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Dynamic mode decomposition of hairpin vortices generated by a hemisphere protuberance

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Science China(Physics,Mechanics & Astronomy) 2012年第1期55卷 118-124页

作者： tang ZhanQi JIANG nan Department of Mechanics Tianjin University Tianjin 300072 China Tianjin Key Laboratory of Modern Engineering Mechanics Tianjin 300072 China

We present dynamic mode decomposition (DMD) for studying the hairpin vortices generated by hemisphere protuberance measured by two-dimensional (2D) time-resolved (TR) particle image velocimetry (PIV) in a water channel. The hairpins dynamic information is extracted by identifying their dominant frequencies and associated spatial structures. For this quasi-periodic data system, the resulting main Dynamic modes illustrate the different spatial structures associated with the wake vortex region and the near-wall region. By comparisons with proper orthogonal decomposition (POD), it can be concluded that the dynamic mode concentrates on a certain frequency component more effectively than the mode determined by POD. During the analysis, DMD has proven itself a robust and reliable algorithm to extract spatial-temporal coherent structures.

关键词： hairpin vortices hemisphere protuberance time-resolved particle image velocimetry dynamic mode decomposition proper orthogonal decomposition

AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice

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Neural Regeneration Research 2025年第1期20卷 253-264页

作者： Zhengwei Hu Jing Yang Shuo Zhang Mengjie Li Chunyan Zuo Chengyuan Mao Zhongxian Zhang Mibo tang Changhe Shi Yuming Xu Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Academy of Medical Sciences of Zhengzhou University ZhengzhouHenan ProvinceChina NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Henan Key Laboratory of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Institute of Neuroscience Zhengzhou UniversityZhengzhouHenan ProvinceChina Sino-British Research Centre for Molecular Oncology National Centre for International Research in Cell and Gene TherapySchool of Basic Medical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Gerontology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina

The E3 ubiquitin ligase,carboxyl terminus of heat shock protein 70(Hsp70)interacting protein(CHIP),also functions as a co-chaperone and plays a crucial role in the protein quality control *** this study,we aimed to investigate the neuroprotective effect of overexpressed CHIP on Alzheimer’s *** used an adeno-associated virus vector that can cross the blood-brain barrier to mediate CHIP overexpression in APP/PS1 mouse *** overexpression significantly ameliorated the performance of APP/PS1 mice in the Morris water maze and nest building tests,reduced amyloid-βplaques,and decreased the expression of both amyloid-βand phosphorylated *** also alleviated the concentration of microglia and astrocytes around *** APP/PS1 mice of a younger age,CHIP overexpression promoted an increase in ADAM10 expression and inhibitedβ-site APP cleaving enzyme 1,insulin degrading enzyme,and neprilysin *** of HSP70 and HSP40,which have functional relevance to CHIP,were also *** nuclei transcriptome sequencing in the hippocampus of CHIP overexpressed mice showed that the lysosomal pathway and oligodendrocyte-related biological processes were up-regulated,which may also reflect a potential mechanism for the neuroprotective effect of *** research shows that CHIP effectively reduces the behavior and pathological manifestations of APP/PS1 ***,overexpression of CHIP could be a beneficial approach for the treatment of Alzheimer’s disease.

关键词： adeno-associated virus Alzheimer’s disease APP/PS1 mice carboxyl terminus of Hsp70 interacting protein gene therapy

Theoretical Investigation of Operation Modes of MHD Generators for Energy-bypass Engines

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Journal of Thermal Science 2014年第6期23卷 580-585页

作者： Jingfeng tang nan Li Daren Yu Harbin Institute of Technology

A MHD generator with different arrangements of electromagnetic fields will lead the generator working in three modes.A quasi-one-dimensional approximation is used for the model of the MHD generator to analyze the inner mechanism of operation *** the MHD generator with a uniform constant magnetic field,a specific critical electric field E_(cr) is required to decelerate a supersonic entrance flow into a subsonic exit ***,the generator works in a steady mode with a larger electric field than E_(cr) in which a steady supersonic flow is provided at the exit,or the generator works in a choked mode with a smaller electric field than E_(cr) in which the supersonic entrance flow is choked in the *** detailed flow field characteristics in different operation modes are discussed,demonstrating the relationship of operation modes with electromagnetic fields.

关键词： Energy-bypass engines MHD generators Operation modes

Quantum noise of a harmonic oscillator under classical feedback control

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Chinese Physics B 2020年第9期29卷 212-216页

作者： Feng tang nan Zhao Beijing Computational Science Research Center Beijing 100193China

Quantum sensing has been receiving researcher's attention these years due to its ultrahigh sensitivity and precision. However, the bandwidth of the sensors may be low, thus limiting the scope of their practical applications. The low-bandwidth problem is conquered by feedback control methods, which are widely utilized in classic control fields. Based on a quantum harmonic oscillator model operating near the resonant point, the bandwidth and sensitivity of the quantum sensor are analyzed. The results give two important conclusions: (a) the bandwidth and sensitivity are two incompatible performance parameters of the sensor, so there must be a trade-off between bandwidth and sensitivity in practical applications;(b) the quantum white noise affects the signal to be detected in a non-white form due to the feedback control.

关键词： quantum sensing feedback sensitivity bandwidth

A portable single-cell analysis system integrating hydrodynamic trapping with broadband impedance spectroscopy

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Science China(Technological Sciences) 2017年第11期60卷 1707-1715页

作者： tang WenLai tang DeZhi NI ZhongHua XIANG nan YI Hong Jiangsu Key Laboratory for Design and Manufacture of Micro-nano Biomedical Instruments School of Mechanical EngineeringSoutheast UniversityNanjing 211189China

In this paper, we present a portable single-cell analysis system with the hydrodynamic cell trapping and the broadband electrical impedance spectroscopy （EIS）. Using the least flow resistance path principle, the hydrodynamic cell trapping in serpentine arrays can be carried out in a deterministic and automatic manner without the assistance of any external fields. The experimental results show that a cell trap rate of higher than 95% can be easily achieved in our ceil trapping microdevices. Using the maximum length sequences （MLS） technique, our home-made EIS is capable of measuring the impedance spectrum ranging from 1.953 kHz to 1 MHz in approximately 0.5 ms. Finally, on the basis of the developed single-cell analysis system, we precisely monitor the trapping process of human breast tumor cells （MCF-7 cells） according to the changes of electrical impedance. The MCF-7 cells with different trapping conditions or sizes can also be clearly distinguished through the impedance signals. Our portable single-cell analysis system may provide a promising tool to monitor single cells for long periods of time or to discriminate cell types.

关键词： single-cell analysis hydrodynamic cell trapping broadband impedance spectroscopy maximum length sequences

TR PIV Experimental Investigation on Bypass Transition Induced by a Cylinder Wake

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Chinese Physics Letters 2011年第5期28卷 172-175页

作者： tang Zhan-Qi JIANG nan Department of Mechanics Tianjin UniversityTianjin 300072 Tianjin Key Laboratory of Modern Engineering Mechanics Tianjin UniversityTianjin 300372

The process of laminar to turbulent transition induced by a cylinder wake is studied by time-resolved(TR)particle image velocimetry(PIV)in a water *** combination of multi-scale local-averaged structure function analysis with criteria is used to identify the generation of secondary transverse vortex structure andto track its evolution along the *** the beginning of transition,with the decent of cylinder wake vortex,the secondary vortex structure is induced near the *** the secondary vortex moves dovnstream,it is induced to lift up by the wake vortex,meanwhile they are diffused and *** to the method of spatial conditional average,a low-speedhump is found in the near-wallregion along the bypass transition zone,accompanied by a low-speed region in the free stream occupied by the vake *** further downstream,the hump in the near-wall region becomes more and more *** the later stage of transition zone,hairpin vortex can be seen by conditional-averaged low-pass filtered *** hairpin head is almost vertical to the wall with an inclination angle of about 90°,which is attributed to the additional lift-up behavior induced by wake *** can be concluded that in the process of bypass transition,the wake vortex would not only induce the secondary vortex but also leaven its growth and evolution,resulting in the robust and rapidly growing hairpin vortex.

关键词： vortex cylinder averaged

Revisiting the Model of Servicing Machines with Repairable Service Facility-A New Analyzing Idea and Some New Results

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Acta Mathematicae Applicatae Sinica 2010年第4期26卷 557-566页

作者： Ying-hui tang School of Fundamental Education Sichuan Normal UniversityChengdu 610066China School of Mathematics and Software Science Sichuan Normal UniversityChengdu 610066China

In this paper the model of servicing machines with repairable facility is further *** standard conditioning decomposition argument,two reliability indices-the probability that the service facility fails at time t and the expected number of failure occurring during（0,t] are *** important relations of them are ***,some new reliability problems are presented and discussed as follows：1） The numbers of the service facility failures during the generalized service time and the generalized busy period;2） The asymptotic expansion of the expected failure number of the service facility during（0,t].A series of new reliability results of the service facility are obtained.

关键词： Repairable service facility reliability index failure number breakdown

Preparation of silver nanoparticles through the reduction of straw-extracted lignin and its antibacterial hydrogel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 504-514页

作者： Lou Zhang Shuo Li Fu tang Jingkai Zhang Yuetong Kang Hean Zhang Lidong Li State Key Laboratory for Advanced Metals and Materials School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China

Silver nanoparticles(Ag NPs)have attracted attention in the field of biomaterials due to their excellent antibacterial ***,the reducing and stabilizing agents used for the chemical reduction of Ag NPs are usually toxic and may cause water *** this work,Ag NPs(31.2 nm in diameter)were prepared using the extract of straw,an agricultural waste,as the reducing and stabilizing *** analysis revealed that the straw extract contained lignin,the structure of which possesses phenolic hydroxyl and methoxy groups that facilitate the reduction of silver salts into Ag *** surfaces of Ag NPs were negatively charged due to the encapsulation of a thin layer of lignin molecules that prevented their *** the prepared Ag NPs were added to the precursor solution of acrylamide,free radical polymerization was triggered without the need for extra heating or light irradiation,resulting in the rapid formation of an Ag NP-polyacrylamide composite *** inhibition zone test proved that the composite hydrogel possessed excellent antibacterial ability due to the presence of Ag *** prepared hydrogel may have potential applications in the fabrication of biomedical materials,such as antibacterial dressings.

关键词： silver nanoparticles hydrogel straw extraction antibacterial

Endoscopic submucosal dissection combined with adjuvant chemotherapy for early-stage neuroendocrine carcinoma of the esophagus:A case report

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World Journal of Clinical Cases 2022年第10期10卷 3164-3169页

作者： nan tang Zhen Feng Department of Gastroenterology Shanghai Xuhui Center HospitalShanghai 200031China

BACKGROUND Neuroendocrine carcinoma(NEC)of the esophagus is rare and highly aggressive,and lacks biological ***,there are no established standard treatments for this *** this report,we describe a patient with large-cell NEC of the esophagus who was successfully treated using endoscopic submucosal dissection(ESD)combined with adjuvant *** SUMMARY A 55-year-old woman presented with intermittent mild dysphagia for 2 *** revealed a disc-shaped protruding lesion about 18 mm×18 mm in size on the upper *** ultrasonography demonstrated that the bulged lesion originated from the muscularis *** assessed en bloc resections using ESD for therapeutic diagnosis to devise a safe and appropriate *** examination revealed a poorly differentiated neoplasm comprising of large cells with marked nuclear atypia and multifocal *** addition,the specimens had a negative horizontal margin and vertical *** of invasion was classified as submucosa 2(SM2)without lymphovascular *** histopathological results were consistent with a diagnosis of esophageal NEC,large cell *** therapy has been considered for ESD patients with SM2/SM3 lesions and patients with poorly differentiated *** comprehensive consideration,we initiated combination treatment,i.e.,ESD plus adjuvant *** patient remained disease-free at the 2-year *** En bloc resection approach using ESD may play a vital role as a diagnostic and therapeutic modality for esophageal NEC.

关键词： Esophagus Neuroendocrine carcinoma Endoscopy Dissection Case report