yuan Chao Zhai En-Peng zhang Hua-Wei zhang Jian-Nan zhang Li-Pin zhang Wei zhang Yong zhang Yan-xia zhang Zheng-Chao zhang Ming Zhao Fang Zhou Xu Zhou Jie Zhu Yong-Tian Zhu Si-Cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

在线全文

学校读者我要写书评

暂无评论

遗传性耳聋基因治疗临床指南

实用医院临床杂志 2024年第2期21卷 39-44页

作者：齐洁玉谈方志张李燕陆玲王洪阳李文妍刘闻闻付小龙贺祖宏丁小琼孙珊方巧军董耀东朱学伟童步升曹现宝郭敏范欣淼汪芹马璐张天虹于亚峰李永新樊建刚崔勇吴佩娜张宏征唐杰郭维维查定军叶放蕾何双八曹卫杨见明钱晓云赵宇孙敬武陈晓巍孙宇夏明王秋菊袁慧军冯永孔维佳杨仕明王海波高下李华伟徐磊柴人杰东南大学数字医学工程全国重点实验室附属中大医院耳鼻咽喉头颈外科生命科学与技术学院生命与健康高等研究院江苏省生物医学高新技术研究重点实验室江苏南京210096 南通大学神经再生联合创新中心江苏南通226001 北京理工大学航天中心医院神经内科生命学院北京10081 南京大学医学院附属鼓楼医院耳鼻喉头颈外科江苏省医学重点学科(实验室)江苏南京210008 中国人民解放军总医院耳鼻咽喉头颈外科医学部北京100853 听觉与平衡觉全国重点实验室北京100853 国家耳鼻咽喉疾病临床医学研究中心北京100853 聋病教育部重点实验室北京100853 聋病防治北京市重点实验室北京100853 复旦大学附属眼耳鼻喉科医院医学神经生物学国家重点实验室教育部脑科学前沿研究中心上海200031 复旦大学生物医学研究所上海200032 国家卫健委听觉医学重点实验室上海200031 复旦大学脑科学研究院和脑科学协同创新中心上海200032 山东大学山东省耳鼻喉医院耳鼻咽喉头颈外科山东济南250022 山东省耳鼻喉研究所山东济南250022 山东第一医科大学/山东省医学科学院医学科技创新中心山东济南250000 武汉大学中南医院耳鼻咽喉头颈外科湖北武汉430071 东南大学附属中大医院耳鼻咽喉头颈外科江苏南京210009 复旦大学附属眼耳鼻喉科医院耳鼻喉科上海200032 安徽医科大学第二附属医院耳鼻咽喉头颈外科安徽合肥230601 中国医科大学附属盛京医院耳鼻咽喉头颈外科辽宁沈阳110004 吉林大学中日联谊医院耳鼻咽喉头颈外科吉林长春130033 安徽医科大学第一附属医院耳鼻咽喉头颈外科安徽合肥230022 云南省第一人民医院耳鼻喉科云南昆明650032 昆明医科大学第一附属医院耳鼻喉科云南昆明650032 中国医学科学院北京协和医学院北京协和医院耳鼻咽喉科北京100730 中南大学湘雅二医院耳鼻咽喉头颈外科湖南长沙410008 南华大学衡阳医学院基础医学院细胞生物学与遗传学教研室细胞应激生物学衡阳市重点实验室湖南衡阳421001 哈尔滨医科大学附属第一医院黑龙江哈尔滨150001 苏州大学附属第一医院耳鼻咽喉科江苏苏州215006 首都医科大学附属北京同仁医院耳鼻咽喉头颈外科北京100730 四川省医学科学院·四川省人民医院/电子科技大学附属医院耳鼻咽喉头颈外科四川成都610072 广东省人民医院耳鼻咽喉头颈外科/广东省医学科学院/南方医科大学广东广州510080 南方医科大学珠江医院耳鼻咽喉头颈外科广东广州510282 空军军医大学西京医院耳鼻咽喉-头颈外科陕西西安710032 郑州大学第一附属医院耳科河南郑州450000 东南大学医学院附属南京同仁医院耳鼻咽喉头颈外科江苏南京211102 四川大学华西医院耳鼻咽喉头颈外科四川成都610041 中国科学技术大学附属第一医院耳鼻咽喉头颈外科安徽合肥230001 华中科技大学同济医学院附属协和医院耳鼻咽喉头颈外科湖北武汉430022 山东第一医科大学附属山东省立医院耳鼻咽喉科山东济南250021 山东省医学科学院医学科技创新中心山东济南250021 山东大学附属山东省立医院耳鼻咽喉科山东济南250021 国家卫生健康委耳鼻咽喉重点实验室山东济南250021 四川大学华西医院罕见病研究院四川成都6010041 南华大学衡阳医学院南华大学附属妇幼保健院湖南长沙410008 中南大学湘雅医院耳鼻咽喉头颈外科湖南长沙410008 上海人工耳蜗工程技术研究中心上海200031 东南大学深圳研究院广东深圳518063

遗传性耳聋是一种常见的遗传性疾病,新生儿的发病率为1‰~3‰。患者终身携带致病突变,导致不可逆性耳聋,至今尚无临床可用的治疗药物。在部分遗传性耳聋动物模型中,基因治疗已被证实为潜在有效的治疗方法。国内外已开展了多项遗传性耳... 详细信息

遗传性耳聋是一种常见的遗传性疾病,新生儿的发病率为1‰~3‰。患者终身携带致病突变,导致不可逆性耳聋,至今尚无临床可用的治疗药物。在部分遗传性耳聋动物模型中,基因治疗已被证实为潜在有效的治疗方法。国内外已开展了多项遗传性耳聋基因治疗的临床试验。其中,由东南大学附属中大医院牵头,联合国内多家医院成功开展的遗传性耳聋基因治疗临床试验,取得了显著的疗效,并积累了丰富的经验。为规范遗传性耳聋基因治疗并提供临床研究指导,全国多家医院的耳科专家讨论制定了遗传性耳聋基因治疗临床指南,内容涵盖了伦理审查、遗传性耳聋的诊断和入组标准、临床前准备、药物、疗效与安全性评估标准、术后言语康复等。本指南将为耳聋基因治疗的临床诊疗提供规范的理论和技术指导。

关键词：遗传性耳聋基因治疗临床指南

Prenatal Exposure to Inflammation Induced by Zymosan Results in Activation of Intrarenal Renin-Angiotensin System in Adult Offspring Rats

在线全文

学校读者我要写书评

暂无评论

Prenatal Exposure to Inflammation Induced by Zymosan Results...

Efficacy and safety of sirolimus early conversion protocol in liver transplant patients with hepatocellular carcinoma:A single-arm, multicenter, prospective study

第十届全国心血管药理学术会议暨2010（重庆）国际心血管疾病与药物高峰论坛

作者： Xue-Qin Hao,hai-gang zhang,Shu-Hui Li,Yi Jia,Ya liu,Jian-Zhi Zhou, Yan-Ling Wei,Li-yun Hao,yuan tang,Min su,and xiao-Hui Li (Institute of Materia Medica,College of Pharmacy,Third Military Medical University,Chongqing 400038,China)

Prenatal exposure to inflammation produces offspring that are hypertensive in *** present study was to explore the role of intrarenal renin-angiotensin(Ang) system in the development of hypertension programmed by prenatal exposure to *** rats were randomly divided into control group and zymosan group(n=6).Rats in these two groups were administered intraperitoneally with 0.5 ml vehicle and 2.37 mg/kg zymosan,respectively,on the eighth,tenth,and 12th day during gestation. The results showed the glomerular number and creatinine clearance rate decreased significantly in offspring of zymosan-treated *** renal cortex renin mRNA expression,AngⅡ-positive cells in renal cortex,and AngⅡexpression in renal medulla increased significantly in offspring of zymosan-treated rats at 7,16,and 25 weeks of *** plasma renin activity and AngⅡconcentration were *** conclusion, prenatal exposure to zymosan resulted in the activation of intrarenal renin-Ang system in adult offspring rats.Prenatal exposure to inflammation produces offspring that are hypertensive in *** present study was to explore the role of intrarenal renin-angiotensin(Ang) system in the development of hypertension programmed by prenatal exposure to *** rats were randomly divided into control group and zymosan group(n=6).Rats in these two groups were administered intraperitoneally with 0.5 ml vehicle and 2.37 mg/kg zymosan,respectively,on the eighth,tenth,and 12th day during gestation. The results showed the glomerular number and creatinine clearance rate decreased significantly in offspring of zymosan-treated *** renal cortex renin mRNA expression,AngⅡ-positive cells in renal cortex,and AngⅡexpression in renal medulla increased significantly in offspring of zymosan-treated rats at 7,16,and 25 weeks of *** plasma renin activity and AngⅡconcentration were *** conclusion, prenatal exposure to zymosan resulted in the activation of intrarenal

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 106-112页

作者： Ren-Yi su sun-Bin Ling Qiao-Nan Shan Xu-Yong Wei Rui Wang Chang-Ku Jia Li Zhuang Tian Shen Li-Min Ding Zhi-Dan Xu Lai-Bang Luo Li-Bo sun Guang-Ming Li Tai-Shi Fang Nan Jiang Kun zhang Zhao-Jie su Zhi-hai Peng Ren Lang Tao Jiang Qiang He Lin-Sen Ye Yang Yang yu-Ting He Wen-Zhi Guo liu-Gen Lan Xu-Yong sun Dong Chen Zhi-Shui Chen Da-Wei Zhou Shao-Jun Ye Qi-Fa Ye Min Tian Jian-Hua Shi Bo Wang Jiang liu Qian Lu Wei Rao Jin-Zhen Cai Tao Lv Jia-Yin Yang Pu-Sen Wang Lin Zhong Jing-Sheng Ma Qi-Gen Li Sheng-Dong Wu Chang-Jiang Lu Cai-De Lu Dong-Hua zhang Xuan Wang Zi-Qiang Li Mu-Jian Teng Jun-Jie Li Wen-Tao Jiang Jian-Hua Li Quan-Bao zhang Ning-Qi Zhu Zheng-Xin Wang Kang He Qiang xia Shao-Hua Song Zhi-Ren Fu Wei Qiu Guo-yue Lv Rui-Peng Song Ji-Zhou Wang Zheng Wang Jian Zhou gang Chen Ying-Peng Zhao Li Li Ze-Min Hu Qi-Jie Luo Zhong-Zhou Si Bin Xie xiao-Shun He Zhi-Yong Guo Shu-Sen Zheng xiao Xu Department of Hepatobiliary and Pancreatic surgery The Center for Integrated Oncology and Precision MedicineAffiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Department of Hepatobiliary and Pancreatic surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Department of Hepatobiliary and Pancreatic surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Transplantation Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang 330006China Liver Transplantation Center Beijing You’an HospitalCapital Medical UniversityBeijing 100069China Department of Hepatic surgery National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyShenzhen 518112China Department of General surgery Xiang’an Hospital of Xiamen UniversityXiamen 361000China Deartment of Hepatobiliary and Pancreaticosplenic surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Hepatic surgery and Liver Transplantation Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Hepatobiliary and Pancreatic surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Liver Transplantation The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530000China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Hepatobiliary Diseases of Wuhan University Transplant Center of Wuhan UniversityHubei Key Laboratory of Medical Technology on TransplantationZhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Hepatobiliary surgery The First Affiliated Hos

Mammalian target of rapamycin(m TOR) inhibitor as an attractive drug target with promising antitumor effects has been widely investigated. High quality clinical trial has been conducted in liver transplant(LT) recipients in Western countries. However, the pertinent studies in Eastern world are paucity. Therefore, we designed a clinical trial to test whether sirolimus can improve recurrence-free survival(RFS) in hepatocellular carcinoma(HCC) patients beyond the Milan criteria after LT. This is an open-labeled, single-arm, prospective, multicenter, and real-world study aiming to evaluate the clinical outcomes of early switch to sirolimus-based regimens in HCC patients after LT. Patients with a histologically proven HCC and beyond the Milan criteria will be enrolled. The initial immunosuppressant regimens are center-specifc for the frst 4-6 weeks. The following regimens integrated sirolimus into the regimens as a combination therapy with reduced calcineurin inhibitors based on the condition of patients and centers. The study is planned for 4 years in total with a 2-year enrollment period and a 2-year follow-up. We predict that sirolimus conversion regimen will provide survival benefts for patients particular in the key indicator RFS as well as better quality of life. If the trial is conducted successfully, we will have a continued monitoring over a longer follow-up time to estimate indicator of overall survival. We hope that the outcome will provide better evidence for clinical decision-making and revising treatment guidelines based on Chinese population data.

关键词： Sirolimus Immunosuppressive agents Hepatocellular carcinoma Liver transplantation Conversion

在线全文

学校读者我要写书评

暂无评论

新型毒品成瘾者在不同情境下的决策特点

中国临床心理学杂志 2017年第4期25卷 626-629,634页

作者：张峰殷海博苏贵生史庆国贾志刚王立勋杜妍刘宁夏嫣雨郭笑张卓杨波中国政法大学刑事司法学院北京100088 中国政法大学社会学院北京100088 长治大辛庄强制隔离戒毒所长治046000

目的:探讨甲卡西酮成瘾者和冰毒成瘾者的决策特点。方法:从某强制隔离戒毒所筛选出甲卡西酮成瘾者45人,冰毒成瘾者41人,从某大学后勤工作人员中招募对照组被试33人,分别使用冲动性量表(BIS-11)、杯子任务研究被试的冲动性水平和决策特... 详细信息

目的:探讨甲卡西酮成瘾者和冰毒成瘾者的决策特点。方法:从某强制隔离戒毒所筛选出甲卡西酮成瘾者45人,冰毒成瘾者41人,从某大学后勤工作人员中招募对照组被试33人,分别使用冲动性量表(BIS-11)、杯子任务研究被试的冲动性水平和决策特点。结果:冰毒成瘾组的冲动性显著高于对照组和甲卡西酮成瘾组;在收益情境下,甲卡西酮成瘾组和冰毒成瘾组选择风险选项的比例显著高于对照组,甲卡西酮成瘾组和对照组比冰毒成瘾组选择更多的适应性选项;在损失情境下,三组被试选择风险选项和适应性选项的比例不存在显著差异。结论:在收益情境下,成瘾组比对照表现出更明显的风险决策偏好,只有冰毒成瘾组表现出非适应性决策。

关键词：甲卡西酮成瘾冰毒成瘾风险决策适应性决策