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Dexamethasone implant for refractory macular edema secondary to diabetic retinopathy and retinal vein occlusion

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1837-1842页

作者： Yuan-Yuan Zhong Chong tang Lan-Yue Zhang xue-Dong Zhang Shu-lin Liu The First Affiliated Hospital of Chongqing Medical University Chongqing Key Laboratory for the Prevention and Treatment of Major Blinding Eye DiseasesChongqing 400016China

AIM:To evaluate the efficacy,timing of retreatment and safety of dexamethasone(DEX)implant on macular edema(ME)secondary to diabetic retinopathy(DME)and retinal vein occlusion(RVO-ME)patients who were refractory to anti-vascular endothelial growth factor(VEGF)***:This retrospective study included 37 eyes received at least one DEX implant treatment for DME or RVO-ME between January 1,2019,and January 1,*** refractory DME and RVO-ME cases received at least 5 anti-VEGF injections and failure to gain more than 5 letters or a significant reduction in central retinal thickness(CRT).The best corrected visual acuity(BCVA)and CRT were measured at baseline,and at 1,3,4 and 6mo post-DEX implant *** events such as elevated intraocular pressure(IOP)and cataract were ***:For RVO cases(n=22),there was a significant increase in BCVA from 0.27±0.19 to 0.35±0.20 at 6mo post-DEX injection(P<0.05)and CRT decreased from 472.1±90.6 to 240.5±39.0μm at 6mo(P<0.0001).DME cases(n=15)experienced an improvement in BCVA from 0.26±0.15 to 0.43±0.20 at 6mo post-DEX implant injection(P=0.0098),with CRT reducing from 445.7±55.7 to 271.7±34.1μm at 6mo(P<0.0001).Elevated IOP occurred in 45.9% of patients but was well-controlled with topical *** cases of cataract or other adverse events were ***:DEX implants effectively improve BCVA and reduce CRT in refractory DME and *** research with larger cohorts and longer follow-up periods is needed to confirm these findings and assess long-term outcomes.

关键词： macular edema dexamethasone implant anti-vascular endothelial growth factor retinal vein occlusion diabetic retinopathy

Deformation analysis of transversely isotropic coal-rock mass with porous and cracks

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International Journal of Mining Science and Technology 2012年第6期22卷 814-820页

作者： xue Dongjie Zhou Hongwei Kong lin tang Xianli Zhao Tian Yi Haiyang Zhao Yufeng School of Mechanics Architecture and Civil EngineeringChina University of Mining & Technology

Coal-rock as a typical sedimentary rock has obvious stratification,namely it has transversely isotropic ***,deformation leads to coal-rock mass having the characteristics of different porous and crack structures as well as local *** axial and circumferential strain' formulas of the pure coal-rock mass specimen with a single crack were derived through the establishment of equivalent mechanical model of standard cylindrical coal-rock specimen,and have been widely used to a variety of media combined different structures containing multiple *** complete stress strain curve of a real coal-rock specimen was obtained by the CTC ***,according to the comparison with the theoretical value,the theoretical mechanical model could well explain the deformation characteristics of coal-rock mass and verify its ***,following features were analyzed:strain normalized coefficient and elastic modulus(Poisson's ratio) in vertical and parallel direction to the stratification,stratification angle,porosity,pore radius,normal and tangential stiffness of crack,and the relationship of different crack width with different tangential stiffness of *** the analysis above,it substantiate this claim that the theoretical model with better reliability reflects the transversely isotropic nature of the coal-rock and the local anisotropy caused by the porous and cracks.

关键词： Coal-rock mass Transversely isotropic Porous and crack Mechanical model

A Numerical Investigation of Vortex-Induced Vibration Response and Fatigue Damage for Flexible Cylinders Under Combined Uniform and Oscillatory Flow

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China Ocean Engineering 2020年第4期34卷 488-499页

作者： YUAN Yu-chao xue Hong-xiang tang Wen-yong State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Vortex-induced vibration(VIV)for flexible cylinders under combined uniform and oscillatory flow is a challenging and practical issue in ocean *** this paper,a time domain numerical model is adopted to investigate the characteristics of cross-flow VIV response and fatigue damage under different combined flow ***,the adopted VIV model and fatigue analysis procedure are validated well against the published experimental results of a4-m cylinder model under pure oscillatory ***,forty-five combined flow cases of the same cylinder model are designed to reveal the VIV response characteristics with different non-dimensional oscillation period T^*and combined ratio *** combined flow cases are classified into three categories to investigate the effect of r on cylinder’s dynamic response,and the effect of T*is described under long and short period ***,fatigue analysis is carried out to investigate how the structural fatigue damage varies with the variations of r and T^*.The captured characteristics of structural response and fatigue damage are explained through the VIV mechanism analysis.

关键词： vortex-induced vibration fatigue damage flexible cylinders combined flow

The potential mechanism and clinical application value of remote ischemic conditioning in stroke

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Neural Regeneration Research 2025年第6期20卷 1613-1627页

作者： Yajun Zhu Xiaoguo Li Xingwei Lei Liuyang tang Daochen Wen Bo Zeng Xiaofeng Zhang Zichao Huang Zongduo Guo The First Affiliated Hospital of Chongqing Medical University ChongqingChina

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved.

关键词： Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke neuroinflammation neuroprotection Notch1 PI3K remote ischemic conditioning stroke

Long-tailed object detection of kitchen waste with class-instance balanced detector

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Science China(Technological Sciences) 2023年第8期66卷 2361-2372页

作者： FANG LeYuan tang Qi OUYANG LiHan YU JunWu lin JiaXing DING ShuaiYu tang lin College of Electrical and Information Engineering Hunan UniversityChangsha 410082China College of Environmental Science and Engineering Hunan UniversityChangsha 410082China

Intelligent detection and classification of kitchen waste can promote ecological sustainability by replacing inefficient manual ***,the presence of non-degradable waste mixed in kitchen waste often follows a long-tailed distribution,making it challenging to train convolutional neural network-based object detectors,which results in the unsatisfactory detection of tailclass *** address this challenge,we propose a class-instance balanced detector(CIB-Det) for intelligent detection and classification of kitchen ***-Det implements two strategies for the loss function:the class-balanced strategy(CBS)and the instance-balanced strategy(IBS).The CBS focuses more on tail classes,and the IBS concentrates on hard-to-classify instances adaptively during ***,CIB-Det comprehensively and adaptively addresses the long-tailed *** experiments on a real dataset of kitchen waste images support the effectiveness of CIB-Det for kitchen waste detection.

关键词： kitchen waste detection and classification object detection long-tailed distribution convolutional neural networks

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Using deep learning to detect small targets in infrared oversampling images

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Journal of Systems Engineering and Electronics 2018年第5期29卷 947-952页

作者： lin Liangkui WANG Shaoyou tang Zhongxing Shanghai Institute of Satellite Engineering Shanghai 201109China

According to the oversampling imaging characteristics, an infrared small target detection method based on deep learning is proposed. A 7-layer deep convolutional neural network(CNN) is designed to automatically extract small target features and suppress clutters in an end-to-end manner. The input of CNN is an original oversampling image while the output is a cluttersuppressed feature map. The CNN contains only convolution and non-linear operations, and the resolution of the output feature map is the same as that of the input image. The L1-norm loss function is used, and a mass of training data is generated to train the network effectively. Results show that compared with several baseline methods, the proposed method improves the signal clutter ratio gain and background suppression factor by 3–4 orders of magnitude, and has more powerful target detection performance.

关键词： infrared small target detection oversampling deep learning convolutional neural network(CNN)

Improved catalytic performance of CO_(2) electrochemical reduction reaction towards ethanol on chlorine-modified Cu-based electrocatalyst

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Nano Research 2024年第5期17卷 3761-3768页

作者： Yifan Liu Hehua tang Yitian Zhou Bo-lin lin School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China

Effective electrochemical conversion of CO_(2) to value-added liquid multi-carbon products driven by renewable energy is a promising approach to alleviate excessive CO_(2) emission and achieve large-scale renewable energy ***,the selectivity and catalytic activity towards liquid multi-carbon products of CO_(2) electroreduction reaction are still unsatisfactory due to the sluggish C-C coupling process and the formation of complex oxygen-containing ***,designing and fabricating highly effective electrocatalysts is crucial for practical applications in this ***,we developed Cl-modified Cu catalyst(Cu-Cl)for efficient electrochemical reduction of CO_(2) to *** optimal Faradaic efficiency and partial current density of ethanol on the Cu-Cl sample reached 26.2%and 343.2 mA·cm^(-2) at-0.74 V(*** hydrogen electrode(RHE)),which were 1.66 and 1.76 times higher than those of the catalyst without Cl decoration,outperforming those in most previously reported *** functional theory(DFT)calculations revealed that the Cl-modified Cu surface suppressed the parasitic hydrogen evolution reaction(HER)and reduced the energy barrier for the C-C coupling process,making the formation of key intermediates favorable for ethanol ***,the decoration of Cl on the Cu surface facilitated ethanol formation.

关键词： CO_(2)electrochemical reduction halogen chlorine Cu-based catalysts ethanol multi-carbon products

A Novel CA4P Polymeric Nanoparticle for Murine Hepatoma Therapy

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Chinese Journal of Polymer Science 2023年第8期41卷 1223-1229,I0007页

作者： Zhi-lin Liu Xi-Tong Ren Yue Huang Jia-Li Sun Xiao-Shuang Wang Meng-Fei Zheng lin-Jie Cui xue-Fei Zhang Zhao-Hui tang Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Jilin Biomedical Polymers Engineering Laboratory Changchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China No.1 Department of Neurology China-Japan Union Hospital of Jilin UniversityChangchun 130033China Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education and Key Laboratory of Polymeric Materials&Application Technology of Hunan Province College of ChemistryXiangtan UniversityXiangtan 411105China

Combretastatin A4 phosphate(CA4P)is a potent vascular disrupting agent with good water ***,it is only effective at high doses,which decreases clinical ***,we designed stable CA4P polymeric nanoparticles(CA4P NPs)consisting of various cholesterol derivatives,and with a drug loading efficacy of 93%.The nanoparticles released CA4P in a sustained manner and achieved a 72%inhibition rate in the murine H22 liver tumor model,which was about 2.9-fold higher than that of free CA4P(24.6%).Furthermore,the carrier components of CA4P NPs were metabolized to arginine,cholesterol,ethanol and poly(ethylene glycol)in vivo;therefore,the CA4P NPs are safe and have significant potential for clinical translation.

关键词： CA4P polymeric nanoparticle Cholesterol derivatives Vascular disrupting agent Phosphate-guanidine coordination Drug controlled release

Relationships between Terrain Features and Forecasting Errors of Surface Wind Speeds in a Mesoscale Numerical Weather Prediction Model

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Advances in Atmospheric Sciences 2024年第6期41卷 1161-1170页

作者： Wenbo xue Hui YU Shengming tang Wei HUANG Chinese Academy of Meteorological Sciences Beijing 100081China University of Chinese Academy of Sciences Beijing 101408China Shanghai Typhoon Institute/CMA Shanghai 200030China Key Laboratory of Numerical Modeling for Tropical Cyclone/CMA Shanghai 200030China

Numerical weather prediction(NWP)models have always presented large forecasting errors of surface wind speeds over regions with complex *** this study,surface wind forecasts from an operational NWP model,the SMS-WARR(Shanghai Meteorological Service-WRF ADAS Rapid Refresh System),are analyzed to quantitatively reveal the relationships between the forecasted surface wind speed errors and terrain features,with the intent of providing clues to better apply the NWP model to complex terrain *** terrain features are described by three parameters:the standard deviation of the model grid-scale orography,terrain height error of the model,and slope *** results show that the forecast bias has a unimodal distribution with a change in the standard deviation of *** minimum ME(the mean value of bias)is 1.2 m s^(-1) when the standard deviation is between 60 and 70 m.A positive correlation exists between bias and terrain height error,with the ME increasing by 10%−30%for every 200 m increase in terrain height *** ME decreases by 65.6%when slope angle increases from(0.5°−1.5°)to larger than 3.5°for uphill winds but increases by 35.4%when the absolute value of slope angle increases from(0.5°−1.5°)to(2.5°−3.5°)for downhill *** sensitivity experiments are carried out with a model output statistical(MOS)calibration model for surface wind speeds and ME(RMSE)has been reduced by 90%(30%)by introducing terrain parameters,demonstrating the value of this study.

关键词： surface wind speed terrain features error analysis MOS calibration model