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Safety and immunogenicity of a mosaic vaccine booster against Omicron and other SARS-CoV-2 variants:a randomized phase 2 trial

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Signal Transduction and Targeted Therapy 2023年第2期8卷 672-682页

作者： Nawal Al Kaabi Yun kai yang Yu Liang Ke xu xue Feng zhang Yun Kang Yu Qin Jin Jun wei Hou jing zhang Tian yang Salah Hussein Mohamed Saif ElDein Ze Hua Lei Hao zhang Shuai Shao zhao Ming Liu Ning Liu Xiang Zheng Ji Guo Su Sen Sen yang Xiangfeng Cong yao Tan Wenwen Lei xue Jun Gao Zhiwei Jiang Hui Wang Meng Li Hanadi Mekki Mekki Walid Zaher Sally Mahmoud xue zhang Chang Qu Dan ying Liu jing zhang Mengjie yang Islam Eltantawy Peng Xiao Fu Jie Shen Jin Juan Wu Zi Bo Han Li Fang Du Fang tang Shi chen Zhi jing Ma Fan Zheng ya Nan Hou Xin Yu Li Xin Li zhao Nian Wang Jin Liang Yin Xiao yan Mao Jin zhang Liang Qu Yun Tao zhang Xiao Ming yang Guizhen Wu Qi Ming Li Sheikh Khalifa Medical City SEHAAbu DhabiUAE College of Medicine and Health Sciences Khalifa UniversityAbu DhabiUAE China National Biotec Group Company Limited BeijingChina The Sixth Laboratory National Vaccine and Serum Institute(NVSI)BeijingChina National Engineering Center for New Vaccine Research BeijingChina National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention(China CDC)BeijingChina Clinical Medicine Office National Vaccine and Serum Institute(NVSI)BeijingChina Lanzhou Institute of Biological Products Company Limited LanzhouChina Beijing Key Tech Statistical Consulting Co. LtdBeijingChina Beijing Institute of Biological Products Company Limited BeijingChina Union 71 Abu DhabiUAE G42 Healthcare Abu DhabiUAE

An ongoing randomized,double-blind,controlled phase 2 trial was conducted to evaluate the safety and immunogenicity of a mosaic-type recombinant vaccine candidate,named NVSI-06-09,as a booster dose in subjects aged 18 years and older from the United Arab Emirates(UAE),who had administered two or three doses of inactivated vaccine BBIBP-CorV at least 6 months prior to *** participants were randomly assigned with 1:1 to receive a booster dose of NVSI-06-09 or *** primary outcomes were immunogenicity and safety against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron variant,and the exploratory outcome was cross-immunogenicity against other circulating *** May 25 and 30,2022,516 adults received booster vaccination with 260 in NVSI-06-09 group and 256 in BBIBP-CorV *** results showed a similar safety profile between two booster groups,with low incidence of adverse reactions of grade 1 or *** immunogenicity,by day 14 post-booster,the fold rises in neutralizing antibody geometric mean titers(GMTs)from baseline elicited by NVSI-06-09 were remarkably higher than those by BBIBP-CorV against the prototype strain(19.67 vs 4.47-fold),Omicron BA.1.1(42.35 vs 3.78-fold),BA.2(25.09 vs 2.91-fold),BA.4(22.42 vs 2.69-fold),and BA.5 variants(27.06 vs 4.73-fold).Similarly,the neutralizing GMTs boosted by NVSI-06-09 against Beta and Delta variants were also 6.60-fold and 7.17-fold higher than those by *** findings indicated that a booster dose of NVSI-06-09 was well-tolerated and elicited broad-spectrum neutralizing responses against divergent SARS-CoV-2 variants,including Omicron and its sub-lineages.

关键词： phase neutral spectrum

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10B-doped MCP detector developed for neutron resonance imaging at Back-n white neutron source

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Nuclear Science and Techniques 2024年第8期35卷 58-68页

作者： Qiang Li Li‑Jiao Wang jing‑Yu tang Xiang‑Biao Qiu Zhen chen Mao‑Yuan zhao Chang‑Jun Ning kai Pan wei xu Tao Li Su‑Peng Lu Han Yi Rui‑Rui Fan Chang‑qing Feng Rong zhang Xiao‑yang Sun Qi An Hao‑Fan Bai Jiang‑Bo Bai Jie Bao Ping Cao Qi‑Ping chen Yong‑Hao chen Zeng‑Qi Cui An‑Chuan Fan Fan‑Zhen Feng Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑Zhu He Yong‑cheng He yang Hong Yi‑wei Hu Han‑Xiong Huang wei Jiang Zhi‑Jie Jiang Zheng‑yao Jin Ling Kang Bo Li Gong Li Xiao Li yang Li Jie Liu Rong Liu Shu‑Bin Liu Yi‑Na Liu Guang‑Yuan Luan Jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan zhao‑Hui Song Kang Sun Zhi‑Xin Tan Sheng‑Da tang Jin‑cheng Wang Peng‑cheng Wang zhao‑Hui Wang Zhong‑wei Wen Xiao‑Guang Wu xuan Wu Cong Xia Yong‑Ji Yu Guo‑Hui zhang Hang‑Chang zhang Lin‑Hao zhang Qi‑wei zhang Xian‑Peng zhang Yu‑Liang zhang Yue zhang Zhi‑Yong zhang Zhi‑Hao Zhou Ke‑Jun Zhu Chong Zou Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China dongguan Songshan Lake Future School Dongguan 523808China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China North Night Vision Science and Technology(Nanjing)Research Institute Co.Ltd Nanjing 211106China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Modern Physics Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China China Academy of Engineering Physics Institute of Nuclear Physics and ChemistryMianyang 621900China USTC archaeometry lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China China Shipbuilding Trading Co. LtdBeijing 100044China

Neutron resonance imaging(NRI)has recently emerged as an appealing technique for neutron *** complexity surpasses that of conventional transmission imaging,as it requires a high demand for both a neutron source and ***,the progression of NRI technology has been sluggish since its inception in the 1980s,particularly considering the limited studies analyzing the neutron energy range above *** white neutron source(Back-n)at the China Spallation Neutron Source(CSNS)provides favorable beam conditions for the development of the NRI technique over a wide neutron energy range from eV to ***-sensitive microchannel plates(MCP)have emerged as a cutting-edge tool in the field of neutron detection owing to their high temporal and spatial resolutions,high detection efficiency,and low *** this study,we report the development of a 10B-doped MCP detector,along with its associated electronics,data processing system,and NRI experiments at the *** heavy elements such as gold,silver,tungsten,and indium can be easily identified in the transmission images by their characteristic resonance peaks in the 1–100 eV energy range;the more difficult medium-weight elements such as iron,copper,and aluminum with resonance peaks in the 1–100 keV energy range can also be *** particular,results in the neutron energy range of dozens of keV(Aluminum)are reported here for the first time.

关键词： Neutron resonance imaging 10B doped MCP detector White neutron source Sample nuclide identification

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Digital LLRF controller for SSRF booster RF system upgrade

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Nuclear Science and Techniques 2015年第3期26卷 26-32页

作者：张志刚赵玉彬徐凯郑湘李正赵申杰常强侯洪涛马震宇罗琛毛冬青是晶王岩刘建飞 Shanghai Institute of Applied Physics Chinese Academy of Sciences University of Chinese Academy of Sciences Shanghai Key Laboratory of Cryogenics & Superconducting RF Technology

The low level radio frequency(LLRF) system for booster accelerator at Shanghai Synchrotron Radiation Facility(SSRF) was upgraded by a digital controller based on field programmable gate array(FPGA) *** of voltage, frequency and field flatness in the two 5-cell cavities are controlled to meet the requirements of booster. In this article, the ramping curve of cavity voltage, amplitude and phase control loop with vector sum of the two 5-cell cavities, tuning loop and field flatness loop are analyzed and discussed in detail.A different method in tuning loop is adopted due to the limitations of ADC channels. The function realizes energy ramping of electron beam from 150 Me V to 3.5 Ge V with a repetition rate of 2 Hz. With the new LLRF controller, the phase stability at ramping mode in 10 hours long operation is improved from ±1.5°(RMS) with open loop to ±0.15°(RMS) with close loop, while the detuning phase and field flatness are maintained to within ±2°and ±1%, respectively.

关键词：数字控制器射频系统 SSRF 低电平增强器现场可编程门阵列上海同步辐射装置控制回路

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In-beam gamma rays of CSNS Back-n characterized by black resonance filter

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Nuclear Science and Techniques 2024年第10期35卷 149-160页

作者： Jin-cheng Wang Jie Ren wei Jiang Xi-Chao Ruan ying-Yi Liu Hao-Lan yang Kuo-Zhi xu Xin-Yi Pan Qi Sun Jie Bao Han-Xiong Huang Hao-Fan Bai Jiang-Bo Bai Ping Cao Qi-Ping chen Yong-Hao chen Wen-Hao Duan An-Chuan Fan Rui-Rui Fan Chang-qing Feng Min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-Zhu He Yong-cheng He yang Hong Yi-wei Hu Zhi-Jie Jiang Ling Kang Chang-Lin Lan Bo Li Feng Li Qiang Li Xiao Li yang Li Jie Liu Rong Liu Shu-Bin Liu Yi-Na Liu Guang-Yuan Luan Chang-Jun Ning Yi-Jia Qiu Wen-kai Ren Zhi-Zhou Ren zhao-Hui Song Kang Sun Zhi-Xin Tan jing-Yu tang Sheng-Da tang Li-Jiao Wang Peng-cheng Wang zhao-Hui Wang Zhong-wei Wen Xiao-Guang Wu xuan Wu Ze-Peng Wu Cong Xia Li-Kun Xie Han Yi Tao Yu Yong-Ji Yu Guo-Hui zhang Hang-Chang zhang Qi-wei zhang Xian-Peng zhang Yu-Liang zhang Zhi-Yong zhang Mao-Yuan zhao Zhi-Hao Zhou Ke-Jun Zhu Chong Zou Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Modern Physics Fudan UniversityShanghai 200433China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China USTC Archaeometry Lab University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China Institute of Advanced Technology University of Science and Technology of ChinaHefei 230027China

The back-streaming white-neutron beamline(Back-n)of the China Spallation Neutron Source is an essential neutronresearch platform built for the study of nuclear data,neutron physics,and neutron *** types of cross-sectional neutron-reaction measurements have been performed at Back-n since early *** measurements have shown that a significant number of gamma rays can be transmitted to the experimental stations of Back-n along with the neutron *** gamma rays,commonly referred to as in-beam gamma rays,can induce a non-negligible experimental background in neutron-reaction *** the characteristics of in-beam gamma rays is important for understanding the experimental ***,measuring in-beam gamma rays is challenging because most gamma-ray detectors are sensitive to neutrons;thus,discriminating between neutron-induced signals and those from in-beam gamma rays is *** this study,we propose the use of the black resonance filter method and a CeBr_(3) scintillation detector to measure the characteristics of the in-beam gamma rays of *** types of black resonance filters,^(181)Ta,^(59)Co,^(nat)Ag,and^(nat)Cd,were used in this *** time-of-flight(TOF)technique was used to select the detector signals remaining in the absorption region of the TOF spectra,which were mainly induced by in-beam gamma *** energy distribution and flux of the in-beam gamma rays of Back-n were determined by analyzing the deposited energy spectra of the CeBr_(3) scintillation detector and using Monte Carlo *** on the results of this study,the background contributions from in-beam gamma rays in neutron-reaction measurements at Back-n can be reasonably evaluated,which is beneficial for enhancing both the experimental methodology and data analysis.

关键词： In-beam gamma rays Back-n CeBr_(3)scintillator Black filter resonance technique

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顶空固相微萃取/气相色谱/质谱法测定水中氯酚

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中国给水排水 2015年第21期31卷 138-140页

作者：张泾凯顾青清许小燕何敏董晓晨赵赛君苏州工业园区清源华衍水务有限公司水质检测中心江苏苏州215021

建立顶空固相微萃取／气相色谱／质谱法测定地表水和生活饮用水中2，4-二氯酚、2，4，6-三氯酚、五氯酚。结果表明，方法浓度范围均达到0．05～200μg／L，相关系数〉0．9980，2，4-二氯酚、2，4，6-三氯酚、五氯酚的检出限分别为0．01... 详细信息

建立顶空固相微萃取／气相色谱／质谱法测定地表水和生活饮用水中2，4-二氯酚、2，4，6-三氯酚、五氯酚。结果表明，方法浓度范围均达到0．05～200μg／L，相关系数〉0．9980，2，4-二氯酚、2，4，6-三氯酚、五氯酚的检出限分别为0．01、0．01、0．03μg／L，在加标量为1．00、15．0、160μg／L时，3种氯酚的平均回收率分别为（87．4％～109％）、（95．6％-107％）和（88．6％-102％），精密度RSD分别为（3．2％-7．2％）、（2．9％～6．9％）和（2．1％～6．3％），满足地表水和生活饮用水的检测要求。

关键词：氯酚固相微萃取气相色谱/质谱

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Associations of sleeping patterns and isotemporal substitution of other behavior with the prevalence of CKD in Chinese adults

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Frontiers of Medicine 2024年第2期18卷 303-314页

作者： Yi Ding Xiaoli xu Zhuojun Xin Qiuyu Cao Jiaojiao Huang Xianglin Wu yanan Huo Qin Wan yingfen Qin Ruying Hu Lixin Shi qing Su xuefeng Yu Li yan Guijun Qin xulei tang Gang chen Min xu Tiange Wang Zhiyun zhao Zhengnan Gao Guixia Wang Feixia Shen Zuojie Luo Li chen Qiang Li Zhen Ye Yinfei zhang Chao Liu Youmin Wang Tao yang Huacong Deng Lulu chen Tianshu Zeng Jiajun zhao Yiming Mu Shengli Wu Yuhong chen Jieli Lu weiqing Wang Guang Ning Yu xu Yufang Bi Mian Li Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of ChinaShanghai Key Laboratory for Endocrine TumorState Key Laboratory of Medical GenomicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang330000China Department of Endocrinology The Affiliated Hospital of Southwest Medical UniversityLuzhou646000China Department of Endocrinology The First Affiliated Hospital of Guangxi Medical UniversityNanning530000China Zhejiang Provincial Center for Disease Control and Prevention Hangzhou310000China Department of Endocrinology Affiliated Hospital of Guiyang Medical UniversityGuiyang550000China Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200000China Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430000China Sun yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou510000China Department of Endocrinology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450000China Department of Endocrinology The First Hospital of Lanzhou UniversityLanzhou730000China Fujian Provincial Hospital Fujian Medical UniversityFuzhou350000China Dalian Municipal Central Hospital Affiliated of Dalian Medical UniversityDalian116000China Department of Endocrinology The First Hospital of Jilin UniversityChangchun130000China Department of Endocrinology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325000China Qilu Hospital of Shandong University Jinan250000China Department of Endocrinology The Second Affiliated Hospital of Harbin Medical UniversityHarbin150000China Department of Endocrinology Cen

Studies have found a U-shaped relationship between sleep duration and chronic kidney disease(CKD)risk,but limited research evaluated the association of reallocating excessive sleep to other behavior with *** included 104538 participants from the nationwide cohort of the Risk Evaluation of Cancers in Chinese Diabetic Individuals:A Longitudinal Study,with self-reported time of daily-life *** isotemporal substitution models,we found that substituting 1 h of sleeping with sitting,walking,or moderate-to-vigorous physical activity was associated with a lower CKD ***-time physical activity displacement was associated with a greater prevalence reduction than occupational physical activity in working *** stratified analysis,a lower CKD prevalence related to substitution toward physical activity was found in long *** pronounced correlations were observed in long sleepers with diabetes than in those with prediabetes,and they benefited from other behavior substitutions toward a more active *** U-shaped association between sleep duration and CKD prevalence implied the potential effects of insufficient and excessive sleep on the kidneys,in which the pernicious link with oversleep could be reversed by time reallocation to physical *** divergence in the predicted effect on CKD following time reallocation to behavior of different domains and intensities and in subpopulations with diverse metabolic statuses underlined the importance of optimizing sleeping patterns and adjusting integral behavioral composition.

关键词： sleep physical activity chronic kidney disease isotemporal substitution behavioral pattern

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Panda X-III： Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers

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Science China(Physics,Mechanics & Astronomy) 2017年第6期60卷 8-47页

作者： xun chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling Hui Gu Ke Han Xiang dong Ji Heng Lin Jiang Lai Liu kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong yang Dan zhang Tao zhang Li zhao Xiang Ming Sun Shou yang Hu Si Yu Jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao zhang Ming Rui zhao jing Zhou ya Jun Mao Hao Qiao Si Guang Wang ying Yuan Meng Wang Amir N.Khan Neill Raper Jian tang wei Wang Jia Ning dong Chang qing Feng cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on Hector Mirallas Stephan Aune Eric Berthoumieux yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan Wick Haxton Yuan Mei Chinorat Kobdaj Yu-Peng yan NPAC and Department of Physics and Astronomy Shanghai Jiao Tong University Shanghai Laboratory for Particle Physics and Cosmology Shanghai 200240 China College of Physical Science and Technology Central China Normal University Wuhan 430079 China China Institute of Atomic Energy Beijing 102413 China School of Physics Peking University Beijing 100871 China School of Physics and Key Laboratory of Particle Physics and Particle Irradiation (MOE) Shandong University Jinan 250100 China School of Physics and Engineering Sun Yat-Sen University Guangzhou 510275 China Department of Modern Physics University of Science and Technology of China Hefei 230026 China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of China Hefei 230026 China University ofZaragoza C/P Cerbuna 12 50009 Zaragoza Spain IRFU CEA Universite Paris-Saclay F-91191 Gif-sur-Yvette France Department of Physics University of Maryland College Park MD 20742 USA Nuclear Science Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA Center for Excellence in High Energy Physics and Astrophysics Suranaree University of Technology Nakhon Ratchasima 30000 Thailand

Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation *** X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 *** pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the *** signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial *** detector will be immersed in a large water tank to ensure～5 m of water shielding in all *** second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds.

关键词： neutrinoless double beta decay lepton number violation underground experiment TPC Micromegas

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Er^(3+)/Yb^(3+)共掺杂氧氟硼硅酸盐微晶玻璃绿色上转换发光的温度特性

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发光学报 2015年第9期36卷 1001-1005页

作者：林杨杨陈铠炀唐霞艳赵士龙徐时清中国计量学院材料科学与工程学院浙江杭州310018

采用高温熔融法和热处理工艺制备得到透明的Er3+/Yb3+共掺杂氧氟微晶玻璃。XRD结果证实析出的纳米晶相为Ba YF5。在980 nm激发下,观察到强的绿光发射,源于Er3+的2H11/2→4I15/2和4S3/2→4I15/2跃迁的上转换发光。根据荧光强度比(FIR)的... 详细信息

采用高温熔融法和热处理工艺制备得到透明的Er3+/Yb3+共掺杂氧氟微晶玻璃。XRD结果证实析出的纳米晶相为Ba YF5。在980 nm激发下,观察到强的绿光发射,源于Er3+的2H11/2→4I15/2和4S3/2→4I15/2跃迁的上转换发光。根据荧光强度比(FIR)的方法研究了微晶玻璃上转换荧光的温度传感特性,其最大灵敏度在523 K时为0.003 4 K-1,表明Er3+/Yb3+共掺氧氟硼硅酸盐微晶玻璃上转换发光在高精度温度传感器方面具有一定的应用前景。

关键词：上转换荧光 Er3+离子氧氟微晶玻璃温度传感

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An all-round Al-Chemist with a scientific mind

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National Science Review 2022年第10期9卷 158-168页

作者： qing Zhu Fei zhang yan Huang Hengyu Xiao Lu Yuan zhao xu Chun zhang Tao Song Xin Sheng tang Xiang Li Guo He Bao chen Chong Jun Yi Zhou Yi Han zhang Baicheng zhang Jia Qi Cao Man Luo Song Wang Gui Lin Ye Wan Jun zhang Xin chen Shuang Cong donglai Zhou Huirong Li Jialei Li Gang Zou wei wei Shang Jun Jiang Yi Luo Hefei National Research Center for Physical Sciences at the Microscale School of Chemistry and Materials Science University of Science and Technology of China School of Information Science and Technology University of Science and Technology of China Hefei Ji Shu Quantum Technology Co.Ltd Hefei National Laboratory University of Science and Technology of China

The realization of automated chemical experiments by robots unveiled the prelude to an artificial intelligence(AI) *** AI-based systems or robots with specific chemical skills have been demonstrated,but conducting all-round scientific research remains ***,we present an all-round AI-Chemist e quipped with scientific data intelligence that is capable of performing basic tasks generally re quired in chemical *** on a service platform,the AI-Chemist is able to automatically read the literatures from a cloud database and propose experimental plans *** can control a mobile robot in-house or online to automatically execute the complete experimental process on 14workstations,including synthesis,characterization and performance *** experimental data can be simultaneously analysed by the computational brain of the AI-Chemist through machine learning and Bayesian optimization,allowing a new hypothesis for the next iteration to be *** competence of the AI-Chemist has been scrutinized by three different chemical *** the future,the more advanced all-round AI-Chemists equipped with scientific data intelligence may cause changes to the landscape of the chemical laboratory.

关键词： AI-Chemist computational brain mobile robot machine reading all-round research

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应用重叠参考图像透视技术易化环肺静脉电隔离术操作治疗阵发性心房颤动

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中华心律失常学杂志 2012年第2期16卷 107-110页

作者：唐恺肖彬赵冬冬张敬莹陈艳清徐亚伟同济大学附属第十人民医院心内科上海200072 浙江建德市第一人民医院心脏科

目的探讨重叠参考图像透视技术（OverlayRef）对环肺静脉电隔离术治疗阵发性心房颤动（房颤）的影响。方法人选194例阵发性房颤患者，随机分为OvedayRef组（97例）及对照组（97例）。OverlayRef组使用OverlayRef技术（将参考图像以反白... 详细信息

目的探讨重叠参考图像透视技术（OverlayRef）对环肺静脉电隔离术治疗阵发性心房颤动（房颤）的影响。方法人选194例阵发性房颤患者，随机分为OvedayRef组（97例）及对照组（97例）。OverlayRef组使用OverlayRef技术（将参考图像以反白的形式叠加于透视屏上）辅助环肺静脉电隔离术的操作。对照组常规方法完成环肺静脉电隔离术。比较两组的总消融手术时间、消融时间、X线曝光量、肺静脉隔离率及随访1年的成功率。结果两组患者的基线临床特征差异无统计学意义。所有患者均接受了环肺静脉电隔离术。OverlayRef组的消融时间[（89±13）min对（102±22）min，P〈0．01]和总消融术时间[（139±22）min对（162±31）min，P〈0．01]均明显比对照组短。OverlayRef组的x线曝光量[（13531±283）mGy对（13123±369）mGy]稍大，但差异无统计学意义（P〉0．05）。两组的环肺静脉电隔离率（97．9％对96．9％，P=NS）及随访1年的成功率（84．5％对81．4％，P〉0．05）差异也无统计学意义。结论OverlayRef技术可以易化环肺静脉电隔离术的操作，缩短房颤导管消融术的学习曲线。

关键词：环肺静脉电隔离术重叠参考图像透视技术电解剖标测心房颤动

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