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Behavioral and Neurogenomic Responses to Acoustic and Visual Sexual Cues are Correlated in Female Torrent Frogs

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Asian Herpetological Research 2021年第1期12卷 88-99页

作者： Longhui ZHAO Jichao WANG yanlin CAI Jianghong RAN Steven E.BRAUTH Yezhong tang Jianguo CUI Chengdu Institute of Biology Chinese Academy of SciencesChengdu 610041SichuanChina Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education College of Life SciencesSichuan UniversityChengdu 610041SichuanChina University of the Chinese Academy of Sciences Beijing 100049China Key Laboratory for Tropical Plant and Animal Ecology of Ministry of Education College of Life SciencesHainan NormalUniversityHaikou 571158HainanChina Department of Psychology University of MarylandCollege ParkMaryland 27042USA

Diverse a nimal species use multimodal communica tion signals to coordina te reproductive *** active research in this field,the brain mechanisms underlying multimodal communication remain poorly *** to humans and many mammalian species,anurans often produce auditory signals accompanied by conspicuous visual cues(e.g.,vocal sac inflation).In this study,we used video playbacks to determine the role of vocal-sac inflation in little torrent frogs(Amolops torrentis).Then we exposed females to blank,visual,auditory,and audiovisual stimuli and analyzed whole brain tissue gene expression changes using *** results showed that both auditory cues(i.e.,male advertisement calls)and visual cues were attractive to female frogs,although auditory cues were more attractive than visual *** preferred simultaneous bimodal cues to unimodal *** hierarchical clustering of differentially expressed genes showed a close relationship between neurogenomic states and momentarily expressed sexual *** also found that the Gene Ontology terms and KEGG pathways involved in energy metabolism were mostly increased in blank contrast versus visual,acoustic,or audiovisual stimuli,indicating that brain energy use may play an important role in response to these *** sum,behavioral and neurogenomic responses to acoustic and visual cues are correlated in female little torrent frogs.

关键词： energy metabolism multimodal communication little torrent frogs neurogenomic states sexual traits

单剂小剂量利妥昔单抗降低致敏肾移植等待者HLA抗体的效果及机制

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暨南大学学报（自然科学与医学版） 2022年第5期43卷 493-499页

作者：田凯文程守钰朱平刘艳君刘桂欢林恩宇汤延淋曾加义叶楚津余玉明华南理工大学医学院广东广州511436 广东省人民医院泌尿外科广东广州510080 南方医科大学免疫学教研室广东广州510515

目的:探讨单剂小剂量利妥昔单抗(RTX)对等待肾移植的致敏患者脱敏治疗的效果及机制,观察单剂小剂量RTX作用下致敏患者体内B淋巴细胞的动态变化规律。方法:分析8名等待肾移植的致敏患者使用单剂小剂量(200 mg)RTX脱敏方案治疗前、后的临... 详细信息

目的:探讨单剂小剂量利妥昔单抗(RTX)对等待肾移植的致敏患者脱敏治疗的效果及机制,观察单剂小剂量RTX作用下致敏患者体内B淋巴细胞的动态变化规律。方法:分析8名等待肾移植的致敏患者使用单剂小剂量(200 mg)RTX脱敏方案治疗前、后的临床资料,使用Luminex单抗原珠和流式细胞术对致敏患者抗人类白细胞抗原(HLA)抗体及外周血B淋巴细胞的变化情况进行动态观察。结果:抗HLA抗体在用药后3个月可降至用药前水平的(46.03±13.09)%;致敏患者外周血中B淋巴细胞在RTX治疗后2周内清除,6个月时仍处于较低水平(24.1±17.4)个细胞/μL,B淋巴细胞重建以CD19^(+)CD5^(+)B1细胞和CD19^(+)IgD^(+)CD27^(-)幼稚性B细胞为主。结论:单剂小剂量RTX可降低部分致敏患者抗HLA抗体强度,患者外周血B淋巴细胞重建在用药后6个月仍处于较低水平。

关键词：肾移植致敏患者抗HLA抗体利妥昔单抗 B淋巴细胞

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基于同态加密的物联网军火管理系统

北京电子科技学院学报 2013年第2期21卷 81-85页

作者：刘培鹤孟一诺涂津尘蔡曾毅汤燕临何文才北京电子科技学院通信工程系北京100070

本文就物联网技术的革新,分析世界各主要国家通过物流信息化来应对现代战争对物流提出的挑战,近年来同态加密技术不断发展和突破,它的优势对于物联网而言是得天独厚的。本文就此,分析物联网的发展趋势,分析比较加密算法的特点,最终设计... 详细信息

本文就物联网技术的革新,分析世界各主要国家通过物流信息化来应对现代战争对物流提出的挑战,近年来同态加密技术不断发展和突破,它的优势对于物联网而言是得天独厚的。本文就此,分析物联网的发展趋势,分析比较加密算法的特点,最终设计一种运用同态加密于物联网的军火管理系统的解决方案,考虑其实现可能性,介绍其中算法的简单代码实现。展望其未来在国与国之间的现代化战争中发挥其重要作用。

关键词：军火管理系统同态加密物联网 RSA Elgamal

Changes in wintering Hooded Cranes and their habitats at Chongming Dongtan over the past 20 years

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Avian Research 2023年第1期14卷 119-125页

作者： yanlin Cui Yanan tang Sen Yang Wei Wu Xuesong Feng Qiang Ma Dongliang Niu Jun Ma Zhijun Ma Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering National Observation and Research Station for Wetland Ecosystems of the Yangtze EstuaryFudan UniversityShanghai200438China Management Office of Chongming Dongtan Nature Reserve Chongming202183China

The Hooded Crane(Grus monacha)is listed as a Vulnerable species in the IUCN red *** wetland(tideland),the major habitat for wintering Hooded Cranes at East China’s Chongming Dongtan,has dramatically changed in the past two decades,but there is limited knowledge about the population and habitat changes of the Hooded *** study investigated the population size and distribution of wintering Hooded Cranes at Chongming Dongtan from 2000 to *** used remote sensing images combined with a vegetation classification algorithm to analyse the distribution of saltmarsh *** quadrat method was used to investigate the density and weight of the underground corms of Sea Bulrush(Scirpus mariquter),the main food on tideland for the Hooded *** 2000 to 2021,the population number of wintering Hooded Cranes at Chongming Dongtan remained stable at approximately *** 2000,the area of Scirpus *** Common Reed(Phragmites australis)accounted for approximately half of the total saltmarsh area at Chongming Dongtan,*** invasive Smooth Cordgrass(Spartina alterniflora)rapidly expanded on tideland in the 2000s while the Scirpus *** competed out and thus significantly reduced in *** the implementation of an ecological project to control Smooth Cordgrass and to restore Scirpus *** the 2010s,the area of the Smooth Cordgrass decreased considerably while the area of Scirpus *** corms of Sea Bulrush decreased on the southeastern tideland during the study period,which might be the cause of the northward movement of the foraging Hooded Cranes on *** also found Hooded Cranes foraged crops in the nearby farmland in mid-winter,causing human-bird conflicts in the recent *** results found that changes in habitat and food conditions on tideland impacted wintering Hooded *** in farmland with human disturbance in the recent decade might be related to insufficient food on *** suggest active interventi

关键词： Food Habitat change Salt marsh Scirpus mariquter Tidal flat Wintering ground

Bone targeted nano-drug and nano-delivery

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Bone Research 2024年第3期12卷 517-538页

作者： Yilun Wu Bing Sun Ying tang Aining Shen yanlin Lin Xiaohui Zhao Jingui Li Michael J.Monteiro Wenyi Gu College of Biotechnology and Pharmaceutical Engineering Nanjing Tech UniversityNanjingChina Australian Institute for Bioengineering and Nanotechnology The University of QueenslandSt.LuciaQLDAustralia Science and Technology Innovation Centre Guangzhou University of Chinese MedicineGuangzhouChina Shenzhen Bay Laboratory ShenzhenGuangdongChina GMU-GIBH Joint School of Life Sciences Guangzhou Medical UniversityGuangzhouChina School of Veterinary Medicine Jiangsu Coinnovation Centre for Prevention and Control of Important Animal Infectious Diseases and ZoonosesYangzhou UniversityYangzhouChina

There are currently no targeted delivery systems to satisfactorily treat bone-related *** clinical drugs consisting of small organic molecules have a short circulation half-life and do not effectively reach the diseas... 详细信息

关键词： repeatedly satis targeted

The Preliminary Analysis of the Characteristics of Geomagnetic Harmonic Wave Amplitude Ratios before the Gaoyou-Baoying MS4.9 Earthquake

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Earthquake Research in China 2016年第4期30卷 578-583页

作者： Jiang yanlin Yuan Guiping Li Hongyu tang Tingmei Zhao Weihong Gaoyou Seismic Station of Earthquake Administration of Jiangsu Province Gaoyou 225601JiangsuChina Earthquake Administration of Jiangsu Province Nanjing 210014China Earthquake Administration of Shandong Province Jinan 250014China

In this paper,the Gaoyou-Baoying M_S4.9 earthquake was analyzed by the geomagnetic harmonic wave amplitude ratios method. The earthquake was an isolated seismic event,before and after which there were no other earthquakes occurred in this region. The dense distribution of geomagnetic observataries provided an advantage condition for the analysis of characteristics of the geomagnetic harmonic amplitude ratios. The analysis results verify the former knowledge of anomaly characteristics of the geomagnetic harmonic amplitude ratio,that is,the anomalous characteristics of the earthquake mostly appeared during the decline-turning-recovery rising process. The results also show that the change of the anomalies was asynchronous at the observatories close to the epicenter, namely, the anomalous characteristics were different between the H and the D components,as well as between the long and short periods.

关键词： Geomagnetic Anomaly Harmonic wave Gaoyou-Baoying Ms4.9 earthquake

Synthesis and luminescence properties of bluish-green emitting K2MgSi3O8:Eu^2+ phosphor

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Journal of Rare Earths 2016年第1期34卷 17-20页

作者：唐惠东杨蓉黄彦林 Institute of Chemistry and Materials Engineering Changzhou Vocational Institute of Engineering Changzhou 213164 China College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou 215123 China

Eu2＋doped K2MgSi3O8 phosphors were synthesized by conventional solid-state reaction method. The phase formation of as-prepared samples was characterized by X-ray powder diffraction. The luminescence properties were investigated by the photolu- minescence excitation and emission spectra, decay curve and CIE coordinates. The phosphor showed bluish-green emission centered at 460 nm under the excitation of UV and near UV light with the wavelength range of 25（L430 nm. Two Eu〉 emission centers existed in the K2MgSi3O8：EU2＋ phosphor according to the luminescence spectra and the decay curves. The critical quenching concentration ofEu〉 doping was determined to be 3.0 mol.% and the concentration quenching mechanism was dipole-dipole interactions between Eu2＋ ions. These results suggested that K2MgSi3O8：Eu2＋ was a potential bluish-green phosphor candidate for white UV-LED.

关键词： K2MgSi3O8 phosphors luminescence white UV-LED rare earths

Mutational escape prevention by combination of four neutralizing antibodies that target RBD conserved regions and stem helix

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Virologica Sinica 2022年第6期37卷 860-873页

作者： Haoneng tang Yong Ke Yunji Liao yanlin Bian Yunsheng Yuan Ziqi Wang Li Yang Hang Ma Tao Sun Baohong Zhang Xiaoju Zhang Mingyuan Wu Jianwei Zhu Engineering Research Center of Cell and Therapeutic Antibody Ministry of EducationShanghai200240China School of Pharmacy Shanghai Jiao Tong UniversityShanghai200240China Department of Respiratory and Critical Care Medicine Zhengzhou University People's Hospital/Henan Provincial People's HospitalZhengzhou450003China School of Agriculture and Biology Shanghai Jiao Tong UniversityShanghai200240China Shanghai Municipal Veterinary Key Laboratory Shanghai200240China Jecho Institute Shanghai200240China

New variants of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) appear rapidly every few *** have showed powerful adaptive ability to circumvent the immune system. To further understand SARS-CoV-2’s adaptability so as to seek for strategies to mitigate the emergence of new variants, herein we investigated the viral adaptation in the presence of broadly neutralizing antibodies and their combinations. First, we selected four broadly neutralizing antibodies, including pan-sarbecovirus and pan-betacoronavirus neutralizing antibodies that recognize distinct conserved regions on receptor-binding domain(RBD) or conserved stem-helix region on S2 *** binding competition analysis, we demonstrated that they were capable of simultaneously ***, a replication-competent vesicular stomatitis virus pseudotyped with SARS-CoV-2 spike protein was employed to study the viral adaptation. Twenty consecutive passages of the virus under the selective pressure of individual antibodies or their combinations were performed. It was found that it was not hard for the virus to adapt to broadly neutralizing antibodies, even for pan-sarbecovirus and pan-betacoronavirus antibodies. The virus was more and more difficult to escape the combinations of two/three/four antibodies. In addition, mutations in the viral population revealed by high-throughput sequencing showed that under the selective pressure of three/four combinational antibodies, viral mutations were not prone to present in the highly conserved region across betacoronaviruses(stem-helix region), while this was not true under the selective pressure of single/two ***, combining neutralizing antibodies targeting RBD conserved regions and stem helix synergistically prevented the emergence of escape mutations. These studies will guide future vaccine and therapeutic development efforts and provide a rationale for the design of RBD-stem helix tandem vaccine, which may help to impede

关键词： SARS-CoV-2 Adaptation Spike protein Stem helix Broadly neutralizing antibody

Acute Effects of Exposure to Fine Particulate Matter and Its Constituents on Sex Hormone Among Postmenopausal Women — Beijing, Tianjin, and Hebei PLADs, China, 2018–2019

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China CDC weekly 2024年第13期6卷 249-253,I0001-I0004页

作者： yanlin Tian Jiaonan Wang Jianlong Fang Chen Chen Feng Zhao Yi Zhang Peng Du Yawei Li Wanying Shi Yuanyuan Liu Enmin Ding Song tang Xu Yue Xiaoming Shi Chinese Research Academy of Environmental Sciences BeijingChina Collaborative Innovation Center of Atmospheric Environment and Equipment Technology Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control(AEMPC)Nanjing University of Information Science&TechnologyNanjing CityJiangsu ProvinceChina China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijingChina Department of Epidemiology and Health Statistics School of Public HealthCapital Medical Universityand Beijing Municipal Key Laboratory of Clinical EpidemiologyBeijingChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijingChina

What is already known on this topic?Exposure to fine particulate matter(PM_(2.5))was linked to endocrine hormone disruption in the reproductive ***,it was unclear which specific components of PM_(2.5) were primarily responsible for these *** is added by this report?The study presented the initial epidemiological evidence that brief exposure to PM_(2.5) can elevate estradiol levels in postmenopausal *** particle components had unique effects,with watersoluble ions and specific inorganic elements like Ag,As,Cd,Hg,Ni,Sb,Se,Sn,and Tl potentially playing significant roles in increasing estradiol *** are the implications for public health practice?The study established that the prevalence of air pollution,along with its specific components,has been recognized as a novel risk factor affecting the balance of sex hormones.

关键词： pollution Particulate primarily