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芽孢表面展示系统及其在水产疫苗研发中的应用

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水生生物学报 2024年第4期48卷 694-706页

作者：昝子叶柯飞赵威山邹红王桂堂吴山功中国科学院水生生物研究所农业农村部淡水养殖病害防控重点实验室水产品种创制与高效养殖重点实验室(中国科学院)武汉430072 中国科学院大学北京100049

水产养殖动物疾病的发生日益频繁,给整个行业造成了巨大的经济损失。口服疫苗可以有效预防疾病的发生,同时不会造成应激反应,更适用于水产动物疾病的预防。芽孢杆菌是水产中常用益生菌,能够形成抗逆性强的芽孢,芽孢能够被用来构建芽孢... 详细信息

水产养殖动物疾病的发生日益频繁,给整个行业造成了巨大的经济损失。口服疫苗可以有效预防疾病的发生,同时不会造成应激反应,更适用于水产动物疾病的预防。芽孢杆菌是水产中常用益生菌,能够形成抗逆性强的芽孢,芽孢能够被用来构建芽孢表面展示系统,进而成为抗原呈递的理想平台。因而,利用芽孢表面展示口服疫苗并将抗原稳定地呈递到肠道,发挥更加高效的免疫性能的研究受到了越来越多的关注。文章综述了芽孢杆菌芽孢和感受态,以及芽孢表面展示系统,此外,还特别概述了芽孢作为口服疫苗载体在预防水产动物细菌病、病毒病和寄生虫病方面的研究与应用,以期为水产养殖动物高效稳定口服疫苗的开发提供参考。

关键词：芽孢表面展示系统芽孢口服疫苗水产动物疾病

Avoiding misdiagnosis of multilocular thymic cysts as malignant tumors on computer tomography

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World Journal of Clinical Cases 2024年第19期12卷 3671-3675页

作者： Yu-Hong Zhang Yan-Miao Liu Kai-Li Shen Jing-Jing Wu Fu-shan tang Key Laboratory of Clinical Pharmacy in Zunyi City Zunyi Medical UniversityZunyi 563006Guizhou ProvinceChina Department of Traditional Chinese Medicine Central Hospital in Jinchang CityJinchang 737102Gansu ProvinceChina The First Clinical Institute Zunyi Medical UniversityZunyi 563006Guizhou ProvinceChina Department of Clinical Pharmacy Key Laboratory of Basic Pharmacology of Guizhou Province and School of PharmacyZunyi Medical UniversityZunyi 563006Guizhou ProvinceChina

This editorial provides insights from a case report by Sun et al published in the World Journal of Clinical *** case report focuses on a case where a multilocular thymic cyst(MTC)was misdiagnosed as a thymic tumor,resulting in an unnecessary surgical *** MTCs and thymic tumors are rare conditions that heavily rely on radiological imaging for accurate ***,the similarity in their imaging presentations can lead to misinterpretation,resulting in unnecessary surgical *** to the ongoing lack of comprehensive knowledge about MTCs and thymic tumors,we offer a summary of diagnostic techniques documented in recent literature and examine potential causes of *** computer tomography(CT)values surpass 20 Hounsfield units and display comparable morphology,there is a risk of misdiagnosing MTCs as thymic *** various differential diagnostic methods like biopsy,molecular biology,multi-slice CT,CT functional imaging,positron emission tomography/CT molecular functional imaging,magnetic resonance imaging and radiomics,proves advantageous in reducing clinical misdiagnosis.A deeper understanding of these conditions requires increased attention and exploration by healthcare ***,the continued advancement and utilization of various diagnostic methods are expected to enhance precise diagnoses,provide appropriate treatment options,and improve the quality of life for patients with thymic tumors and MTCs in the *** advancement and utilization of various diagnostic methods are expected to enhance precise diagnoses,provide appropriate treatment options,and improve the quality of life for patients with thymic tumors and MTCs in the future.

关键词： Thymic tumor Multilocular thymic cyst Misdiagnosis Differential diagnosis Imaging manifestation Computed tomography

Ganoboninketal C from Ganoderma boninense improves the efficacy of CDDP-based chemotherapy through inhibiting translesion DNA synthesis

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Food Science and Human Wellness 2024年第5期13卷 2982-2992页

作者： Xiaolu Ma Fei Yang Ke Ma Hongyan Shen Junjie Han Kai Wang Yeran Yang Jiawei Zhu Ruiyuan An Qilin Wang Tie-shan tang Bo Zhou Hongwei Liu Caixia Guo College of Biomedical Engineering Taiyuan University of TechnologyTaiyuan 030024China CAS Key Laboratory of Genomics and Precision Medicine Beijing Institute of Genomics/China National Center for BioinformationUniversity of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100101China State Key Laboratory of Membrane Biology Institute of ZoologyUniversity of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100101China Institute of Microbiology University of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100101China

Translesion DNA synthesis(TLS)can bypass DNA lesions caused by chemotherapeutic drugs,which usually result in drug *** its key role in mutagenesis and cell survival after DNA damage,inhibition of the TLS pathway has emerged as a potential target for improving the efficacy of DNA-damaging agents such as cisplatin(CDDP),a widely used anticancer ***,few suitable natural TLS inhibitors have been ***,we found that a triterpenoid compound Ganoboninketal C(26-3)from Ganoderma boninense,a traditional Chinese medicine,can impair CDDP-induced TLS polymerase eta(Polη)focus formation,PCNA monoubiquitination as well as ***,26-3 can significantly sensitize tumor cells to CDDP killing and reduce the proportion of cancer stem cells in AGS and promote apoptosis after CDDP ***,26-3 can also sensitize tumor cells to Gefitinib ***,through RNA-seq analysis,we found that 26-3 could abrogate the CDDP-induced upregulation of Polηand PIDD(p53-induced protein with a death domain),2 known factors promoting TLS ***,we found that activating transcription factor 3 is a potential novel TLS *** together,we have identified a natural TLS inhibitor 26-3,which can be potentially used as an adjuvant to improve clinical efficacy.

关键词： Ganoderma boninense Ganoboninketal C Cisplatin chemotherapy Translesion DNA synthesis

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基于逆变器死区补偿电流极性检测方法的改进

制造业自动化 2018年第7期40卷 15-18页

作者：刘辉钟俊唐珊珊安徽职业技术学院机电工程学院合肥230011

在传统坐标变换法的基础上,提出了一种改进坐标变换法的电流极性检测方法。首先将三相定子电流通过dq变换到同步旋转坐标系下,利用低通滤波器对变换后的电流进行滤波;然后通过2/3变换矩阵,将滤波后的旋转坐标系下两相直流电流转换成基... 详细信息

在传统坐标变换法的基础上,提出了一种改进坐标变换法的电流极性检测方法。首先将三相定子电流通过dq变换到同步旋转坐标系下,利用低通滤波器对变换后的电流进行滤波;然后通过2/3变换矩阵,将滤波后的旋转坐标系下两相直流电流转换成基波三相交流电流,进而可以直接判断三相电流的极性。实验表明该方法简单易于实现,检测速率高,具有良好工程应用价值。

关键词：死区补偿坐标变换法电流极性仿真

基于校本论的大学英语课程体系构建——以泰州学院为例

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宁波教育学院学报 2017年第6期19卷 14-18页

作者：徐佳唐姗姗姚悦江苏省泰州学院江苏泰州225300

根据教育部最新《大学英语教学指南》,大学英语课程设置不能千校一面,应具有多样性和针对性。文章从校本的角度,分析了当前大学英语课程设置现状,通过教师访谈,采用质性研究的方法找出存在问题和影响因素,并以泰州学院为例探讨如何构建... 详细信息

根据教育部最新《大学英语教学指南》,大学英语课程设置不能千校一面,应具有多样性和针对性。文章从校本的角度,分析了当前大学英语课程设置现状,通过教师访谈,采用质性研究的方法找出存在问题和影响因素,并以泰州学院为例探讨如何构建符合自身学校特色的大学英语课程体系,以实现大学英语的课程价值。

关键词：校本大学英语课程体系

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创新型人才英语应用能力需求调查和分析

湖北函授大学学报 2017年第6期30卷 141-142,145页

作者：徐佳唐姗姗姚悦泰州学院外国语学院江苏泰州225300

创新型人才是知识经济时代发展的关键资源,而人才的英语应用能力是企业融入国际市场的必备素质。本文以泰州学院16级非英语专业本科生和参与16年冬季高校毕业生招聘会泰州分会场的企业为调查对象,以问卷形式调查分析了企业对于创新型人... 详细信息

创新型人才是知识经济时代发展的关键资源,而人才的英语应用能力是企业融入国际市场的必备素质。本文以泰州学院16级非英语专业本科生和参与16年冬季高校毕业生招聘会泰州分会场的企业为调查对象,以问卷形式调查分析了企业对于创新型人才英语应用能力的需求以及影响学生英语应用能力的因素,并提出措施和建议,以期能够提升人才的创新能力和英语应用能力。

关键词：知识经济创新型人才英语应用能力

Autophagy-dependent ferroptosis may play a critical role in early stages of diabetic retinopathy

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World Journal of Diabetes 2024年第11期15卷 2189-2202页

作者： Wen-Jie Sun Xue-Dong An Yue-Hong Zhang shan-shan tang Yu-Ting Sun Xiao-Min Kang Lin-Lin Jiang Xue-Fei Zhao Qing Gao Hang-Yu Ji Feng-Mei Lian Department of Endocrinology Guang’anmen HospitalBeijing 100053China Department of Endocrinology Fangshan Hospital of Beijing University of Chinese MedicineBeijing 102400China Department of Endocrinology Changchun University of Chinese MedicineChangchun 130117Jilin ProvinceChina

Diabetic retinopathy(DR),as one of the most common and significant microvascular complications of diabetes mellitus(DM),continues to elude effective targeted treatment for vision loss despite ongoing enrichment of the understanding of its pathogenic mechanisms from perspectives such as inflammation and oxidative *** studies have indicated that characteristic neuroglial degeneration induced by DM occurs before the onset of apparent microvascular *** order to comprehensively grasp the early-stage pathological changes of DR,the retinal neurovascular unit(NVU)will become a crucial focal point for future research into the occurrence and progression of *** on existing evidence,ferroptosis,a form of cell death regulated by processes like ferritinophagy and chaperone-mediated autophagy,mediates apoptosis in retinal NVU components,including pericytes and ganglion ***-dependent ferroptosis-related factors,including BECN1 and FABP4,may serve as both biomarkers for DR occurrence and development and potentially crucial targets for future effective DR *** aforementioned findings present novel perspectives for comprehending the mechanisms underlying the early-stage pathological alterations in DR and open up innovative avenues for investigating supplementary therapeutic strategies.

关键词： Diabetic retinopathy Diabetes mellitus Retinal neurovascular unit Autophagy-dependent ferroptosis Early stage Mechanisms

A piezoelectric-driven microneedle platform for skin disease therapy

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The Innovation 2024年第3期5卷 110-121页

作者： Ziyan Chen Xin Liu Zixi Jiang Huayi Wu Tao Yang Lanyuan Peng Lisha Wu Zhongling Luo Mi Zhang Juan Su Yan tang Jinmao Li Yang Xie Han shan Qibo Lin Xiuli Wang Xiang Chen Hanmin Peng Shuang Zhao Zeyu Chen Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China Furong Laboratory(Precision Medicine) Changsha 410008China National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Engineering Research Center of Skin Health and Disease Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Skin Cancer and Psoriasis Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center of Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China School of Mechanical and Electrical Engineering Central South UniversityChangsha 410083China Department of Dermatology Xijing HospitalThe Fourth Military Medical UniversityXi’anShaanxi 710000China State Key Laboratory of Mechanics and Control for Aerospace Structures Nanjing University of Aeronautics&AstronauticsNanjing 210016China Institute of Photomedicine Shanghai Skin Disease HospitalSchool of MedicineTongji UniversityShanghai 200443China

With over a million cases detected each year,skin disease is a global public health problem that diminishes the quality of life due to its difficulty to eradicate,propensity for recurrence,and potential for post-treatment *** therapy(PDT)is a treatment with minimal invasiveness or scarring and few side effects,making it well tolerated by ***,this treatment requires further research and development to improve its effective clinical ***,a piezoelectric-driven microneedle(PDMN)platform that achieves high efficiency,safety,and non-invasiveness for enhanced PDT is *** platform induces deep tissue cavitation,increasing the level of protoporphyrin IX and significantly enhancing drug penetration.A clinical trial involving 25 patients with skin disease was conducted to investigate the timeliness and efficacy of PDMN-assisted PDT(PDMN-PDT).Our findings suggested that PDMN-PDT boosted treatment effectiveness and reduced the required incubation time and drug concentration by 25%and 50%,respectively,without any anesthesia compared to traditional *** findings suggest that PDMN-PDT is a safe and minimally invasive approach for skin disease treatment,which may improve the therapeutic efficacy of topical medications and enable translation for future clinical applications.

关键词： needle anesthesia clinical

基于课程中心平台的《仪器分析》课程思政研究与实践

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广州化工 2020年第6期48卷 184-185,194页

作者：肖新生唐珊珊湖南科技学院化学与生物工程学院湖南永州425199

全国高校思想政治工作会议强调,要促使各类课程与思想政治理论课同向同行,形成协同效应。本文通过对仪器分析课程思政改革的现状进行分析,对课程中蕴含的思政元素进行挖掘,结合课程中心的网络教学功能,积极探索仪器分析专业教育与思政... 详细信息

全国高校思想政治工作会议强调,要促使各类课程与思想政治理论课同向同行,形成协同效应。本文通过对仪器分析课程思政改革的现状进行分析,对课程中蕴含的思政元素进行挖掘,结合课程中心的网络教学功能,积极探索仪器分析专业教育与思政教育有机结合的方法。同时本文通过科研和实践与课程平台有机结合提升学生掌握先进仪器分析技能,以期为类似课程的课程思政教学改革提供参考。

关键词：课程思政仪器分析课程教学改革课程中心